Pharmacotherapy challenges in HIV patient with Plummer-Vinson Syndrome
July 2025
Plummer-Vinson Syndrome (PVS) is a rare condition characterized by the classic triad of dysphagia, iron-deficiency anemia or long-standing anemia, and esophageal web. We present a case of a 38-year-old...
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Ilaprazole: Distinctive pharmacokinetic and pharmacodynamic properties among proton pump inhibitors
July 2025
Ilaprazole is a new proton pump inhibitor (PPI) that provides effective and sustained intragastric acid suppression. As PPIs are foundational medications in the treatment of acid-related disorders,...
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Identification of key genes and pathways in the following pancreatic ductal adenocarcinoma (PDAC) using integrated bioinformatics analysis
July 2025
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, and understanding its molecular mechanisms is critical for improving diagnosis and treatment. This study analyzed microarray datasets...
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Upper GI endoscopy in children with Helicobacter pylori Infection: Insights from a six-year retrospective review
July 2025
Helicobacter pylori (H. pylori) is a prevalent bacterial infection acquired primarily during childhood, particularly in regions with poor sanitation and overcrowding. In Bangladesh, limited data exists...
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Endoscopic marginal assessment of fixed colorectal polyps accurately predicts complete resection after cold snare polypectomy:a prospective single-center observational study
July 2025
This study aimed to ascertain the effectiveness of using fixed cold snare polypectomy (CSP) specimens, accompanied by endoscopic assessment, in predicting complete resection outcomes....
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When the gut Speaks: The hidden toll of irritable bowel syndrome on body and mind
July 2025
Irritable bowel syndrome (IBS) is a multifaceted gastrointestinal disorder that transcends the gut, affecting the physical, psychological, and social well-being of millions worldwide. Despite its prevalence,...
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Prevalence of sleep apnea amongst the population of Saudi Arabia
July 2025
This cross-sectional study aimed to assess the prevalence of sleep apnea among the gastritis population in Saudi Arabia and explore its associations with sociodemographic factors, health conditions,...
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Prospects of clinical trials for novel therapeutic approaches in celiac disease
July 2025
Celiac disease (CD) is a chronic a multifactorial immune-mediated systemic inflammatory disease of the small intestine caused by genetic and environmental factors, elicited by the ingestion of dietary...
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The Frequency and Characteristics of Inflammatory Bowel Disease in Pediatric Patients with Hirschsprung's Disease: A Case-Control Study
Available online 4 June 2025
Hirschsprung disease is associated with enterocolitis and inflammatory bowel disease (IBD) as it affects bowel innervation from birth. This study is about the evaluation of IBD in children with diagnosed...
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The Human-AI Frontier: An In-Depth Exploration of Physicians' Apprehension and Outlook Towards Artificial Intelligence in Gastroenterology Healthcare
Available online 11 May 2025
Recent advances in artificial intelligence (AI) have transformed healthcare, offering potential in diagnosis, treatment, and patient management in gastroenterology. Understanding physicians' attitudes...
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The digestive system under microgravity environment: Changes, mechanisms and the prospects of the future
April 2025
In recent years, the space industry has continued to improve and develop, and human beings have been staying in space for longer periods while facing the challenges of microgravity to human life. The...
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Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies
April 2025
Colorectal cancer (CRC) has an incidence rate of 10 % and is the third most common cause of mortality worldwide, following breast and lung cancer. The clinical symptoms of CRC appear in the last phases...
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Alcohol-associated liver disease: A review
April 2025
Alcohol-associated Liver Disease (ALD) is a collection of liver disorders caused by prolonged and excessive alcohol consumption, ranging from fatty liver alterations to fibrosis and cirrhosis. This...
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Esophageal adenocarcinoma with unexpectedly high AFP levels: A diagnostic challenge
April 2025
Alpha-fetoprotein (AFP)-producing Esophageal Adenocarcinoma (EAC) is an extremely rare entity with only a few cases reported till date. Reporting the first case of AFP producing EAC from Pakistan....
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Extensive recurrence of colon adenocarcinoma: A case of cutaneous metastasis to the legs and its clinical implication
April 2025
The rate of cutaneous metastases in cancer patients overall is reported at highly variable rates, presenting in up to 5% of visceral malignancies. Colorectal carcinoma most commonly metastasizes to...
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Ultrasonic diagnosis of hepatic and splenic infarction: A case report
April 2025
It is extremely rare for both the liver and spleen to experience infarction simultaneously. Hepatic and splenic infarction is a severe condition, and early diagnosis has a significant impact on the...
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Automated liver segmentation from CT images using modified ResUNet
April 2025
The Segmentation of liver from computed tomography (CT) images is a critical task in medical research particularly when employing deep learning methods. Most doctors prefer to use Computed tomography...
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Diagnostic efficacy of computed tomography angiography for acute gastrointestinal bleeding
April 2025
Computed tomography angiography (CTA) is the radiologic test for acute gastrointestinal bleeding (GIB). We aimed to (1) identify the clinical factors associated with (a) positive CTA findings, (b) positive...
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Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia
January 2025
Peptic ulcer disease's (PUD) global significance, emphasizing its health burdens and associations with factors like Helicobacter pylori infection and lifestyle habits. The need for comprehensive approaches...
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Subcutaneous panniculitis as complication of valproate-induced pancreatitis
January 2025
Medications and drugs constitute a well-known etiology of pancreatitis. Rare signs and symptoms of the disease can occur. We present a case of pancreatitis caused by valproic acid and that was complicated...
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Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis
January 2025
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unpredictable colon and rectum inflammation episodes. Evaluating disease activity is essential for effective management. The systemic...
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Liver lobes and cirrhosis: Diagnostic insights from lobar ratios
January 2025
Liver cirrhosis is the formation of abnormal nodular structure and fibrosis. Globally it accounts for 4 % of all deaths. Alcohol, viral hepatitis, and non-alcoholic fatty liver disease are the most...
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A rare case of hemobilia caused by acute cholecystitis with an underlying gallbladder aneurysm
January 2025
We present a case of a patient who presented with upper gastrointestinal bleeding, obstructive jaundice and bacteremia, of which the underlying cause turned out to be hemobilia from acute cholecystitis...
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