Most Cited Articles

Open access

ISSN: 2352-3042
CN: 50-1221/R
p-ISSN: 2352-4820

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

CCL5/CCR5 axis in human diseases and related treatments

The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases

Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials

Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation

Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine

A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics

The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Pretreating and normalizing metabolomics data for statistical analysis

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

Mitochondrial dysfunction: A promising therapeutic target for liver diseases

Cancer: An unknown territory; rethinking before going ahead

Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

Targeting LIF/LIFR signaling in cancer

Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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