Most Cited Articles

Open access

ISSN: 2352-3042
CN: 50-1221/R
p-ISSN: 2352-4820

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

CCL5/CCR5 axis in human diseases and related treatments

The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases

Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials

Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation

Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine

The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Cancer: An unknown territory; rethinking before going ahead

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics

Mitochondrial dysfunction: A promising therapeutic target for liver diseases

Targeting LIF/LIFR signaling in cancer

Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications

Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

Pretreating and normalizing metabolomics data for statistical analysis

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

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