Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
June 2018
As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public health challenge on a global scale. Breast cancer consists of a group of biologically and molecularly...
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Bone Morphogenetic Protein (BMP) signaling in development and human diseases
September 2014
Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially discovered for their ability to induce...
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Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy
January 2022
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina...
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Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics
Available online 18 March 2022
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that cause millions of deaths every year. With the new understanding of the molecular...
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Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine
March 2021
Molecular subtypes-based therapies offer new potential framework for desired and precise outcome in clinical settings. Current treatment strategies in colorectal cancer are largely ‘one drug fit all’...
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3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends
December 2017
Advances in three-dimensional (3D) printing have increased feasibility towards the synthesis of living tissues. Known as 3D bioprinting, this technology involves the precise layering of cells, biologic...
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Temozolomide resistance in glioblastoma multiforme
September 2016
Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocytomas. However, at least 50% of TMZ treated patients do not respond to TMZ. This is due primarily...
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Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; a critical review
June 2019
The emergence of antibiotic resistant bacteria in the healthcare is a serious concern. In the Healthcare premises precisely intensive care unit are major sources of microbial diversity. Recent findings...
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The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases
May 2021
The nuclear factor kappa B (NF-kB) family of transcription factors plays an essential role as stressors in the cellular environment, and controls the expression of important regulatory genes such as...
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Dirty environment for adult life: The bad, the good, the unknown
September 2016
We know the bad things of dirty environment which is associated with infectious diseases. In this Research Watch, we discuss the good and the unknown of dirty environment, based on a recent Nature paper....
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Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine
July 2022
Latin-America (LATAM) is the second region in gastric cancer incidence; gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic...
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Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance
March 2021
Colorectal cancer is a leading cause of cancer deaths. Most colorectal cancer patients eventually develop chemoresistance to the current standard-of-care therapies. Here, we used patient-derived colorectal...
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Highlighting novel genes associated with the classical Rett syndrome patient from India
November 2022
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Fibroblast growth factor (FGF) signaling in development and skeletal diseases
December 2014
Fibroblast growth factors (FGF) and their receptors serve many functions in both the developing and adult organism. Humans contain 18 FGF ligands and four FGF receptors (FGFR). FGF ligands are polypeptide...
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Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine
June 2017
With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology, it is anticipated that increasing numbers of therapeutic genes or targets...
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Drugging IGF-1R in cancer: New insights and emerging opportunities
January 2023
The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long been recognized for...
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Autophagy in pulmonary fibrosis: friend or foe?
November 2022
Autophagy is an evolutionarily conserved process where long-lived and damaged organelles are degraded. Autophagy has been widely associated with several ageing-process as well in diseases such as neurodegeneration,...
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With newer tools for gene editing, is it time to revisit genetic therapy for cystic fibrosis?
March 2021
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PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells
January 2022
Filopodia, a finger-like structure and actin-rich plasma-membrane protrusion at the leading edge of the cell, has important roles in cell motility. However, the mechanisms of filopodia generation are...
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Genetic diseases conferring resistance to infectious diseases
September 2015
This review considers available evidence for mechanisms of conferred adaptive advantages in the face of specific infectious diseases. In short, we explore a number of genetic conditions, which carry...
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Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials
January 2023
Molecular target inhibitors have been regularly approved by Food and Drug Administration (FDA) for tumor treatment, and most of them intervene in tumor cell proliferation and metabolism. The RAS–RAF–MEK–ERK...
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PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling
November 2022
Progranulin (PGRN) is a growth factor that is involved in the progression of multiple tumors. However, the effects and molecular mechanisms by which PGRN induces lung cancer remain unclear. The expression...
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The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer
September 2020
Metastasis and metabolism reprogramming are two major hallmarks of cancer. In the initiation and progression of cancer, tumor cells are known to undergo fundamental metabolic changes to sustain their...
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CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1/2 and RUNX2 pathways
November 2021
Osteoporosis, fracture, large-scale craniofacial defects and osteonecrosis are hot topics and are still underdiagnosed and undertreated in the clinic. It is urgent to understand the molecular mechanisms...
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