The oncogenic role of CCDC178 in intrahepatic cholangiocarcinoma through LGR4-dependent signaling and immune modulation
September 2026
Decoding age-stratified mutational landscapes in CNS lymphoma via genomic and survival profiling for precision oncology
September 2026
SERTAD4-AS1 suppresses pancreatic cancer progression by stabilizing SERTAD4 and inhibiting the Notch1 pathway
September 2026
NLRP3 deficiency reprograms hepatic glucose metabolism but fails to ameliorate hepatic inflammation and fibrosis in the MCD model
September 2026
Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes
September 2026
An autophagy-related molecule reticulon 3 functions as a novel prognostic biomarker in hepatocellular carcinoma
September 2026
miR-27a expression during inflammatory organ injury associated with ARDS and a novel tissue-specific knockout model
September 2026
GBM-Dx SIGNAL: Blood transcriptomics complementing neuroimaging to differentiate glioblastoma recurrence from treatment effects
September 2026
Two novel murine esophageal cancer cell line models exhibiting distinct sensitivities to immunotherapy
September 2026
Human Gordon Holmes Syndrome modeling in mice reveals essential function of RNF216 ubiquitination in spermatogenesis and male fertility
September 2026
Ammonia-induced cell death patterns in glioblastoma: Immune landscape, prognostic signature, and therapeutic target identification
September 2026
From inactivation to intervention: X chromosome silencing in disease pathogenesis and emerging therapeutic strategies
September 2026
X chromosome inactivation (XCI) is a crucial epigenetic mechanism that balances X-linked gene expression in females via random silencing of one X chromosome. Skewed XCI—non-random inactivation favoring...
Current progress and role of lncRNAs in HBV infection and progression of hepatocellular carcinoma
September 2026
Infection with hepatitis B virus (HBV) remains a severe concern to public health, with roughly 292 million people worldwide suffering from the chronic form of the disease, for which there is no cure....
Trained immunity: New insights into pathogenesis and therapeutic targets in diabetes and diabetic complications
September 2026
Diabetes mellitus, a chronic metabolic condition, is marked by ongoing hyperglycemia and poses an increasing global health issue. Beyond its recognized contribution to the development of cardiovascular...
Pan-cancer analysis and mechanistic insights of tuft cell-like tumors
September 2026
Tuft cells are rare, chemosensory epithelial cells present in various tissues, including the respiratory and gastrointestinal tracts. Recent studies have revealed their significant role in cancer biology,...
Pathophysiological mechanisms of organ injury in Fabry disease: Update via multi-omics
September 2026
Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in GLA gene, which result in deficient α-galactosidase A activity, leading to intralysosomal accumulation of metabolic...
Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies
September 2026
Piezo ion channels, notably Piezo1 and Piezo2, are key mechanosensors that transduce mechanical forces into intracellular signals, playing indispensable roles in digestive physiology. These channels...
Interaction between N6-methyladenosine (m6A) modification and toxicant-related neurodegeneration: From neural development to pathophysiology
September 2026
N6-methyladenosine (m6A) modification is a crucial epigenetic mechanism that is widely expressed across various tissues and biological systems. It regulates gene expression by influencing the stability...
