Recent Articles

Targeting TMEM16A/ANO1 inhibits the progression of BRAF mutant (V600E) melanoma through the MEK/ERK and AKT signaling pathways

November 2024

Meiyun Shi | Jiahui Wang | Xingyu Huang | Linsu Liu | Lutao Liu | Na Zhou | Xinqi Shan | Huaqun Chen

Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia

November 2024

Fei Ao | Fan Chen | Minhong Lv | Yuming Cao | Jinfeng Xu | Jingbo Xu | Anskar Yu-Hung Leung | Qiwen Yuan | Li Wang | Bailiang He

Identification of a novel germline APC N-terminal pathogenic variant associated with attenuated familial adenomatous polyposis

November 2024

Giovanna Forte | Valentina Grossi | Filomena Cariola | Antonia Lucia Buonadonna | Paola Sanese | Katia De Marco | Candida Fasano | Martina Lepore Signorile | Vittoria Disciglio | Cristiano Simone

PDLIM1 sustains DNA damage response by promoting chromatin relaxation and activating DNA–PK complex

November 2024

Yue Lang | Dexuan Gao | Lan Yu | Xiang-Xiang Zhang | Debabrata Saha | Benjamin P.C. Chen | Meng-Meng Gu | Zeng-Fu Shang

In-depth profiling of tumor tissue derived from malignant pleural mesothelioma patients identifies potential biomarkers predicting response to immune-checkpoint inhibitor therapy

November 2024

Dmitrii Shek | Bo Gao | Hema Mahajan | Adnan Nagrial | Matteo S. Carlino | Fabio Luciani | Scott A. Read | Golo Ahlenstiel

RNA binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma metastasis by regulating Slug mRNA stability

November 2024

Yao Liu | Huan Feng | Qi Zhao | Xiao Liang | Ying Wang | Shuai Xiao | Suqin Shen | Jiaxue Wu

The efficacy and safety of NeuroWell antidepressant dietary supplement, Deanxit, and their combination in the treatment of mild-to-moderate depression: A randomized clinical trial

November 2024

Honglei Yin | Zhuxin Sui | Yutong Wang | Dechen Liu | Qinglu Wang | Yanchao Wang | Lei Sun | Jinfeng Li | Zhen Li | Yue Liu | Shang Guo | Wenwen Wang | Hongtao Yin | Ping Liu | Kezhong Zhang | Huaibo Zhang | Yajun Liu | Yanqiu Liu | Qiqi Zhou | Dianfang Wei | Hui Zhang | Shanshan Wang | Yaochao Ning | Shuang Geng | Xuejun Wen | Youping Deng | Hongwei Wang | Yunliang Wang

Single-cell analyses revealed key tumor-infiltrating myeloid cell subsets associated with clinical outcomes in different subtypes of breast cancer

November 2024

Dingjie Wu | Si Chen | Yijin Liu | Bowen Yang | Ruixin Li | Feng Jin | Fan Yao | Yue Fang

Adeno-associated virus-mediated intraprostatic suppression of MIR375 inhibits tumor progression in the TRAMP mouse model of prostate cancer

November 2024

Xianyanling Yi | Jin Li | Zeyu Han | Tianyi Zhang | Dazhou Liao | Jia You | Jianzhong Ai

Properdin deficiency associated with systemic meningococcal disease due to a novel p.Cys337Arg pathogenic variant

November 2024

Laura González-Sánchez | Ana Mei Agudo | Anne Van Den Rym | María Isabel Begiristain | Alazne Saizar | Rebeca Pérez de Diego | Pilar Nozal | Alberto López-Lera | Margarita López-Trascasa | Fernando Corvillo

Performance analysis of markers for prostate cell typing in single-cell data

November 2024

Yanting Shen | Xiawei Fei | Junyan Xu | Rui Yang | Qinyu Ge | Zhong Wang

CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice

November 2024

Fucheng Dong | Xiuge Wang | Tao Huang | Yingying Yin | Sai Xiao | Yanjie Ma | Huafang Wei | Bingbing Wu | Ruidan Zhang | Liying Wang | Xuejiang Guo | Fei Gao | Chao Liu | Hongbin Liu | Jianguo Zhao | Wei Li

Whole exome sequencing identifies new susceptibility candidates underlying community-acquired pneumonia

November 2024

Jacobo Pardo-Seco | Sandra Viz-Lasheras | Xabier Bello | Alberto Gómez-Carballa | Alba Camino-Mera | Sara Pischedda | María José Currás-Tuala | Irene Rivero-Calle | Ana Dacosta-Urbieta | Fernando Caamaño-Viña | Carmen Rodríguez-Tenreiro Sánchez | Isabel Cifuentes | Cristina Méndez | Chiea Chuen Khor | Federico Martinón-Torres | Antonio Salas

Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia

November 2024

Ilaria Della Valle | Martina Milani | Simona Rossi | Riccardo Turchi | Flavia Tortolici | Valentina Nesci | Alberto Ferri | Cristiana Valle | Daniele Lettieri-Barbato | Katia Aquilano | Mauro Cozzolino | Savina Apolloni | Nadia D'Ambrosi

Protein lysine crotonylation in cellular processions and disease associations

September 2024

Hongling Zhao | Yang Han | Pingkun Zhou | Hua Guan | Shanshan Gao

Protein lysine crotonylation (Kcr) is one conserved form of posttranslational modifications of proteins, which plays an important role in a series of cellular physiological and pathological processes....

Depletion of anti-CD47mAb in plasma by genetically modified cells for pre-transfusion testing

September 2024

Fei Wang | Wenting Wang | Xiaoshuang Wu | Zhixin Liu | Yafen Wang | Rong Zhang | Shunli Gu | Qunxing An | Yaozhen Chen | Xingbin Hu

MAL2 DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma

September 2024

Hao Luo | Xing Xiao | Weiliang Hou | Jing Cai | Ming Chen | Qisheng Tang | Yusheng Tong | Zengxin Qi | Kaicheng Li | Liang Chen

Serum metabolic profiling implicates mTOR activation and insulin resistance in the development of pulmonary hypertension in a rat model of pressure overload-induced heart failure

September 2024

Qi Zhou | Chao Tang | Xinke Xu | Junhao Hu | Shengsen Yao | Bo Dong | Xiaojing Wu

Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment

September 2024

Ling Li | Bing Han | Yan Kong | Gaojia Zhang | Zhijun Zhang

Vitamin D binding protein (VDBP) serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target organs. VDBP plays a crucial part in the inflammatory...

Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy

September 2024

Kaida Mu | Yanping Yang | Xiaofei An | Jie Zhu | Jing Zhang | Yanfei Jiang | Xiaorong Yang | Jinan Zhang

Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression

September 2024

Lixin Liang | Tian Cai | Xiaojia Li | Jianhong An | Sen Yu | Yang Zhang | Fengjie Guo | Fang Wei | Jie He | Keping Xie | Tingting Jiang

Transcriptional factor Forkhead box M1 (FOXM1) plays an important role in pancreatic ductal adenocarcinoma (PDAC) development and progression. The molecular mechanisms underlying its dysregulation remain...

Comprehensive analysis of mitochondrial dynamic-related genes on their functions and prognostic values for glioblastoma multiforme

September 2024

Zhu Xie | Wei Hua | Hongyan Wang

Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia

September 2024

Xudong Li | Wei Li | Yanli Zhang | Linping Xu | Yongping Song

The advent of tyrosine kinase inhibitors (TKI) targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia (CML), greatly prolonged the life of CML patients, and improved...