CXorf67 in malignancies: Deciphering epigenetic landscapes and clinical implications for precision oncology
September 2026
The emerging focus on epigenetic regulation in cancer biology has unveiled the significant role of CXorf67, a protein encoded by a gene on the X chromosome. CXorf67 interacts with core components of...
The multifaceted landscape of T cell exhaustion in organ transplantation: From molecular mechanisms (epigenetics, transcription, metabolism) to induction strategies
September 2026
T cell exhaustion is a state of T cell dysfunction resulting from persistent antigenic stimulation, characterized primarily by the high expression of inhibitory receptors, metabolic reprogramming, and...
Ferroptosis and prostate cancer: A translational path from molecular mechanisms to precision therapy
September 2026
Castration-resistant prostate cancer represents a critical clinical challenge due to its propensity for resistance to conventional therapies and limited treatment efficacy. Ferroptosis is an iron-dependent...
Obesity accelerates aging: Mechanisms and therapeutic implications
September 2026
Global aging is increasing, and both aging and age-related diseases have emerged as significant public health challenges. According to previous literature, aging is characterized by multiple hallmarks,...
Autophagy as a therapeutic target for cisplatin-resistant gastric cancer
September 2026
Cisplatin is widely employed in the treatment of gastric cancer (GC). However, the resistance mechanisms exhibited by GC cells often result in suboptimal clinical outcomes associated with cisplatin...
Research progress on the mechanisms and animal models of Ménière’s disease
September 2026
Ménière’s disease is a prevalent chronic condition that triggers a range of vestibular and auditory symptoms. Despite significant advances in mechanisms such as genetic susceptibility, immunity, and...
Unraveling the role of PIWI/piRNAs in stem cell therapy: Epigenetic mechanisms and therapeutic potentials
September 2026
The therapeutic potential of stem cell therapy critically depends on precise epigenetic regulation mediated by PIWI/piRNA complexes. This review synthesizes current literature to analyze the structure,...
Purinergic signaling in osteoarthritis: Mechanistic insights into pathogenesis and therapeutic targeting
September 2026
Osteoarthritis (OA) is a degenerative joint disease driven by a complex interplay of inflammation, extracellular matrix degradation, subchondral bone remodeling, and chronic pain. Purinergic signaling...
SP1 lactylation promotes endometrial cancer cell stemness via regulation of CENPL expression
July 2026
Lgr6+ cells in the biological system during homeostasis and injury
July 2026
Lgr6 has attracted significant attention in biomedical research in recent years. As a member of the G protein-coupled receptor family, Lgr6 plays a crucial role in the occurrence and development of...
Context-dependent actions of STING pathway in colitis and associated colon cancer
July 2026
Inflammatory bowel disease (IBD), a prevalent chronic inflammatory disorder with unsatisfactory therapeutic outcomes, significantly increases the risk of colorectal cancer. The cyclic GMP-AMP synthase...
Receptor-mediated endocytosis by Megalin: Exploring its role in ligand interaction and disease mechanisms
July 2026
This review comprehensively summarizes the interaction mechanisms between Megalin and several key ligands, including calcium ions, gentamicin, ApoE, ANKRA2, FVIII, TTR, STC1, RAP, and MMP-9, focusing...
Suppression of UCP2 alleviates leukemogenesis by enhancing branched-chain amino acids-induced oxidative stress via activating the PI3K/AKT/mTOR signaling pathway
July 2026
Although the cellular role of uncoupling protein 2 (UCP2) in tumorigenesis has been reported in various solid tumor models, its role in leukemogenesis remains elusive. Herein, we demonstrated that UCP2...
Identification of PLXNC1 as a novel biomarker for consensus molecular subtype 4 in colorectal cancer
July 2026
Colorectal cancer (CRC) is a highly heterogeneous malignancy that is divided into four consensus molecular subtypes (CMSs), with CMS4 considered to be the worst type of CRC. The CMS classification has...
Deciphering the impact of SNAI1 gene on renal tubular cell proteome, nucleolar stress, ribosome biogenesis, senescence, DNA damage response, and focal adhesion dynamics
July 2026
Snail1, encoded by SNAI1 gene, is an essential protein that regulates epithelial–mesenchymal transition, which leads to extracellular matrix accumulation and kidney fibrosis, but with unclear cellular...
Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury
July 2026
Traumatic brain injury (TBI) is characterized by high rates of death and disability. Necroptosis is reported to be involved in neuronal death after TBI. However, additional molecules and related mechanisms...
