The regulatory role of CASZ1 in keratinocyte differentiation and skin barrier function in atopic dermatitis
January 2026
Emerging roles and therapeutic implications of lipid droplet protein perilipin 2 in liver disease
January 2026
Lipid droplets (LDs) are dynamic organelles that store neutral lipids when energy is in excess and serve as an energy reservoir during energy deprivation. Altered hepatic lipid metabolism is a critical...
The mechanism of m6A modification in cardiovascular diseases: A systematic review
January 2026
N6-methyladenosine (m6A) is the most prolific and conserved epigenetic modification of eukaryotic RNAs and is closely associated with the transcription, cleavage, translation, and degradation of target...
The roles of cell cycle proteins in regulating the tumor immune microenvironment
January 2026
Recent studies have shown that in addition to regulating the growth of tumor cells, cell cycle proteins can also regulate immune cells and factors in the tumor immune microenvironment (TIME), thus playing...
Advancing cancer research: Cutting-edge insights from colorectal cancer patient-derived xenograft mouse models
January 2026
Colorectal cancer is the third most common malignant tumor globally. The current clinical therapeutic outcome is often jeopardized by the complex pathological process that is highly heterogenous among...
In vivo gene therapy: A strategy for mutations, degenerations, and tumors
January 2026
Gene mutations, organ function degeneration, and carcinogenesis are the primary threats to human health. Gene therapy, which involves the addition, deletion, regulation, and editing of genes, as well...
The significance of epithelial–mesenchymal transition (EMT) in the initiation, plasticity, and treatment of glioblastoma
January 2026
Epithelial‒mesenchymal transition (EMT) is a dynamic cellular process in which epithelial cells lose their characteristics and acquire mesenchymal traits, leading to enhanced migratory, invasive, and...
Bmp9 modulates cell proliferation and intercellular junctions in HERS during tooth root development
January 2026
Tooth formation is a highly orchestrated process that precisely regulates the size and shape of the tooth. During typical tooth development, Hertwig's epithelial root sheath (HERS) interacts with mesenchymal...
Targeting Wnt/β-catenin activation in combination with temozolomide leads to glioblastoma inhibition and long-term survival in mice
January 2026
Glioblastoma (GBM) is one of the most treatment-resistant brain malignancies. Dysregulation of Wnt/β-catenin signaling might be implicated in tumorigenesis of GBM. In this study, spatial transcriptomic...
Transcriptional rewiring by enhancer methylation in CBFA2T3-GLIS2–driven pediatric acute megakaryoblastic leukemia
January 2026
Resistance to chemotherapy and subsequent relapse remain the primary challenge in pediatric acute myeloid leukemia (pAML), particularly in CBFA2T3-GLIS2 (C/G) fusion-positive acute megakaryoblastic...
Vitamin D receptor loss promotes endometrial fibrosis via autophagy-mediated epithelial–mesenchymal transition
January 2026
Intrauterine adhesion (IUA) leads to infertility or recurrent abortion; however, its etiology and pathological mechanism remain unclear. To explore the role and mechanism of the vitamin D receptor (VDR)...
SIGLEC15 modulates the immunosuppressive microenvironment and suppresses malignant phenotypes in triple-negative breast cancer
January 2026
Previous studies have demonstrated a significant association between sialic acid binding Ig-like lectin 15 (SIGLEC15) and both the progression of malignant tumors and immune infiltration. This study...
Druggable target ATAD2 enhances the malignant progression and cooperates with E2F1 to up-regulate PDK1 expression in glioma
January 2026
Gliomas are characterized by high mortality and disability rates. Cancer-testis antigens (CTAs) are among the most promising therapeutic targets for combating cancer. While several CTAs have been associated...
MiR-378 mediates the ovariectomy induced bone loss via exaggerating osteoclastogenesis and transforming growth factor beta impaired osteogenesis
January 2026
Osteoporosis (OP) is a disease characterized by decreased bone mass and damaged architectures. The promising treatment strategy for OP is to inhibit bone resorption while promoting bone formation. MicroRNAs...
ROS accelerates the progression of hypertrophic cardiomyopathy
January 2026
MYBPC3 mutations are the leading cause of hypertrophic cardiomyopathy. Here, to study the pathogenesis of hypertrophic cardiomyopathy, we created a MYBPC3 knockout (KO) model using human induced pluripotent...