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ISSN: 2352-3042
CN: 50-1221/R
p-ISSN: 2352-4820

Integrating spatial transcriptomics and single-cell RNA-sequencing reveals epithelial cell alterations in benign prostatic hyperplasia following finasteride treatment

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HOPX inhibits skin cutaneous melanoma growth and induces macrophage M1 polarization

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Identifying functional subtypes and common mechanisms of rheumatoid arthritis and systemic lupus erythematosus

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Glial subtype-specific modulation of disease pathogenesis in Drosophila models of ALS

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Sirolimus may improve bile excretion in ABCB11 mutants: A case report of a patient with bile salt export pump deficiency

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Data-informed insights into sex differences in peripheral blood mononuclear cells from single-cell transcriptomics

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A novel oridonin analogue, CYD0682, suppresses breast cancer growth, angiogenesis, and metastasis by inhibiting the ANGPTL4/MAPK signaling axis

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TET1: The epigenetic architect of clinical disease progression

The ten-eleven translocation 1 (TET1) protein, a member of the human α-ketoglutarate-dependent dioxygenase TET family, functions as a 5-methylcytosine hydroxylase with a strong affinity for genomic...

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Ribosome biogenesis: A central player in liver diseases

Ribosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining...

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Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration

Mammalian hair follicles undergo periodic regeneration, with recent research highlighting the immunological niche as a critical regulator of stem cell activity and hair follicle regeneration. Chemotactic...

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Fibroblast growth factor 8: Multifaceted role in development and developmental disorder

Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly dynamic gene expression pattern...

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Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines

Older age is one of the leading risk indicators for advanced breast cancer. It is critical to extensively investigate how aging affects breast cancer, considering the increasing rate of population aging....

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Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances

Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced...

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Ribonucleases in Mendelian disease: Characterization and insight from model organisms

Ribonucleases (RNases), essential for RNA metabolism, are implicated in human diseases, including neurodevelopmental, developmental, hematopoietic and other dysfunctions through mutations that disrupt...

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Expression of LINE-1 elements is required for preimplantation development and totipotency

Transposable elements, long considered genomic intruders, have been found to play significant and intriguing roles during early embryonic development based on the paradigm shift that has undergone in...

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Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines

The major histocompatibility complex (MHC) region plays a crucial role in immune function and is implicated in various diseases and cancer immunoediting. However, its high polymorphism poses challenges...

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Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation

Galectin-3 (Gal-3) plays a multifaceted role in the development and progression of pancreatic adenocarcinoma (PAAD), which is associated with a poor prognosis. Its interaction with tumor microenvironment...

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Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity

The aggregation of the peptide hormone amylin in the pancreas is a pathological hallmark of type-2 diabetes. Additionally, amylin can form aggregates in the brain, promoting β-amyloid deposition and...

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Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway

Left ventricular non-compaction (LVNC), is a hereditary cardiomyopathy with limited treatments. Our previous study linked phosphodiesterase 4D interacting protein (PDE4DIP) to LVNC development. To explore...

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The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer

Pancreatic cancer (PC) is a highly malignant neoplasm of the digestive system. The primary objective of this investigation is to elucidate the intricate mechanisms underlying the role of the aging process...

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Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis

Ovarian cancer (OC) peritoneal metastasis (OCPM) is a major cause of high mortality of OC, in which cancer cells incubated in ascites evolve various mechanisms to survive. Hippo/YAP singling plays multiple...

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Genetically predicted blood metabolites mediate the association between immune cell characteristics and urolithiasis: A Mendelian randomization study and mediation analysis

Urolithiasis, a disease characterized by the formation of urinary stones, is influenced by immune system dysregulation and metabolic factors. This study investigated the interplay between specific immune...

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miR-146b/Btg2 axis as a potential inducer of islet beta-cell decline during the progression of obesity to T2DM

We evaluated the potential mechanisms responsible for inducing beta-cell decline during the progression of obesity to type 2 diabetes mellitus (T2DM). Between February 2021 and February 2022, 25 subjects...

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XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy

Immune checkpoint inhibitors have a poor effect in treating ovarian cancer, and the specific mechanism is unknown. The purpose of this research was to investigate the impact of XPR1 on controlling autophagy...

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Chlorpyrifos induces spermatogenic dysfunction via ferroptosis in Sertoli cells

Chlorpyrifos (CPF), a widely used organophosphate pesticide, accumulates in the environment and affects human health. Its neurotoxicity has been extensively studied, and recent research has revealed...

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