Therapeutic resistance in cancer: lncRNAs as modulators and targets for cancer therapy
November 2026
Therapeutic resistance continues to be a significant challenge in cancer treatment, often leading to tumor recurrence, metastasis, and limited therapeutic efficacy despite advancements in chemotherapy...
DNA-based vaccines: Advances, applications, and future prospects
November 2026
DNA-based vaccines represent a promising advancement in immunization strategies, offering a novel approach for preventing infectious diseases and treating various conditions, including cancers and autoimmune...
Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma
November 2026
Clear cell renal cell carcinoma (ccRCC), the most common pathological subtype of renal cancer, is characterized by distinctive metabolic reprogramming that serves as a core molecular pathological basis...
The role of FGF19–FGFR4 signaling pathway in liver health and disease: Guardian or destroyer
November 2026
The fibroblast growth factor (FGF) 15/19–FGF receptor (FGFR) 4 signaling pathway is a crucial endocrine regulatory pathway within the FGF family. The FGF15/19–FGFR4 signaling pathway plays multiple...
Protein arginine methylation and ubiquitination: A prominent crosstalk and its functions in cancer
November 2026
Protein arginine methyltransferases (PRMTs) catalyze the formation of arginine methylations in histones and nonhistone proteins. PRMT family members strongly affect the malignant progression of cancer....
The emerging roles of small nucleolar RNAs, piwi-interacting RNAs, tRNA-derived small RNAs, and circular RNAs in the regulation of cardiac hypertrophy, ischemic heart disease, and heart failure
November 2026
Heart disease, including cardiac hypertrophy, ischemic heart disease, and heart failure, remains a global health challenge. Given the limitations of existing diagnostic and treatment methods, finding...
Mitochondrial dynamics: A promising tool for personalized TNBC management
November 2026
Triple-negative breast cancer (TNBC) is an aggressive and highly metastatic form of breast cancer and is associated with poor prognosis due to the lack of targeted therapies. Mitochondrial dysfunction...
The update of prostaglandin E2 receptor subtype 4 (EP4) in inflammatory diseases
November 2026
Inflammation is a defensive response of the organism to stimuli and is crucial for maintaining the stability of the internal environment. However, abnormal inflammatory responses, including over-activation...
The ubiquitin system in heart and vessel pathobiology: From mechanisms to therapeutic strategies
November 2026
Cardiovascular disease is currently a major global challenge, and its causes are complex, encompassing genetic, lifestyle, environmental, and other factors. Ubiquitination, an important post-translational...
The role, regulatory mechanisms, and therapeutic implications of FTO in gastrointestinal cancer
November 2026
N6-methyladenosine (m6A) is the most common post-transcriptional modification in mRNA, playing a crucial role in cancer development by modulating RNA stability, translation, and nuclear export. As the...
Aberrant sialylation in cancer: From molecular mechanisms to potential therapeutics
November 2026
Sialylation, a dynamic post-translational modification catalyzed by sialyltransferases and counterbalanced by neuraminidases, entails the attachment of sialic acids to the terminal residues of glycoproteins...
Lipophagy: A key regulator in oxidative stress and metabolic disorders
November 2026
Lipophagy, the selective autophagic degradation of lipid droplets, is essential for regulating cellular lipid levels and energy balance while preventing lipotoxicity. This process integrates with metabolic...
The potential role of the lung–brain axis in the pathophysiology of epilepsy: A hypothesis-driven perspective
November 2026
The pathophysiology of epilepsy remains poorly understood. One of the less explored areas is the role of the lung–brain axis, a sophisticated and intricate bidirectional connection between these two...
DLL3 serves as a pivotal hub bridging malignant progression and immunosuppression in NECC with therapeutic implications validated via the organoid-TIL co-culture system
November 2026
Neuroendocrine carcinoma of the cervix (NECC) represents a highly aggressive cervical cancer subtype with a poorly characterized tumor immune microenvironment (TIME) and unclear oncogenic mechanisms....
Loss of med14 causes developmental malformations characteristic of VACTERL association by disrupting the Mediator complex
November 2026
MED14 is the largest subunit in the Mediator complex and plays a key role in regulating RNA polymerase II-mediated transcription, but its developmental function remains largely unknown. Here, we show...
CCT2 enhances c-Myc stabilization to drive tumor progression and chemoresistance in head and neck squamous cell carcinoma
November 2026
CCT2, a vital subunit of the chaperonin-containing TCP-1 (CCT) complex, has emerged as a critical regulator of protein homeostasis and cancer progression. In this study, we highlight the essential role...
Co-localization of TAZ and H2A.Z up-regulates IL-6 expression in alveolar epithelial cells to polarize M2 cells to alleviate hypoxia-induced lung injury
November 2026
Transcriptional co-activator with PDZ-binding motif (TAZ) plays a critical role in the repair process following lung injury by enhancing the proliferation of alveolar epithelial cells (AECs) and exerting...
Neoliensinine promotes lysosomal cell death in T cell malignancies via a novel STING-TUBA1B pathway
November 2026
The clinical treatment options for T cell malignancies (T-CMs) remain limited, and even the current popular immunotherapies have yet to demonstrate significant efficacy in addressing this disease. Identifying...
SERHL regulates invasion and metastasis through KLF16-PLCB1/PRKCA signaling in gastric cancer cells
November 2026
Human SERHL, a pseudogene-derived lncRNA, plays a key role in cancer progression. However, the mechanism by which SERHL modulates gastric cancer (GC) is mostly unknown. This study found that SERHL was...
Age-dependent mitochondrial toxicity in renal stem cells: A precise 3D silk matrix model
November 2026
Aging is a significant risk factor for drug-induced kidney injury, underscoring the need for advanced preclinical models. The impact of age on the susceptibility of human primary kidney stem cells to...
N6-methyladenosine-modified circLPAR3 drives docetaxel resistance in prostate cancer by suppressing ferroptosis through the PCBP2/CHAC1 axis
November 2026
Epigenetic mechanisms represented by N6-methyladenosine (m6A) modifications and circular RNAs (circRNAs) regulate chemotherapy resistance in prostate cancer (PCa). Here, we stuided the role of m6A-modified...
Dynamic single-cell landscape reveals a T-cell-suppressed microenvironment and a conserved neutrophil program in the lung metastatic niche
November 2026
While the immune landscape of primary tumors is increasingly understood, the dynamic immune remodeling within the evolving lung metastatic microenvironment remains poorly characterized. Here, by systematically...
psiTPTE22-HERV functions as a tumor suppressor by inhibiting PI3K/AKT/mTOR/EIF4E signaling
November 2026
psiTPTE22-HERV is a human-specific gene with unexplored functions. This study investigated its regulation, molecular mechanism, and clinical significance in gastric cancer. psiTPTE22-HERV expression...
First-trimester preeclampsia prediction model via integrative machine learning of maternal risk profiles and laboratory markers
November 2026
Preeclampsia (PE) affects 2%–8% of pregnancies worldwide and remains a major cause of maternal and perinatal complications. Early risk identification is essential, yet current models, such as those...
A comprehensive review on apoptotic miRNAs and antagomiRs in breast cancer: Enhancing radio sensitization
November 2026
Breast cancer (BC) is the most fatal cancer in women worldwide, and in spite of progresses in cancer treatment methods, its therapy has remained as a primary health issue. Inadequate apoptosis level...