Lgr6+ cells in the biological system during homeostasis and injury
July 2026
Lgr6 has attracted significant attention in biomedical research in recent years. As a member of the G protein-coupled receptor family, Lgr6 plays a crucial role in the occurrence and development of...
Understanding nerve–tumor interactions: From basic biology to therapeutic innovation
July 2026
The study of nerve–tumor interactions has emerged as a rapidly advancing and interdisciplinary field with profound implications for understanding cancer progression, prognosis, and therapeutic innovation....
Mitochondrial transplantation in lung diseases: From mechanisms to application prospects
July 2026
Mitochondria are double-membrane organelles in eukaryotic cells, which play an important role in energy metabolism, cell cycle and apoptosis. Therefore, mitochondrial abnormalities can affect various...
Crosstalk between autophagy and ferroptosis in diabetes
July 2026
Diabetes is a multifactorial metabolic disease involving complex disruptions in cellular homeostasis and multiple forms of regulated cell death. Among them, the interaction between autophagy and ferroptosis...
Dendritic cell vaccines: Current research progress, challenges, and opportunities
July 2026
This review examines the advancements in cancer immunotherapies, particularly focusing on dendritic cell (DC)-based vaccines developed through in vitro methods. DCs are essential for connecting innate...
Context-dependent actions of STING pathway in colitis and associated colon cancer
July 2026
Inflammatory bowel disease (IBD), a prevalent chronic inflammatory disorder with unsatisfactory therapeutic outcomes, significantly increases the risk of colorectal cancer. The cyclic GMP-AMP synthase...
Receptor-mediated endocytosis by Megalin: Exploring its role in ligand interaction and disease mechanisms
July 2026
This review comprehensively summarizes the interaction mechanisms between Megalin and several key ligands, including calcium ions, gentamicin, ApoE, ANKRA2, FVIII, TTR, STC1, RAP, and MMP-9, focusing...
Emerging roles of the metabolic regulator 3-hydroxy-3-methylglutaryl coenzyme-CoA reductase in human cancers: From biology to therapeutics
July 2026
Tumor cells alter several critical metabolic pathways to satisfy their demands for rapid proliferation and survival. Maladjustment of cholesterol metabolism is present in diverse types of tumor cells....
FOXK2 gene expression in cancer: Potential regulatory mechanisms and clinical implications
July 2026
FOXK2 is a transcription factor known to regulate a wide range of biological processes that are critically involved in determining cell fate. Increasing evidence shows aberrant FOXK2 expression in some...
FOXA2 in islet biology: Orchestrating pancreatic development and glucose homeostasis
July 2026
Forkhead Box A2 (FOXA2) is a transcription factor essential for endodermal development and the formation and function of several metabolic organs, including the liver and pancreas. Within the pancreatic...
Selenoproteins: Minute yet vital players governing cellular fate
July 2026
Selenoproteins represent a distinct class of proteins that incorporate selenocysteine (Sec), whose biosynthesis and translational integration are dependent on selenium availability and the presence...
Intra-tumoral microbiota: Key modulators of tumor immunity and therapeutic potential
July 2026
The tumor microenvironment is increasingly recognized as a complex ecosystem in which the intra-tumoral microbiota (comprising bacteria, fungi, viruses, etc.) plays a pivotal, underappreciated role...
Lactylation-driven therapeutic resistance in cancer: Mechanisms and therapeutic opportunities
July 2026
Lactylation, a type of post-translational modification (PTM) of proteins driven by cancer metabolic reprogramming, not only offers new perspectives on the Warburg effect but also has drawn increasing...
Suppression of UCP2 alleviates leukemogenesis by enhancing branched-chain amino acids-induced oxidative stress via activating the PI3K/AKT/mTOR signaling pathway
July 2026
Although the cellular role of uncoupling protein 2 (UCP2) in tumorigenesis has been reported in various solid tumor models, its role in leukemogenesis remains elusive. Herein, we demonstrated that UCP2...
Immune checkpoint B7x promotes immune evasion and resistance to PD-1/PD-L1 blockade in bladder cancer
July 2026
Cancer cells adopt multiple strategies to avoid detection and destruction by the immune system, including exploiting immune checkpoint pathways. B7x (B7-H4, B7S1, or VTCN1), a member of the B7/CD28...
Identification of PLXNC1 as a novel biomarker for consensus molecular subtype 4 in colorectal cancer
July 2026
Colorectal cancer (CRC) is a highly heterogeneous malignancy that is divided into four consensus molecular subtypes (CMSs), with CMS4 considered to be the worst type of CRC. The CMS classification has...
Impact of maternal lipopolysaccharide and polyinosinic-polycytidylic acid-induced infections on offspring cardiac development: Mitochondrial dysfunction and metabolic alterations
July 2026
Maternal infections can have profound effects on embryonic heart development, yet the precise pathways through which these impacts manifest are still largely unexplored. This research explores the influence...
Androgen receptor acts as the transcriptional repressor of the nuclear receptor LRH-1 via the androgen-driven chromatin looping conformation in prostate cancer
July 2026
The androgen receptor (AR) signaling axis is regarded as the key driver of prostate cancer (PCa). Besides acting as a well-characterized transactivator of diverse targets, accumulating evidence suggests...
Elevated diurnal CD36 expression disrupts the bile acid synthesis rhythm leading to cholestatic liver injury and inflammation via the HMGCR/CYP7A1 axis
July 2026
Cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are characterized by disrupted bile acid (BA) homeostasis and subsequent liver injury....
Deciphering the impact of SNAI1 gene on renal tubular cell proteome, nucleolar stress, ribosome biogenesis, senescence, DNA damage response, and focal adhesion dynamics
July 2026
Snail1, encoded by SNAI1 gene, is an essential protein that regulates epithelial–mesenchymal transition, which leads to extracellular matrix accumulation and kidney fibrosis, but with unclear cellular...
PDK1 elevation was induced by epigenetic modifications of KDM3A and METTL16 to mediate TKI resistance and cancer development
July 2026
Lung cancer is the leading cause of cancer-related death and has the second-highest incidence worldwide. For patients with advanced EGFR-mutated non-small cell lung cancer, EGFR tyrosine kinase inhibitors...
CD14+CXCL10+ monocytes are associated with peripheral immune network alterations in systemic juvenile idiopathic arthritis: From multiple centers
July 2026
Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disorder characterized by systemic immune dysregulation, yet reliable biomarkers to predict its unpredictable disease course are...
