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Mechanism and application of feedback loops formed by mechanotransduction and histone modifications
September 2024
Mechanical stimulation is the key physical factor in cell environment. Mechanotransduction acts as a fundamental regulator of cell behavior, regulating cell proliferation, differentiation, apoptosis,...
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EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma
September 2024
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CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency
September 2024
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SPNS1 ablation drives skeletal muscle atrophy by disrupting mitophagy, mitochondrial function, and apoptosis in mice
September 2024
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PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype
September 2024
Programmed cell death 2 (PDCD2) is related to cancer progression and chemotherapy sensitivity. The role of PDCD2 in solid cancers (excluding hematopoietic malignancies) and their diagnosis and prognosis...
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Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium
September 2024
Developmental defects of enamel are common due to genetic and environmental factors before and after birth. Cdc42, a Rho family small GTPase, regulates prenatal tooth development in mice. However, its...
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Tumor immunological phenotype-derived gene classification predicts prognosis, treatment response, and drug candidates in ovarian cancer
September 2024
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LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway
September 2024
A long noncoding RNA (lncRNA) is longer than 200 bp. It regulates various biological processes mainly by interacting with DNA, RNA, or protein in multiple kinds of biological processes. Adenosine monophosphate-activated...
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MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma
September 2024
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Unique anti-angiogenic effects, pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis
September 2024
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MMP-9 deficiency accelerates the progress of periodontitis
September 2024
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Clinical and genetic heterogeneity of adult polyglucosan body disease caused by GBE1 biallelic mutations in China
September 2024
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MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts
September 2024
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Genome-wide DNA methylome analysis reveals a critical role of methylation-dysregulated lncRNAs in autophagy regulation in glioblastoma
September 2024
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Narciclasine induces colon carcinoma cell apoptosis by inhibiting the IL-17A/Act1/TRAF6/NF-κB signaling pathway
September 2024
IL-17 A is a promoter of colorectal cancer initiation and progression. Narciclasine is a polyhydroxy alkaloid compound isolated from Narcissus plants, which has potent anti-inflammatory and antitumor...
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Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia
September 2024
T-cell acute lymphoblastic leukemia (T-ALL), a heterogeneous hematological malignancy, is caused by the developmental arrest of normal T-cell progenitors. The development of targeted therapeutic regimens...
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Rare dentin defects: Understanding the pathophysiological mechanisms of COLXVA1 mutations
September 2024
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Dominant negative effect as a novel mechanism of SPAST gene mutation in a large family with hereditary spastic paraplegia
September 2024
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Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis
September 2024
The clearance of apoptotic cell debris, containing professional phagocytosis and non-professional phagocytosis, is essential for maintaining the homeostasis of healthy tissues. Here, we discovered that...
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