Hypoxia-mediated CRIP2 activation via NICD1 translocation regulates glycolysis and cell death
March 2026
Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4+ resident macrophages
March 2026
Hypoxia-induced right ventricular (RV) remodeling and dysfunction present a significant health risk to populations experiencing prolonged hypoxic conditions. Intense light, a noninvasive and easily...
Deficiency of TMEM16F in hair cells prevents diabetes-related and noise-induced hearing loss
March 2026
RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation
March 2026
Intestinal macrophages are critical regulators of mucosal immunity, playing essential roles in microbial surveillance, barrier maintenance, and tissue repair. As highly responsive immune cells, they...
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma
March 2026
Esophageal squamous cell carcinoma (ESCC) ranks among the top six deadliest malignancies globally, characterized by an alarmingly low five-year survival rate. This aggressive cancer is especially prevalent...
Immune microenvironment in autosomal dominant polycystic kidney disease
March 2026
Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary renal disorder characterized by the progressive development of fluid-filled cysts within the kidneys, leading to renal dysfunction...
Ferroptosis: The dawn of reversing drug resistance in digestive cancers
March 2026
Ferroptosis, a form of iron-dependent cell death characterized by lipid peroxidation, has emerged as a promising strategy to overcome resistance to chemotherapy. This review explores the mechanisms...
The role of positive feedback loop between LINC00862 and RBM47 in hepatocellular carcinoma suppression
March 2026
While the dynamic interaction between long non-coding RNA (lncRNA) and RNA binding proteins is widely recognized as pivotal in the regulation of hepatocellular carcinoma (HCC), the precise underlying...
TIGAR promotes osteogenic differentiation and ameliorates glucocorticoid-induced osteoporosis via autophagy-Nrf2-ROS axis
March 2026
Glucocorticoid-induced osteoporosis (GIOP) is a public health problem that needs urgently to be resolved, and oxidative stress is closely related to osteogenic impairment. TP53-induced glycolysis and...
cGAS knockout inhibited endotoxin-induced uveitis in mice
March 2026
Our research focused on the impact of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) pathway on retinal inflammation and employed an...
Integrative high-throughput studies to develop novel targets and drugs for the treatment of advanced prostate cancer
March 2026
Androgen deprivation therapies targeting the androgen receptor (AR) signaling pathway are the primary treatment strategy for prostate cancer. However, these therapies often lead to castration resistance....
UBR5 regulates the progression of colorectal cancer cells through Snail-induced epithelial–mesenchymal transition
March 2026
Snail is a core inducer of epithelial-to-mesenchymal transition. Here, we show that UBR5 promotes ubiquitin-mediated degradation of Snail and regulates the progression of colorectal cancer cells through...
GXYLT2 serves as a prognostic biomarker and is associated with β-catenin activation and gastric cancer aggressiveness
March 2026
Gastric cancer (GC) is a significant global health challenge due to its high incidence and mortality rate. However, the existing classification methods for GC still have limitations. Given the pivotal...
Macrophage κ-opioid receptor inhibits hypoxic pulmonary hypertension progression and right heart dysfunction via an SCD1-dependent anti-inflammatory response
March 2026
We aimed to investigate the effects and mechanism(s) of macrophage κ-opioid receptor (κ-OR) on macrophage inflammatory response and hypoxic pulmonary hypertension (HPH). Macrophage κ-OR-deficient mice...
