Region-specific functions of S100A9-derived peptides in inflammation and intracellular delivery
February 2027
Host diets drive microbiome evolution and functional divergence
February 2027
Substantial variation in gut microbiome function across individuals underscores the pivotal role of the host in shaping microbial diversity. Increasing evidence indicates that diet is a major selective...
Genetic kidney diseases: Decoding molecular taxonomies to drive precision nephrology and therapeutic innovation
February 2027
Genomic advances have transformed the landscape of genetic kidney diseases, enabling a shift from traditional phenotype-based diagnostics to molecularly precise classification. Large-scale genetic testing...
Molecular mechanisms and targeted therapeutic strategies for glycolytic reprogramming in osteosarcoma
February 2027
Osteosarcoma, a highly invasive and metastatic malignant bone tumor, has a poor prognosis primarily because of early pulmonary metastasis and resistance to conventional treatments. The malignant progression...
Disulfidptosis-based cancer therapy: Opportunity and challenge
February 2027
Cancer represents a significant global health threat, with traditional treatment modalities often facing substantial limitations. Consequently, novel therapeutic strategies have garnered considerable...
Not only as a Cullin3 ligase adaptor, SPOP may also act as a molecular bridge
February 2027
Speckle-type POZ protein (SPOP), a substrate-binding adaptor of the Cullin3/RING-box1 E3 ubiquitin ligase complex, induces degradative or non-degradative ubiquitination of substrates, playing a vital...
In vivo CAR-T for the treatment of autoimmune diseases: Current progress and future directions
February 2027
Autoimmune diseases are a clinical challenge because current immunosuppressive therapies fail to eliminate pathogenic immunocytes, such as autoreactive B cells, plasma cells, and antigen-presenting...
A panoramic study of circulating tumor DNA in diffuse large B-cell lymphoma
February 2027
Diffuse large B-cell lymphoma (DLBCL) is a frequently encountered aggressive form of non-Hodgkin's lymphoma, characterized by significant clinical and molecular heterogeneity. Owing to inherent limitations...
Identification and functional analysis of sRNAs in Pseudomonas aeruginosa quorum sensing and virulence regulation
February 2027
Small RNAs (sRNAs) act as critical regulators of post-transcriptional activity and diverse cellular processes in bacteria. However, the entire repertoire of sRNAs and their functions has not yet been...
Identification of platelet-derived biomarker in a cohort of Parkinson's disease
February 2027
Evidence has suggested that platelets (PLTs) share biochemical properties with neurons. However, whether PLTs might serve as biomarkers of Parkinson's disease (PD) remains uncertain. In this study,...
Targeting hepatic CREBZF protects against atherosclerosis via exosomal miR-210-3p mediated inhibition of endothelial inflammation
February 2027
Cardiovascular diseases (CVDs) continue to be the primary cause of mortality globally. Abnormal liver function has been widely recognized as an independent risk factor for atherosclerotic CVDs. However,...
Echinocystic acid inhibits the growth of human bladder cancer cells by suppressing AKT1/GSKβ/β-Catenin signaling and synergizes with gemcitabine
February 2027
Bladder cancer (BC) is an aggressive and treatment-resistant malignancy with a high recurrence rate. Current first-line therapies only provide limited relief due to chemoresistance and toxicity. Natural...
Glis1 regulates metabolic programming by promoting H3K18 lactylation to alleviate neuronal senescence following spinal cord injury
February 2027
Neuronal senescence is a significant factor impeding spinal cord injury (SCI) repair. Research indicates that Glis1, a Kruppel-like zinc finger transcription factor, is pivotal in reprogramming senescent...
Betaine alleviates renal osteodystrophy by stabilizing ABCG1 mRNA to inhibit HMOX1-mediated ferroptosis in BMSCs
February 2027
Renal osteodystrophy is a debilitating complication of chronic kidney disease characterized by deteriorated bone microarchitecture and impaired bone formation, leading to increased fracture risk. Despite...
Activation of AIM2 inflammasome cascade by extracellular trap-laden neutrophil vesicles triggered by Fusobacterium nucleatum exacerbates ulcerative colitis
February 2027
Neutrophil dysfunction and activation of the absent in melanoma 2 (AIM2) inflammasome have been implicated in ulcerative colitis (UC) pathogenesis. However, whether these two immune responses interact...
Gut microbial histamine and serotonin promote cerebrovascular angiogenesis: Evidence from moyamoya disease
February 2027
Moyamoya disease (MMD) is a progressive cerebrovascular disorder characterized by arterial stenosis and compensatory neovascularization, but its upstream drivers remain poorly defined. Here, we identify...
Mapping intestinal microenvironment heterogeneity in Hirschsprung's disease by spatial transcriptomics: Role of THBS1 in macrophage polarization and neural stem cell regulation
February 2027
The pathogenic role of the intestinal microenvironment on Hirschsprung's disease (HSCR) is increasingly recognized; however, the spatial expression patterns and underlying molecular mechanisms of the...
PTHrP suppresses BMP2-induced osteochondral differentiation and preserves cartilage phenotype in mesenchymal stem cells via inactivating PI3K–AKT signaling
February 2027
Bone morphogenetic protein 2 (BMP2) has the potential to drive multipotent mesenchymal stem cells (MSCs) to undergo chondral–osteogenic (including hypertrophic chondrocyte) differentiation. Parathyroid...