Forward genetics identifies HN1L/JPT2 as a novel carboplatin resistance gene in ovarian cancer
January 2026
Exploring the role of migrasomes in myocardial injury and repair: A novel mechanism of mitochondrial quality control
November 2025
Role of angiogenesis-related lncRNAs in tumor microenvironment and prognosis of lung adenocarcinoma
November 2025
In vivo adeno-associated virus-mediated LDLR/PCSK9 intervention for familial hypercholesterolemia
November 2025
Investigation of long-term epigenetic changes in the Nr3c1 gene by neonatal valproate exposure in juvenile rats
November 2025
circ-miR-524 accelerates the growth of liver cancer cells by inducing DNA damage repair through K-RAS
November 2025
Genetics, epidemiology and management of clubfoot and related disorders
November 2025
Clubfoot, medically termed congenital talipes equinovarus (CTEV), is a prevalent musculoskeletal birth defect, affecting approximately 0.3% of all live births. This serious congenital anomaly results...
Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
November 2025
Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer...
Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation
November 2025
Fucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable...
Unveiling the regulatory potential of the non-coding genome: Insights from the human genome project to precision medicine
November 2025
The Human Genome Project marked a milestone in scientific exploration, unraveling the genetic blueprint of humanity. However, expectations of direct gene–disease associations gave way to realizing the...
Recent advances in oncolytic virus combined immunotherapy in tumor treatment
November 2025
Oncolytic viruses (OVs), a kind of emerging therapeutics for treating tumors, are characterized by high replication efficiency, superior killing effects, and few adverse reactions, which have shown...
In vivo production of CAR T cell: Opportunities and challenges
November 2025
Chimeric antigen receptor T (CAR T) cell therapy has achieved remarkable efficacy for patients with hematological malignancies. However, in vitro viral vector-mediated production of CAR T cells is time-consuming...
Selectively targeting BCL6 using a small-molecule inhibitor is a potential therapeutic strategy for glioblastoma
November 2025
Glioblastoma multiforme (GBM) is the deadliest form of brain tumor, and effective treatments are lacking. Thus, a new generation of effective treatments is urgently needed. B-cell lymphoma 6 (BCL6)...
Elevated miR-34a induced by lipotoxicity and inflammation mediates pathophysiological communication between hepatocytes and hepatic stellate cells in liver fibrosis
November 2025
Increased mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) imposes an urgent need to elucidate the pathogenesis of MASLD so that novel therapeutic strategies...
ADAMTS2: More than a procollagen N-proteinase
November 2025
A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2) is a member of the ADAMTS zinc metalloproteinase family, best known for its role as a procollagen I N-proteinase in the maturation...