Mitochondrial dynamics: A promising tool for personalized TNBC management
November 2026
Triple-negative breast cancer (TNBC) is an aggressive and highly metastatic form of breast cancer and is associated with poor prognosis due to the lack of targeted therapies. Mitochondrial dysfunction...
Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology
November 2026
Beyond somatic initiation, cancer progression is governed by a multidimensional systemic metabolic architecture. This permissive macroenvironment, shaped by systemic nutrient fluxes, endocrine networks,...
The update of prostaglandin E2 receptor subtype 4 (EP4) in inflammatory diseases
November 2026
Inflammation is a defensive response of the organism to stimuli and is crucial for maintaining the stability of the internal environment. However, abnormal inflammatory responses, including over-activation...
The ubiquitin system in heart and vessel pathobiology: From mechanisms to therapeutic strategies
November 2026
Cardiovascular disease is currently a major global challenge, and its causes are complex, encompassing genetic, lifestyle, environmental, and other factors. Ubiquitination, an important post-translational...
Roles of Piezo channels in dentofacial deformity: Onset, orthodontic treatment, and associated diseases
November 2026
The onset and treatment of dentofacial deformities are closely associated with mechanical stimuli. As mechanosensitive ion channels, Piezo channels play a critical role in the mechanotransduction processes...
The role, regulatory mechanisms, and therapeutic implications of FTO in gastrointestinal cancer
November 2026
N6-methyladenosine (m6A) is the most common post-transcriptional modification in mRNA, playing a crucial role in cancer development by modulating RNA stability, translation, and nuclear export. As the...
Aberrant sialylation in cancer: From molecular mechanisms to potential therapeutics
November 2026
Sialylation, a dynamic post-translational modification catalyzed by sialyltransferases and counterbalanced by neuraminidases, entails the attachment of sialic acids to the terminal residues of glycoproteins...
Lipophagy: A key regulator in oxidative stress and metabolic disorders
November 2026
Lipophagy, the selective autophagic degradation of lipid droplets, is essential for regulating cellular lipid levels and energy balance while preventing lipotoxicity. This process integrates with metabolic...
Perspectives of EGFR co-targeting with nanocarriers for anti-TNBC purposes
November 2026
Triple-negative breast cancer (TNBC) is a particularly aggressive and therapeutically challenging subtype of breast tumor, frequently marked by the relatively high expression of epidermal growth factor...
Respiratory mucosal immunity: Biological functions, diseases, prevention and therapy
November 2026
Respiratory mucosal (RM) immunity is a highly specialized and dynamic network that safeguards the airways from inhaled pathogens while preserving tissue homeostasis. Acting as the body’s first line...
The potential role of the lung–brain axis in the pathophysiology of epilepsy: A hypothesis-driven perspective
November 2026
The pathophysiology of epilepsy remains poorly understood. One of the less explored areas is the role of the lung–brain axis, a sophisticated and intricate bidirectional connection between these two...
DLL3 serves as a pivotal hub bridging malignant progression and immunosuppression in NECC with therapeutic implications validated via the organoid-TIL co-culture system
November 2026
Neuroendocrine carcinoma of the cervix (NECC) represents a highly aggressive cervical cancer subtype with a poorly characterized tumor immune microenvironment (TIME) and unclear oncogenic mechanisms....
Dlc1 deletion activates the canonical Wnt pathway at an early stage and affects subsequent cardiac differentiation in mouse embryonic stem cells
November 2026
Cardiomyocyte differentiation is an important process during heart development that involves the specification of a series of cardiac lineage cells differentiated from mesendoderm to cardiac mesoderm,...
H2AX phosphorylation driven by the SET-PP2A axis maintains glioma stem cell properties
November 2026
Glioblastoma harbors a subpopulation of glioma stem cells (GSCs) that drive tumor relapse and invasion. Although GSC properties are known to be regulated by key transcription factors and chromatin remodeling,...
Loss of med14 causes developmental malformations characteristic of VACTERL association by disrupting the Mediator complex
November 2026
MED14 is the largest subunit in the Mediator complex and plays a key role in regulating RNA polymerase II-mediated transcription, but its developmental function remains largely unknown. Here, we show...
CCT2 enhances c-Myc stabilization to drive tumor progression and chemoresistance in head and neck squamous cell carcinoma
November 2026
CCT2, a vital subunit of the chaperonin-containing TCP-1 (CCT) complex, has emerged as a critical regulator of protein homeostasis and cancer progression. In this study, we highlight the essential role...
Co-localization of TAZ and H2A.Z up-regulates IL-6 expression in alveolar epithelial cells to polarize M2 cells to alleviate hypoxia-induced lung injury
November 2026
Transcriptional co-activator with PDZ-binding motif (TAZ) plays a critical role in the repair process following lung injury by enhancing the proliferation of alveolar epithelial cells (AECs) and exerting...
Neoliensinine promotes lysosomal cell death in T cell malignancies via a novel STING-TUBA1B pathway
November 2026
The clinical treatment options for T cell malignancies (T-CMs) remain limited, and even the current popular immunotherapies have yet to demonstrate significant efficacy in addressing this disease. Identifying...
Decoding age-stratified mutational landscapes in CNS lymphoma via genomic and survival profiling for precision oncology
September 2026
Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes
September 2026
Ammonia-induced cell death patterns in glioblastoma: Immune landscape, prognostic signature, and therapeutic target identification
September 2026
Pan-cancer analysis and mechanistic insights of tuft cell-like tumors
September 2026
Tuft cells are rare, chemosensory epithelial cells present in various tissues, including the respiratory and gastrointestinal tracts. Recent studies have revealed their significant role in cancer biology,...
IRP1/ARID3A complex promotes pancreatic cancer chemoresistance by suppressing CYGB-related ferroptosis
September 2026
Ferroptosis, a unique modality of regulated cell death, has become an emerging strategy for tumor therapy. Multiple cellular pathways, including redox homeostasis, iron handling, epigenetic regulation,...
A parallel-risk framework accurately predicts hematopoietic stem cell transplantation outcomes and identifies benefiting patients in pediatric AML
September 2026
Pediatric acute myeloid leukemia (pAML) has a poorer prognosis than acute lymphoblastic leukemia, and hematopoietic stem cell transplantation (HSCT) offers curative potential in high-risk or relapsed...