Landscape of metabolic alterations and treatment strategies in breast cancer
September 2025
Breast cancer, the most prevalent cancer in women, poses a significant threat to their health. One of the prominent characteristics of malignant transformation in breast cancer cells is metabolic reprogramming,...
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Fibroblast growth factor 8: Multifaceted role in development and developmental disorder
September 2025
Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly dynamic gene expression pattern...
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Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines
September 2025
Older age is one of the leading risk indicators for advanced breast cancer. It is critical to extensively investigate how aging affects breast cancer, considering the increasing rate of population aging....
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The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma
September 2025
Long noncoding RNAs (lncRNAs) are endogenous noncoding RNAs exceeding 200 bases in length that are prevalent in malignant tumors and are closely associated with the onset and progression of hepatocellular...
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Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances
September 2025
Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced...
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The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer
September 2025
N6-methyladenosine (m6A) is the most abundant and well-investigated internal RNA modification in eukaryotic RNAs, affecting its target gene expression by controlling RNA localization, splicing, stability,...
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Fusion genes in cancers: Biogenesis, functions, and therapeutic implications
September 2025
The processes of tumorigenesis and development are intricate, involving numerous genes and molecular pathways. Fusion genes, direct products of abnormal chromosomal rearrangements, are key factors in...
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Ribonucleases in Mendelian disease: Characterization and insight from model organisms
September 2025
Ribonucleases (RNases), essential for RNA metabolism, are implicated in human diseases, including neurodevelopmental, developmental, hematopoietic and other dysfunctions through mutations that disrupt...
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Expression of LINE-1 elements is required for preimplantation development and totipotency
September 2025
Transposable elements, long considered genomic intruders, have been found to play significant and intriguing roles during early embryonic development based on the paradigm shift that has undergone in...
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Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines
September 2025
The major histocompatibility complex (MHC) region plays a crucial role in immune function and is implicated in various diseases and cancer immunoediting. However, its high polymorphism poses challenges...
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Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation
September 2025
Galectin-3 (Gal-3) plays a multifaceted role in the development and progression of pancreatic adenocarcinoma (PAAD), which is associated with a poor prognosis. Its interaction with tumor microenvironment...
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TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy
September 2025
Several factors during pregnancy, such as changes in serotonin (5-HT) levels, can affect intestinal function in offspring mice. The role of 5-HT in regulating intestinal motility after lipopolysaccharide...
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Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity
September 2025
The aggregation of the peptide hormone amylin in the pancreas is a pathological hallmark of type-2 diabetes. Additionally, amylin can form aggregates in the brain, promoting β-amyloid deposition and...
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Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway
September 2025
Left ventricular non-compaction (LVNC), is a hereditary cardiomyopathy with limited treatments. Our previous study linked phosphodiesterase 4D interacting protein (PDE4DIP) to LVNC development. To explore...
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The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer
September 2025
Pancreatic cancer (PC) is a highly malignant neoplasm of the digestive system. The primary objective of this investigation is to elucidate the intricate mechanisms underlying the role of the aging process...
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Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis
September 2025
Ovarian cancer (OC) peritoneal metastasis (OCPM) is a major cause of high mortality of OC, in which cancer cells incubated in ascites evolve various mechanisms to survive. Hippo/YAP singling plays multiple...
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Genetically predicted blood metabolites mediate the association between immune cell characteristics and urolithiasis: A Mendelian randomization study and mediation analysis
September 2025
Urolithiasis, a disease characterized by the formation of urinary stones, is influenced by immune system dysregulation and metabolic factors. This study investigated the interplay between specific immune...
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miR-146b/Btg2 axis as a potential inducer of islet beta-cell decline during the progression of obesity to T2DM
September 2025
We evaluated the potential mechanisms responsible for inducing beta-cell decline during the progression of obesity to type 2 diabetes mellitus (T2DM). Between February 2021 and February 2022, 25 subjects...
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XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy
September 2025
Immune checkpoint inhibitors have a poor effect in treating ovarian cancer, and the specific mechanism is unknown. The purpose of this research was to investigate the impact of XPR1 on controlling autophagy...
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Chlorpyrifos induces spermatogenic dysfunction via ferroptosis in Sertoli cells
September 2025
Chlorpyrifos (CPF), a widely used organophosphate pesticide, accumulates in the environment and affects human health. Its neurotoxicity has been extensively studied, and recent research has revealed...
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Clinical relevance of loss-of-function mutations of NEMO/IKBKG
September 2025
Dysfunctional inhibitor of nuclear factor-κB (NF-κB) kinase regulatory subunit gamma (IKBKG) is known to trigger incontinentia pigmenti (IP), anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID),...
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Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy
September 2025
Liquid biopsy has emerged as a valuable clinical tool due to its non-invasive nature and real-time molecular profiling capabilities. Transfer RNA-derived small RNAs (tsRNAs) are a group of small non-coding...
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Single-cell landscape of immunological responses in patients with juvenile idiopathic arthritis
September 2025
The study aimed to analyze the single-cell transcriptomes of immune cells in juvenile idiopathic arthritis (JIA) patients to understand the cellular heterogeneity within the immune system. Peripheral...
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Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3
September 2025
Neuropathic pain (NP) is a chronic debilitating disease caused by nerve damage or various diseases, significantly impairs patients’ quality of life. Super-enhancers (SEs) are important cis-regulatory...
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