Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications
March 2026
Distraction osteogenesis, or the Illizarov technique, induces bone regeneration using distractive mechanical forces. Nevertheless, Wolff's law holds that bone adapts to reverse compressive mechanical...
Non-clinical safety considerations on genome editing using the CRISPR/Cas system
March 2026
Recent advances in gene editing using the CRISPR/Cas system have revolutionized genome editing, opening new horizons for human cellular and gene therapy products. Genome editing technologies are rapidly...
Defective biological networks associated with pseudogene-derived lncRNAs in cancer drug resistance: Promising prospects for their clinical targets in cancer therapy
March 2026
Cancer is a major cause of mortality globally, characterized by its multifactorial nature and intricate treatment procedures. The main treatment options include targeted drug therapies and chemotherapy....
RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation
March 2026
Intestinal macrophages are critical regulators of mucosal immunity, playing essential roles in microbial surveillance, barrier maintenance, and tissue repair. As highly responsive immune cells, they...
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma
March 2026
Esophageal squamous cell carcinoma (ESCC) ranks among the top six deadliest malignancies globally, characterized by an alarmingly low five-year survival rate. This aggressive cancer is especially prevalent...
Extracellular vesicles-associated tRNA-derived fragments: Emerging insights into cancer progression and clinical application potential
March 2026
Exosome-associated tRNA-derived fragments (tRFs) play crucial roles in cancer progression, influencing cell proliferation, metastasis, immune evasion, and drug resistance. Due to their stability and...
Platinum-resistant ovarian cancer: From mechanisms to treatment strategies
March 2026
Over the last few decades, platinum-based chemotherapy has served as the standard chemotherapy in treating ovarian cancer (OC). While most patients initially respond well to platinum-based chemotherapy,...
High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges
March 2026
Vitamin C, also known as ascorbic acid, has sparked controversy since it first emerged as a potential anti-cancer agent. However, an increasing number of preclinical studies have demonstrated that high-dose...
Engineering HSV-1 for oncolytic therapy: From molecular entry mechanisms to retargeting strategies
March 2026
Oncolytic viruses (OVs) represent a cutting-edge approach to cancer immunotherapy, characterized by their ability to selectively infect and eliminate tumor cells while sparing healthy tissues. Among...
Immune microenvironment in autosomal dominant polycystic kidney disease
March 2026
Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary renal disorder characterized by the progressive development of fluid-filled cysts within the kidneys, leading to renal dysfunction...
Emerging roles of pseudogene-derived lncRNAs in cancer stem cells: Non-coding clues and therapeutic targets in cancer medicine
March 2026
Cancer stem cells (CSCs), progenitor tumor cells with stemness characteristics, play key roles in cancer's onset, progression, metastasis, relapse, and chemotherapy resistance. While the exact molecular...
LRRC8A: A multifaceted regulator in cancer, neurological disorders, metabolic diseases and immune modulation
March 2026
Leucine-rich repeat containing 8A (LRRC8A) is a member of the LRRC8 family, exhibiting broad expression across various tissues and cells in vertebrates. Like other LRRC8 family members, LRRC8A contributes...
Unraveling Parkinson's disease: The mystery of mitochondria and the role of aging
March 2026
Parkinson's disease (PD) is a complex neurodegenerative disorder that poses significant burden on patients and families. Its exact cause is unknown, resulting in limited effective treatments. Mitochondrial...
Multifaceted role of T-box transcription factor 4: From embryonic development to disease pathogenesis
March 2026
T-box transcription factor 4 (TBX4), a crucial member of the T-box gene family, is essential for embryonic development, particularly in the formation of hindlimbs and lungs. Beyond these developmental...
Ferroptosis: The dawn of reversing drug resistance in digestive cancers
March 2026
Ferroptosis, a form of iron-dependent cell death characterized by lipid peroxidation, has emerged as a promising strategy to overcome resistance to chemotherapy. This review explores the mechanisms...
cTnIR193H restrictive cardiomyopathy mice satisfy high-energy metabolic demands through regulating glucose metabolism
March 2026
This work aims to investigate the energy metabolism in mice with restrictive cardiomyopathy induced by cardiac troponin I (cTnI) R193H mutation. Echocardiography was used to monitor cardiac function....
