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Factor analysis and subtyping significance of CTNNB1 gene mutation detection in adamantinomatous craniopharyngioma
November 2024
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The mucolipidosis III-causing mutation in GNPTAB, c.1760G>C, disrupts the development of somites in rats
November 2024
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Constitutive androstane receptor: A tumor suppressor and a biomarker for favorable prognosis of liver diseases
November 2024
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GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus
November 2024
Recombinant adenovirus (rAdV) is a commonly used vector system for gene transfer. Efficient initial packaging and subsequent production of rAdV remains time-consuming and labor-intensive, possibly attributable...
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Focus on cardiac troponin complex: From gene expression to cardiomyopathy
November 2024
The cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca2+ sensitivity to muscle; cTnI, which inhibits the...
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A comprehensive review of animal models for cancer cachexia: Implications for translational research
November 2024
Cancer cachexia is a multifactorial syndrome characterized by progressive weight loss and a disease process that nutritional support cannot reverse. Although progress has been made in preclinical research,...
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Single-cell spatial transcriptomics in cardiovascular development, disease, and medicine
November 2024
Cardiovascular diseases (CVDs) impose a significant burden worldwide. Despite the elucidation of the etiology and underlying molecular mechanisms of CVDs by numerous studies and recent discovery of...
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New insights into the cardio-renal benefits of SGLT2 inhibitors and the coordinated role of miR-30 family
November 2024
Sodium-glucose co-transporter inhibitors (SGLTis) are the latest class of anti-hyperglycemic agents. In addition to inhibiting the absorption of glucose by the kidney causing glycosuria, these drugs...
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Molecular mechanisms of cisplatin resistance in ovarian cancer
November 2024
Ovarian cancer is one of the most common malignant tumors of the female reproductive system. The majority of patients with advanced ovarian cancer are mainly treated with cisplatin-based chemotherapy....
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Novel perspectives on leptin in osteoarthritis: Focus on aging
November 2024
Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration, subchondral sclerosis, synovitis, and osteophyte formation. OA is associated with disability...
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Comprehensive multi-omics profiling identifies novel molecular subtypes of pancreatic ductal adenocarcinoma
November 2024
Pancreatic cancer, a highly fatal malignancy, is predicted to rank as the second leading cause of cancer-related death in the next decade. This highlights the urgent need for new insights into personalized...
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Exosome-mediated renal protection: Halting the progression of fibrosis
November 2024
Renal fibrosis is a complex and multifactorial process that involves inflammation, cell proliferation, collagen, and fibronectin deposition in the kidney, ultimately leading to chronic kidney disease...
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MDM2 inhibitors in cancer immunotherapy: Current status and perspective
November 2024
Murine double minute 2 (MDM2) plays an essential role in the cell cycle, apoptosis, DNA repair, and oncogene activation through p53-dependent and p53-independent signaling pathways. Several preclinical...
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NRF2 in age-related musculoskeletal diseases: Role and treatment prospects
November 2024
The NRF2 pathway is a metabolic- and redox-sensitive signaling axis in which the transcription factor controls the expression of a multitude of genes that enable cells to survive environmental stressors,...
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STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma
November 2024
Dysregulated calcium (Ca2+) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for...
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Identification of ferroptosis-associated tumor antigens as the potential targets to prevent head and neck squamous cell carcinoma
November 2024
Head and neck squamous cell carcinoma (HNSC) represents nearly 90% of all head and neck tumors. The current treatment modality for HNSC patients primarily involves surgical intervention and radiotherapy,...
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Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1
November 2024
Resistance to sorafenib, an effective first-line treatment for advanced hepatocellular carcinoma (HCC), greatly compromised the prognosis of patients. The extracellular matrix is one of the most abundant...
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Gene interactions analysis of brain spatial transcriptome for Alzheimer's disease
November 2024
Recent studies have explored the spatial transcriptomics patterns of Alzheimer's disease (AD) brain by spatial sequencing in mouse models, enabling the identification of unique genome-wide transcriptomic...
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VPS13D affects epileptic seizures by regulating mitochondrial fission and autophagy in epileptic rats
November 2024
Abnormal mitochondrial dynamics can lead to seizures, and improved mitochondrial dynamics can alleviate seizures. Vacuolar protein sorting 13D (VPS13D) is closely associated with regulating mitochondrial...
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