AP2B1, a protein involved in endocytic trafficking, is associated with congenital heart defects when mutated
November 2026
Hemilateral adipose and muscular atrophy associated with a somatic PDGFRB p.N666K variant
November 2026
Progesterone and selective progesterone receptor modulator regulate tumor-associated fibroblasts in uterine leiomyomas
November 2026
Specific RNA structures and elements in the 5′-UTR of the SARS-CoV-2 genome and subgenomic RNA are critical for its infection
November 2026
DNA-based vaccines: Advances, applications, and future prospects
November 2026
DNA-based vaccines represent a promising advancement in immunization strategies, offering a novel approach for preventing infectious diseases and treating various conditions, including cancers and autoimmune...
Protein arginine methylation and ubiquitination: A prominent crosstalk and its functions in cancer
November 2026
Protein arginine methyltransferases (PRMTs) catalyze the formation of arginine methylations in histones and nonhistone proteins. PRMT family members strongly affect the malignant progression of cancer....
The role, regulatory mechanisms, and therapeutic implications of FTO in gastrointestinal cancer
November 2026
N6-methyladenosine (m6A) is the most common post-transcriptional modification in mRNA, playing a crucial role in cancer development by modulating RNA stability, translation, and nuclear export. As the...
Aberrant sialylation in cancer: From molecular mechanisms to potential therapeutics
November 2026
Sialylation, a dynamic post-translational modification catalyzed by sialyltransferases and counterbalanced by neuraminidases, entails the attachment of sialic acids to the terminal residues of glycoproteins...
Lipophagy: A key regulator in oxidative stress and metabolic disorders
November 2026
Lipophagy, the selective autophagic degradation of lipid droplets, is essential for regulating cellular lipid levels and energy balance while preventing lipotoxicity. This process integrates with metabolic...
The potential role of the lung–brain axis in the pathophysiology of epilepsy: A hypothesis-driven perspective
November 2026
The pathophysiology of epilepsy remains poorly understood. One of the less explored areas is the role of the lung–brain axis, a sophisticated and intricate bidirectional connection between these two...
Loss of med14 causes developmental malformations characteristic of VACTERL association by disrupting the Mediator complex
November 2026
MED14 is the largest subunit in the Mediator complex and plays a key role in regulating RNA polymerase II-mediated transcription, but its developmental function remains largely unknown. Here, we show...
CCT2 enhances c-Myc stabilization to drive tumor progression and chemoresistance in head and neck squamous cell carcinoma
November 2026
CCT2, a vital subunit of the chaperonin-containing TCP-1 (CCT) complex, has emerged as a critical regulator of protein homeostasis and cancer progression. In this study, we highlight the essential role...
N6-methyladenosine-modified circLPAR3 drives docetaxel resistance in prostate cancer by suppressing ferroptosis through the PCBP2/CHAC1 axis
November 2026
Epigenetic mechanisms represented by N6-methyladenosine (m6A) modifications and circular RNAs (circRNAs) regulate chemotherapy resistance in prostate cancer (PCa). Here, we stuided the role of m6A-modified...
Dynamic single-cell landscape reveals a T-cell-suppressed microenvironment and a conserved neutrophil program in the lung metastatic niche
November 2026
While the immune landscape of primary tumors is increasingly understood, the dynamic immune remodeling within the evolving lung metastatic microenvironment remains poorly characterized. Here, by systematically...
psiTPTE22-HERV functions as a tumor suppressor by inhibiting PI3K/AKT/mTOR/EIF4E signaling
November 2026
psiTPTE22-HERV is a human-specific gene with unexplored functions. This study investigated its regulation, molecular mechanism, and clinical significance in gastric cancer. psiTPTE22-HERV expression...
First-trimester preeclampsia prediction model via integrative machine learning of maternal risk profiles and laboratory markers
November 2026
Preeclampsia (PE) affects 2%–8% of pregnancies worldwide and remains a major cause of maternal and perinatal complications. Early risk identification is essential, yet current models, such as those...
A comprehensive review on apoptotic miRNAs and antagomiRs in breast cancer: Enhancing radio sensitization
November 2026
Breast cancer (BC) is the most fatal cancer in women worldwide, and in spite of progresses in cancer treatment methods, its therapy has remained as a primary health issue. Inadequate apoptosis level...
OFC
November 2026