Mitochondrial dynamics: A promising tool for personalized TNBC management
November 2026
Triple-negative breast cancer (TNBC) is an aggressive and highly metastatic form of breast cancer and is associated with poor prognosis due to the lack of targeted therapies. Mitochondrial dysfunction...
Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology
November 2026
Beyond somatic initiation, cancer progression is governed by a multidimensional systemic metabolic architecture. This permissive macroenvironment, shaped by systemic nutrient fluxes, endocrine networks,...
The update of prostaglandin E2 receptor subtype 4 (EP4) in inflammatory diseases
November 2026
Inflammation is a defensive response of the organism to stimuli and is crucial for maintaining the stability of the internal environment. However, abnormal inflammatory responses, including over-activation...
The ubiquitin system in heart and vessel pathobiology: From mechanisms to therapeutic strategies
November 2026
Cardiovascular disease is currently a major global challenge, and its causes are complex, encompassing genetic, lifestyle, environmental, and other factors. Ubiquitination, an important post-translational...
Roles of Piezo channels in dentofacial deformity: Onset, orthodontic treatment, and associated diseases
November 2026
The onset and treatment of dentofacial deformities are closely associated with mechanical stimuli. As mechanosensitive ion channels, Piezo channels play a critical role in the mechanotransduction processes...
The role, regulatory mechanisms, and therapeutic implications of FTO in gastrointestinal cancer
November 2026
N6-methyladenosine (m6A) is the most common post-transcriptional modification in mRNA, playing a crucial role in cancer development by modulating RNA stability, translation, and nuclear export. As the...
Aberrant sialylation in cancer: From molecular mechanisms to potential therapeutics
November 2026
Sialylation, a dynamic post-translational modification catalyzed by sialyltransferases and counterbalanced by neuraminidases, entails the attachment of sialic acids to the terminal residues of glycoproteins...
Lipophagy: A key regulator in oxidative stress and metabolic disorders
November 2026
Lipophagy, the selective autophagic degradation of lipid droplets, is essential for regulating cellular lipid levels and energy balance while preventing lipotoxicity. This process integrates with metabolic...
Perspectives of EGFR co-targeting with nanocarriers for anti-TNBC purposes
November 2026
Triple-negative breast cancer (TNBC) is a particularly aggressive and therapeutically challenging subtype of breast tumor, frequently marked by the relatively high expression of epidermal growth factor...
Respiratory mucosal immunity: Biological functions, diseases, prevention and therapy
November 2026
Respiratory mucosal (RM) immunity is a highly specialized and dynamic network that safeguards the airways from inhaled pathogens while preserving tissue homeostasis. Acting as the body’s first line...
The potential role of the lung–brain axis in the pathophysiology of epilepsy: A hypothesis-driven perspective
November 2026
The pathophysiology of epilepsy remains poorly understood. One of the less explored areas is the role of the lung–brain axis, a sophisticated and intricate bidirectional connection between these two...
Variants in ARHGAP21, encoding a Rho GTPase-activating protein, are associated with focal epilepsy and neurodevelopmental disorders
September 2026
Decoding age-stratified mutational landscapes in CNS lymphoma via genomic and survival profiling for precision oncology
September 2026
Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes
September 2026
An autophagy-related molecule reticulon 3 functions as a novel prognostic biomarker in hepatocellular carcinoma
September 2026
Ammonia-induced cell death patterns in glioblastoma: Immune landscape, prognostic signature, and therapeutic target identification
September 2026
Pan-cancer analysis and mechanistic insights of tuft cell-like tumors
September 2026
Tuft cells are rare, chemosensory epithelial cells present in various tissues, including the respiratory and gastrointestinal tracts. Recent studies have revealed their significant role in cancer biology,...
Interaction between N6-methyladenosine (m6A) modification and toxicant-related neurodegeneration: From neural development to pathophysiology
September 2026
N6-methyladenosine (m6A) modification is a crucial epigenetic mechanism that is widely expressed across various tissues and biological systems. It regulates gene expression by influencing the stability...
CXorf67 in malignancies: Deciphering epigenetic landscapes and clinical implications for precision oncology
September 2026
The emerging focus on epigenetic regulation in cancer biology has unveiled the significant role of CXorf67, a protein encoded by a gene on the X chromosome. CXorf67 interacts with core components of...
Research progress on the mechanisms and animal models of Ménière’s disease
September 2026
Ménière’s disease is a prevalent chronic condition that triggers a range of vestibular and auditory symptoms. Despite significant advances in mechanisms such as genetic susceptibility, immunity, and...
Unraveling the role of PIWI/piRNAs in stem cell therapy: Epigenetic mechanisms and therapeutic potentials
September 2026
The therapeutic potential of stem cell therapy critically depends on precise epigenetic regulation mediated by PIWI/piRNA complexes. This review synthesizes current literature to analyze the structure,...
IRP1/ARID3A complex promotes pancreatic cancer chemoresistance by suppressing CYGB-related ferroptosis
September 2026
Ferroptosis, a unique modality of regulated cell death, has become an emerging strategy for tumor therapy. Multiple cellular pathways, including redox homeostasis, iron handling, epigenetic regulation,...
A parallel-risk framework accurately predicts hematopoietic stem cell transplantation outcomes and identifies benefiting patients in pediatric AML
September 2026
Pediatric acute myeloid leukemia (pAML) has a poorer prognosis than acute lymphoblastic leukemia, and hematopoietic stem cell transplantation (HSCT) offers curative potential in high-risk or relapsed...