Transcriptional circuits of the glioma microenvironment: FOSL2 as a master regulator of the pathological niche
January 2027
A novel causative LMNA variant in acrogeria syndrome and literature review of genotype–phenotype correlations
January 2027
Ionizing radiation induces senescence of dermal papilla cells through inhibiting the FOXM1–KIF20A pathway
January 2027
VCP at the crossroads of UPS and autophagy in cancer
January 2027
Proteostasis is maintained by the coordinated action of the ubiquitin–proteasome system (UPS) and autophagy–lysosome pathways. Valosin-containing protein (VCP/p97), an AAA + unfoldase, sits at its intersection...
ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions
January 2027
ONC201 (dordaviprone) has recently received accelerated approval for the treatment of recurrent H3 K27M–mutant diffuse midline glioma. Originally identified as TRAIL-inducing compound 10 (TIC10), ONC201...
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights
January 2027
Metabolic reprogramming is an important factor contributing to tumor medication resistance and recurrence in cancer cells. There is ample proof that metabolic remodeling is vital in colorectal cancer’s...
Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress
January 2027
In recent years, research has highlighted that necroptosis plays a significant role in various diseases, suggesting that studying the pathways of necroptosis may offer novel avenues for developing treatments...
Lactylation: Metabolic epigenetic regulation and cell death mechanisms in myocardial ischemia‒reperfusion injury
January 2027
One important pathogenic process that contributes to subsequent damage after myocardial infarction (MI) revascularization is myocardial ischemia/reperfusion injury (MI/RI). Its underlying mechanisms...
Functions of exosome-derived noncoding RNA-encoded polypeptides/proteins in human diseases
January 2027
Exosomes are nanoscale vesicles that are ubiquitously present in biological fluids and exhibit remarkable stability, carrying a diverse array of biologically active molecules, including various RNAs,...
Rewiring redox defense: Nrf2-driven antioxidant signaling as a gateway to programmed cell death activation in colorectal cancer
January 2027
Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and phase II detoxification genes, plays a dual role in colorectal cancer (CRC) progression by maintaining redox...
Influence of oncogenic drivers and signaling pathways on immune checkpoint inhibitor efficacy in NSCLC
January 2027
Non-small cell lung cancer (NSCLC) is characterized by intricate genetic modifications and mechanisms that allow it to evade immune detection, which complicates the pursuit of lasting therapeutic responses....
Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency
January 2027
Actin cytoskeleton defects underlie immuno-actinopathies. We identified three patients with heterozygous LCP1 gain-of-function mutations (L362F, A365D) causing activated LCP1-associated immunodeficiency...
Efineptakin alfa (NT-I7) improves overall survival and induces immune niches in murine tumors
January 2027
Tertiary lymphoid structures (TLSs) are emerging as good predictive biomarkers of response to cancer immunotherapy. However, therapeutic strategies to induce these structures are currently limited....
Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia–reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade
January 2027
Steatotic liver grafts exhibit heightened susceptibility to hepatic ischemia–reperfusion injury (HIRI), contributing to poor outcomes in liver transplantation; however, the underling mechanisms remain...
PINK1 deficiency exacerbates age-related bone loss in association with enhanced inflammatory adipocyte differentiation
January 2027
Age-related bone loss contributes to frailty, fractures, and increased mortality in the elderly, yet current osteoporosis treatments have limited long-term efficacy. Mitochondrial dysfunction is a hallmark...