Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications
March 2026
Distraction osteogenesis, or the Illizarov technique, induces bone regeneration using distractive mechanical forces. Nevertheless, Wolff's law holds that bone adapts to reverse compressive mechanical...
Non-clinical safety considerations on genome editing using the CRISPR/Cas system
March 2026
Recent advances in gene editing using the CRISPR/Cas system have revolutionized genome editing, opening new horizons for human cellular and gene therapy products. Genome editing technologies are rapidly...
Defective biological networks associated with pseudogene-derived lncRNAs in cancer drug resistance: Promising prospects for their clinical targets in cancer therapy
March 2026
Cancer is a major cause of mortality globally, characterized by its multifactorial nature and intricate treatment procedures. The main treatment options include targeted drug therapies and chemotherapy....
RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation
March 2026
Intestinal macrophages are critical regulators of mucosal immunity, playing essential roles in microbial surveillance, barrier maintenance, and tissue repair. As highly responsive immune cells, they...
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma
March 2026
Esophageal squamous cell carcinoma (ESCC) ranks among the top six deadliest malignancies globally, characterized by an alarmingly low five-year survival rate. This aggressive cancer is especially prevalent...
Extracellular vesicles-associated tRNA-derived fragments: Emerging insights into cancer progression and clinical application potential
March 2026
Exosome-associated tRNA-derived fragments (tRFs) play crucial roles in cancer progression, influencing cell proliferation, metastasis, immune evasion, and drug resistance. Due to their stability and...
Platinum-resistant ovarian cancer: From mechanisms to treatment strategies
March 2026
Over the last few decades, platinum-based chemotherapy has served as the standard chemotherapy in treating ovarian cancer (OC). While most patients initially respond well to platinum-based chemotherapy,...
High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges
March 2026
Vitamin C, also known as ascorbic acid, has sparked controversy since it first emerged as a potential anti-cancer agent. However, an increasing number of preclinical studies have demonstrated that high-dose...
Immune microenvironment in autosomal dominant polycystic kidney disease
March 2026
Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary renal disorder characterized by the progressive development of fluid-filled cysts within the kidneys, leading to renal dysfunction...
Emerging roles of pseudogene-derived lncRNAs in cancer stem cells: Non-coding clues and therapeutic targets in cancer medicine
March 2026
Cancer stem cells (CSCs), progenitor tumor cells with stemness characteristics, play key roles in cancer's onset, progression, metastasis, relapse, and chemotherapy resistance. While the exact molecular...
LRRC8A: A multifaceted regulator in cancer, neurological disorders, metabolic diseases and immune modulation
March 2026
Leucine-rich repeat containing 8A (LRRC8A) is a member of the LRRC8 family, exhibiting broad expression across various tissues and cells in vertebrates. Like other LRRC8 family members, LRRC8A contributes...
Unraveling Parkinson's disease: The mystery of mitochondria and the role of aging
March 2026
Parkinson's disease (PD) is a complex neurodegenerative disorder that poses significant burden on patients and families. Its exact cause is unknown, resulting in limited effective treatments. Mitochondrial...
Multifaceted role of T-box transcription factor 4: From embryonic development to disease pathogenesis
March 2026
T-box transcription factor 4 (TBX4), a crucial member of the T-box gene family, is essential for embryonic development, particularly in the formation of hindlimbs and lungs. Beyond these developmental...
Ferroptosis: The dawn of reversing drug resistance in digestive cancers
March 2026
Ferroptosis, a form of iron-dependent cell death characterized by lipid peroxidation, has emerged as a promising strategy to overcome resistance to chemotherapy. This review explores the mechanisms...
circFKBP8(5S,6)-encoded protein promotes stress susceptibility in mice by down-regulating dopamine D3 receptor expression and its downstream AMPK/mTOR/ULK1 autophagy signaling
March 2026
Major depressive disorder (MDD) is a serious mental disorder, yet the mechanism by which circular RNAs (circRNAs) are involved in the pathogenesis of MDD by encoding proteins is unknown. Our previous...
METTL16 in cancer: Roles and regulatory mechanisms
March 2026
The regulation of gene expression is pivotal in cancer development, with increasing emphasis on epigenetic modifications such as RNA methylation. N6-methyladenosine (m6A), the most abundant RNA modification,...
The role of positive feedback loop between LINC00862 and RBM47 in hepatocellular carcinoma suppression
March 2026
While the dynamic interaction between long non-coding RNA (lncRNA) and RNA binding proteins is widely recognized as pivotal in the regulation of hepatocellular carcinoma (HCC), the precise underlying...
TIGAR promotes osteogenic differentiation and ameliorates glucocorticoid-induced osteoporosis via autophagy-Nrf2-ROS axis
March 2026
Glucocorticoid-induced osteoporosis (GIOP) is a public health problem that needs urgently to be resolved, and oxidative stress is closely related to osteogenic impairment. TP53-induced glycolysis and...
cGAS knockout inhibited endotoxin-induced uveitis in mice
March 2026
Our research focused on the impact of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) pathway on retinal inflammation and employed an...
Integrative high-throughput studies to develop novel targets and drugs for the treatment of advanced prostate cancer
March 2026
Androgen deprivation therapies targeting the androgen receptor (AR) signaling pathway are the primary treatment strategy for prostate cancer. However, these therapies often lead to castration resistance....
UBR5 regulates the progression of colorectal cancer cells through Snail-induced epithelial–mesenchymal transition
March 2026
Snail is a core inducer of epithelial-to-mesenchymal transition. Here, we show that UBR5 promotes ubiquitin-mediated degradation of Snail and regulates the progression of colorectal cancer cells through...
GXYLT2 serves as a prognostic biomarker and is associated with β-catenin activation and gastric cancer aggressiveness
March 2026
Gastric cancer (GC) is a significant global health challenge due to its high incidence and mortality rate. However, the existing classification methods for GC still have limitations. Given the pivotal...
Macrophage κ-opioid receptor inhibits hypoxic pulmonary hypertension progression and right heart dysfunction via an SCD1-dependent anti-inflammatory response
March 2026
We aimed to investigate the effects and mechanism(s) of macrophage κ-opioid receptor (κ-OR) on macrophage inflammatory response and hypoxic pulmonary hypertension (HPH). Macrophage κ-OR-deficient mice...
Chondrogenic potential of mesenchymal progenitors from somatic and cartilage-derived iPSCs is predicted by their transcriptomic signatures
March 2026
Mesenchymal stem cells (MSCs) are widely used in regenerative therapy but face limitations like low abundance, replicative senescence, donor variability, and restricted plasticity. Induced pluripotent...
Nuclear and cytoplasmic USP30-AS1 coordinately regulate breast cancer progression through HnRNPF/p21 and EZH2/c-Myc/p21 axes
March 2026
Emerging evidence suggests that aberrant expression of long non-coding RNAs (lncRNAs) is strongly associated with the occurrence and progression of breast cancer. Herein, we identified ubiquitin specific...
