Targeting hepatic CREBZF protects against atherosclerosis via exosomal miR-210-3p mediated inhibition of endothelial inflammation
February 2027
Cardiovascular diseases (CVDs) continue to be the primary cause of mortality globally. Abnormal liver function has been widely recognized as an independent risk factor for atherosclerotic CVDs. However,...
Echinocystic acid inhibits the growth of human bladder cancer cells by suppressing AKT1/GSKβ/β-Catenin signaling and synergizes with gemcitabine
February 2027
Bladder cancer (BC) is an aggressive and treatment-resistant malignancy with a high recurrence rate. Current first-line therapies only provide limited relief due to chemoresistance and toxicity. Natural...
Glis1 regulates metabolic programming by promoting H3K18 lactylation to alleviate neuronal senescence following spinal cord injury
February 2027
Neuronal senescence is a significant factor impeding spinal cord injury (SCI) repair. Research indicates that Glis1, a Kruppel-like zinc finger transcription factor, is pivotal in reprogramming senescent...
Betaine alleviates renal osteodystrophy by stabilizing ABCG1 mRNA to inhibit HMOX1-mediated ferroptosis in BMSCs
February 2027
Renal osteodystrophy is a debilitating complication of chronic kidney disease characterized by deteriorated bone microarchitecture and impaired bone formation, leading to increased fracture risk. Despite...
Activation of AIM2 inflammasome cascade by extracellular trap-laden neutrophil vesicles triggered by Fusobacterium nucleatum exacerbates ulcerative colitis
February 2027
Neutrophil dysfunction and activation of the absent in melanoma 2 (AIM2) inflammasome have been implicated in ulcerative colitis (UC) pathogenesis. However, whether these two immune responses interact...
Gut microbial histamine and serotonin promote cerebrovascular angiogenesis: Evidence from moyamoya disease
February 2027
Moyamoya disease (MMD) is a progressive cerebrovascular disorder characterized by arterial stenosis and compensatory neovascularization, but its upstream drivers remain poorly defined. Here, we identify...
Mapping intestinal microenvironment heterogeneity in Hirschsprung's disease by spatial transcriptomics: Role of THBS1 in macrophage polarization and neural stem cell regulation
February 2027
The pathogenic role of the intestinal microenvironment on Hirschsprung's disease (HSCR) is increasingly recognized; however, the spatial expression patterns and underlying molecular mechanisms of the...
PTHrP suppresses BMP2-induced osteochondral differentiation and preserves cartilage phenotype in mesenchymal stem cells via inactivating PI3K–AKT signaling
February 2027
Bone morphogenetic protein 2 (BMP2) has the potential to drive multipotent mesenchymal stem cells (MSCs) to undergo chondral–osteogenic (including hypertrophic chondrocyte) differentiation. Parathyroid...
Targeting Src/FN1 adhesion circuitry to suppress circulating tumor cell clusters and lung cancer metastasis
January 2027
Ionizing radiation induces senescence of dermal papilla cells through inhibiting the FOXM1–KIF20A pathway
January 2027
VCP at the crossroads of UPS and autophagy in cancer
January 2027
Proteostasis is maintained by the coordinated action of the ubiquitin–proteasome system (UPS) and autophagy–lysosome pathways. Valosin-containing protein (VCP/p97), an AAA + unfoldase, sits at its intersection...
ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions
January 2027
ONC201 (dordaviprone) has recently received accelerated approval for the treatment of recurrent H3 K27M–mutant diffuse midline glioma. Originally identified as TRAIL-inducing compound 10 (TIC10), ONC201...
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights
January 2027
Metabolic reprogramming is an important factor contributing to tumor medication resistance and recurrence in cancer cells. There is ample proof that metabolic remodeling is vital in colorectal cancer’s...
Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress
January 2027
In recent years, research has highlighted that necroptosis plays a significant role in various diseases, suggesting that studying the pathways of necroptosis may offer novel avenues for developing treatments...
Lactylation: Metabolic epigenetic regulation and cell death mechanisms in myocardial ischemia‒reperfusion injury
January 2027
One important pathogenic process that contributes to subsequent damage after myocardial infarction (MI) revascularization is myocardial ischemia/reperfusion injury (MI/RI). Its underlying mechanisms...
Functions of exosome-derived noncoding RNA-encoded polypeptides/proteins in human diseases
January 2027
Exosomes are nanoscale vesicles that are ubiquitously present in biological fluids and exhibit remarkable stability, carrying a diverse array of biologically active molecules, including various RNAs,...
Rewiring redox defense: Nrf2-driven antioxidant signaling as a gateway to programmed cell death activation in colorectal cancer
January 2027
Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and phase II detoxification genes, plays a dual role in colorectal cancer (CRC) progression by maintaining redox...
Influence of oncogenic drivers and signaling pathways on immune checkpoint inhibitor efficacy in NSCLC
January 2027
Non-small cell lung cancer (NSCLC) is characterized by intricate genetic modifications and mechanisms that allow it to evade immune detection, which complicates the pursuit of lasting therapeutic responses....
Efineptakin alfa (NT-I7) improves overall survival and induces immune niches in murine tumors
January 2027
Tertiary lymphoid structures (TLSs) are emerging as good predictive biomarkers of response to cancer immunotherapy. However, therapeutic strategies to induce these structures are currently limited....
Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia–reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade
January 2027
Steatotic liver grafts exhibit heightened susceptibility to hepatic ischemia–reperfusion injury (HIRI), contributing to poor outcomes in liver transplantation; however, the underling mechanisms remain...