Pathophysiological mechanisms of organ injury in Fabry disease: Update via multi-omics
September 2026
Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in GLA gene, which result in deficient α-galactosidase A activity, leading to intralysosomal accumulation of metabolic...
Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies
September 2026
Piezo ion channels, notably Piezo1 and Piezo2, are key mechanosensors that transduce mechanical forces into intracellular signals, playing indispensable roles in digestive physiology. These channels...
Interaction between N6-methyladenosine (m6A) modification and toxicant-related neurodegeneration: From neural development to pathophysiology
September 2026
N6-methyladenosine (m6A) modification is a crucial epigenetic mechanism that is widely expressed across various tissues and biological systems. It regulates gene expression by influencing the stability...
CXorf67 in malignancies: Deciphering epigenetic landscapes and clinical implications for precision oncology
September 2026
The emerging focus on epigenetic regulation in cancer biology has unveiled the significant role of CXorf67, a protein encoded by a gene on the X chromosome. CXorf67 interacts with core components of...
The multifaceted landscape of T cell exhaustion in organ transplantation: From molecular mechanisms (epigenetics, transcription, metabolism) to induction strategies
September 2026
T cell exhaustion is a state of T cell dysfunction resulting from persistent antigenic stimulation, characterized primarily by the high expression of inhibitory receptors, metabolic reprogramming, and...
Research progress on the mechanisms and animal models of Ménière’s disease
September 2026
Ménière’s disease is a prevalent chronic condition that triggers a range of vestibular and auditory symptoms. Despite significant advances in mechanisms such as genetic susceptibility, immunity, and...
Unraveling the role of PIWI/piRNAs in stem cell therapy: Epigenetic mechanisms and therapeutic potentials
September 2026
The therapeutic potential of stem cell therapy critically depends on precise epigenetic regulation mediated by PIWI/piRNA complexes. This review synthesizes current literature to analyze the structure,...
Purinergic signaling in osteoarthritis: Mechanistic insights into pathogenesis and therapeutic targeting
September 2026
Osteoarthritis (OA) is a degenerative joint disease driven by a complex interplay of inflammation, extracellular matrix degradation, subchondral bone remodeling, and chronic pain. Purinergic signaling...
IRP1/ARID3A complex promotes pancreatic cancer chemoresistance by suppressing CYGB-related ferroptosis
September 2026
Ferroptosis, a unique modality of regulated cell death, has become an emerging strategy for tumor therapy. Multiple cellular pathways, including redox homeostasis, iron handling, epigenetic regulation,...
Uncovering genes driving developmental stage progression in prostate cancer through spatial transcriptomics
September 2026
Precisely delineating the transcriptomic profiles of glandular epithelial (GE) cells in prostate cancer (PCa) remains a significant challenge primarily due to their diffuse and multifocal distribution....
ADAR1p110 promotes hepatocellular carcinoma metastasis via the miR-451a/TUBA1A axis
September 2026
ADAR1 is overexpressed in hepatocellular carcinoma (HCC) and has been linked to poor prognosis, metastasis, and recurrence; however, its precise functions and underlying mechanisms, particularly in...
CUDC-907 inhibits glioblastoma and enhances glioblastoma sensitivity to temozolomide by inhibiting DNA damage repair
September 2026
CUDC-907, referred to as Fimepinostat, functions as a dual inhibitor of PI3K and HDAC, exhibiting significant anti-tumor efficacy in a range of cancer types. However, its specific role in glioblastoma...
Transcription cofactor Hes6 interacts with Twist1 to facilitate EMT and promote gastric carcinogenesis by activating the PI3K/AKT signaling
September 2026
Advanced gastric cancer (GC) poses a significant threat to public health, leading to substantial consumption of healthcare resources due to its aggressive nature and poor prognosis. Hairy and enhancer...
SIRT5 mediates the pro-osteogenic effects of estrogen through FDX1 demalonylation and cuproptosis inhibition in mesenchymal stem cells
September 2026
Osteoporosis, a common orthopedic disease predominantly caused by estrogen deficiency in postmenopausal women, continues to pose a significant public health challenge due to the poorly understood molecular...
CXCR4 reduces aldosterone synthesis via regulating CYP11B2 expression
September 2026
C-X-C motif chemokine receptor 4 (CXCR4) is highly expressed in aldosterone-producing adenoma, and gallium-68 pentixafor PET-CT imaging targeting CXCR4 has been utilized for subtype diagnosis in primary...
A parallel-risk framework accurately predicts hematopoietic stem cell transplantation outcomes and identifies benefiting patients in pediatric AML
September 2026
Pediatric acute myeloid leukemia (pAML) has a poorer prognosis than acute lymphoblastic leukemia, and hematopoietic stem cell transplantation (HSCT) offers curative potential in high-risk or relapsed...
Type III interferons attenuates Th1/Th17 cell pathogenicity and regulates retinal pigment epithelium cells via NLRP1/NLRP3 signaling axis in autoimmune uveitis
September 2026
Accumulating data implicate Type III interferons (IFN-λs) in autoimmune disorders, prompting our exploration of their role in uveitis pathogenesis. Serum and peripheral blood mononuclear cells (PBMCs)...
Agrimoniin ameliorates intrapulmonary angiogenesis and improves hypoxemia in hepatopulmonary syndrome via PGC-1α activation and glycolysis down-regulation
September 2026
Hepatopulmonary syndrome (HPS) is a condition characterized by pulmonary angiogenesis and refractory hypoxemia, often seen in patients with chronic liver disease. Its unclear mechanism means that liver...
The therapeutic effect of nicotinamide riboside chloride on ameliorating alcohol-induced neuronal damage with a focus on mitochondrial unfolded protein response and mitophagy
September 2026
Excessive alcohol consumption leads to neurodegeneration, driven primarily by oxidative stress and mitochondrial dysfunction, yet no specific treatment exists. Nicotinamide riboside chloride (NRC),...
Identification of the homozygous truncating mutation in CNTD1 as a novel genetic cause of diminished ovarian reserve
September 2026
Diminished ovarian reserve (DOR) is one of the leading causes of infertility, which accounts for approximately 10% of women seeking fertility treatment. However, their genetic etiology and pathogenesis...
Potential oncogenic role of occult hepatitis B virus pre-S mutations: Activation of Akt/mTOR/Cyclin D1 signaling drives cell cycle dysregulation and proliferation in hepatocellular carcinogenesis
September 2026
Hepatitis B virus (HBV) infection remains a severe global public health challenge, with hepatocellular carcinoma being a primary cause of HBV-related mortality. Occult HBV infection (OBI) represents...
Artesunate directly targets glucosylceramidase to suppress hepatocellular carcinoma proliferation and trigger apoptosis
September 2026
Our previous preclinical study determined artesunate as a candidate drug for hepatocellular carcinoma (HCC) and identified glucosylceramidase (GBA) as one of its direct targets. This research aimed...
8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism
September 2026
The invasive and metastatic potential of hepatocellular carcinoma (HCC) is tightly linked to lipid metabolic reprogramming. However, existing knowledge of the molecular regulatory network governing...
Lipid droplet-associated gene signatures classify metabolic subtypes and identify PLIN3 as a key driver in hepatocellular carcinoma
September 2026
Hepatocellular carcinoma is characterized by considerable molecular heterogeneity, which complicates prognostic predictions and contributes to therapeutic resistance. This study aimed to develop a molecular...
