Recent Articles

Open access

ISSN: 2352-3042
CN: 50-1221/R
p-ISSN: 2352-4820

Magnolol mitigates morphine-induced analgesic tolerance via EGFR-mediated inhibition of microglial activation and neuroinflammatory reduction

LINC00431 modulates KRAS and p53 stability to drive pancreatic cancer progression under hypoxia

Non-coding somatic single-nucleotide variations affecting glioblastoma-specific enhancer elements regulate tumor-promoting gene networks

Forward genetics identifies HN1L/JPT2 as a novel carboplatin resistance gene in ovarian cancer

Single-cell transcriptomics unveils iron dysregulation in macrophages: Implicated genes in periodontitis pathogenesis identified via Mendelian randomization

A novel method for the detection of Cas9 gRNAs using a fluorophore-labeled DNA oligo

Investigation of the temporal distribution of anti-VEGF drugs in the retina and the correlation with the distribution of FcR isoforms

A multi-omic integrative approach combining m6A-epitranscriptomic, transcriptomic, and splicing alternative events reveals potential candidates for colorectal cancer diagnosis

Role of angiogenesis-related lncRNAs in tumor microenvironment and prognosis of lung adenocarcinoma

Genetics, epidemiology and management of clubfoot and related disorders

Clubfoot, medically termed congenital talipes equinovarus (CTEV), is a prevalent musculoskeletal birth defect, affecting approximately 0.3% of all live births. This serious congenital anomaly results...

Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment

Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer...

Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation

Fucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable...

Unveiling the regulatory potential of the non-coding genome: Insights from the human genome project to precision medicine

The Human Genome Project marked a milestone in scientific exploration, unraveling the genetic blueprint of humanity. However, expectations of direct gene–disease associations gave way to realizing the...

Recent advances in oncolytic virus combined immunotherapy in tumor treatment

Oncolytic viruses (OVs), a kind of emerging therapeutics for treating tumors, are characterized by high replication efficiency, superior killing effects, and few adverse reactions, which have shown...

In vivo production of CAR T cell: Opportunities and challenges

Chimeric antigen receptor T (CAR T) cell therapy has achieved remarkable efficacy for patients with hematological malignancies. However, in vitro viral vector-mediated production of CAR T cells is time-consuming...

Selectively targeting BCL6 using a small-molecule inhibitor is a potential therapeutic strategy for glioblastoma

Glioblastoma multiforme (GBM) is the deadliest form of brain tumor, and effective treatments are lacking. Thus, a new generation of effective treatments is urgently needed. B-cell lymphoma 6 (BCL6)...

Elevated miR-34a induced by lipotoxicity and inflammation mediates pathophysiological communication between hepatocytes and hepatic stellate cells in liver fibrosis

Increased mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) imposes an urgent need to elucidate the pathogenesis of MASLD so that novel therapeutic strategies...

ADAMTS2: More than a procollagen N-proteinase

A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2) is a member of the ADAMTS zinc metalloproteinase family, best known for its role as a procollagen I N-proteinase in the maturation...

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