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ISSN: 2352-3042
CN: 50-1221/R
p-ISSN: 2352-4820

Mechanosensitive adhesion G protein-coupled receptors: Insights from health and disease

Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals through mechanotransduction. As...

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Cardiomyocyte proliferation: Advances and insights in macrophage-targeted therapy for myocardial injury

In the mammalian heart, cardiomyocytes undergo a transient window of proliferation that leads to regenerative impairment, limiting cardiomyocyte proliferation and myocardial repair capacity. Cardiac...

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The subventricular zone structure, function and implications for neurological disease

The subventricular zone (SVZ) is a region surrounding the lateral ventricles that contains neural stem cells and neural progenitor cells, which can proliferate and differentiate into various neural...

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The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis

Post-translational modifications (PTMs) of proteins play a crucial role in living organisms, altering the properties and functions of proteins. There are over 450 known PTMs involved in various life...

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Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion

Mitochondria serve as the energy provider and enable life activities, and they are the only organelles containing extra-chromosomal DNA. Each mitochondrion contains multiple copies of its genome, which...

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Treating human cancer by targeting EZH2

Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that primarily inhibits downstream gene expression by tri-methylating histone H3, which is usually overexpressed in tumors and participates...

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The crosstalk between non-coding RNAs and oxidative stress in cancer progression

As living standards elevate, cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing years. One of the reasons is that instability in the...

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Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality

The ubiquitin (Ub) system, a ubiquitous presence across eukaryotes, plays a crucial role in the precise orchestration of diverse cellular protein processes. From steering cellular signaling pathways...

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Coding circular RNA in human cancer

circular RNA (circRNA) is a covalently closed single-stranded RNA that lacks 5' and 3' ends and has long been considered a noncoding RNA. With the development of high-throughput sequencing and bioinformatics...

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Predicting anti-cancer drug sensitivity through WRE-XGBoost algorithm with weighted feature selection

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Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma

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Expanding the spectrum of novel candidate genes using trio exome sequencing and identification of monogenic cause in 27.5% of 320 families with steroid-resistant nephrotic syndrome

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The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma

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The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis

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Construction and validation of a novel SUMOylation-related lncRNAs signature for predicting the prognosis, tumor immune microenvironment, and therapeutic sensitivity of lung adenocarcinoma

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SNORD3B-2 promotes endometrial carcinoma progression by 2′-O-methylation modification of PLK1 and regulating RAB17 alternative splice

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De novo missense variants of UNC13A are implicated in epileptic encephalopathies and neurodevelopmental disorders

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Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer

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Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration

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Gene expression analysis in subcutaneous adipose tissue reveals a predominant influence of lncRNAs during growth

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DARG: An integrated knowledge base for analyzing addictive drug-related genes

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Reactive oxygen species mediate ovarian cancer development, platinum resistance, and angiogenesis via CXCL8 and GSK-3β/p70S6K1 axis

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Multi-time point transcriptomics and metabolomics reveal key transcription and metabolic features of hepatic ischemia-reperfusion injury in mice

Hepatic ischemia-reperfusion injury is an unavoidable surgical complication of liver transplantation and the leading cause of poor graft function and increased mortality post-transplantation. Multiple...

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Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation

Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs), which sense biomechanical stimuli and initiate alveolar bone remodeling. Light (optimal) forces accelerate OTM, whereas...

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Targeting the MYCN-MDM2 pathways for cancer therapy: Are they druggable?

Targeting oncogenes and their interactive partners is an effective approach to developing novel targeted therapies for cancer and other chronic diseases. We and others have long suggested the MDM2 oncogene...

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