Circulating tumor DNA predicts tumor recurrence in early-stage breast cancer: A meta-analysis
July 2026
Lgr6+ cells in the biological system during homeostasis and injury
July 2026
Lgr6 has attracted significant attention in biomedical research in recent years. As a member of the G protein-coupled receptor family, Lgr6 plays a crucial role in the occurrence and development of...
Mitochondrial transplantation in lung diseases: From mechanisms to application prospects
July 2026
Mitochondria are double-membrane organelles in eukaryotic cells, which play an important role in energy metabolism, cell cycle and apoptosis. Therefore, mitochondrial abnormalities can affect various...
Crosstalk between autophagy and ferroptosis in diabetes
July 2026
Diabetes is a multifactorial metabolic disease involving complex disruptions in cellular homeostasis and multiple forms of regulated cell death. Among them, the interaction between autophagy and ferroptosis...
Context-dependent actions of STING pathway in colitis and associated colon cancer
July 2026
Inflammatory bowel disease (IBD), a prevalent chronic inflammatory disorder with unsatisfactory therapeutic outcomes, significantly increases the risk of colorectal cancer. The cyclic GMP-AMP synthase...
Receptor-mediated endocytosis by Megalin: Exploring its role in ligand interaction and disease mechanisms
July 2026
This review comprehensively summarizes the interaction mechanisms between Megalin and several key ligands, including calcium ions, gentamicin, ApoE, ANKRA2, FVIII, TTR, STC1, RAP, and MMP-9, focusing...
Suppression of UCP2 alleviates leukemogenesis by enhancing branched-chain amino acids-induced oxidative stress via activating the PI3K/AKT/mTOR signaling pathway
July 2026
Although the cellular role of uncoupling protein 2 (UCP2) in tumorigenesis has been reported in various solid tumor models, its role in leukemogenesis remains elusive. Herein, we demonstrated that UCP2...
Identification of PLXNC1 as a novel biomarker for consensus molecular subtype 4 in colorectal cancer
July 2026
Colorectal cancer (CRC) is a highly heterogeneous malignancy that is divided into four consensus molecular subtypes (CMSs), with CMS4 considered to be the worst type of CRC. The CMS classification has...
Impact of maternal lipopolysaccharide and polyinosinic-polycytidylic acid-induced infections on offspring cardiac development: Mitochondrial dysfunction and metabolic alterations
July 2026
Maternal infections can have profound effects on embryonic heart development, yet the precise pathways through which these impacts manifest are still largely unexplored. This research explores the influence...
Androgen receptor acts as the transcriptional repressor of the nuclear receptor LRH-1 via the androgen-driven chromatin looping conformation in prostate cancer
July 2026
The androgen receptor (AR) signaling axis is regarded as the key driver of prostate cancer (PCa). Besides acting as a well-characterized transactivator of diverse targets, accumulating evidence suggests...
Deciphering the impact of SNAI1 gene on renal tubular cell proteome, nucleolar stress, ribosome biogenesis, senescence, DNA damage response, and focal adhesion dynamics
July 2026
Snail1, encoded by SNAI1 gene, is an essential protein that regulates epithelial–mesenchymal transition, which leads to extracellular matrix accumulation and kidney fibrosis, but with unclear cellular...
PDK1 elevation was induced by epigenetic modifications of KDM3A and METTL16 to mediate TKI resistance and cancer development
July 2026
Lung cancer is the leading cause of cancer-related death and has the second-highest incidence worldwide. For patients with advanced EGFR-mutated non-small cell lung cancer, EGFR tyrosine kinase inhibitors...
ATOX1 overexpression mitigates copper homeostasis in microglia: Implications for Alzheimer's disease therapy
July 2026
Copper (Cu2+) is a known contributor to the pathogenesis of Alzheimer's disease (AD). However, it is uncertain whether proteins regulating copper homeostasis affect Cu2+ in microglia. Antioxidant protein...
Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury
July 2026
Traumatic brain injury (TBI) is characterized by high rates of death and disability. Necroptosis is reported to be involved in neuronal death after TBI. However, additional molecules and related mechanisms...
