Share article
Share article
Identifying functional subtypes and common mechanisms of rheumatoid arthritis and systemic lupus erythematosus
September 2025
Share article
Glial subtype-specific modulation of disease pathogenesis in Drosophila models of ALS
September 2025
Share article
Sirolimus may improve bile excretion in ABCB11 mutants: A case report of a patient with bile salt export pump deficiency
September 2025
Share article
Data-informed insights into sex differences in peripheral blood mononuclear cells from single-cell transcriptomics
September 2025
Share article
Share article
TET1: The epigenetic architect of clinical disease progression
September 2025
The ten-eleven translocation 1 (TET1) protein, a member of the human α-ketoglutarate-dependent dioxygenase TET family, functions as a 5-methylcytosine hydroxylase with a strong affinity for genomic...
Share article
Ribosome biogenesis: A central player in liver diseases
September 2025
Ribosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining...
Share article
Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration
September 2025
Mammalian hair follicles undergo periodic regeneration, with recent research highlighting the immunological niche as a critical regulator of stem cell activity and hair follicle regeneration. Chemotactic...
Share article
Fibroblast growth factor 8: Multifaceted role in development and developmental disorder
September 2025
Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly dynamic gene expression pattern...
Share article
Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines
September 2025
Older age is one of the leading risk indicators for advanced breast cancer. It is critical to extensively investigate how aging affects breast cancer, considering the increasing rate of population aging....
Share article
Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances
September 2025
Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced...
Share article
Ribonucleases in Mendelian disease: Characterization and insight from model organisms
September 2025
Ribonucleases (RNases), essential for RNA metabolism, are implicated in human diseases, including neurodevelopmental, developmental, hematopoietic and other dysfunctions through mutations that disrupt...
Share article
Expression of LINE-1 elements is required for preimplantation development and totipotency
September 2025
Transposable elements, long considered genomic intruders, have been found to play significant and intriguing roles during early embryonic development based on the paradigm shift that has undergone in...
Share article
Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines
September 2025
The major histocompatibility complex (MHC) region plays a crucial role in immune function and is implicated in various diseases and cancer immunoediting. However, its high polymorphism poses challenges...
Share article
Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation
September 2025
Galectin-3 (Gal-3) plays a multifaceted role in the development and progression of pancreatic adenocarcinoma (PAAD), which is associated with a poor prognosis. Its interaction with tumor microenvironment...
Share article
Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity
September 2025
The aggregation of the peptide hormone amylin in the pancreas is a pathological hallmark of type-2 diabetes. Additionally, amylin can form aggregates in the brain, promoting β-amyloid deposition and...
Share article
Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway
September 2025
Left ventricular non-compaction (LVNC), is a hereditary cardiomyopathy with limited treatments. Our previous study linked phosphodiesterase 4D interacting protein (PDE4DIP) to LVNC development. To explore...
Share article
The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer
September 2025
Pancreatic cancer (PC) is a highly malignant neoplasm of the digestive system. The primary objective of this investigation is to elucidate the intricate mechanisms underlying the role of the aging process...
Share article
Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis
September 2025
Ovarian cancer (OC) peritoneal metastasis (OCPM) is a major cause of high mortality of OC, in which cancer cells incubated in ascites evolve various mechanisms to survive. Hippo/YAP singling plays multiple...
Share article
Genetically predicted blood metabolites mediate the association between immune cell characteristics and urolithiasis: A Mendelian randomization study and mediation analysis
September 2025
Urolithiasis, a disease characterized by the formation of urinary stones, is influenced by immune system dysregulation and metabolic factors. This study investigated the interplay between specific immune...
Share article
miR-146b/Btg2 axis as a potential inducer of islet beta-cell decline during the progression of obesity to T2DM
September 2025
We evaluated the potential mechanisms responsible for inducing beta-cell decline during the progression of obesity to type 2 diabetes mellitus (T2DM). Between February 2021 and February 2022, 25 subjects...
Share article
XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy
September 2025
Immune checkpoint inhibitors have a poor effect in treating ovarian cancer, and the specific mechanism is unknown. The purpose of this research was to investigate the impact of XPR1 on controlling autophagy...
Share article
Chlorpyrifos induces spermatogenic dysfunction via ferroptosis in Sertoli cells
September 2025
Chlorpyrifos (CPF), a widely used organophosphate pesticide, accumulates in the environment and affects human health. Its neurotoxicity has been extensively studied, and recent research has revealed...
Share article
