Rewiring redox defense: Nrf2-driven antioxidant signaling as a gateway to programmed cell death activation in colorectal cancer
January 2027
Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and phase II detoxification genes, plays a dual role in colorectal cancer (CRC) progression by maintaining redox...
Influence of oncogenic drivers and signaling pathways on immune checkpoint inhibitor efficacy in NSCLC
January 2027
Non-small cell lung cancer (NSCLC) is characterized by intricate genetic modifications and mechanisms that allow it to evade immune detection, which complicates the pursuit of lasting therapeutic responses....
Single-cell sequencing-guided discovery of narciclasine as a dual VCAM-1/ICAM-1 inhibitor for atherosclerosis management
January 2027
Atherosclerosis (AS) remains a leading cause of cardiovascular morbidity and mortality worldwide, with current treatments focused primarily on reducing low-density lipoprotein levels while failing to...
ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming
January 2027
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death with limited treatment options, and there is an urgent need to develop effective therapeutic strategies....
Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency
January 2027
Actin cytoskeleton defects underlie immuno-actinopathies. We identified three patients with heterozygous LCP1 gain-of-function mutations (L362F, A365D) causing activated LCP1-associated immunodeficiency...
PINK1 deficiency exacerbates age-related bone loss in association with enhanced inflammatory adipocyte differentiation
January 2027
Age-related bone loss contributes to frailty, fractures, and increased mortality in the elderly, yet current osteoporosis treatments have limited long-term efficacy. Mitochondrial dysfunction is a hallmark...
LAMA5 pathogenic variant uncovers a novel autoantigen in membranous nephropathy
January 2027
Membranous nephropathy is a leading cause of nephrotic syndrome, driven by autoantibodies targeting podocyte antigens. Although antibodies against PLA2R and THSD7A account for the majority of cases,...
High-throughput chemical screen identifies epothilone B in modulating inflammatory bowel disease by triggering neutrophil apoptosis
January 2027
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract characterized by a complex interplay of genetic, environmental, and immunological factors. Neutrophils,...
Efineptakin alfa (NT-I7) improves overall survival and induces immune niches in murine tumors
January 2027
Tertiary lymphoid structures (TLSs) are emerging as good predictive biomarkers of response to cancer immunotherapy. However, therapeutic strategies to induce these structures are currently limited....
Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia–reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade
January 2027
Steatotic liver grafts exhibit heightened susceptibility to hepatic ischemia–reperfusion injury (HIRI), contributing to poor outcomes in liver transplantation; however, the underling mechanisms remain...
Commentary on clim-TIME: A paradigm shift in spatially resolved perturbation mapping of the metastatic tumor microenvironment
November 2026
A novel chimeric RNA RPGR-EEF1A1 enhances autophagy by interaction with the small GTPase RAB37 in a GTP-dependent manner
November 2026
Hemilateral adipose and muscular atrophy associated with a somatic PDGFRB p.N666K variant
November 2026
Progesterone and selective progesterone receptor modulator regulate tumor-associated fibroblasts in uterine leiomyomas
November 2026
Protein arginine methylation and ubiquitination: A prominent crosstalk and its functions in cancer
November 2026
Protein arginine methyltransferases (PRMTs) catalyze the formation of arginine methylations in histones and nonhistone proteins. PRMT family members strongly affect the malignant progression of cancer....
The role, regulatory mechanisms, and therapeutic implications of FTO in gastrointestinal cancer
November 2026
N6-methyladenosine (m6A) is the most common post-transcriptional modification in mRNA, playing a crucial role in cancer development by modulating RNA stability, translation, and nuclear export. As the...
CCT2 enhances c-Myc stabilization to drive tumor progression and chemoresistance in head and neck squamous cell carcinoma
November 2026
CCT2, a vital subunit of the chaperonin-containing TCP-1 (CCT) complex, has emerged as a critical regulator of protein homeostasis and cancer progression. In this study, we highlight the essential role...
psiTPTE22-HERV functions as a tumor suppressor by inhibiting PI3K/AKT/mTOR/EIF4E signaling
November 2026
psiTPTE22-HERV is a human-specific gene with unexplored functions. This study investigated its regulation, molecular mechanism, and clinical significance in gastric cancer. psiTPTE22-HERV expression...
OFC
November 2026
Epigenetic insights into cancer metastasis via lineage trans-differentiation
Available online 6 June 2026