Recent Articles

Systematic druggable genome-wide analysis to identify potential therapeutic targets for urologic diseases

May 2026

Yongwang Shi | Hongyan Chen | Xinlei Zhang | Chengliang Yin | Penghu Lian

Epigenetic insights into minimal residual disease detection in cancer

May 2026

Lingao Ju | Gang Wang | Zilin Xu | Wan Xiang | Hongwei Peng | Mengxue Yu | Shenjuan Li | Yi Zhang | Kaiyu Qian | Yu Xiao

Molecular characterization of a new R1925X point mutation mouse model for dysferlinopathy

May 2026

Camille Bouchard | Louis Despax | Joël Rousseau | Jacques P. Tremblay

PI3Kα-RAS interface disruption as a new therapeutic strategy

May 2026

Abdelhalim Azzi

Deubiquitinase USP17 negatively regulates 3T3-L1 adipocyte differentiation via HDAC1

May 2026

Yuankuan Li | Meiyu Piao | Yujian Jin | Sung Ho Lee | Kwang Youl Lee

HSF5: A novel switch for meiotic pachynema progression in male germ cells

May 2026

Chunhai Luo | Ziqi Yu | Dalin Liu | Haoran Xu | Junfeng Zhan | Fei Sun

Kitlg dysfunction is associated with hearing and pigmentation abnormalities

May 2026

Yun Xiao | Ruifeng Qiao | Jing Cai | Lei Chen | Yu Jin | Aizhen Zhang | Shuhui Kong | Yongdong Song | Haibo Wang | Lei Xu

The molecular and immune landscape of the forkhead-box gene family in different subtypes of breast cancer

May 2026

Xiaoman Bi | Liyang Chen | Deng Wu | Dahua Xu | Dehua Zheng | Zhizhou Xu | Zhenling Wan | Shaoping Zheng | Kongning Li | Shaojiang Zheng

Data-driven identification of core tumor-secreted factors associated with cachexia prevalence

May 2026

Sarah Santiloni Cury | Paula Paccielli Freire | Robson Francisco Carvalho

TNFAIP8/TIPE2 inactivation modulates extracellular matrix organization gene expression and preserves the intervertebral disc structure in mice

May 2026

Zuozhen Tian | Ken Chen | Frances S. Shofer | Srish S. Chenna | Daniel Z. Sandroni | Ling Qin | Yejia Zhang

Spatial transcriptomic characterization of the pathologic niche in a patient with pulmonary crystal-storing histiocytosis

May 2026

Yao Chen | Zhining Huang | Gaoxiang Wang | Mingsheng Wu | Xiao Chen | Xiaohui Sun | Lei Gao | Mingran Xie

In vivo CRISPR/Cas9-mediated gene integration corrects mucopolysaccharidosis type II in mice

May 2026

Hanfei Yu | Qian Qin | Shiyu Cui | Yujuan Wa | Kexian Dong | Wei Ji | Xueyuan Jia | Songbin Fu | Jie Wu | Wenjing Sun

DNA damage-induced nuclear STING translocation orchestrates innate immune activation and chromatin remodeling

May 2026

Yihao Wang | Zan Shen | Lingjie Li | Jianfeng Shen

A novel truncating variant in PRDM16 causes severe familial cardiomyopathy with variable clinical presentations

May 2026

Yuan Che | Lindsey Walker | Lillian Sau | Tingting Tang | Wei Li | Chao Shen | Nick Shillingford | Ramzi Bawab | Jianjun Chen | Miao Sun

Enhanced transcriptomic profiling of esophageal tissue through optimized PAXgene fixation protocols

May 2026

Fadi Charara | Louison Descampe | Ligia Craciun | Laurine Verset | Alexandre Spinette | Meriem Ennaji | Maarten Vander Kuylen | Calliope Maris | Pieter Demetter | Benjamin Beck

Novel PIK3CG compound heterozygous variants cause inactivated PI3Kγ syndrome presenting as necrotizing enterocolitis in a preterm infant

March 2026

Wenting Zhang | Xiaoying Zhou | Bixia Zheng | Xinyi Yang | Yongcheng Ni | Dong Zhou | Chunli Wang

Synergistic anti-tumor activity of ciclopirox olamine and metformin in triple-negative breast cancer

March 2026

Yakun Wu | Hui Lyu | Congcong Tan | Margaret E. Larsen | Shou-Ching Tang | Shile Huang | Bolin Liu

Molecular profiling unveils genetic complexity and identifies potential new driver mechanisms in head and neck paragangliomas

March 2026

Sara Mellid | Eduardo Caleiras | Ángel M. Martínez-Montes | Alicia Arenas | Scherezade Jiménez | María Monteagudo | Rocío Letón | Roberta Radu | Ruth Álvarez-Díaz | Ester Arroba | Alberto Diaz-Talavera | Natalia Martínez-Puente | Cristina Álvarez-Escolá | Marta Pineda | Milagros Balbín | Fátima Al-Shahrour | Cristina Rodriguez-Antona | Cristina Montero-Conde | Luis J. Leandro-García | Emiliano Honrado | Miguel Soria-Tristán | Mercedes Robledo | Alberto Cascón

TTC21B variants disrupt the left-right asymmetry and pronephric development in zebrafish

March 2026

Linxia Deng | Yuan Yang | Xiaoling Yin | Jing Yang | Yijie Duan | Kang Wang | Weicheng Duan | Yu Zhang | Bo Xiong | Jianhua Zhou

SLC1A3 promotes survival and immune escape of pancreatic adenocarcinoma by regulating the JAK/STAT pathway

March 2026

Yihang Liu | Huimin Chang | Xiaobo Wang | Xue Zhao | Yongjun Dang | Ling Zhang | Shuai Wang

Hypoxia-mediated CRIP2 activation via NICD1 translocation regulates glycolysis and cell death

March 2026

Sunyoung Park | Sang-Ha Baik | Leon F. Palomera | Eunae Kim | Hark Kyun Kim | Jun-Sik Kim | Jong Ho Kim | Chanhee Kim | Thiruma V. Arumugam | Dong-Gyu Jo

Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4+ resident macrophages

March 2026

Dingyuan Tian | Yingzi Pan | Xiaoyue Lai | Xinyu Bao | Pan Zheng | Yan Tan | Chun Liu | Ziyang Wang | Qingyuan Yang | Yang Liu | Xiaoqin Wan | Zhihui Zhang | Fang Deng

Hypoxia-induced right ventricular (RV) remodeling and dysfunction present a significant health risk to populations experiencing prolonged hypoxic conditions. Intense light, a noninvasive and easily...

Deficiency of TMEM16F in hair cells prevents diabetes-related and noise-induced hearing loss

March 2026

Liyuan Chen | Na Wang | Jiajia Li | Yan Li | Li Yi | Yupeng Ling | Qiuling Zhao | Yibing Fang | Guilan Chen | Bo Zeng