Recent Articles

Systematic druggable genome-wide analysis to identify potential therapeutic targets for urologic diseases

May 2026

Yongwang Shi | Hongyan Chen | Xinlei Zhang | Chengliang Yin | Penghu Lian

Epigenetic insights into minimal residual disease detection in cancer

May 2026

Lingao Ju | Gang Wang | Zilin Xu | Wan Xiang | Hongwei Peng | Mengxue Yu | Shenjuan Li | Yi Zhang | Kaiyu Qian | Yu Xiao

Molecular characterization of a new R1925X point mutation mouse model for dysferlinopathy

May 2026

Camille Bouchard | Louis Despax | Joël Rousseau | Jacques P. Tremblay

PI3Kα-RAS interface disruption as a new therapeutic strategy

May 2026

Abdelhalim Azzi

Deubiquitinase USP17 negatively regulates 3T3-L1 adipocyte differentiation via HDAC1

May 2026

Yuankuan Li | Meiyu Piao | Yujian Jin | Sung Ho Lee | Kwang Youl Lee

Data-driven identification of core tumor-secreted factors associated with cachexia prevalence

May 2026

Sarah Santiloni Cury | Paula Paccielli Freire | Robson Francisco Carvalho

TNFAIP8/TIPE2 inactivation modulates extracellular matrix organization gene expression and preserves the intervertebral disc structure in mice

May 2026

Zuozhen Tian | Ken Chen | Frances S. Shofer | Srish S. Chenna | Daniel Z. Sandroni | Ling Qin | Yejia Zhang

Spatial transcriptomic characterization of the pathologic niche in a patient with pulmonary crystal-storing histiocytosis

May 2026

Yao Chen | Zhining Huang | Gaoxiang Wang | Mingsheng Wu | Xiao Chen | Xiaohui Sun | Lei Gao | Mingran Xie

DNA damage-induced nuclear STING translocation orchestrates innate immune activation and chromatin remodeling

May 2026

Yihao Wang | Zan Shen | Lingjie Li | Jianfeng Shen

A novel truncating variant in PRDM16 causes severe familial cardiomyopathy with variable clinical presentations

May 2026

Yuan Che | Lindsey Walker | Lillian Sau | Tingting Tang | Wei Li | Chao Shen | Nick Shillingford | Ramzi Bawab | Jianjun Chen | Miao Sun

CBS promotes tumor immune evasion by reducing MHC-I stability

May 2026

Yanrong Yang | Yadong Guo | Shiyu Mao | Chengyuan Dong | Zhu Yu | Xudong Yao | Bing Shen

Serum tRF-4575 may regulate osteoclast differentiation and serve as a promising biomarker for enthesitis-related arthritis diagnosis

May 2026

Jing Jin | Lingzhi Qiu | Yuting Pan | Yifan Xie | Xiaoyan Shao | Zhidan Fan | Haiguo Yu

Rare variants in NRSN2 cause non-syndromic orofacial cleft through dysregulation of TGF-β signaling

May 2026

Xiaowen Zheng | Xuqin Liang | Xiantao Wu | Qing He | Chunyan Yin | Yuhua Jiao | Yanhao Wang | Yuxia Hou | Yi Ding | Huaxiang Zhao

Identification and functional characterization of a novel nonsense mutation of CASR gene in a familial hypocalciuric hypercalcemia pedigree

May 2026

Yang Tian | Bingyang Liu | Yang Xudan | Ruojun Qiu | Zhang Shaojun | Huang Haoshu | Wu Fang | Fenping Zheng

Genetic variability in the PLIN4 gene: A new sequence duplication causing autophagic vacuolar myopathy

May 2026

Alessandra Carnazzi | Eliana Iannibelli | Sara Gibertini | Lucia Nicolini De Gaetano | Giorgia Riolo | Franco Salerno | Andrea Legati | Daniele Ghezzi | Lorenzo Maggi | Alessandra Ruggieri

Lactylation-driven METTL3 regulates wound healing by enhancing m6A/HNRNPA2B1/DNMT1 signaling in keratinocytes

May 2026

Xue-ting Hu | Lu-min Sui | Cheng-xiu Pu | Luo-quan Ao | Mu Yuan | Li Deng | Qing Zhao | Xiao-feng Wu | Xiang Xu

Identification and analysis of extrachromosomal circular DNAs in pancreatic islets during the early and late stages of T2DM mice

May 2026

Zhichao Li | Yue Sun | Shujun Wan | Hongwen Chu | Deguo Wang | Kun Lv | Xiang Kong | Xinming Yao

Pathogenic variation in human DNA damage repair genes was originated from the evolutionary process of modern humans

May 2026

Jiaheng Li | Bojin Zhao | Zixin Qin | Si Hoi Kou | Jia Sheng Chian | Fengxia Xiao | Huijun Lei | Stephanie Andaluz | Jun He | Siddharth Sinha | Xiaowei Mao | San Ming Wang

DNA damage repair (DDR) genes play critical roles in maintaining genome stability. However, they are prone to genetic variation, of which pathogenic variation (PV) is a predisposing factor for high...

SPP1 expression serves as a potential peripheral circulating biomarker for lung cancer prognostics and drives tumorigenesis

May 2026

Xu-Ran Zhang | Fan-Li Sun | Bing Wei | Bing-Hua Jiang

Sox11 deficiency induces paravertebral muscle injury and scoliosis via Mlxipl upregulation

May 2026

Ruohao Wu | Wenting Tang | Yu Li | Zihao Deng | Jing Zhang | Xiaojuan Li | Chunwei Cao | Liyang Liang

Roles of efferocytosis in wound repair: Process, cells, and signals

May 2026

Yilin Sun | Haiying Guo | Yang Bai | Jin Chen | Yuhong Li

Efficient clearance of apoptotic cells, termed efferocytosis, is essential for resolving excessive inflammation, promoting wound repair, and maintaining homeostasis. Defective clearance results in the...

DNA methylation heterogeneity in complex tumor microenvironment: Quantitative methods, influencing factors, and clinical implications

May 2026

Yongle Xu | Shuangyue Ma | Manyi Xu | Hongbo Zhu | Yuncong Wang | Wenbo Dong | Jing Gan | Yusen Zhao | Xinrong Li | Shuangshuang Wang | Haoyu Hu | Jiaheng He | Shangwei Ning | Hui Zhi

5-Methylcytosine (5-mC) is the most prevalent DNA methylation modification in the human genome, and its abnormal patterns are strongly associated with tumor progression. Intratumoral and intertumoral...

eQTL analysis: A bridge from genome to mechanism

May 2026

Zhe Jia | Jing Xu | Yingnan Ma | Siyu Wei | Chen Sun | Xingyu Chen | Jingxuan Kang | Haiyan Chen | Chen Zhang | Yu Dong | Junxian Tao | Xuying Guo | Hongchao Lv | Guoping Tang | Yongshuai Jiang | Mingming Zhang

Expression quantitative trait locus (eQTL) refers to a genetic variation associated with the expression of specific genes. It has been widely applied to explain the regulatory mechanisms linking genetic...