Recent Articles

A novel chimeric RNA RPGR-EEF1A1 enhances autophagy by interaction with the small GTPase RAB37 in a GTP-dependent manner

November 2026

Cong Li | Anqi Zhu | Wenhui Shi | Yifei Wang | Rongjia Zhou | Yanghua Tian | Zhimin Zhai | Qiang Hong

Loss of microbial signals reprograms endocrine microenvironments and consistently reduces RESISTIN expression in the adrenal and thyroid cells of germ-free pigs

November 2026

Jingjing Tian | Teng Wang | Ting Zhou | Yu Pan | Haitao Shang | Song Li | Shengjun Yang | Li Li | Shuai Tan | Gaohui Zhu

Immunotherapy for sepsis: From single-cell scenarios to clinical translation

November 2026

Zhengtao Zhang | Fang Xu

Prochlorperazine dimaleate elicits antiproliferative activity of gastric cancer cells via inhibiting the PI3K/AKT/mTOR signaling pathway

November 2026

Yunhao Ma | Zhenzhen Si | Zhongkun Zhou | Yuanchun Zhao | Yanan Tian | Xuanru Zhang | Huanxiang Liu | Hongmei Zhu | Yingqian Liu | Peng Chen

Proteomic profiling identifies SMARCA1 as a stage-specific epigenetic regulator of colorectal cancer metastasis through MMP modulation

November 2026

Chunqing Fu | Shoufeng Duan | Chengwen Zhang | Xinyu Cui | Fengxian Wang | Lichen Wang | Jinglei Hu | Tengjiao Li | Lin Li

AP2B1, a protein involved in endocytic trafficking, is associated with congenital heart defects when mutated

November 2026

Carla Guzman | WenJuan Zhu | Anupma Jha | Yanji Tong | Angelo Arrigo | Ivet Bahar | Cecilia Lo | Jiuann-Huey Ivy Lin

Optimal combination of immune cells for predicting outcomes in ESCC patients following neoadjuvant immunochemotherapy: Results from a prospective phase II trial

November 2026

Peipei Wang | Yueyun Chen | Lin Lu | Yue Zheng | Xia Liu | Haibo Mao | Zexin Yi | Jiajun Li | Qin Zhang | Chengwu Zeng | Yong Wu | Zhenyu Ding | Cunte Chen

Integrative optical genome mapping and long-read sequencing dissect a pathogenic complex structural variant in a multigenerational Chinese retinitis pigmentosa pedigree

November 2026

Yuqiao Ju | Cong Duan | Kaixin Chen | Qing Chang | Yuan Zong | Fengjuan Gao | Ge-zhi Xu

Integrated analysis of tumor mechanical microenvironment-based signature reveals prognostic risk and immune landscape in endometrial carcinoma

November 2026

Yue Qi | Yuman Wu | Xinyi Bi | Xiaoyang Wang | Yiqin Wang | Jingyuan Wang | Jianliu Wang | Xingchen Li

A rare variant in TRIOBP linked to occupational noise exposure in Meniere disease

November 2026

Pablo Cruz-Granados | Giselle Bianco-Bortoletto | Yuzhong Zhang | Prathamesh T. Nadar-Ponniah | Kiana Bagheri-Loftabad | Edi Lúcia Sartorato | Ines Sanchez-Sellero | Andres Soto-Varela | Jose A. Lopez-Escamez

Hemilateral adipose and muscular atrophy associated with a somatic PDGFRB p.N666K variant

November 2026

Yuan-yang Zheng | Hongrui Chen | Bin Sun | Chen Hua | Xiaoxi Lin

Progesterone and selective progesterone receptor modulator regulate tumor-associated fibroblasts in uterine leiomyomas

November 2026

Weronika Szucio | Gabriela Milewska | Michał Szamatowicz | Weronika Lebiedzińska | Oana Lupu | Piotr Bernaczyk | Monika Leśniewska | Peilan Guo | Ilpo Huhtaniemi | Xiangdong Li | Sławomir Wołczyński | Donata Ponikwicka–Tyszko | Nafis A. Rahman

Identification of novel compound heterozygous variants in isovaleric acidemia with hyperammonemia: Implications for continuous renal replacement therapy management

November 2026

Huan Huang | Ye Zhang | Limin Guo | Zijing Hu | Xiaolin Miao | Chao Lu

Queuine tRNA ribosyltransferase 1 deficiency ameliorates hepatic steatosis and atherosclerosis possibly via modulating lipogenesis

November 2026

Runda Wu | Shuning Zhang | Wanxin Wang | Zheng Dong | Wei Gao | Yongduan Teng | Yuxiang Dai | Shangyu Hong | Kang Yao | Junbo Ge

Specific RNA structures and elements in the 5′-UTR of the SARS-CoV-2 genome and subgenomic RNA are critical for its infection

November 2026

Yan Zhan | Xi Li | Ke Liu | Qian-Ying Ouyang | Jia-Jia Cui | Chen-Hui Luo | Ji-Ye Yin

Tobacco's dual genomic footprints in bladder cancer revealed by multi-omics analysis: An SBS4-like LumU-enriched signature and smoking-driven HRD-related genomic instability

November 2026

Xiang-Yu Meng | Ming-Jun Shi | Shuo Li | Min Liu | Jacqueline Fontugne | Jian Song | Francois Radvanyi | Fu-Bing Wang | Isabelle Bernard-Pierrot | Xing-Huan Wang

Gremlin-2 inhibits hepatocellular carcinoma progression by suppressing Akt/MEK–RPL23 signaling pathway

November 2026

Dayeon Lim | Jayeon Park | World Gil | Jiwoo Jung | Minji Kwon | Seoha Jo | Ye Hwang Cheong | Mee-Hyun Lee | Hee Sun Park | Sin-Aye Park

Therapeutic resistance in cancer: lncRNAs as modulators and targets for cancer therapy

November 2026

Ashiq Ali | Urooj Azmat | Aisha Khatoon | Bilal Murtaza | Kaynaat Akbar | Ziyi Ji | Urooj Irshad | Kinza Ishaque | Zhongjing Su

Therapeutic resistance continues to be a significant challenge in cancer treatment, often leading to tumor recurrence, metastasis, and limited therapeutic efficacy despite advancements in chemotherapy...

DNA-based vaccines: Advances, applications, and future prospects

November 2026

Zhichang Peter Zhou | Ziyan Rachel Chen | Ranmal Avinash Bandara | Rongqi Duan | Huibi Cao | Jun Liu | Jim Hu

DNA-based vaccines represent a promising advancement in immunization strategies, offering a novel approach for preventing infectious diseases and treating various conditions, including cancers and autoimmune...

Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma

November 2026

Jia-tao Yao | Peng-cheng Hu | Xiao-wei Li | Jia-cheng Xu | Ke-jie Wang | Sha-zhou Ye | Xiang-yu Meng | Hai-chao Chen | Yu Liang | Qi Ma

Clear cell renal cell carcinoma (ccRCC), the most common pathological subtype of renal cancer, is characterized by distinctive metabolic reprogramming that serves as a core molecular pathological basis...

The role of FGF19–FGFR4 signaling pathway in liver health and disease: Guardian or destroyer

November 2026

Zhangfan Wu | Yijun Wang | Jiaqian Zhang | Siwen Li | Junjie Wen | Dian Hu | Junqing Jiang | Zerui Zhang | Xiangyuan Luo | Limin Xia

The fibroblast growth factor (FGF) 15/19–FGF receptor (FGFR) 4 signaling pathway is a crucial endocrine regulatory pathway within the FGF family. The FGF15/19–FGFR4 signaling pathway plays multiple...

Variants in ARHGAP21, encoding a Rho GTPase-activating protein, are associated with focal epilepsy and neurodevelopmental disorders

September 2026

Zilong Ye | Bingmei Li | Longshan Xie | Lingxia Fei | Xinguo Lu | Yunhua He | Jie Wang | Yongjun Chen | Weiping Liao | Yiwu Shi

Integrative analysis reveals the clinical utility of cancer-associated fibroblast-derived signature, and its implication for young-onset thyroid cancer

September 2026

Shenglong Xu | Tianyao Chu | Hongyan Chen | Jing Wang | Yufei Wang | Yaoyao Liang | Xinlei Zhang | Yan Zhao | Peng Zhang