Recent Articles

The oncogenic role of CCDC178 in intrahepatic cholangiocarcinoma through LGR4-dependent signaling and immune modulation

September 2026

Yunlu Jia | Yanli Wang | Yongxia Chen | Dayong Zheng | Wenguang Fu | Xiaochen Zhang | Yunkun Lu | Jian Ruan

Integrative analysis reveals the clinical utility of cancer-associated fibroblast-derived signature, and its implication for young-onset thyroid cancer

September 2026

Shenglong Xu | Tianyao Chu | Hongyan Chen | Jing Wang | Yufei Wang | Yaoyao Liang | Xinlei Zhang | Yan Zhao | Peng Zhang

Decoding age-stratified mutational landscapes in CNS lymphoma via genomic and survival profiling for precision oncology

September 2026

Jiawen Chen | Hongwei Liu | Qisheng Tang | Huihui Chai | Peng Wang | Ruize Zhu | Tong Chen | Tianwen Li | Zhifeng Shi

SERTAD4-AS1 suppresses pancreatic cancer progression by stabilizing SERTAD4 and inhibiting the Notch1 pathway

September 2026

Yuchen Tang | Jie Wang | Jun Yao | Haoran Li | Bin Yi | Chengqing Yu | Yijun Wei | Jian Yang | Zixiang Zhang | Jian Zhou

NLRP3 deficiency reprograms hepatic glucose metabolism but fails to ameliorate hepatic inflammation and fibrosis in the MCD model

September 2026

Yong Zou | Xiaowen Wu | Jingyi Wang | Jie Xia | Sen Zhang | Shuzhe Ding | Weina Liu | Zhengtang Qi

Integrative pan-cancer analysis identifies CCHCR1 as a prognostic biomarker and therapeutic target driving EMT in hepatocellular carcinoma via PI3K/AKT activation

September 2026

Shuting Huang | Wanqiu Li | Kaifang Wang | Yu Cai | Lirui Qian | Yiran Liu | Feng Gao | Tong Fang | Kin Yip Tam | Ou Sha

Identification of novel compound heterozygous variants of the PNPLA6 gene in Oliver-McFarlane syndrome with concomitant insulin resistance

September 2026

Ruojun Qiu | Mingming Tang | Weifen Zhu | Binghong Wang | Wenyu Li | Yongzhen Lei | Fenping Zheng

Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes

September 2026

Jing Huang | Hui-Ling Xiang | Qian Yuan | Chun Zhang | Xian-Fang Meng

An autophagy-related molecule reticulon 3 functions as a novel prognostic biomarker in hepatocellular carcinoma

September 2026

Zhu Xie | Wei Wang | Peng Yu | Mingdong Zhang | Zixin Hu | Hongyan Wang

miR-27a expression during inflammatory organ injury associated with ARDS and a novel tissue-specific knockout model

September 2026

Jieun Kim | Synthea Horton | Oleg D. Makarevich | Yan Levitsky | Thu Thien Tran | In Hyuk Bang | Xiangsheng Huang | Xuebo Chen | Katherine Figarella | Xiaoyi Yuan

GBM-Dx SIGNAL: Blood transcriptomics complementing neuroimaging to differentiate glioblastoma recurrence from treatment effects

September 2026

Dan Qi | James Murchison | Ekokobe Fonkem | Jason H. Huang | Erxi Wu

Two novel murine esophageal cancer cell line models exhibiting distinct sensitivities to immunotherapy

September 2026

Jinling Zhang | Yichen Yao | Jiajia Hu | Chenyi Wu | Jiaying Chen | Yanxing Chen | Zixin Qin | Qi Zhao | Runjie Huang | Feng Wang | Yingnan Wang

Human Gordon Holmes Syndrome modeling in mice reveals essential function of RNF216 ubiquitination in spermatogenesis and male fertility

September 2026

Jeffrey M. Mann | Chao Wei | Xiaoyuan Yan | Huirong Xie | Elena Y. Demireva | Chen Chen

Multi-omics Mendelian randomization combined with single-cell and spatial transcriptomics: Multidimensional validation of drug targets for osteoarthritis

September 2026

Bo Yang | Feng Li | Jindong Cao | Yuxuan Xie | Yifeng Da | Xuejun Yang | Xiaodong Zhao | Wenhua Xing | Jing Tian

Single-cell transcriptomics reveals EpCAM regulates the development and morphology of intestinal epithelium via controlling the EGFR pathway

September 2026

Zili Lei | Ya Nie | Lulu Liu | Yanhong Yang | Xuan Liu | Guibin Chen | Yunjuan Wang | Wanwan Liu | Qing Hu | Ting Lin | Jiao Guo

Ammonia-induced cell death patterns in glioblastoma: Immune landscape, prognostic signature, and therapeutic target identification

September 2026

Sheng-Qi Hu | Jing Wang | Jing Wang | Chun Zeng | Rudong Chen

From inactivation to intervention: X chromosome silencing in disease pathogenesis and emerging therapeutic strategies

September 2026

Yuan Fu | Xuling Tan | Lixia Qin | Chunyu Wang

X chromosome inactivation (XCI) is a crucial epigenetic mechanism that balances X-linked gene expression in females via random silencing of one X chromosome. Skewed XCI—non-random inactivation favoring...

Current progress and role of lncRNAs in HBV infection and progression of hepatocellular carcinoma

September 2026

Faisal Mahmood | Maher Un Nisa Awan | Meng-Ting Luo | Xiao Li | Xiao-bin Peng | Jun Xu | Jia Wei | Tai-Cheng Zhou

Infection with hepatitis B virus (HBV) remains a severe concern to public health, with roughly 292 million people worldwide suffering from the chronic form of the disease, for which there is no cure....

Trained immunity: New insights into pathogenesis and therapeutic targets in diabetes and diabetic complications

September 2026

Qiming Gong | Yuqing Huang | Fahui Liu | Tingting Zhou | Wei Huang | Yong Xu

Diabetes mellitus, a chronic metabolic condition, is marked by ongoing hyperglycemia and poses an increasing global health issue. Beyond its recognized contribution to the development of cardiovascular...

Translating multimodal foundation models into oncology: Toward a future where AI directs diagnosis and therapy

July 2026

Kyung Chan Park | Wonbeak Yoo

SP1 lactylation promotes endometrial cancer cell stemness via regulation of CENPL expression

July 2026

Jian Ma | Ziyu Zhang | Bo Wang | Wantong Wang | Fanfei Kong | Xiao-Xin Ma

MAFA-expressing panniculus carnosus regulates skin twitching in mice

July 2026

Junqi Jia | Xinyue Mei | Yixiu Liu | Yang Yan | Guang Yu | Lan Zhou | Changming Wang

Optimizing anti-seizure medication selection for epilepsy in EAST/SeSAME syndrome: Insights from DrugBank and STRING databases

July 2026

Lin-Yan Hu | Lin Wan | Fang Han | Yang Huang | Gang Zhu | Wen-Qi Cao | Wen He | Xiu-Yu Shi | Guang Yang | Li-Ping Zou