Carbohydrate-based vaccine engineering (CVE): An integrated strategy against bacterial infections
June 2026
Carbohydrate-based vaccines are an effective means for combating bacterial infections, particularly in the face of rising antibiotic resistance. This perspective provides an overview of carbohydrate...
Beyond the genome: GlycoRNAs as a nexus of glycobiology and RNA biology
June 2026
The discovery of glycoRNAs—RNAs covalently conjugated to complex glycans—is a transformative development that establishes a new class of epitranscriptomic modifications, challenging the longstanding...
Dietary glycans and their role in human health: implications for gut health, metabolism, and functional foods
December 2025
Dietary glycans, a diverse class of carbohydrate-based biomolecules, play a crucial role in human health by modulating gut microbiota, enhancing immune responses, and influencing metabolic processes....
Mass spectrometry-based glycomics towards GlycoRNA
March 2026
Glycosylated RNAs (glycoRNA), a newly discovered and rapidly emerging class of glycosylated biomolecules, challenge the long-standing view that glycosylation occurs exclusively on proteins and lipids....
Advances in glycosaminoglycan based diagnostic strategies for mucopolysaccharidoses
June 2026
Rare diseases collectively represent a major public health concern, affecting millions worldwide. Their low prevalence, lack of awareness, and overlapping clinical features often lead to misdiagnosis...
Selective editing of N-glycan signals on living cell surface
March 2026
Glycan signals on living cell surface act as biological codes that enable communication between cells and their external environment. They play pivotal roles in processes such as cell recognition and...
Targeting the gut-liver-heart axis: Role of bacterial TMA lyase and human FMO-3 in atherosclerosis and dietary interventions
June 2026
Cardiovascular diseases (CVD) are the most common and leading cause of death worldwide. Atherosclerosis, a chronic inflammatory disease, is one of the onsets of CVD and is caused by the accumulation...
Advances in biosynthetic preparation and application of human milk oligosaccharides
December 2025
Human milk oligosaccharides (HMOs) are bioactive molecules present in human milk and play an important role in shaping up infant gut microbiota and enhancing infant immunity and ability against infection...
GlycoHBF: Mass spectrometry-based glycoproteomics data from 15 types of human body fluids
June 2026
The study of proteins and N-glycosylation in human body fluids (HBFs) is crucial for understanding both physiological and pathological states, providing valuable insights for disease diagnostics and...
Enzyme diagnostic criteria for polysaccharide purity: A model study using polymer reference standards
June 2026
Some natural polysaccharides may be purified as mixtures of simpler polymers having close molecular size, and elucidated to have complicated structures. To address this concern, an enzyme diagnostic...
Natural polysaccharide-based microneedles: A promising frontier in cancer immunotherapy
December 2025
Microneedles (MNs) represent a minimally invasive transdermal drug delivery platform that has attracted considerable interest in pharmaceutical research owing to their ability to bypass the first-pass...
The chemical structures of surface polysaccharides from Acinetobacter baumannii for glycoconjugate vaccines
December 2025
Acinetobacter baumannii (A. baumannii) is a multidrug-resistant Gram-negative pathogen of global clinical concern. Its surface polysaccharides, including capsular polysaccharides (CPS) and lipopolysaccharides...
Lentinus edodes-derived β-glucan inhibits human cervical cancer progression through a potential target of DMBT1 on HeLa cell
June 2026
Based on the reported strong anti-cervical cancer activity of Lentinus edodes-derived β-glucan (LNT), this study further explored the potential target of LNT in HeLa cancer cells. Our findings demonstrate...
Chain conformation characterization of polysaccharides: Current strategies, challenges, and emerging technologies
September 2026
Polysaccharides are the third most diverse biopolymers in nature, after proteins or nucleic acids. Structure determines activity. Increasing evidence has shown that the conformations of polysaccharides...
Glycan sequencing, a brief primer
March 2026
Polysaccharides are among the most important biopolymers in nature. Besides playing an important structural role, polysaccharides in all organisms are vital modulators of cellular processes and control...
Antibody recognition of the hyper-glucosylated adhesin protein HMW1Ct of non-typeable Haemophilus influenzae in Rett syndrome
June 2026
Rett syndrome (RTT) is an X-linked neurodevelopment disorder associated with the single monogenic mutation in methyl-CpG binding protein 2 (MeCP2) in up to 95 % of cases. The growing number of genome-wide...
Electrogenerated acid-catalyzed diastereoselective glycosylation with glycosyl acetates
September 2026
Chemical glycosylation plays an indispensable role in the synthesis of bioactive glycans and glycoconjugates, which typically requires deliberate design of glycosyl donors and promoters. Here we report...
Stearylamine enriched lipid-polymer hybrid nanoparticles of ursolic acid for targeting Leishmania donovani: In-vitro studies
March 2026
Visceral leishmaniasis (VL) is a systemic parasitic infection resulting from Leishmania species that primarily targets macrophages and leads to fatal organ damage if left untreated. Ursolic acid (UA),...
Synthesis of and characterization of differentially sulfated disaccharide repeating units of keratan sulfate
March 2026
Keratan sulfate (KS) is a member of a broad family of sulfated polysaccharides known as glycosaminoglycans. Synthetic KS derivatives can lead to the advancement in early detection of mucopolysaccharidoses...
A cancer vaccine based on N-linked sialyl-Tn antigen elicits robust and selective antitumor immunity
December 2025
Cancer vaccines hold great promise for cancer prevention and treatment. Tumor-associated carbohydrate antigens (TACAs) are attractive targets for cancer vaccine development, yet suffer from their inherent...
A recombinant lipidated receptor-binding domain is a promising self-adjuvanting antigen for mucosal vaccine
March 2026
The SARS-CoV-2 pandemic has resulted in millions of fatalities, and the continual emergence of variants highlights the vital need for effective mucosal vaccines. Novel antigen designs and delivery strategies...
The importance of IgG N-glycosylation in Health, Disease, and Neonatal hemochromatosis
December 2025
Neonatal hemochromatosis (NH) is a unique disease with an unknown etiology, characterized by neonatal liver failure (NLF) and associated with iron deposition in the fetal liver and extrahepatic organs,...
Bioengineered bilayer scaffold with dual-modal delivery for alveolar bone regeneration in periodontitis therapy
September 2026
Periodontitis, a prevalent and progressive infectious inflammatory disease, is characterized by alveolar bone resorption and loss of periodontal attachment, presenting a formidable challenge for complete...
AJDW, polysaccharide from Albizia julibrissin, binds to PI3K and induces cell cycle arrest and ROS-mediated pancreatic cancer cell apoptosis
December 2025
To understand the material basis of the extraction from Albizia julibrissin, a traditional oriental medicine that has reported antitumor activity, a novel neutral polysaccharide fraction and its anti-pancreatic...
Development of marine organisms derived carbohydrate-based drugs: From bioactivity to clinical translation
September 2026
Marine organism-derived carbohydrates, ubiquitously distributed in marine algae, invertebrates and microorganisms, represent a chemically diverse class of biomolecules with promising therapeutic potential....