N-glycosylation in organ fibrosis from mechanistic regulation to biomarker and therapeutic translation
December 2026
Organ fibrosis is the common endpoint of diverse chronic diseases of the liver, kidney, lung, heart, and skin, and accounts for a substantial fraction of global mortality, yet no antifibrotic therapy...
SUMOylation targets OGA to mitochondria via PRKN for respiratory homeostasis
December 2026
O-GlcNAcylation, dynamically orchestrated by OGA and OGT, modifies nearly all mitochondrial bioenergetic enzymes to sustain respiratory homeostasis. However, the mechanisms whereby cells fine-tune the...
Bioengineered bilayer scaffold with dual-modal delivery for alveolar bone regeneration in periodontitis therapy
September 2026
Periodontitis, a prevalent and progressive infectious inflammatory disease, is characterized by alveolar bone resorption and loss of periodontal attachment, presenting a formidable challenge for complete...
Chain conformation characterization of polysaccharides: Current strategies, challenges, and emerging technologies
September 2026
Polysaccharides are the third most diverse biopolymers in nature, after proteins or nucleic acids. Structure determines activity. Increasing evidence has shown that the conformations of polysaccharides...
Electrogenerated acid-catalyzed diastereoselective glycosylation with glycosyl acetates
September 2026
Chemical glycosylation plays an indispensable role in the synthesis of bioactive glycans and glycoconjugates, which typically requires deliberate design of glycosyl donors and promoters. Here we report...
Development of marine organisms derived carbohydrate-based drugs: From bioactivity to clinical translation
September 2026
Marine organism-derived carbohydrates, ubiquitously distributed in marine algae, invertebrates and microorganisms, represent a chemically diverse class of biomolecules with promising therapeutic potential....
Functional reversals and fate switches driven by posttranslational modifications: Insights from advanced techniques
September 2026
The identical protein precursor encoded by the identical gene is capable of forming mature proteins with opposing phenotypes or distinct functions via different posttranslational modifications (PTMs),...
Decoding the bio-functional domain of chondroitin sulfate oligosaccharide by uronic acid reduction coupled with online HILIC-ESI-HCD-MS/MS
September 2026
Chondroitin sulfate (CS) plays critical regulatory roles in numerous biological processes, but definitive sequence of these bio-active polymers is still lacking, with only a few natural/synthetic CS...
Orally administered Gentiana dahurica arabinogalacturonan alleviates CCl₄-induced acute liver injury in mice by reaching liver and kidney tissue
September 2026
Gentiana dahurica Fisch. (G. dahurica), a traditional medicine used for "damp-heat" ailments, contains polysaccharides whose in vivo fate and mechanistic contribution remain unclear. This study investigated...
Pd-catalyzed direct S−C cross-coupling with glycosyl 1-thioacetates to synthesize thioglucoside analogues of gliflozins
September 2026
In this study, we developed a green method for direct S−C cross-coupling between glycosyl 1-thioacetates and aryl iodides under mild conditions, affording S−C cross-coupling products in excellent yields....
Mass spectrometry‐based O-GalNAc glycoproteomics analysis in complex biological samples
Available online 24 July 2026
O-GalNAc glycosylation, a prevalent and important post-translational modification of proteins, participates in a variety of physiological and pathological processes including development, immune recognition,...
Traditional Chinese Medicine in Modulating Protein Glycosylation: New Perspectives and Molecular Mechanisms for Cancer Treatment
Available online 23 July 2026
Protein glycosylation is a fundamental post-translational modification regulating protein stability, localization, and signaling. Aberrant N-linked, O-linked, and O-GlcNAc glycosylation actively drives...
Antibody recognition of the hyper-glucosylated adhesin protein HMW1Ct of non-typeable Haemophilus influenzae in Rett syndrome
June 2026
Rett syndrome (RTT) is an X-linked neurodevelopment disorder associated with the single monogenic mutation in methyl-CpG binding protein 2 (MeCP2) in up to 95 % of cases. The growing number of genome-wide...
Targeting the gut-liver-heart axis: Role of bacterial TMA lyase and human FMO-3 in atherosclerosis and dietary interventions
June 2026
Cardiovascular diseases (CVD) are the most common and leading cause of death worldwide. Atherosclerosis, a chronic inflammatory disease, is one of the onsets of CVD and is caused by the accumulation...
GlycoHBF: Mass spectrometry-based glycoproteomics data from 15 types of human body fluids
June 2026
The study of proteins and N-glycosylation in human body fluids (HBFs) is crucial for understanding both physiological and pathological states, providing valuable insights for disease diagnostics and...
Lentinus edodes-derived β-glucan inhibits human cervical cancer progression through a potential target of DMBT1 on HeLa cell
June 2026
Based on the reported strong anti-cervical cancer activity of Lentinus edodes-derived β-glucan (LNT), this study further explored the potential target of LNT in HeLa cancer cells. Our findings demonstrate...
Advances in glycosaminoglycan based diagnostic strategies for mucopolysaccharidoses
June 2026
Rare diseases collectively represent a major public health concern, affecting millions worldwide. Their low prevalence, lack of awareness, and overlapping clinical features often lead to misdiagnosis...
Beyond the genome: GlycoRNAs as a nexus of glycobiology and RNA biology
June 2026
The discovery of glycoRNAs—RNAs covalently conjugated to complex glycans—is a transformative development that establishes a new class of epitranscriptomic modifications, challenging the longstanding...
Enzyme diagnostic criteria for polysaccharide purity: A model study using polymer reference standards
June 2026
Some natural polysaccharides may be purified as mixtures of simpler polymers having close molecular size, and elucidated to have complicated structures. To address this concern, an enzyme diagnostic...
Carbohydrate-based vaccine engineering (CVE): An integrated strategy against bacterial infections
June 2026
Carbohydrate-based vaccines are an effective means for combating bacterial infections, particularly in the face of rising antibiotic resistance. This perspective provides an overview of carbohydrate...
A recombinant lipidated receptor-binding domain is a promising self-adjuvanting antigen for mucosal vaccine
March 2026
The SARS-CoV-2 pandemic has resulted in millions of fatalities, and the continual emergence of variants highlights the vital need for effective mucosal vaccines. Novel antigen designs and delivery strategies...
Polysaccharide-based multilayers as reservoir for metal ions programming osteogenic differentiation of stem cells
March 2026
The modification of biomaterial surfaces with polyelectrolyte multilayers (PEM) represents a promising strategy for regulation of cell proliferation, and differentiation. This study examines how uploading...
Mass spectrometry-based glycomics towards GlycoRNA
March 2026
Glycosylated RNAs (glycoRNA), a newly discovered and rapidly emerging class of glycosylated biomolecules, challenge the long-standing view that glycosylation occurs exclusively on proteins and lipids....
Glycan sequencing, a brief primer
March 2026
Polysaccharides are among the most important biopolymers in nature. Besides playing an important structural role, polysaccharides in all organisms are vital modulators of cellular processes and control...
Synthesis of and characterization of differentially sulfated disaccharide repeating units of keratan sulfate
March 2026
Keratan sulfate (KS) is a member of a broad family of sulfated polysaccharides known as glycosaminoglycans. Synthetic KS derivatives can lead to the advancement in early detection of mucopolysaccharidoses...