A recombinant lipidated receptor-binding domain is a promising self-adjuvanting antigen for mucosal vaccine
March 2026
The SARS-CoV-2 pandemic has resulted in millions of fatalities, and the continual emergence of variants highlights the vital need for effective mucosal vaccines. Novel antigen designs and delivery strategies...
Polysaccharide-based multilayers as reservoir for metal ions programming osteogenic differentiation of stem cells
March 2026
The modification of biomaterial surfaces with polyelectrolyte multilayers (PEM) represents a promising strategy for regulation of cell proliferation, and differentiation. This study examines how uploading...
Mass spectrometry-based glycomics towards GlycoRNA
March 2026
Glycosylated RNAs (glycoRNA), a newly discovered and rapidly emerging class of glycosylated biomolecules, challenge the long-standing view that glycosylation occurs exclusively on proteins and lipids....
Glycan sequencing, a brief primer
March 2026
Polysaccharides are among the most important biopolymers in nature. Besides playing an important structural role, polysaccharides in all organisms are vital modulators of cellular processes and control...
Synthesis of and characterization of differentially sulfated disaccharide repeating units of keratan sulfate
March 2026
Keratan sulfate (KS) is a member of a broad family of sulfated polysaccharides known as glycosaminoglycans. Synthetic KS derivatives can lead to the advancement in early detection of mucopolysaccharidoses...
Stearylamine enriched lipid-polymer hybrid nanoparticles of ursolic acid for targeting Leishmania donovani: In-vitro studies
March 2026
Visceral leishmaniasis (VL) is a systemic parasitic infection resulting from Leishmania species that primarily targets macrophages and leads to fatal organ damage if left untreated. Ursolic acid (UA),...
The importance of IgG N-glycosylation in Health, Disease, and Neonatal hemochromatosis
December 2025
Neonatal hemochromatosis (NH) is a unique disease with an unknown etiology, characterized by neonatal liver failure (NLF) and associated with iron deposition in the fetal liver and extrahepatic organs,...
AJDW, polysaccharide from Albizia julibrissin, binds to PI3K and induces cell cycle arrest and ROS-mediated pancreatic cancer cell apoptosis
December 2025
To understand the material basis of the extraction from Albizia julibrissin, a traditional oriental medicine that has reported antitumor activity, a novel neutral polysaccharide fraction and its anti-pancreatic...
Dietary glycans and their role in human health: implications for gut health, metabolism, and functional foods
December 2025
Dietary glycans, a diverse class of carbohydrate-based biomolecules, play a crucial role in human health by modulating gut microbiota, enhancing immune responses, and influencing metabolic processes....
Expression patterns, structural features, and roles of SRPX2 in disease pathogenesis
December 2025
SRPX2 (Sushi Repeat-Containing Protein X-Linked 2) is a multifunctional regulatory protein that has recently been implicated in various pathological conditions, including tumorigenesis, neurodevelopmental...
A cancer vaccine based on N-linked sialyl-Tn antigen elicits robust and selective antitumor immunity
December 2025
Cancer vaccines hold great promise for cancer prevention and treatment. Tumor-associated carbohydrate antigens (TACAs) are attractive targets for cancer vaccine development, yet suffer from their inherent...
Endothelial neuraminidase 1 inhibition attenuates LPS-induced acute lung injury through the CXCR4 pathway
December 2025
Neuraminidase 1 (NEU1), a key sialidase in human pulmonary microvascular endothelial cells, plays a central role in idiopathic pulmonary fibrosis. However, its contribution to endothelial dysfunction...
Natural polysaccharide-based microneedles: A promising frontier in cancer immunotherapy
December 2025
Microneedles (MNs) represent a minimally invasive transdermal drug delivery platform that has attracted considerable interest in pharmaceutical research owing to their ability to bypass the first-pass...
The chemical structures of surface polysaccharides from Acinetobacter baumannii for glycoconjugate vaccines
December 2025
Acinetobacter baumannii (A. baumannii) is a multidrug-resistant Gram-negative pathogen of global clinical concern. Its surface polysaccharides, including capsular polysaccharides (CPS) and lipopolysaccharides...
A supramolecular self-assembly with dual functions of GSH-synthesis inhibition and -consumption for efficient enhancing chemodynamic therapy
December 2025
The excessive reduced GSH obviously restrict the chemodynamic therapy (CDT) efficacy through the consumption of ·OH. Therefore, the design of nano-systems to consume GSH is one effective method to enhance...
Advances in biosynthetic preparation and application of human milk oligosaccharides
December 2025
Human milk oligosaccharides (HMOs) are bioactive molecules present in human milk and play an important role in shaping up infant gut microbiota and enhancing infant immunity and ability against infection...