Bioengineered bilayer scaffold with dual-modal delivery for alveolar bone regeneration in periodontitis therapy
September 2026
Periodontitis, a prevalent and progressive infectious inflammatory disease, is characterized by alveolar bone resorption and loss of periodontal attachment, presenting a formidable challenge for complete...
Electrogenerated acid-catalyzed diastereoselective glycosylation with glycosyl acetates
September 2026
Chemical glycosylation plays an indispensable role in the synthesis of bioactive glycans and glycoconjugates, which typically requires deliberate design of glycosyl donors and promoters. Here we report...
Antibody recognition of the hyper-glucosylated adhesin protein HMW1Ct of non-typeable Haemophilus influenzae in Rett syndrome
June 2026
Rett syndrome (RTT) is an X-linked neurodevelopment disorder associated with the single monogenic mutation in methyl-CpG binding protein 2 (MeCP2) in up to 95 % of cases. The growing number of genome-wide...
Targeting the gut-liver-heart axis: Role of bacterial TMA lyase and human FMO-3 in atherosclerosis and dietary interventions
June 2026
Cardiovascular diseases (CVD) are the most common and leading cause of death worldwide. Atherosclerosis, a chronic inflammatory disease, is one of the onsets of CVD and is caused by the accumulation...
GlycoHBF: Mass spectrometry-based glycoproteomics data from 15 types of human body fluids
June 2026
The study of proteins and N-glycosylation in human body fluids (HBFs) is crucial for understanding both physiological and pathological states, providing valuable insights for disease diagnostics and...
Lentinus edodes-derived β-glucan inhibits human cervical cancer progression through a potential target of DMBT1 on HeLa cell
June 2026
Based on the reported strong anti-cervical cancer activity of Lentinus edodes-derived β-glucan (LNT), this study further explored the potential target of LNT in HeLa cancer cells. Our findings demonstrate...
Advances in glycosaminoglycan based diagnostic strategies for mucopolysaccharidoses
June 2026
Rare diseases collectively represent a major public health concern, affecting millions worldwide. Their low prevalence, lack of awareness, and overlapping clinical features often lead to misdiagnosis...
Beyond the genome: GlycoRNAs as a nexus of glycobiology and RNA biology
June 2026
The discovery of glycoRNAs—RNAs covalently conjugated to complex glycans—is a transformative development that establishes a new class of epitranscriptomic modifications, challenging the longstanding...
Enzyme diagnostic criteria for polysaccharide purity: A model study using polymer reference standards
June 2026
Some natural polysaccharides may be purified as mixtures of simpler polymers having close molecular size, and elucidated to have complicated structures. To address this concern, an enzyme diagnostic...
Carbohydrate-based vaccine engineering (CVE): An integrated strategy against bacterial infections
June 2026
Carbohydrate-based vaccines are an effective means for combating bacterial infections, particularly in the face of rising antibiotic resistance. This perspective provides an overview of carbohydrate...
Development of Marine Organisms Derived Carbohydrate-Based Drugs: From Bioactivity to Clinical Translation
Available online 7 April 2026
Marine organism-derived carbohydrates, ubiquitously distributed in marine algae, invertebrates and microorganisms, represent a chemically diverse class of biomolecules with promising therapeutic potential....
Chain Conformation Characterization of Polysaccharides: Current Strategies, Challenges, and Emerging Technologies
Available online 2 April 2026
Polysaccharides are the third most diverse biopolymers in nature, after proteins or nucleic acids. Structure determines activity. Increasing evidence has shown that the conformations of polysaccharides...
A recombinant lipidated receptor-binding domain is a promising self-adjuvanting antigen for mucosal vaccine
March 2026
The SARS-CoV-2 pandemic has resulted in millions of fatalities, and the continual emergence of variants highlights the vital need for effective mucosal vaccines. Novel antigen designs and delivery strategies...
Polysaccharide-based multilayers as reservoir for metal ions programming osteogenic differentiation of stem cells
March 2026
The modification of biomaterial surfaces with polyelectrolyte multilayers (PEM) represents a promising strategy for regulation of cell proliferation, and differentiation. This study examines how uploading...
Mass spectrometry-based glycomics towards GlycoRNA
March 2026
Glycosylated RNAs (glycoRNA), a newly discovered and rapidly emerging class of glycosylated biomolecules, challenge the long-standing view that glycosylation occurs exclusively on proteins and lipids....
Glycan sequencing, a brief primer
March 2026
Polysaccharides are among the most important biopolymers in nature. Besides playing an important structural role, polysaccharides in all organisms are vital modulators of cellular processes and control...
Synthesis of and characterization of differentially sulfated disaccharide repeating units of keratan sulfate
March 2026
Keratan sulfate (KS) is a member of a broad family of sulfated polysaccharides known as glycosaminoglycans. Synthetic KS derivatives can lead to the advancement in early detection of mucopolysaccharidoses...
Stearylamine enriched lipid-polymer hybrid nanoparticles of ursolic acid for targeting Leishmania donovani: In-vitro studies
March 2026
Visceral leishmaniasis (VL) is a systemic parasitic infection resulting from Leishmania species that primarily targets macrophages and leads to fatal organ damage if left untreated. Ursolic acid (UA),...
Selective editing of N-glycan signals on living cell surface
March 2026
Glycan signals on living cell surface act as biological codes that enable communication between cells and their external environment. They play pivotal roles in processes such as cell recognition and...
NSFC major research program “Deciphering the glycocode of life” 2025 Annual Academic Conference successfully held in Wuhan
March 2026
The 2025 National Natural Science Foundation of China (NSFC) Major Research Program “Decoding the Glycan Code of Life” has been sucessfully held at the East Lake International Conference Center in Wuhan,...
The importance of IgG N-glycosylation in Health, Disease, and Neonatal hemochromatosis
December 2025
Neonatal hemochromatosis (NH) is a unique disease with an unknown etiology, characterized by neonatal liver failure (NLF) and associated with iron deposition in the fetal liver and extrahepatic organs,...
AJDW, polysaccharide from Albizia julibrissin, binds to PI3K and induces cell cycle arrest and ROS-mediated pancreatic cancer cell apoptosis
December 2025
To understand the material basis of the extraction from Albizia julibrissin, a traditional oriental medicine that has reported antitumor activity, a novel neutral polysaccharide fraction and its anti-pancreatic...
Dietary glycans and their role in human health: implications for gut health, metabolism, and functional foods
December 2025
Dietary glycans, a diverse class of carbohydrate-based biomolecules, play a crucial role in human health by modulating gut microbiota, enhancing immune responses, and influencing metabolic processes....
Expression patterns, structural features, and roles of SRPX2 in disease pathogenesis
December 2025
SRPX2 (Sushi Repeat-Containing Protein X-Linked 2) is a multifunctional regulatory protein that has recently been implicated in various pathological conditions, including tumorigenesis, neurodevelopmental...