The importance of IgG N-glycosylation in Health, Disease, and Neonatal hemochromatosis
December 2025
Neonatal hemochromatosis (NH) is a unique disease with an unknown etiology, characterized by neonatal liver failure (NLF) and associated with iron deposition in the fetal liver and extrahepatic organs,...
AJDW, polysaccharide from Albizia julibrissin, binds to PI3K and induces cell cycle arrest and ROS-mediated pancreatic cancer cell apoptosis
December 2025
To understand the material basis of the extraction from Albizia julibrissin, a traditional oriental medicine that has reported antitumor activity, a novel neutral polysaccharide fraction and its anti-pancreatic...
Dietary glycans and their role in human health: implications for gut health, metabolism, and functional foods
December 2025
Dietary glycans, a diverse class of carbohydrate-based biomolecules, play a crucial role in human health by modulating gut microbiota, enhancing immune responses, and influencing metabolic processes....
Expression patterns, structural features, and roles of SRPX2 in disease pathogenesis
December 2025
SRPX2 (Sushi Repeat-Containing Protein X-Linked 2) is a multifunctional regulatory protein that has recently been implicated in various pathological conditions, including tumorigenesis, neurodevelopmental...
A cancer vaccine based on N-linked sialyl-Tn antigen elicits robust and selective antitumor immunity
December 2025
Cancer vaccines hold great promise for cancer prevention and treatment. Tumor-associated carbohydrate antigens (TACAs) are attractive targets for cancer vaccine development, yet suffer from their inherent...
Endothelial neuraminidase 1 inhibition attenuates LPS-induced acute lung injury through the CXCR4 pathway
December 2025
Neuraminidase 1 (NEU1), a key sialidase in human pulmonary microvascular endothelial cells, plays a central role in idiopathic pulmonary fibrosis. However, its contribution to endothelial dysfunction...
Advances in Biosynthetic Preparation and Application of Human Milk Oligosaccharides
Available online 16 November 2025
Human milk oligosaccharides (HMOs) are bioactive molecules present in human milk and play an important role in shaping up infant gut microbiota and enhancing infant immunity and ability against infection...
Natural Polysaccharide-Based Microneedles: A Promising Frontier in Cancer Immunotherapy
Available online 12 November 2025
Microneedles (MNs) represent a minimally invasive transdermal drug delivery platform that has attracted considerable interest in pharmaceutical research owing to their ability to bypass the first-pass...
The Chemical Structures of Surface Polysaccharides from Acinetobacter baumannii for Glycoconjugate Vaccines
Available online 12 November 2025
Acinetobacter baumannii (A. baumannii) is a multidrug-resistant Gram-negative pathogen of global clinical concern. Its surface polysaccharides, including capsular polysaccharides (CPS) and lipopolysaccharides...
A supramolecular self-assembly with dual functions of GSH-synthesis inhibition and -consumption for efficient enhancing chemodynamic therapy
Available online 12 November 2025
The excessive reduced GSH obviously restrict the chemodynamic therapy (CDT) efficacy through the consumption of ·OH. Therefore, the design of nano-systems to consume GSH is one effective method to enhance...