Evidence for the causal relationship between age at first sexual intercourse and multidimensional aging phenotypes from a full life cycle perspective: A mendelian randomization study
March 2026
The full life cycle perspective emphasizes the profound impact of early-life events on later health. Age at first sexual intercourse (AFS) marks the onset of an individual’s sexual development and behavior,...
Neuromodulation therapy for phantom limb pain: A review of the current status and future perspectives
March 2026
Phantom Limb Pain (PLP) is a common and intractable neuropathic pain condition that occurs following limb amputation, significantly impacting patients’ quality of life. The prevalence of PLP ranges...
Effects of home-based strength training with different intensities on muscle strength and physical functions in patients with Duchenne muscular dystrophy: Study protocol for an exploratory pilot randomized controlled trial
March 2026
Regular submaximal strengthening exercises are recommended for patients with Duchenne muscular dystrophy (DMD); however, evidence regarding the optimal intensity is limited....
Construction of risky sexual behaviors intervention program for college students based on Behavior Change Wheel theory: A mixed-methods study
March 2026
Risky sexual behaviors (RSBs) among college students pose a substantial threat to both physical and mental health and are associated with sexually transmitted infections and unintended pregnancies....
Artificial intelligence and medical-engineering integration in diabetes management: Advances, opportunities, and challenges
January 2025
Global incidence and prevalence of diabetes have been rising steadily, leading to increased disability, mortality, and a significant economic burden. Despite advances in medical care, challenges such...
The impact of intergenerational support on older adults’ life satisfaction in China: Rural-urban differences
January 2025
As the population ages, the importance of improving the well-being of older adults grows....
A rehabilitation design concept based on brain–computer interface and McKibben artificial muscle
March 2026
This perspective proposes a restrained rehabilitation design that reframes an electroencephalography (EEG)-based brain–computer interface (BCI) from continuous motor control to an intention-gating signal...
Comparative study of demographic information, clinical scales and questionnaires, and mobility tests for fall risk assessment in older adults
March 2026
Falls are the leading cause of injury and mortality in older adults; however, the relative contributions of different fall risk factor domains remain unclear. A past fall history strongly predicts future...
Eye movements and emotional memory images (EMIs): Unravelling the path to adult health from childhood adversity
July 2025
Subtle eye movements offer a valuable yet underexplored window into how individuals encode and retrieve emotional memories, particularly in the context of psychological trauma....
Efficacy of functional electrical stimulation for hemiplegic shoulder pain: A systematic review and meta-analysis
April 2025
Hemiplegic shoulder pain is a common issue after stroke and affects many stroke survivors. Emerging studies have shown the positive effects of functional electrical stimulation in the management of...
Effects of music therapy on the pressure pain threshold, cognitive function, and emotions of college students: A randomized controlled trial
January 2025
Nonpharmacological interventions, including music therapy, are widely used for pain management and improving cognitive function and emotional well-being. Music therapy has particularly shown significant...
Relative importance of home environment domains to behavior problems in preschool children with developmental disabilities: A cross-sectional study using relative weights analysis
July 2025
Developmental disabilities (DD) encompass a wide range of medical conditions and disorders that affect a child’s physical, learning, or behavior functioning. The home environment is closely associated...
Patient-reported outcome measures in adults with hemophilia: A scoping review
January 2025
Hemophilia is a generic bleeding disorder that significantly affects patient quality of life (QoL). Patient-reported outcome measures (PROMs) can capture health outcomes from a patient’s perspective....
Advances in the clinical application of noninvasive physical therapy for treating spinal cord injury: A narrative review
April 2025
In recent years, the use of noninvasive physical therapy for spinal cord injury (SCI) has attracted widespread attention owing to its minimal side effects, cost-effectiveness, and high patient comp...
Association between cognitive function and hip fracture among middle-aged and older Chinese adults: A prospective study using the China Health and Retirement Longitudinal Study
June 2026
The relationship between cognitive function and hip fracture risk among middle-aged and older adults in China remains unclear, with limited longitudinal evidence....
Factors influencing dietary behavior among elderly patients with hypertension in Wenzhou, China: A qualitative descriptive study
April 2025
More than half of the elderly in China have high blood pressure. Dietary management is essential for maintaining ideal blood pressure levels and reducing the risk of hypertension-related complications....
Research progress on mobile health technology in the management of patients with heart failure out-of-hospital
July 2025
Alongside conventional treatment, out-of-hospital management is pivotal for patients with heart failure, demonstrating improvements in clinical outcomes and health-related quality of life, while decreasing...
Effect of caregiver burden on subjective well-being among caregivers of older patients with multiple chronic conditions in Chinese rural areas
October 2025
Rural caregivers of older patients with multiple chronic conditions bear a substantial caregiver burden. Self-efficacy and family support may mediate the relationship between caregiver burden and subjective...
The conceptualization of safe care for older inpatients: A model based on socio-ecological theory
June 2026
Safe care for older adults is a crucial component of clinical practice. Understanding the conceptual connotation of safe care for older hospitalized patients can help improve the safety of geriatric...
Glycemic control, medications, and onset of Alzheimer’s disease and related dementias: A scoping review on diabetes management in people with mild cognitive impairment
January 2025
Diabetes management after mild cognitive impairment (MCI) onset remains controversial, with no consensus on optimal treatment goals and appropriate medication use....
Fatigue and associated factors among middle-aged patients with breast cancer undergoing chemotherapy in China: A cross-sectional study
October 2025
Fatigue is a prevalent and burdensome symptom in patients with breast cancer undergoing chemotherapy, and middle-aged women may be especially vulnerable....
Clinical application and molecular mechanisms of Chinese medicine formulas in fibrotic diseases: A narrative review
April 2025
Fibrotic diseases, characterized by excessive extracellular matrix deposition and parenchymal cell loss, represent a critical pathological outcome of chronic tissue injury across multiple organs, including...
Exploring Ilaprazole-CYP2C19 interaction: A computational study on metabolic stability and drug-drug interaction potential
October 2025
Proton pump inhibitors (PPIs) have been shown to reduce the therapeutic efficacy and alter the clinical outcomes of co-administered medications due to cytochrome P450 family 2 subfamily C member 19...