Cirrhotic refractory ascites: Pathogenesis, current therapeutic strategies, and future directions
September 2026
Refractory ascites (RA) develops in approximately 10% of patients with cirrhotic ascites. The onset of RA heralds entry into a high-mortality-risk phase, characterized by a marked decline in 1-year...
Systems and spatial informatics approaches for liver disease progression and hepatocellular carcinoma
September 2026
Chronic liver disease evolves through a complex, heterogeneous trajectory from inflammation and fibrosis to cirrhosis and ultimately hepatocellular carcinoma (HCC). Despite advances in surveillance...
Aging, liver, and alcohol-associated liver disease
September 2026
Against the dual backdrop of an aging population and the high incidence of ALD, the driving role of aging in ALD has emerged as a central issue in this field. Emerging evidence indicates that aging...
Neutrophils in alcohol-associated hepatitis: Recruitment, intrahepatic amplification, and pathogenic functions
September 2027
Alcohol-associated hepatitis (AH) is a severe inflammatory form of alcohol-associated liver disease characterized by prominent hepatic neutrophil accumulation. While neutrophils have long been recognized...
Dynamic changes in visceral fat density and skeletal muscle index predict new-onset decompensation in chronic hepatitis B-related cirrhosis
September 2026
The occurrence of decompensation events in patients with cirrhosis is a critical determinant of adverse prognosis, yet their accurate prediction remains clinically challenging. This study evaluated...
The medicinal effect of ulinastatin in various liver diseases
September 2026
Ulinastatin (UTI) is an endogenous broad-spectrum serine protease inhibitor naturally present in human plasma and urine. It exerts therapeutic effects through multiple mechanisms, including inhibition...
Interleukin-27 in liver diseases: Pathological mechanisms and therapeutic targets
September 2026
Interleukin-27 (IL-27), generally regarded as a member of the interleukin-12 cytokine family, is a heterodimer composed of the p28 and EBI3 subunits. It signals through IL-27Ralpha/WSX-1 and gp130 to...
Stem Cell-Derived Exosomes for Acute Liver Failure: Mechanisms, Therapeutic Potential, and Translational Challenges
Available online 12 October 2026
Acute liver failure (ALF) is a rapidly progressive and life-threatening syndrome marked by massive hepatocyte loss, systemic inflammation, and high short-term mortality, with treatment still largely...