The medicinal effect of ulinastatin in various liver diseases
September 2026
Ulinastatin (UTI) is an endogenous broad-spectrum serine protease inhibitor naturally present in human plasma and urine. It exerts therapeutic effects through multiple mechanisms, including inhibition...
Dynamic changes in visceral fat density and skeletal muscle index predict new-onset decompensation in chronic hepatitis B-related cirrhosis
September 2026
The occurrence of decompensation events in patients with cirrhosis is a critical determinant of adverse prognosis, yet their accurate prediction remains clinically challenging. This study evaluated...
Interleukin-27 in Liver Diseases: Pathological Mechanisms and Therapeutic Targets
Available online 20 July 2026
Interleukin-27 (IL-27), generally regarded as a member of the interleukin-12 cytokine family, is a heterodimer composed of the p28 and EBI3 subunits. It signals through IL-27Ralpha/WSX-1 and gp130 to...
Aging, liver, and Alcohol-associated Liver Disease
Available online 15 July 2026
Against the dual backdrop of an aging population and the high incidence of ALD, the driving role of aging in ALD has emerged as a central issue in this field. Emerging evidence indicates that aging...
Cirrhotic Refractory Ascites: Pathogenesis, Current Therapeutic Strategies, and Future Directions
Available online 8 July 2026
Refractory ascites (RA) develops in approximately 10% of patients with cirrhotic ascites. The onset of RA heralds entry into a high-mortality-risk phase, characterized by a marked decline in 1-year...