Tissue perfusion pressure and its potential role in the management of circulatory failure
December 2026
From early warning to endotype-guided care in sepsis: A critical narrative review of AI, multi-omics, and clinical translation
December 2026
Sepsis is a highly heterogeneous syndrome characterized by dynamic host responses, which has limited the effectiveness of conventional “one-size-fits-all” therapeutic strategies. Precision medicine...
Toward precision medicine in ARDS: Heterogeneity, subphenotypes, and individualized therapy − A narrative review
December 2026
Acute respiratory distress syndrome (ARDS) remains a major unmet challenge in critical care, with substantial mortality despite advances in supportive management. A central reason for repeated therapeutic...
Management of abdominal sepsis: Principles, pitfalls, and perspectives
December 2026
Sepsis of abdominal origin remains one of the most complex and time-sensitive conditions in acute care surgery. Despite significant advances in diagnostics and therapeutics, outcomes continue to depend...
Clostridioides difficile infection in the critically ill: Recent advances and emerging challenges
December 2026
Clostridioides difficile infection (CDI) are the most frequent healthcare-associated diarrhoeal disease in the intensive care unit (ICU). Critically ill patients face multiple risk factors—including...
Integrated rescue: A narrative review of machine learning in hospitalized patient rescue
December 2026
Hospitals currently rely on episodic, intermittent recognition of clinical deterioration, with emergency medical responses often delayed. While rapid response teams may serve as a valuable patient safety...
Balanced crystalloids versus saline for initial resuscitation in sepsis and 30-day major adverse kidney events: A target trial emulation across two critical-care databases
December 2026
Whether balanced crystalloids improve kidney outcomes in sepsis remains uncertain, and observational comparisons are vulnerable to time-zero misalignment, post-treatment selection, confounding by indication,...
Does dexmedetomidine influence opioid requirements among non-surgical critically ill children?
December 2026
Mechanically ventilated, critically ill children require a multitude of potent sedative-analgesic medications in the pediatric intensive care unit (PICU). We aimed to evaluate whether early dexmedetomidine...
Beyond the lung: How intestinal microbiota shape pulmonary immunity in critical illness
December 2026
A perspective on acquisition and virulence transformation of gut pathogens during treatment of the ICU patient
December 2026
Multi-tissue transcriptional profiling resolves opposing acute and chronic host-response programs along the bone marrow–to–periphery axis in bacterial pneumonia
December 2026
Whether the host response to severe bacterial pneumonia is shared across pathogens or tailored to the infecting organism is unresolved, yet it bears directly on host-directed therapy and on risk stratification...
Flexible bronchoscopy in the intensive care unit: Artificial intelligence in simulation-based training to robotic automation
December 2026
Advances in clinical research on acute kidney injury, 2025–2026: A narrative review
December 2026
Acute kidney injury (AKI) is a common clinical syndrome in the intensive care unit (ICU) that not only substantially increases in-hospital mortality but is also closely associated with the development...