Clostridioides difficile infection in the critically ill: Recent advances and emerging challenges
December 2026
Clostridioides difficile infection (CDI) are the most frequent healthcare-associated diarrhoeal disease in the intensive care unit (ICU). Critically ill patients face multiple risk factors—including...
Toward precision medicine in ARDS: Heterogeneity, subphenotypes, and individualized therapy − A narrative review
December 2026
Acute respiratory distress syndrome (ARDS) remains a major unmet challenge in critical care, with substantial mortality despite advances in supportive management. A central reason for repeated therapeutic...
Tissue perfusion pressure and its potential role in the management of circulatory failure
December 2026
From early warning to endotype-guided care in sepsis: A critical narrative review of AI, multi-omics, and clinical translation
December 2026
Sepsis is a highly heterogeneous syndrome characterized by dynamic host responses, which has limited the effectiveness of conventional “one-size-fits-all” therapeutic strategies. Precision medicine...