Formulation, antimicrobial, and antioxidant effect of anti-acne serum containing extracts of striata scrophularia and rosemary plants
June 2025
Infectious diseases like acne, caused by bacteria and fungi, are prevalent worldwide. The rise of antibiotic-resistant bacteria has prompted the search for natural alternatives....
Innovative approaches in insulin delivery: Exploring molecular techniques and system developments
July 2025
Diabetes is the most prevalent endocrine disease, divided into Type I and Type II, affecting a large number of people globally. The most effective and safest drug for reducing blood sugar levels is...
An update on the role of inflammation in insulin resistance and islet β cell failure- A crosstalk between immune cells, adipose tissue, cytokines, and oxidative stress
March 2025
One of the characteristics of type 2 diabetes mellitus (T2DM) is the growing malfunctioning of β-cells and the presence of insulin resistance. The recent literature on this aspect is reviewed in this...
Identification of breast cancer biomarkers through bioinformatics approach
July 2025
Breast cancer (BC) remains a major global health burden, particularly among women, and early identification of molecular biomarkers is critical for improving diagnostic and therapeutic strategies. This...
Exploring N-acetyl-1,3,4-oxadiazoline derivatives against Alzheimer's disease: ADMET, molecular docking, and DFT analysis
July 2025
Alzheimer's disease is a progressive neurodegenerative illness characterized by cognitive decline and memory loss. It is primarily caused by the buildup of neurofibrillary tangles made of hyperphosphorylated...
Synthesis, characterization, and neuroprotective effect of taxifolin-conjugated gold nanoparticles against amyloid βeta induced Alzheimer’s disease
August 2025
Alzheimer's disease (AD) is characterized by amyloid beta peptide (Aβ) accumulation, oxidative stress, neuro inflammation, and progressive memory loss. Taxifolin, a flavonoid with neuroprotective effects,...
Scutellaria Baicalensis Georgi: A review on botany, phytoconstituents, and pharmacological activities
Available online 8 November 2025
Scutellaria baicalensis (Huang-Qin), prominently avowed as Chinese Skullcap, is a traditional herb that has been historically diversified and used culturally in Chinese medicine. The review focused...
Exploring DPP-IV inhibitors for diabetes treatment: A comprehensive study on molecular docking, molecular dynamics simulation, and in-vitro DPP-IV assay
August 2025
Dipeptidyl peptidase-4 (DPP-IV) inhibitors are established medications for type 2 diabetes, but there's a continuous search for even more potent and effective options....
Design and screening of novel geniposide derivatives as xanthine oxidase inhibitors for hyperuricemia treatment using QSAR, Molecular docking, Molecular dynamics simulation, ADMET, and DFT Approaches
September 2025
Design of novel xanthine oxidase inhibitors via computational modeling of geniposide derivatives for treatment of hyperuricemia. Due to the excessive use of geniposide inhibitors and the detrimental...
Development and characterization of suppository formulation for rectal delivery of clarithromycin
August 2025
Clarithromycin (CLR), a broad-spectrum antibiotic, is widely used to treat genitourinary infections caused by Gram positive bacteria via conventional drug delivery approaches, such as tablets. However,...
Targeting Ngt1-mediated GlcNAc transport in Candida albicans: An in silico approach for antifungal therapy
July 2025
The commensal yeast, Candida albicans, has the enormous metabolic flexibility to utilize alternative carbon sources such as N-acetylglucosamine (GlcNAc) at infection sites, thereby facilitating its...
TRPV receptors in pain research: Bridging molecular mechanisms to clinical treatments
Available online 24 July 2025
The cation channels known as transient receptor potential vanilloid (TRPV) are shown in various groups of tissues, such as the heart, lung, and brain, and in both excitable and non-excitable cells....
Computational and experimental evaluation of a dual COX inhibitor: Insights from DFT, molecular simulations, and in-vitro validation
February 2025
Inflammation, a fundamental aspect of numerous chronic disorders, is meticulously regulated by the cyclooxygenase enzymes COX-1 and COX-2, which are essential targets for anti-inflammatory treatments....
Advancements in minimally invasive transdermal drug delivery systems
April 2025
Minimally invasive drug delivery systems (MIDDS) have revolutionized pharmacological therapies by offering substitute techniques that improve therapeutic accuracy and efficacy while reducing pain, discomfort,...
From stem cells to therapeutics: Advancing islet function restoration through mesenchymal stem cell-based drug research
September 2025
Islet transplantation marks a new frontier in diabetes treatment, with considerable application potential in both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM). Recent advances...
Exploring the mechanism of Si Miao Yong An Tang in the treatment of diabetic foot ulcers based on network pharmacology and molecular docking
September 2025
Si Miao Yong An Tang (SMYA), a Chinese herbal formula with a long history of use, that has been found to be effective in Diabetic Foot Ulcers(DFU).An explanation of how the aforementioned formula is...
The effects of hydrogen-rich water on gut microbiota and related health outcomes: A systematic review
September 2025
Hydrogen-rich water (HRW) has emerged as a promising therapeutic intervention due to its antioxidant and anti-inflammatory properties. Recent studies suggest that the ingestion of HRW may alter gut...
AI-driven in silico discovery, design, and evaluation of novel antiviral candidates targeting Marburg virus nucleoprotein for advanced therapeutic development
March 2025
Marburg virus disease (MVD) is a highly virulent hemorrhagic fever caused by the Marburg virus (MARV), with case fatality rates reaching up to 90 %. Currently, no FDA-approved antiviral drugs exist...
Formulation and optimization of Kaempferol nanoemulsion-based gel for treating skin erythema using Box-Behnken statistical design
August 2025
The objective of this study is to develop and characterize Kaempferol (KMF)-loaded nanoemulsion-based gel formulations for the treatment of skin erythema. A Box-Behnken design was utilized to optimize...
From melanocyte loss to targeted therapy: A comprehensive review of vitiligo management
August 2025
Vitiligo is a chronic dermatological condition characterized by the loss of melanocytes, resulting in depigmented patches on the skin. The epidemiology, pathogenesis, existing and developing treatment...
Nanoemulgel-based delivery of 3-O-Acetyl-11-Keto-β-Boswellic Acid and basil oil for enhanced transdermal efficacy: In vitro anti-inflammatory and antioxidant assessment
September 2025
3-O-Acetyl-11-Keto-β-Boswellic Acid (AKBA) has potent anti-inflammatory, anti-oxidant, and anti-arthritic activities. Despite AKBA’s strong therapeutic potential, its clinical utility is hindered by...
Simulation, 3D-QSAR, molecular docking and pharmacophore mapping studies on indole derivatives as aromatase inhibitors
January 2025
Aromatase inhibition is a proven strategy for the treatment of ER+ breast cancer, which accounts for more than 70 % of cases of breast cancer. Indole-based aromatase inhibitors have changed the dynamics...
Susceptibility testing of Escherichia coli and Salmonella enterica to plant essential oils and commercial antibiotics
June 2025
Antimicrobial resistance (AMR) is a global emergency linked to the indiscriminate use of drugs and can be transmitted through food, posing risks to human health. This study aimed to evaluate the antimicrobial...
Virtual screening and molecular dynamics simulations reveal insights into drug repurposing strategies against New Delhi metallo-β-lactamase
September 2025
Antibiotic resistance continues to pose a serious threat to public health globally, drawing attention from health agencies and governments worldwide. Among the various resistance mechanisms, the emergence...
Triptolide and quercetin coordinately regulate the network pharmacology mechanism of renal cancer
Available online 19 November 2025
Renal cell carcinoma (RCC) is characterized by high metastatic potential, therapeutic resistance, and limited treatment options. Traditional Chinese Medicine (TCM)–derived compounds, such as triptolide...