An update on the role of inflammation in insulin resistance and islet β cell failure- A crosstalk between immune cells, adipose tissue, cytokines, and oxidative stress
March 2025
One of the characteristics of type 2 diabetes mellitus (T2DM) is the growing malfunctioning of β-cells and the presence of insulin resistance. The recent literature on this aspect is reviewed in this...
The effects of hydrogen-rich water on gut microbiota and related health outcomes: A systematic review
September 2025
Hydrogen-rich water (HRW) has emerged as a promising therapeutic intervention due to its antioxidant and anti-inflammatory properties. Recent studies suggest that the ingestion of HRW may alter gut...
Scutellaria Baicalensis Georgi: A review on botany, phytoconstituents, and pharmacological activities
October 2025
Scutellaria baicalensis (Huang-Qin), prominently avowed as Chinese Skullcap, is a traditional herb that has been historically diversified and used culturally in Chinese medicine. The review focused...
Virtual screening and molecular dynamics simulations reveal insights into drug repurposing strategies against New Delhi metallo-β-lactamase
September 2025
Antibiotic resistance continues to pose a serious threat to public health globally, drawing attention from health agencies and governments worldwide. Among the various resistance mechanisms, the emergence...
Structural classification of HDAC inhibitors and cancer treatment prospects: A review
September 2025
Histone deacetylase (HDAC) is a protease that plays an important role in chromosomal structural modification and in the regulation of gene expression. It is considered one of the key ways to inhibit...
Formulation, antimicrobial, and antioxidant effect of anti-acne serum containing extracts of striata scrophularia and rosemary plants
June 2025
Infectious diseases like acne, caused by bacteria and fungi, are prevalent worldwide. The rise of antibiotic-resistant bacteria has prompted the search for natural alternatives....
Design and screening of novel geniposide derivatives as xanthine oxidase inhibitors for hyperuricemia treatment using QSAR, Molecular docking, Molecular dynamics simulation, ADMET, and DFT Approaches
September 2025
Design of novel xanthine oxidase inhibitors via computational modeling of geniposide derivatives for treatment of hyperuricemia. Due to the excessive use of geniposide inhibitors and the detrimental...
From stem cells to therapeutics: Advancing islet function restoration through mesenchymal stem cell-based drug research
September 2025
Islet transplantation marks a new frontier in diabetes treatment, with considerable application potential in both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM). Recent advances...
Exploring the mechanism of Si Miao Yong An Tang in the treatment of diabetic foot ulcers based on network pharmacology and molecular docking
September 2025
Si Miao Yong An Tang (SMYA), a Chinese herbal formula with a long history of use, that has been found to be effective in Diabetic Foot Ulcers(DFU).An explanation of how the aforementioned formula is...
AI-driven target discovery and clinical development of candidate drugs for idiopathic pulmonary fibrosis: A review
October 2025
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with high mortality and limited treatment options, urgently requiring new therapeutic targets and drug development strategies. In recent...
Exploring DPP-IV inhibitors for diabetes treatment: A comprehensive study on molecular docking, molecular dynamics simulation, and in-vitro DPP-IV assay
August 2025
Dipeptidyl peptidase-4 (DPP-IV) inhibitors are established medications for type 2 diabetes, but there's a continuous search for even more potent and effective options....
Regulation of hyperglycemia in type 2 diabetes mellitus: Insights into current therapeutic pathways
October 2025
Diabetes mellitus (DM) has emerged as a rapidly growing global health challenge, affecting millions of people worldwide and posing a significant socio-economic burden on healthcare systems in both developing...
Formulation and optimization of Kaempferol nanoemulsion-based gel for treating skin erythema using Box-Behnken statistical design
August 2025
The objective of this study is to develop and characterize Kaempferol (KMF)-loaded nanoemulsion-based gel formulations for the treatment of skin erythema. A Box-Behnken design was utilized to optimize...
Computational design and evaluation of hydrantoin derivatives as potential anti-tubercular agents: Insight from ADMET, molecular docking, DFT, and molecular dynamic simulations
September 2025
The global burden of tuberculosis and the rise of drug-resistant Mycobacterium tuberculosis strains continue to challenge effective disease control, underscoring the need for novel therapeutic agents...
From melanocyte loss to targeted therapy: A comprehensive review of vitiligo management
August 2025
Vitiligo is a chronic dermatological condition characterized by the loss of melanocytes, resulting in depigmented patches on the skin. The epidemiology, pathogenesis, existing and developing treatment...
Nanoemulgel-based delivery of 3-O-Acetyl-11-Keto-β-Boswellic Acid and basil oil for enhanced transdermal efficacy: In vitro anti-inflammatory and antioxidant assessment
September 2025
3-O-Acetyl-11-Keto-β-Boswellic Acid (AKBA) has potent anti-inflammatory, anti-oxidant, and anti-arthritic activities. Despite AKBA’s strong therapeutic potential, its clinical utility is hindered by...
Development and characterization of suppository formulation for rectal delivery of clarithromycin
August 2025
Clarithromycin (CLR), a broad-spectrum antibiotic, is widely used to treat genitourinary infections caused by Gram positive bacteria via conventional drug delivery approaches, such as tablets. However,...
Innovative approaches in insulin delivery: Exploring molecular techniques and system developments
July 2025
Diabetes is the most prevalent endocrine disease, divided into Type I and Type II, affecting a large number of people globally. The most effective and safest drug for reducing blood sugar levels is...
In silico design of potent inhibitors targeting TNF-alpha, IL-1β, and TGF-β of inflammatory disease using QSAR, docking, MD simulation, ADMET, and DFT studies
October 2025
Inflammatory diseases, such as rheumatoid arthritis, pulmonary fibrosis, and autoimmune disorders, remain a challenge to treat with current therapeutics due to limited efficacy and adverse side effects....
Triptolide and quercetin coordinately regulate the network pharmacology mechanism of renal cancer
October 2025
Renal cell carcinoma (RCC) is characterized by high metastatic potential, therapeutic resistance, and limited treatment options. Traditional Chinese Medicine (TCM)–derived compounds, such as triptolide...
Exploring the antimicrobial and biofilm inhibitory potential of Citrus limetta peel essential oil against multidrug-resistant Shigella: In vitro and in silico insights
September 2025
Citrus limetta, commonly known as sweet lime, is widely acclaimed for its sweet flavor and nutritional richness; however, its peels are often discarded as agricultural waste. Utilizing these peels to...
Research on the mechanism by which quercetin affects ferroptosis in breast cancer cells through regulating USP9X/PIAS4
October 2025
Breast cancer stands as a formidable malignant tumor posing a severe threat to women’s health globally, characterized by alarmingly high rates of morbidity and mortality. Quercetin has demonstrated...
Uncovering celecoxib’s anti-breast cancer mechanisms through network pharmacology, molecular docking, and dynamics
October 2025
Celecoxib has gained attention as a potential anti-tumor agent in breast cancer. This study systematically elucidated the therapeutic mechanisms of celecoxib in this malignancy....
Computational and experimental evaluation of a dual COX inhibitor: Insights from DFT, molecular simulations, and in-vitro validation
February 2025
Inflammation, a fundamental aspect of numerous chronic disorders, is meticulously regulated by the cyclooxygenase enzymes COX-1 and COX-2, which are essential targets for anti-inflammatory treatments....
Advancements in minimally invasive transdermal drug delivery systems
April 2025
Minimally invasive drug delivery systems (MIDDS) have revolutionized pharmacological therapies by offering substitute techniques that improve therapeutic accuracy and efficacy while reducing pain, discomfort,...