An update on the role of inflammation in insulin resistance and islet β cell failure- A crosstalk between immune cells, adipose tissue, cytokines, and oxidative stress
March 2025
One of the characteristics of type 2 diabetes mellitus (T2DM) is the growing malfunctioning of β-cells and the presence of insulin resistance. The recent literature on this aspect is reviewed in this...
The effects of hydrogen-rich water on gut microbiota and related health outcomes: A systematic review
September 2025
Hydrogen-rich water (HRW) has emerged as a promising therapeutic intervention due to its antioxidant and anti-inflammatory properties. Recent studies suggest that the ingestion of HRW may alter gut...
AI-driven target discovery and clinical development of candidate drugs for idiopathic pulmonary fibrosis: A review
October 2025
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with high mortality and limited treatment options, urgently requiring new therapeutic targets and drug development strategies. In recent...
Regulation of hyperglycemia in type 2 diabetes mellitus: Insights into current therapeutic pathways
October 2025
Diabetes mellitus (DM) has emerged as a rapidly growing global health challenge, affecting millions of people worldwide and posing a significant socio-economic burden on healthcare systems in both developing...
In silico design of potent inhibitors targeting TNF-alpha, IL-1β, and TGF-β of inflammatory disease using QSAR, docking, MD simulation, ADMET, and DFT studies
October 2025
Inflammatory diseases, such as rheumatoid arthritis, pulmonary fibrosis, and autoimmune disorders, remain a challenge to treat with current therapeutics due to limited efficacy and adverse side effects....
Formulation, antimicrobial, and antioxidant effect of anti-acne serum containing extracts of striata scrophularia and rosemary plants
June 2025
Infectious diseases like acne, caused by bacteria and fungi, are prevalent worldwide. The rise of antibiotic-resistant bacteria has prompted the search for natural alternatives....
Identification of plant-derived secondary metabolites as potential CDK2 inhibitors against colorectal cancer: Molecular docking, dynamics simulations and DFT study
Available online 3 February 2026
Colorectal cancer (CRC) ranks as the third most common cancer globally and remains the second leading cause of cancer-related deaths, with an estimated 1.9 million new cases and 0.93 million fatalities...
Benzimidazole derivatives as anticancer agents: A review of recent literature and structure-activity relationships
November 2025
The structural diversity and associated biological activities of benzimidazole derivatives have made them attractive to medicinal chemists. Due to diverse biological activities of benzimidazole derivatives,...
Quality by design based analytical (RP-HPLC) method development and validation of coenzyme q10 in single and combination with clomiphene citrate: An extensive review
November 2025
Analytical Quality by Design (AQbD) has emerged as a rigorous, science-driven framework that supports the development of robust and regulatory-compliant analytical procedures. Its application to RP-HPLC...
Formulation and optimization of Kaempferol nanoemulsion-based gel for treating skin erythema using Box-Behnken statistical design
August 2025
The objective of this study is to develop and characterize Kaempferol (KMF)-loaded nanoemulsion-based gel formulations for the treatment of skin erythema. A Box-Behnken design was utilized to optimize...
Scutellaria Baicalensis Georgi: A review on botany, phytoconstituents, and pharmacological activities
October 2025
Scutellaria baicalensis (Huang-Qin), prominently avowed as Chinese Skullcap, is a traditional herb that has been historically diversified and used culturally in Chinese medicine. The review focused...
Development and characterization of suppository formulation for rectal delivery of clarithromycin
August 2025
Clarithromycin (CLR), a broad-spectrum antibiotic, is widely used to treat genitourinary infections caused by Gram positive bacteria via conventional drug delivery approaches, such as tablets. However,...
Structural classification of HDAC inhibitors and cancer treatment prospects: A review
September 2025
Histone deacetylase (HDAC) is a protease that plays an important role in chromosomal structural modification and in the regulation of gene expression. It is considered one of the key ways to inhibit...
Virtual screening and molecular dynamics simulations reveal insights into drug repurposing strategies against New Delhi metallo-β-lactamase
September 2025
Antibiotic resistance continues to pose a serious threat to public health globally, drawing attention from health agencies and governments worldwide. Among the various resistance mechanisms, the emergence...
Machine learning–guided optimization of MALT1 inhibitors for diffuse large B-cell lymphoma via QSAR modelling, molecular docking, ADMET profiling, and molecular dynamics simulations
October 2025
The paracaspase MALT1(mucosa-associated lymphoid tissue lymphoma translocation protein 1) plays a pivotal oncogenic role in diffuse large B-cell lymphoma (DLBCL). However, many reported inhibitors exhibit...
Naphthoquinone-triazole hybrids as anti-diabetic agents: An exploration of in silico and in vitro α-glucosidase and α-amylase inhibition
October 2025
Diabetes management requires effective inhibitors of carbohydrate-hydrolyzing enzymes such as α-glucosidase and α-amylase. This study explores naphthoquinone-triazole hybrids as potential anti-diabetic...
Preparation, characterization, and tyrosinase enzyme inhibition activity of biocompatible antibacterial Astragalus campylosema-loaded sodium alginate hydrogel
November 2025
Hydrogels have good water retention, biocompatibility and biodegradability. As a result, their medical use has become increasingly widespread....
Innovative approaches in insulin delivery: Exploring molecular techniques and system developments
July 2025
Diabetes is the most prevalent endocrine disease, divided into Type I and Type II, affecting a large number of people globally. The most effective and safest drug for reducing blood sugar levels is...
Exploring DPP-IV inhibitors for diabetes treatment: A comprehensive study on molecular docking, molecular dynamics simulation, and in-vitro DPP-IV assay
August 2025
Dipeptidyl peptidase-4 (DPP-IV) inhibitors are established medications for type 2 diabetes, but there's a continuous search for even more potent and effective options....
From melanocyte loss to targeted therapy: A comprehensive review of vitiligo management
August 2025
Vitiligo is a chronic dermatological condition characterized by the loss of melanocytes, resulting in depigmented patches on the skin. The epidemiology, pathogenesis, existing and developing treatment...
Indazole, a privileged scaffold: Synthetic strategies, biological potential, and future prospects
November 2025
Indazole, a bicyclic nitrogen-containing heterocycle formed by the fusion of benzene and pyrazole rings, emerges as a versatile scaffold in drug discovery. Although naturally occurring Indazole alkaloids...
Integrated computational analysis of halogenated curcumin derivatives targeting GSK-3β: Pharmacokinetic, docking, MDS, and DFT approaches
October 2025
Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine kinase involved in several diseases, such as cancer, diabetes, and neurodegenerative disorders. Its inhibition has gained significant...
Molecular docking and DFT analysis of a bis-Schiff base ligand: Strong affinity for SARS-CoV-2 main protease and other biological targets
November 2025
The escalating global health crisis of antimicrobial resistance underscores the urgent need for novel chemotherapeutic agents. Schiff bases represent a privileged class of compounds with broad-spectrum...
Investigating the potential of Commelina benghalensis Linn. in breast cancer treatment: Insights from network pharmacology, molecular docking, and dynamic simulations
November 2025
Cancer remains a global health challenge, driven by complex mechanisms, including metabolic dysfunction, genetic mutations, and inflammatory processes....
N′-([1,1′-Biphenyl]-4-ylmethylene)-4-methylbenzenesulfonohydrazide as a potential EGFR inhibitor: ADMET, docking, dynamics, and DFT studies
October 2025
The Epidermal Growth Factor Receptor (EGFR) is a transmembrane tyrosine kinase receptor that regulates key cellular processes such as proliferation, differentiation, and survival. Aberrant activation...