Artificial intelligence and machine learning in drug discovery: From lead discovery to clinical validation (2020–2025)
December 2025
Artificial intelligence (AI) and machine learning (ML) are fundamentally changing the small-molecule drug discovery process, primarily by moving the workflow from being empirically screened to data-driven,...
Alkylating agents in cancer: Current developments
December 2025
The term cancer is derived from a Latin word “cancrum” which means crabs, and associated with group of disease which is related with cellular malfunctions. It is one of the major causes of death in...
Nanotechnology-enhanced herbal sunscreens: A natural approach to UV protection and skin care
January 2026
Prolonged exposure to ultraviolet (UV) radiation is a leading cause of several skin-related concerns, including sunburn, premature aging, pigmentation, and even skin cancer. While conventional sunscreens...
Pharmacological treatment of adolescent depression: Current advances and future perspectives
December 2025
Adolescent depression is a prevalent and increasingly concerning mental health condition, characterized by persistent low mood, loss of interest, and impaired social functioning. Due to the complexity...
An update on the role of inflammation in insulin resistance and islet β cell failure- A crosstalk between immune cells, adipose tissue, cytokines, and oxidative stress
March 2025
One of the characteristics of type 2 diabetes mellitus (T2DM) is the growing malfunctioning of β-cells and the presence of insulin resistance. The recent literature on this aspect is reviewed in this...
Phytochemicals as promising lead compounds for drug discovery: A comprehensive review of mechanisms and pharmacological potentials
January 2026
Phytochemicals, bioactive compounds derived from medicinal plants, have long contributed to drug discovery by providing diverse chemical scaffolds and broad biological activities. Despite strong preclinical...
The effects of hydrogen-rich water on gut microbiota and related health outcomes: A systematic review
September 2025
Hydrogen-rich water (HRW) has emerged as a promising therapeutic intervention due to its antioxidant and anti-inflammatory properties. Recent studies suggest that the ingestion of HRW may alter gut...
Benzimidazole derivatives as anticancer agents: A review of recent literature and structure-activity relationships
November 2025
The structural diversity and associated biological activities of benzimidazole derivatives have made them attractive to medicinal chemists. Due to diverse biological activities of benzimidazole derivatives,...
Automated detection of breast cancer using machine learning and deep learning models from tabular data
December 2025
Detection of breast cancer remains an important global health issue, particularly in patients with dense breast tissue. Despite wide use of machine learning for breast cancer diagnosis, many existing...
Phytochemical profiling, antiviral activities, molecular docking, and dynamic simulation of potential Indian medicinal plants against NDV
December 2025
Newcastle disease remains a major threat to poultry farming, especially in village chickens, causing substantial economic losses estimated at 116,591 metric tons of poultry products annually. Despite...
Formulation, antimicrobial, and antioxidant effect of anti-acne serum containing extracts of striata scrophularia and rosemary plants
June 2025
Infectious diseases like acne, caused by bacteria and fungi, are prevalent worldwide. The rise of antibiotic-resistant bacteria has prompted the search for natural alternatives....
Structure-based drug designing and pharmacological profiling of Withanolide A as potential EGFR inhibitors for glioblastoma treatment
February 2026
Glioblastoma (GBM) remains the most aggressive and lethal form of primary brain tumor, characterized by a poor prognosis and limited therapeutic options. Among the molecular targets under investigation,...
Indazole, a privileged scaffold: Synthetic strategies, biological potential, and future prospects
November 2025
Indazole, a bicyclic nitrogen-containing heterocycle formed by the fusion of benzene and pyrazole rings, emerges as a versatile scaffold in drug discovery. Although naturally occurring Indazole alkaloids...
From prediction to design: A machine learning model for de novo bioactive compounds and personalized biotherapeutics
December 2025
Traditional approaches for identifying and improving bioactive molecules, important for pharmaceutical development, are laborious and inefficient. Therapeutic chemical screening, development, and customization...
Spray on science: Revolutionizing topical drug delivery with film-forming systems
March 2026
Film-forming sprays (FFS) have emerged as advanced topical and transdermal drug delivery systems offering improved drug retention, enhanced bioavailability, and better patient compliance compared to...
Computational strategies for drug discovery in neurodegeneration: Targeting Alzheimer’s and Parkinson’s disease
March 2026
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s remain among the most pressing global health challenges, with more than 50 million people affected worldwide and no curative therapies...
Formulation and optimization of Kaempferol nanoemulsion-based gel for treating skin erythema using Box-Behnken statistical design
August 2025
The objective of this study is to develop and characterize Kaempferol (KMF)-loaded nanoemulsion-based gel formulations for the treatment of skin erythema. A Box-Behnken design was utilized to optimize...
Quality by design based analytical (RP-HPLC) method development and validation of coenzyme q10 in single and combination with clomiphene citrate: An extensive review
November 2025
Analytical Quality by Design (AQbD) has emerged as a rigorous, science-driven framework that supports the development of robust and regulatory-compliant analytical procedures. Its application to RP-HPLC...
Development and evaluation of rectal suppository formulation for antidiabetic activity of repaglinide: A comparative study
February 2026
Diabetes mellitus is a group of metabolic diseases mainly characterized by chronic hyperglycemia. The oral immediate release tablet formulation of Repaglinide (REP) is associated with the sudden hypoglycemia...
AI-driven target discovery and clinical development of candidate drugs for idiopathic pulmonary fibrosis: A review
October 2025
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with high mortality and limited treatment options, urgently requiring new therapeutic targets and drug development strategies. In recent...
Regulation of hyperglycemia in type 2 diabetes mellitus: Insights into current therapeutic pathways
October 2025
Diabetes mellitus (DM) has emerged as a rapidly growing global health challenge, affecting millions of people worldwide and posing a significant socio-economic burden on healthcare systems in both developing...
Network pharmacology and machine learning-driven virtual screening with dynamic simulations of natural compounds for glioblastoma
February 2026
Glioma progression is driven by dysregulated signaling networks, including CDK4-Cyclin D3, PI3K-Akt, and EGFR pathways....
Paraquat-induced neurotoxicity: Mechanisms and potential therapies
November 2025
Paraquat (PQ) is used to control a broad range of broadleaf plants in agriculture. This poisoning has no specific antidote, and the treatment is auxiliary. Free radicals cause neurotoxicity by lipid...
Exploring coumarin derivatives as promising Acetylcholinesrtage inhibitors in alzheimer disease: Integrating QSAR, docking, MD simulations, and DFT study
January 2026
Alzheimer’s disease, a major health concern primarily distressing older population, remains without a cure, with current treatments providing only symptomatic relief. This study focused on identifying...
Benzimidazole derivatives as kinase inhibitors: Synthetic strategies, and therapeutic prospects in cancer
February 2026
The benzimidazole framework is an important heterocyclic pharmacophore in medicinal chemistry, particularly recognised for its structural bioisosterism with purine nucleotides. This resemblance enables...