Molecular docking-guided target identification: Formononetin targets ALOX15 to ameliorate IL-13-induced inflammation, ferroptosis and pyroptosis in nasal epithelial cells
Available online 11 August 2026
Allergic rhinitis (AR) is a prevalent chronic inflammatory disease of the nasal mucosa characterized by elevated levels of T helper 2 cytokines, particularly interleukin-13 (IL-13). Formononetin (FMNT)...
Baicalin ameliorates interleukin-1β-induced inflammation, apoptosis, oxidative stress, and extracellular matrix degradation by regulating COL1A2 expression in chondrocytes
Available online 11 August 2026
Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by progressive cartilage destruction. Interleukin-1β (IL-1β) is a pivotal pro-inflammatory cytokine that drives OA pathogenesis...
Machine learning-driven identification and molecular docking prediction of core therapeutic targets of Baoyuan Danshen Xiefei Decoction in chronic heart failure
Available online 11 August 2026
Chronic heart failure (CHF), a life-threatening complex syndrome, remains a clinical challenge with persistently unmet therapeutic needs. Although the modified Baoyuan Danshen Xiefei Decoction (BDXD)...
Network pharmacology combined with molecular docking and molecular dynamics simulation to analyze the pharmacological mechanisms of Xueshuantong injection in the treatment of fracture
Available online 8 August 2026
As a common clinical orthopedic injury, the healing process of fracture involves a complex molecular regulatory network. Xueshuantong injection (XI) containing (Ginsenoside Rb1, Ginsenoside Rg1, and...
Persistent andexanet thromboembolic signals among reversal agents in FAERS
Available online 6 August 2026
Idarucizumab, andexanet alfa, and four-factor prothrombin complex concentrate (4F-PCC) are the principal strategies for anticoagulant reversal. In December 2025, andexanet alfa was withdrawn from the...
Novel bis-pyrano[2,3-c]pyrazoles as potential antidiabetic agents: Synthesis, biological evaluation, and computational insights
Available online 4 August 2026
Type 2 diabetes mellitus (T2DM) remains a major global health concern, necessitating the development of safer and more effective therapeutic agents. Pyrano[2,3-c]pyrazole derivatives have emerged as...
Screening of key genes associated with trigeminal neuralgia and experimental study on topiramate targeting CA2 for anti-neuroinflammatory and anti-oxidative effects in LPS-induced human microglia
Available online 3 August 2026
Trigeminal neuralgia (TN) is a severe neurological pain condition affecting the quality of human life. The purpose of this research was to screen the key genes and search for candidate drugs, and elucidate...
Expression of ZNF521 in glioma and its role in promoting temozolomide resistance by regulating tumor cell stemness
Available online 3 August 2026
The current study investigated the expression pattern and clinical significance of zinc finger protein 521 (ZNF521) in patients with glioma and effects of ZNF521 knockdown on glioma cell growth, tumorsphere-forming...
In-silico evaluation of zeaxanthin and riboflavin from moringa oleifera as potential insulin receptor modulators for diabetes management
Available online 28 July 2026
Diabetes mellitus represents a metabolic disorder characterized by persistent insulin resistance. Standard synthetic medications produce adverse side effects and elevate healthcare costs. This situation...
Targeting EGFR/PI3K/AKT signaling mediates the anti-tumor effect of Ginsenoside CK in oral cancer
Available online 24 July 2026
Oral cancer (OC) is a common malignancy with high recurrence and mortality. Ginsenoside compound K (GCK), a bioactive metabolite of ginsenosides, has shown potent anti-tumor properties. However, its...
Periplaneta americana extracts induce PI3K/AKT signaling and mitochondrial function enhancement to promote liver regeneration through MCJ down-regulation
Available online 24 July 2026
Studies have shown that Periplaneta americana extracts (PAEs) affect liver regeneration (LR). However, their effects on cell proliferation, mitochondrial activity and related signaling pathways, as...
Phillyrin attenuates inflammatory and ferroptosis-related responses in experimental acute lung injury with potential involvement of JAK2/STAT1 signaling
Available online 24 July 2026
Infection-induced acute lung injury (ALI) is a life-threatening clinical condition characterized by severe pulmonary inflammation. Lipopolysaccharide (LPS) is a core mediator of infectious acute pulmonary...
Croton caudatus Geiseler: Ethnomedicinal roots, phytochemical diversity, and anticancer relevance with implications for hepatocellular carcinoma
Available online 24 July 2026
Hepatocellular carcinoma (HCC) is a major global health concern due to its high morbidity, limited therapeutic options, frequent recurrence, and treatment-associated toxicity. Croton caudatus Geiseler...
Integrating weighted gene co-expression network analysis and machine learning reveals that RETN drives Methicillin-resistant Staphylococcus aureus-induced lung epithelial cell injury by regulating inflammation and oxidative stress
Available online 24 July 2026
Methicillin-resistant Staphylococcus aureus (MRSA) represents an opportunistic pathogen capable of causing severe bacterial pneumonia. Resistin (RETN) is a systemic immune-derived proinflammatory cytokine,...
A rifampin-loaded porous bioceramic box as a drug delivery system for spinal tuberculosis
Available online 21 July 2026
With the increasing incidence of spinal tuberculosis in recent years, existing treatments cannot fully meet clinical requirements. Novel localized drug delivery systems are urgently needed for efficient...
Unveiling the effects of isoflurane on the cell proliferation, migration, invasion, and apoptosis of colorectal cancer cells in vitro via the PI3K/AKT/NF-κB pathway
Available online 21 July 2026
Anesthetics might be involved in tumor progression. This study examined the role of isoflurane in the progression of colorectal cancer (CRC)....
Addressing cancer with thiazole derivatives: Current progress in design, structure-activity relationships, and mechanistic insights
Available online 21 July 2026
Thiazole scaffolds are considered as a promising class of compounds in anticancer drug development because of their structural diversity, and their ability to bind to a variety of oncogenic targets;...
Geniposide regulates mitochondrial dynamics and PINK1/Parkin-mediated mitophagy to mitigate myocardial ischemia–reperfusion injury in rats
Available online 18 July 2026
Myocardial ischemia-reperfusion injury (MIRI) significantly restricts the clinical efficacy of reperfusion therapy. Mitochondrial dysfunction represents the primary pathological mechanism underlying...
Based on network pharmacology and molecular docking to explore the mechanism by which Gigantol alleviates high glucose-induced podocyte apoptosis and mitochondrial dysfunction
Available online 17 July 2026
Podocyte dysfunction has been identified as a crucial pathological characteristic of Diabetic Nephropathy (DN). Previous studies have suggested that Gigantol, a bibenzyl compound derived from orchids,...
A network pharmacology-based study on the mechanism of naringin alleviating LPS-induced HK2 cell injury and inhibiting ferroptosis via regulating the PPARγ-p53 pathway
Available online 17 July 2026
Sepsis-associated acute kidney injury (SA-AKI) is a common sepsis complication with complex pathogenesis and limited treatments, and ferroptosis has been reported to be involved in its development....
Identification of key targets and mechanisms of apigenin against pancreatic cancer via network pharmacology, weighted gene co-expression network analysis, and molecular docking
Available online 17 July 2026
Pancreatic cancer (PC) is characterized by high malignancy and limited therapeutic options. Apigenin, a natural flavonoid compound, has potential anti-tumor activity, yet its molecular targets and anti-PC...
Integrating bioinformatics and machine learning to analyze molecular biomarkers, immune infiltration mechanisms, and small-molecule therapeutic candidates for gallstones
Available online 17 July 2026
Gallstones, a prevalent digestive disease, frequently trigger chronic inflammation, yet traditional methods fail to fully uncover its molecular mechanisms. This study integrates bioinformatics and machine...
Integrated network pharmacology, machine learning and experimental validation reveal that ursolic acid promotes M2-like microglial polarization by targeting CYP51A1 in cerebral ischemia-reperfusion injury
Available online 17 July 2026
Cerebral ischemia-reperfusion injury (CIRI) is a key pathological consequence of ischemic stroke, and an imbalance between pro-inflammatory and anti-inflammatory microglial phenotypes contributes to...
Integrating network pharmacology, molecular docking and cellular experiments reveals that Tanshinone IIA alleviates free fatty acids-induced Huh-7 cell lipogenesis, inflammation and oxidative stress by regulating NFKBIA
Available online 16 July 2026
Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, characterized by hepatocellular fat accumulation ranging from steatosis, non-alcoholic steatohepatitis to cirrhosis....
Bioinformatics-based prediction and in vitro validation of quercetin’s potential targets in congenital spinal deformity: An exploratory study on its role in osteogenic differentiation
Available online 16 July 2026
Congenital spinal deformities (CSDs) are a class of complex spinal malformations arising from abnormal vertebral development, often associated with aberrant osteogenic differentiation. Quercetin (QUE),...