Meta-analysis of tripterygium glycosides combined with immunosuppressants or glucocorticoids in the treatment of various types of connective tissue disease-interstitial lung disease
Available online 3 September 2026
To systematically evaluate the efficacy of tripterygium glycosides combined with immunosuppressants or glucocorticoids in the treatment of various types of connective tissue disease-interstitial lung...
Discovery and exploratory profiling of a novel BCL-XL PROTAC
Available online 3 September 2026
BCL-XL is a key anti-apoptotic protein frequently overexpressed in various malignancies, where it contributes to therapy resistance. PROTAC technology offers a potential strategy to expand the therapeutic...
The combination gene therapy of HSV-TK/IL-12 inhibits non-small cell lung cancer through the bystander effect associated with Cx43 up-regulation and immune activation
Available online 1 September 2026
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) representing a major subtype characterized by high incidence and mortality. Despite...
Xuebijing mitigates myocardial injury induced by organophosphorus poisoning through mediating the HNRNPD/PDK4 signaling pathway
Available online 31 August 2026
To explore the protective mechanism of Xuebijing against myocardial injury caused by organophosphorus poisoning, providing a theoretical basis for its prevention and treatment....
Mechanistic insights into Xuebijing’s therapeutic effects on sepsis-induced cardiomyopathy: Transcriptomics-based approach combining WGCNA, machine learning, network pharmacology, and experimental validation
Available online 29 August 2026
sepsis-induced cardiomyopathy (SIC) is a critical complication of sepsis, contributing significantly to high mortality rates. The underlying molecular mechanisms remain poorly understood, and effective...
Firsekibart, an IL-1β inhibitor, for the treatment of refractory acute gout in an elderly patient with multimorbidity: A case report
Available online 29 August 2026
Refractory acute gout in elderly patients with multimorbidity is difficult to manage because standard anti-inflammatory therapies, including nonsteroidal anti-inflammatory drugs, colchicine, and glucocorticoids,...
Inhibitory effects of traditional Chinese herbal medicine Bushen decoction on osteoclast differentiation and ovariectomy-induced bone loss
Available online 27 August 2026
Osteoporosis (OP) is a prevalent metabolic bone disease characterized by reduced bone mineral density and compromised skeletal integrity, leading to increased fracture risk in the elderly. Current treatments...
Role of health check-ups combined with pharmacological intervention in primary prevention of chronic diseases: A review based on stratified management of blood pressure and blood lipids
Available online 27 August 2026
Chronic diseases, particularly cardiovascular diseases (CVDs), represent the leading cause of mortality worldwide. This burden is disproportionately borne by low- and middle-income countries (LMICs),...
Environmentally benign synthesis, characterization, and in vitro anticancer and anti-TB activity of indolizines, along with anti-TB and anticancer docking studies
Available online 26 August 2026
The escalating prevalence of drug-resistant tuberculosis and cancer, coupled with the limitations of current therapeutics, underscores the urgent need for novel multi-target molecular scaffolds....
Artificial intelligence-guided small-molecule discovery for primary amoebic meningoencephalitis
Available online 25 August 2026
Yikun formula ameliorates cyclophosphamide-induced premature ovarian insufficiency associated with suppression of AGE/RAGE-related NF-κB and p38 MAPK signaling
Available online 24 August 2026
Premature ovarian insufficiency (POI) is an important cause of impaired female fertility. Yikun Formula (YKF), a traditional Chinese medicine prescription, has shown clinical utility in the treatment...
Breaking the barriers: Can multi-route drug delivery improve survival in amoebic encephalitis?
Available online 24 August 2026
Following decades of research, the mortality rate of amoebic infections remains over 90%. It seems that we keep doing the same thing and get the same result. This should be addressed or at the very...
Integrated network pharmacology, molecular docking, and experimental validation reveal that Pterostilbene alleviates lipopolysaccharide-induced AC16 cell inflammation and ferroptosis via regulating ALOX5-mediated NF-κB signaling pathway
Available online 24 August 2026
Pterostilbene has been found to inhibit the progression of sepsis-related diseases, including sepsis-induced myocardial contractile dysfunction. However, the possible molecular mechanisms underlying...
Empirical antimicrobial therapy and pharmacokinetics/pharmacodynamics-based optimization strategies for neonatal severe infection
Available online 24 August 2026
Severe neonatal infections, including sepsis and meningitis, represent a major global cause of neonatal mortality and long-term morbidity. These infections are rapidly progressive and life-threatening,...
Candidate molecular mechanisms of carfilzomib-associated atrial fibrillation: An integrative network toxicology and mendelian randomization study
Available online 24 August 2026
Carfilzomib, a proteasome inhibitor used in multiple myeloma therapy, is associated with an increased risk of atrial fibrillation (AF). However, the precise molecular mechanisms underlying this cardiotoxicity...
Meta-analysis of efficacy and pregnancy outcomes of low molecular weight heparin combined with magnesium sulfate in the treatment of preeclampsia
Available online 24 August 2026
To evaluate the efficacy of low molecular weight heparin (LMWH) combined with magnesium sulfate in preeclampsia and its effect on pregnancy outcomes through a meta-analysis....
Network pharmacology, machine learning, and experimental validation reveal the mechanism by which Trachelospermum jasminoides regulates colorectal cancer progression
Available online 24 August 2026
Colorectal cancer (CRC) is a common digestive malignancy. Trachelospermum jasminoides has potential anti-tumor activity, but its active components and mechanisms against CRC remain unclear. This study...
Moslosooflavone, an active component of Scutellaria barbata D. Don, induces cuproptosis and suppresses the invasive phenotype of lung cancer cells through regulation of the HIF-1α-PDK1/3 axis
Available online 24 August 2026
Cuproptosis has been implicated in lung cancer progression, including cell migration and invasion. Scutellaria barbata D. Don (SBD) has potential antitumor activity; however, the relationship between...
Mechanistic study of Matrine against nasopharyngeal carcinoma based on network pharmacology and molecular dynamics
Available online 24 August 2026
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the nasopharyngeal epithelium. Matrine is a natural quinolizidine alkaloid from the traditional Chinese herb Sophora flavescens....
Molecular recognition of piperidine derivatives as MOR modulators
Available online 22 August 2026
Pain is a naturally unpleasant sensation, and opioids, mainly morphine and its derivatives, have been used for decades to ease it through activation of the μ-opioid receptor (MOR). The piperidine ring,...
CardioSafe: An open-source three-branch fusion model for hERG cardiotoxicity prediction with explainable atom-level attribution
Available online 19 August 2026
hERG potassium channel blockade is a leading cause of drug-induced cardiotoxicity and late-stage clinical attrition, accounting for up to one-third of Phase III trial failures. Existing free computational...
In silico exploration of Syzygium aromaticum bioactive compounds targeting the cancer-associated protein LKB1
Available online 18 August 2026
Breast cancer is one of the leading causes of cancer-related mortality worldwide. Mutations in the tumor suppressor protein liver kinase B1 (LKB1) have been implicated in breast cancer progression,...
Nanotechnology-enabled pharmaceuticals and biomaterials: Innovations in drug delivery, theranostics, and clinical translation
Available online 17 August 2026
Nanotechnology has transformed modern medicine by addressing critical challenges in drug delivery, diagnostics, and biomaterials engineering. The integration of nanoscale materials into pharmaceutical...
Molecular interactions with bovine serum albumin, antibacterial activity, and photophysical characterization of 4-thioxo chromen-2-one derivatives: Integrated biophysical and computational analysis
Available online 16 August 2026
The functional profile of 4-thioxo chromen-2-one analogues, including antimicrobial efficacy, serum protein binding, and photophysical properties, remains largely unexplored despite the pharmacological...
Design and synthesis of an anthracene-chalcone derivative as a novel carbonic anhydrase II inhibitor: A combined DFT, molecular docking and dynamic simulation study
Available online 15 August 2026
Anthracene and chalcone-based derivatives possess diverse pharmacological properties; however, comprehensive studies integrating their synthesis, structural characterization, quantum chemical investigation,...