Epigenetic modulation and antiproliferative effects of Clitoria ternatea methanolic extract on prostate cancer cells via DNMT1 downregulation
September 2025
Clitoria ternatea (C. ternatea) is widely recognized for its medicinal properties, particularly within traditional medicine systems. Its diverse phytochemical constituents, such as flavonoids, anthocyanins,...
In silico investigation of phytocompounds in Bacopa monnieri and Centella asiatica targeting ALS-associated biomarkers HLA-DRB1 and COLIA2
September 2025
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder marked by the degeneration of motor neurons, leading to muscle weakness, paralysis, and ultimately respiratory failure....
KBH4 assisted synthesis of ultra-large mesoporous silica nanosystem encapsulating paclitaxel and glucose oxidase for starvation/chemo-therapy
September 2025
A novel ultra-large mesoporous silica (ULP-MSN) was designed with the assistant of pore expanding agent potassium borohydride (KBH4). ULP-MSN was used as a drug carrier for loading paclitaxel (PTX),...
Therapeutic mechanisms of Radix bupleuri in plasma cell mastitis: A multi-modal study combining network pharmacology, molecular docking, and dynamics simulations
September 2025
Radix bupleuri (Chaihu), a cornerstone botanical in traditional Chinese medicine, exerts anti-inflammatory and immunomodulatory properties. This study combined multiple methods to investigate the pharmacological...
The effects of hydrogen-rich water on gut microbiota and related health outcomes: A systematic review
September 2025
Hydrogen-rich water (HRW) has emerged as a promising therapeutic intervention due to its antioxidant and anti-inflammatory properties. Recent studies suggest that the ingestion of HRW may alter gut...
Exploring the antimicrobial and biofilm inhibitory potential of Citrus limetta peel essential oil against multidrug-resistant Shigella: In vitro and in silico insights
September 2025
Citrus limetta, commonly known as sweet lime, is widely acclaimed for its sweet flavor and nutritional richness; however, its peels are often discarded as agricultural waste. Utilizing these peels to...
Structural classification of HDAC inhibitors and cancer treatment prospects: A review
September 2025
Histone deacetylase (HDAC) is a protease that plays an important role in chromosomal structural modification and in the regulation of gene expression. It is considered one of the key ways to inhibit...
Synthesis, characterization, and neuroprotective effect of taxifolin-conjugated gold nanoparticles against amyloid βeta induced Alzheimer’s disease
August 2025
Alzheimer's disease (AD) is characterized by amyloid beta peptide (Aβ) accumulation, oxidative stress, neuro inflammation, and progressive memory loss. Taxifolin, a flavonoid with neuroprotective effects,...
Development and characterization of suppository formulation for rectal delivery of clarithromycin
August 2025
Clarithromycin (CLR), a broad-spectrum antibiotic, is widely used to treat genitourinary infections caused by Gram positive bacteria via conventional drug delivery approaches, such as tablets. However,...
Efficacy and safety of PD-1/PD-L1 inhibitors for relapsed/metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis
August 2025
A systematic evaluation was performed to investigate the efficacy and safety of programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in relapsed/metastatic nasopharyngeal carcinoma...
The application of immunoprotein inhibitor treatment regimens based on PD-L1: A retrospective analysis after the progression of advanced gastric cancer
August 2025
The aim of this study was to evaluate the therapeutic efficacy and safety of immunotherapy beyond progression in advanced gastric cancer (GC) after the failure of first-line immunotherapy in combination...
Investigation into the mechanism of columbianadin’s inhibition of breast cancer development using network pharmacology and molecular dynamics simulation
August 2025
Breast cancer (BC) remains a significant global health challenge, necessitating the exploration of novel therapeutic agents. Columbianadin (CBN), a natural compound, has shown potential anti-cancer...
Investigating the neuroprotective effects and the potential mechanisms of β-amyrenone in cerebral ischemic/reperfusion injury based on pharmacology network, bioinformatics, and molecular docking simulation
August 2025
Cerebral ischemic/reperfusion injury (CIRI) can cause secondary injury to the neurons, which remains unresolved in the clinic. β-amyrenone harbors anti-inflammatory effects. The present study aims to...
A high dose of 2-APB enhances neurotoxicity induced by 6-hydroxydopamine in rats
August 2025
Boron-containing compounds (BCCs), such as 2-aminodiphenyl borinate (2-APB), are studied as active agents on the central nervous system (CNS). At doses ≤ 10 mg/kg, 2-APB administration induces neuronal...
Identification of active compounds and therapeutic mechanisms of traditional Chinese medicine for periarthritis of shoulder for promoting blood circulation and removing stasis (PBRS): A network pharmacology and randomized controlled study
August 2025
Periarthritis of Shoulder (PS) is a prevalent condition characterized by shoulder pain and restricted movement, affecting 2–5 % of the global population. This study aims to elucidate the active compounds...
An appraisal on biomolecular imaging in diagnosis of neurological disorders and innovation in clinical research
August 2025
Biological indicators, or biomarkers, play an increasingly important role in the study and diagnosis of neurological diseases. Over the last several decades, the use of imaging biomarkers has increased...
Investigating the therapeutic potential of jiawei xuanbi decoction in rheumatoid arthritis via network pharmacology and cell experiments
August 2025
Rheumatoid arthritis (RA) is an autoimmune disease marked by symmetrical chronic polyarticular inflammation, which may increase the risk of disability in severe cases. Jiawei Xuanbi Decoction (JWXB),...
METTL14-induced N6-methyladenosine modification on TPX2 mRNA inhibits tumor progression in clear cell renal cell carcinoma
August 2025
Clear cell renal cell carcinoma (ccRCC) accounts for 70 % of all renal cell carcinoma (RCC) types, and 30 % of patients with ccRCC present with metastasis at the time of initial diagnosis. Given the...
Revealing the neuroprotective mechanism of irisin on stroke based on network pharmacology, molecular docking and experimental validation
August 2025
Irisin has been confirmed to play a neuroprotective effect in stroke. However, the mechanism of irisin in treating stroke remains unclear....
Investigating the mechanism of curcumin against LUAD malignant progression and macrophage M2 polarization based on network pharmacology, bioinformatics, and molecular docking
August 2025
Lung adenocarcinoma (LUAD) is a subtype of non-small cell lung cancer (NSCLC) that poses significant mortality risks. Curcumin, a natural polyphenolic compound with documented anti-inflammatory and...
Formulation and optimization of Kaempferol nanoemulsion-based gel for treating skin erythema using Box-Behnken statistical design
August 2025
The objective of this study is to develop and characterize Kaempferol (KMF)-loaded nanoemulsion-based gel formulations for the treatment of skin erythema. A Box-Behnken design was utilized to optimize...
Loxoprofen relieves osteoarthritis development via repressing PI3K-AKT/NF-κB signaling pathways
August 2025
Loxoprofen, a cyclooxygenase (COX) inhibitor, has been utilized in the management of osteoarthritis (OA). However, the underlying mechanisms of loxoprofen regulating OA process remain unknown....
Exploring the molecular mechanism of Qilian Fuzheng capsule for treatment of non-small cell lung cancer using network pharmacology, RNA-seq, molecular docking and experimental verification
August 2025
Qilian Fuzheng capsule (QL) has been used for the treatment of various malignant tumors, but the underlying mechanisms are largely unclear. In this study, we aimed to explore the effects and potential...
The effect of serotonergic receptors (5HT3) on seizure threshold and mitochondrial damage induced by amitriptyline in the mouse brain
August 2025
Epilepsy is a chronic nervous system disorder in humans, characterized by disturbed brain function and altered levels of consciousness....
From melanocyte loss to targeted therapy: A comprehensive review of vitiligo management
August 2025
Vitiligo is a chronic dermatological condition characterized by the loss of melanocytes, resulting in depigmented patches on the skin. The epidemiology, pathogenesis, existing and developing treatment...