Correspondence on: “Bioinformatics and network pharmacology-based investigation of matrine’s therapeutic roles in breast cancer”
March 2026
This commentary reviews a study by Qu et al. on the potential mechanisms of matrine in breast cancer using bioinformatics and network pharmacology. While commending the systematic approach, the commentary...
Structure-based design of plant-based dual inhibitors targeting AURKA1 and HDAC2 as potential anticancer agents
March 2026
Cancer is a complex metabolic disorder marked by uncontrolled cell proliferation and resistance to conventional therapies, often due to non-selectivity and acquired drug resistance. Aurora kinase A...
Discovery of novel aminomethyl-piperidone derivatives as dipeptidyl peptidase-4 inhibitors
March 2026
DPP-IV inhibitors known as oral antidiabetic drugs manage type 2 diabetes by preventing the breakdown of incretin hormones, which help regulate blood sugar. The current study displayed the effectiveness...
Computational identification of novel DPP-4 inhibitors based on QSAR modeling, molecular docking, and molecular dynamics simulations
March 2026
Dipeptidyl peptidase-4 (DPP-4) inhibitors are important therapeutic agents for type 2 diabetes mellitus, and their efficacy depends on effective inhibition of DPP-4 enzymatic activity....
The evolving role of novel anesthetic agents for obstetric and gynecological anesthesia: The multidimensional value from esketamine to dexmedetomidine
March 2026
Obstetric and gynecological anesthesia requires a delicate balance between maternal safety and fetal/neonatal health. Traditional anesthetic methods have limitations in analgesic efficacy, physiological...
Spray on science: Revolutionizing topical drug delivery with film-forming systems
March 2026
Film-forming sprays (FFS) have emerged as advanced topical and transdermal drug delivery systems offering improved drug retention, enhanced bioavailability, and better patient compliance compared to...
Human microbiome-driven antimicrobial resistance: Biological mechanisms, pharmacological considerations and next-generation therapeutic prospects
March 2026
Antimicrobial resistance (AMR) remains a serious global health challenge, threatening the effectiveness of existing antimicrobial therapies. Although resistance has traditionally been linked to antibiotic...
Geometric structure and electronic properties of phloroglucinol and its isomers
March 2026
As an important bioactive molecule, phloroglucinol (1,3,5-trihydroxybenzene) demands a precise understanding of its structural and electronic properties. In this work, a systematic study of phloroglucinol...
USP13 stabilizes EPHA2 to promote M2 macrophage polarization and cervical cancer progression
March 2026
Cervical cancer (CC) is one of the most common malignant tumors among women. M2 macrophages can participate in the regulation of cancer progression. Ubiquitin-specific protease 13 (USP13) and ephrin...
Applications of nanoparticle drug delivery systems in breast cancer treatment: Targeting, enhanced efficacy with reduced toxicity, and overcoming drug resistance
March 2026
Breast cancer is the most common malignancy among women worldwide, and its high heterogeneity, propensity for metastasis, and susceptibility to drug resistance remain major clinical challenges. Traditional...
Monoterpene-rich essential oils as natural NRF2 activators: Chemistry, mechanism and antioxidant effects
March 2026
Currently, monoterpene-rich essential oils (MREOs), natural products from aromatic plants, have emerged as potent modulators of redox-sensitive signaling pathways, especially the nuclear factor erythroid...
Multi-omics integration reveals the candidate molecular regulatory network and pathway of aFGF regulating BMSCs to promote tendon-bone healing
March 2026
Acidic fibroblast growth factor (aFGF) is considered to be a key regulator for bone marrow mesenchymal stem cells (BMSCs), which are critical mediators of the tendon-bone healing process. However, how...
Computational exploration of Pseudomonas aeruginosa OprF Porin: Structural dynamics and mechanisms of antibiotic uptake
March 2026
Pseudomonas aeruginosa is a multidrug-resistant pathogen responsible for severe hospital-acquired infections exhibiting pronounced antibiotic resistance. Outer membrane protein F (OprF), the most abundant...
EGFR-targeted chalcone derivatives: A rational design using integrated 3D-QSAR, docking, and ADMET analysis
March 2026
Chalcone derivatives exhibit diverse biological activities, including anticancer effects, while Epidermal Growth Factor Receptor (EGFR) is a key therapeutic target requiring novel inhibitors with improved...
Organoid models in lung cancer research: A multidimensional perspective from basic biology to precision medicine
March 2026
Lung cancer ranks among the most common and deadly malignancies worldwide. Its treatment and research face major obstacles due to tumor heterogeneity and the challenges of personalized therapy. Patient-derived...
Multitarget mechanism of berberine against cervical cancer: An integrated study of network pharmacology and molecular docking
February 2026
To investigate the potential targets and molecular mechanisms of berberine in the treatment of cervical cancer via an integrated network pharmacology and molecular docking approach, providing a theoretical...
Network pharmacology and machine learning-driven virtual screening with dynamic simulations of natural compounds for glioblastoma
February 2026
Glioma progression is driven by dysregulated signaling networks, including CDK4-Cyclin D3, PI3K-Akt, and EGFR pathways....
Advances in stem cell therapy, nanomedicine, multi-omics, and artificial intelligence–assisted strategies for the treatment of lung injury and pulmonary fibrosis
February 2026
Lung injury (LI) and pulmonary fibrosis (PF) are major causes of chronic respiratory failure, characterized by alveolar epithelial damage, persistent inflammation, and excessive extracellular matrix...
Bioinformatics and network pharmacology-based investigation of matrine’s therapeutic roles in breast cancer
February 2026
Breast cancer (BC) stands out as a leading malignancy in female populations, exhibiting a gradual global increase in cases. Matrine (MAT), a bioactive alkaloid derived from traditional Chinese medicine...
Benzimidazole derivatives as kinase inhibitors: Synthetic strategies, and therapeutic prospects in cancer
February 2026
The benzimidazole framework is an important heterocyclic pharmacophore in medicinal chemistry, particularly recognised for its structural bioisosterism with purine nucleotides. This resemblance enables...
Exploring MD-LOVIs, DIVATI and DRAGON descriptors for thermolysin inhibition modeling
February 2026
Currently, thousands of molecular descriptors and various software for their calculation have been defined. However, their utility is often associated with the biological problem being modeled....
Camptothecin inhibits HCC progression via modulating MMP9 expression
February 2026
Hepatocellular carcinoma (HCC) is the most common primary malignant liver cancer and a leading cause of cancer-related deaths worldwide. Camptothecin (CPT), a cytotoxic alkaloid, inhibits cancer cell...
Development and evaluation of rectal suppository formulation for antidiabetic activity of repaglinide: A comparative study
February 2026
Diabetes mellitus is a group of metabolic diseases mainly characterized by chronic hyperglycemia. The oral immediate release tablet formulation of Repaglinide (REP) is associated with the sudden hypoglycemia...
Network pharmacology combined with pharmacology to explore the mechanism of Zengye Runzao Decoction in treating Sjögren's Syndrome
February 2026
Sjögren's syndrome is a systemic autoimmune disease characterized by lymphocyte infiltration and dysfunction of exocrine glands, which imposes a huge burden on the healthcare system and socio-economic...
GelMA@DFO hydrogel promotes bone regeneration via HIF-1α-mediated angiogenesis
February 2026
Gelatin methacryloyl (GelMA) hydrogel is a biomaterial used for osteogenesis, supporting bone repair and angiogenesis. Deferoxamine (DFO), an Fe3 + -chelating hypoxia-mimetic agent, activates hypoxia-inducible...
