TRPV receptors in pain research: Bridging molecular mechanisms to clinical treatments
Available online 24 July 2025
The cation channels known as transient receptor potential vanilloid (TRPV) are shown in various groups of tissues, such as the heart, lung, and brain, and in both excitable and non-excitable cells....
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Garcinol: An emerging epigenetic modifier with versatile anticancer properties
Available online 21 July 2025
Garcinol, a phenolic compound found in the fruit rind of the Garcinia plant has gained significant attention for its diverse bioactivities viz. antibacterial, anti-inflammatory, anti-oxidant, and neuroprotective...
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Imperatorin remits malignant progression of endometrial cancer by silencing E2F1/SLC3A2
Available online 16 July 2025
Endometrial cancer (EC) remains the most common gynecologic malignancy. Imperatorin (IMP), a bioactive natural furanocoumarin derivative, has demonstrated diverse pharmacological properties with particular...
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Formulation, antimicrobial, and antioxidant effect of anti-acne serum containing extracts of striata scrophularia and rosemary plants
Available online 8 July 2025
Infectious diseases like acne, caused by bacteria and fungi, are prevalent worldwide. The rise of antibiotic-resistant bacteria has prompted the search for natural alternatives....
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Susceptibility testing of Escherichia coli and Salmonella enterica to plant essential oils and commercial antibiotics
Available online 8 July 2025
Antimicrobial resistance (AMR) is a global emergency linked to the indiscriminate use of drugs and can be transmitted through food, posing risks to human health. This study aimed to evaluate the antimicrobial...
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Network pharmacology, molecular docking, and experimental validation to explore dihydromyricetin attenuates LPS-induced acute lung injury by promoting FGFR1
Available online 7 July 2025
Acute lung injury (ALI) is a serious clinical condition characterized by severe lung inflammation, and its pathogenesis is complex. Dihydromyricetin (DHM), a bioactive flavonoid component isolated from...
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Fosinopril ameliorates renal injury in diabetic nephropathy by inactivating the SRC/NF-κB pathway
Available online 18 June 2025
Diabetic nephropathy (DN) is a serious complication of diabetes, characterized by renal tissue injury. Fosinopril, an ACE inhibitor, has been shown to have renoprotective effects in DN, but the underlying...
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Exploration of the potential molecular mechanism of magnolol in colorectal cancer treatment based on network pharmacology and molecular docking
Available online 18 June 2025
Colorectal cancer (CRC) has experienced a global rise in incidence, with chemotherapy resistance becoming a significant challenge during clinical treatment. Magnolol, a natural compound derived from...
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The inhibitory effects of Cucurbitacin B on hypopharyngeal cancer cell malignant behaviors were investigated based on network pharmacology and molecular docking
Available online 17 June 2025
Hypopharyngeal cancer is a metastatic squamous cell carcinoma of the head and neck (SCCHN), and the early symptoms are not obvious. Cucurbitacin B (Cu-B) is the most abundant member of the Cucurbitacin...
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In silico and in vitro investigation of anticancer effect of novel anthraquinone compound on MDA-MB-231 cells
Available online 6 June 2025
The serious adverse effects of chemotherapeutics forced to produce new bioactive substances such as anthraquinone derivatives....
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Novel antimalarial 2-substituted quinoline thiosemicarbazone derivatives: Rational designing, molecular docking studies, ADME-tox properties, synthesis & in vitro activity
Available online 4 June 2025
Malaria remains a dangerous threat to nearly half of the world’s population, with the potential to be life-threatening. The most effective treatment currently available for uncomplicated and severe...
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Study on the effect of molecular regulation on oxaliplatin resistance and macrophage polarization in esophageal squamous cell carcinoma based on the multiomics bioinformatic analysis and experimental verification
Available online 2 June 2025
Oxaliplatin (OHP) resistance remains a major therapeutic challenge in esophageal squamous cell carcinoma (ESCC). While Wnt1 inducible signaling pathway protein 1 (WISP1) has been implicated in tumor...
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Computational and biological perspective of phytoconstituents and their synthetic derivatives in antidiabetic therapy
Available online 2 June 2025
The global rise in diabetes has intensified the search for safer, multi-target therapeutic options. Plant-based phytoconstituents and their synthetic derivatives are drawing attention for their promising...
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Advancements in minimally invasive transdermal drug delivery systems
April 2025
Minimally invasive drug delivery systems (MIDDS) have revolutionized pharmacological therapies by offering substitute techniques that improve therapeutic accuracy and efficacy while reducing pain, discomfort,...
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The mechanisms of Mahuang decoction in treating COPD: Insights from network pharmacology and in vivo studies
April 2025
Chronic obstructive pulmonary disease (COPD) is a major cause of significant mortality worldwide. Mahuang decoction (MHD), a classic traditional Chinese medicine, has demonstrated encouraging therapeutic...
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Development and evaluation of optimized molecularly imprinted polymer (MIP) for targeted drug delivery of 5-Fluorouracil
April 2025
Our research described in this paper focuses on the development and evaluation of molecularly imprinted polymer (MIP) for targeted drug delivery of 5-Fluorouracil (5-FU)....
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Curcumin-pyrazole a molecular hybrids as potential androgen receptor inhibitors for prostate cancer treatment through molecular docking, ADMET and cytotoxicity prediction, pharmacophore modeling, MDS, and DFT approaches
April 2025
Prostate cancer is a significant cause of cancer-related mortality in men globally. The androgen receptor is a crucial target for drug development. This study investigates curcumin-pyrazole hybrids,...
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Pharmacokinetic, synthesis and biological properties of rottlerin: Anticancer mechanism insights.
April 2025
Rottlerin is a natural plant polyphenol derived from the fruit of Mallotus philippensis and is widely recognized as a selective inhibitor of PKCδ. It has attracted significant attention due to its broad...
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Network pharmacology and molecular docking to explore the potential mechanism of Congerjingming Decoction against sensorineural hearing loss
April 2025
Established formulations of traditional Chinese medicine (TCM) have shown efficacy in the management of age-related sensorineural hearing loss (SNHL). In this study, we developed a novel TCM, Congerjingming...
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Cordycepin inhibits cell proliferation, metastasis and aerobic glycolysis of gallbladder cancer by inactivating TOP2A-related pathway
April 2025
Traditional Chinese Medicines have been reported to exert anti-tumor effects and provide novel therapeutic clues for cancer therapy. The present study aims to explore the regulatory mechanism and functions...
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Synthesis, computational studies of new thymol derived chalcones and their benzotriazoles as antimicrobial agents
March 2025
The ineffectiveness of antimicrobial agents, efforts have been made to synthesize new thymol derived chalcones to treat microbial infections effectively....
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AI-driven in silico discovery, design, and evaluation of novel antiviral candidates targeting Marburg virus nucleoprotein for advanced therapeutic development
March 2025
Marburg virus disease (MVD) is a highly virulent hemorrhagic fever caused by the Marburg virus (MARV), with case fatality rates reaching up to 90 %. Currently, no FDA-approved antiviral drugs exist...
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Epigallocatechin gallate impels osteogenic differentiation of human BMSCs by targeting the METTL3/SATB2/Wnt/β-catenin axis
March 2025
Bone marrow mesenchymal stem cells (BMSCs) are pluripotent cells, and its osteogenic differentiation disorder can lead to osteoporosis and seriously affect the quality of life. Epigallocatechin gallate...
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An update on the role of inflammation in insulin resistance and islet β cell failure- A crosstalk between immune cells, adipose tissue, cytokines, and oxidative stress
March 2025
One of the characteristics of type 2 diabetes mellitus (T2DM) is the growing malfunctioning of β-cells and the presence of insulin resistance. The recent literature on this aspect is reviewed in this...
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