Association of fish oil supplement use with long-term clinical outcomes in metabolic dysfunction-associated steatotic liver disease: A prospective cohort study
December 2026
Evidence on the association between fish oil supplement use and long-term outcomes in metabolic dysfunction-associated steatotic liver disease (MASLD) remains limited. We examined the associations of...
Precision nutrition and metabolic health: Integrating multi-omics for individualized prevention
December 2026
Metabolic diseases affect more than one billion people worldwide, yet population-level dietary recommendations often fail to account for marked inter-individual variation in metabolic responses. This...
Urinary biomarkers of artificial sweeteners and incident type 2 diabetes: a prospective cohort study among Chinese middle-aged and elderly adults
Available online 4 November 2026
To investigate prospective associations of urinary artificial sweeteners (ASs) with incident type 2 diabetes (T2D) and continuous glucose monitoring (CGM)-derived metrics in middle-aged and elderly...
Gut microbial metabolic pathways in tumor progression and treatment response: context-dependent mechanisms and therapeutic implications
Available online 3 November 2026
The gut microbiome influences tumor progression and treatment response through metabolic activities that extend beyond changes in microbial composition. The gut microbiota generates bioactive metabolites,...
Single-Cell Transcriptomics in Nutrition and Metabolic Research: Current Approaches and Emerging Applications
Available online 27 October 2026
Single-cell transcriptomics has emerged as a transformative approach for investigating cellular heterogeneity, nutrient-responsive signaling, and metabolic adaptation at unprecedented resolution. Unlike...
Association of triglyceride-glucose index with incident fracture risk and bone mineral density in the UK Biobank
September 2026
This study aims to investigate the association between the triglyceride-glucose (TyG) index and incident fracture risk, as well as bone mineral density (BMD), in a large prospective cohort from the...
Inhibition of glycogen synthase 1 ameliorates imiquimod-induced psoriasis by suppressing JAK2-STAT3 signaling
September 2026
Psoriasis is a chronic inflammatory skin disorder characterized by epidermal hyperplasia, immune cell infiltration, and aberrant keratinocyte proliferation, with the Janus kinase 2/signal transducer...
Circular RNAs in metabolic liver diseases: Biomarkers, mechanisms, and therapeutic perspectives
September 2026
Metabolic liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), alcohol-associated liver disease (ALD),...
lncMpla mediates hyperhomocysteinemia-associated atherosclerosis by regulating alternative splicing of Ptk2b in macrophage polarization
September 2026
Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis (As), but the molecular mechanisms by which elevated homocysteine (Hcy) drives macrophage inflammatory reprogramming remain...
Glucagon-like peptide-1 regulates lipid metabolism through actions in the gut and liver
September 2026
The two incretins, known as glucagon-like peptide-1 (GLP-1) and glucose‑dependent insulinotropic polypeptide (GIP), were initially identified for their function in enhancing glucose-dependent insulin...
Identification of metabolomics biomarkers of coenzyme Q10 in the improvement of dyslipidemia using serum non-targeted and targeted metabolomics
September 2026
To identify metabolomic biomarkers underlying the lipid-lowering effects of coenzyme Q10 (CoQ10) in individuals with dyslipidemia....
GLP-1 medicine and non-arteritic anterior ischemic optic neuropathy: Literature review and perspectives
June 2026
GLP-1 therapeutics (defined as GLP-1 medicine hereafter), including GLP-1 receptor (GLP-1R) agonists (i.e. semaglutide) and glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor dual agonist...
Integrating multi-omics and digital phenotyping for precision care in gestational diabetes
June 2026
Gestational diabetes mellitus (GDM) is a prevalent and heterogeneous pregnancy complication that elevates cardiometabolic risk for both mother and child. Conventional diagnostic and treatment approaches...
Phytochemicals alter foam cell formation and macrophage cholesterol efflux
June 2026
The accumulation of cholesterol within arterial macrophages, resulting from disrupted processes of cholesterol uptake, esterification, and efflux, is a critical factor in foam cell formation and the...
24-epibrassinolide drives female germline stem cell development via NMT1-mediated in situ interaction between Gm26624 and Abcg2
June 2026
Recent studies indicate that approximately 15% of couples worldwide are affected by infertility. The discovery of female germline stem cells (FGSCs) offers a promising new therapeutic strategy for infertility...
Ketone bodies in metabolism and signaling: Revisiting the paradigm from biochemistry to pancreatic β-cell regulation
June 2026
Ketone bodies, long viewed through the lens of the ketotoxic paradigm, are now being recognized as multifaceted molecules with roles extending far beyond energy substrates. The biochemistry of ketogenesis...
Circulating folate forms and diabetic comorbidities: US National health and nutrition examination survey, 2011–2018
June 2026
To investigate the associations between circulating folate forms and the prevalence of diabetic comorbidities among U.S. adults....