Model organisms research: The foundation for understanding, regulating, and engineering life
July 2026
Model organisms refer to a class of non-human experimental systems that have been widely adopted across the life sciences to uncover fundamental principles of biology [1]. Their defining strengths,...
Recent research progress of plant-derived chlorogenic acid in cancer therapy: Anticancer mechanism and combination therapy
July 2026
Chlorogenic acid (CGA), a natural hydroxycinnamic phenolic acid, is widely found in coffee, Eucommia ulmoides leaves and potatoes. Numerous studies have highlighted that CGA exhibits diverse bioactivities,...
Phytochrome B and CIPK31 coordinate VOZ2-dependent gibberellic acid signaling in rice
July 2026
Light and calcium signaling regulate gibberellic acid (GA) signaling in plants; however, how these signals are coordinated remains unknown. Here, we identified that phyB mutants exhibit dramatic semi-dwarfism,...
Foliar ZnO NPs trigger transcriptional rewiring of starch and hormone pathways to break the yield-quality trade-off in direct-seeded rice
July 2026
Direct-seeded rice (DSR) faces a persistent trade-off between grain yield and cooking quality. Conventional zinc fertilization often fails to overcome this limitation due to inefficient translocation...
Neuroinflammation-targeted natural products for the therapy of Alzheimer’s disease
July 2026
Alzheimer’s disease (AD) is increasingly recognized as a multifactorial disorder characterized by a self-reinforcing pathological network, which involves the interplay of amyloid-beta (Aβ) deposition,...
Postnatal deletion of ZIP9 leads to premature mortality and hippocampal-dependent cognitive decline with disrupted brain–gut–lipid homeostasis
July 2026
Androgen decline during aging contributes to cognitive impairment; androgen supplementation can improve these conditions. The zinc transporter ZIP9 has been identified as a membrane androgen receptor;...