Evidence-based pharmacological investigation of the clinical practice and rational use of metformin in prediabetes mellitus
June 2025
Prediabetes is a condition where blood glucose levels have deviated from the normal range but have not yet reached the diagnostic criteria for diabetes. It represents a transitional phase between health...
Advances and challenges in personalized diagnosis and therapies for the management of recurrent glioblastoma
September 2025
Recurrent glioblastoma (rGBM) remains one of the most formidable challenges in neuro-oncology due to its aggressive evolution, treatment resistance, and profound intratumoral heterogeneity. Despite...
Efficacy and safety of semaglutide in patients with heart failure: A meta-analysis
December 2025
The pleiotropic effects of semaglutide make it a breakthrough therapy for managing diabetes and obesity, particularly in patients with comorbid cardiovascular diseases. However, its clinical application...
A comprehensive evaluation of ALK inhibitors in the first-line treatment of patients with ALK-positive non-small cell lung cancer
March 2025
There are currently six ALK inhibitors available for the first-line treatment of patients diagnosed with ALK-positive advanced non-small cell lung cancer (NSCLC). However, clinicians face challenges...
Molecular aspects of metformin’s anti-aging properties for muscle function and longevity in Drosophila melanogaster
December 2025
Muscle aging, characterized by the progressive loss of muscle mass and function, presents a significant clinical challenge, contributing to sarcopenia and age-related frailty. Recent research highlights...
Unlocking precision medicine: Innovative strategies for druggable target identification and therapeutic enhancement
November 2024
Precision medication emphasizes tailored treatment approaches based on individual patient characteristics, yet the limitations in current drug target identification hinder therapeutic advancements....
Towards precision medicine: Leading with big data and multidisciplinary collaboration
November 2024
Precision medicine relies on individuals’ genetic information, omics characteristics, and environmental factors to achieve personalized disease prevention, diagnosis, and treatment. With the successful...
A micro review on the role of recently emerged Artificial Intelligence (AI) tools and algorithms in microbiome-gut-brain-axis associated disease therapy via psychobiotics
September 2025
The microbiome-gut-brain axis involves the bidirectional connection between the gastrointestinal tract, gut microbiome, and central nervous system, and it is pivotal for mental well-being. Imbalances...
Evaluation of the efficacy, safety and economy of different amphotericin B formulations in invasive fungal disease: A retrospective cohort study
September 2025
Fungal infections have emerged as an increasingly serious public health challenge globally. Four Formulations of amphotericin B are widely used in antifungal therapy. Despite the same active ingredient,...
Biologic therapy for immune-mediated inflammatory diseases during pregnancy and lactation: Efficacy, safety, and challenges
June 2025
Immune-mediated inflammatory diseases (IMIDs) commonly affect women of reproductive age, and concerns regarding the impact of therapeutic drugs on pregnancy outcomes, fetal development, and infant health...
Multi-omics mendelian randomization identifies ferroptosis-related genetic variants linked to NAFLD risk
December 2025
Ferroptosis, an iron-dependent cell death, contributes to non-alcoholic fatty liver disease (NAFLD), but causal genes remain unclear. This study identifies ferroptosis-related genes driving NAFLD to...
Surgical pharmacy for catalyzing pharmacy service throughout surgical continuum
November 2024
The greater the complementarity between pharmacists’ knowledge and doctors’ knowledge, the more significant the role pharmacists can play in clinical practice. Physicians extensively use drugs for disease...
Therapeutic drug monitoring for promotion of rational medication in the elderly: Overview, challenges and opportunities
November 2024
In the context of rapid development of clinical pharmacy in China, therapeutic drug monitoring (TDM) has become a vital tool for rational medication and is widely concerned. TDM combines the knowledge...
Integrative multi-omics approach for drug repositioning in Alzheimer's disease
September 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an insidious onset, and effective therapeutic agents are urgently needed....
Anti-platelet aggregation effect of Compound Danshen dripping pill: An integrated study of meta-analysis, network pharmacology, and in vivo and vitro experiments
December 2025
Compound Danshen Dripping Pill (CDDP) is a marketed Chinese patent medicine, primarily efficacious in “promoting blood circulation to remove blood stasis, regulating Qi to relieve pain”. CDDP, as an...
Simultaneous determination of concentration of sulfamethoxazole and trimethoprim in human plasma by dual-quaternary HPLC and its clinical application
December 2024
Sulfamethoxazole compound, a combination of sulfamethoxazole and trimethoprim, is commonly prescribed to organ transplant recipients for infections caused by Nocardia, Burkholderia cepacia, and Pneumocystis...
Adverse drug event signal detection and risk factor analysis of blinatumomab in ten years of post-marketing use
December 2025
To analyze factors influencing the safety of blinatumomab based on real-world adverse drug event (ADE) reports collected from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS)...
Precision individualized medication strategies and challenges for cardiovascular diseases
November 2024
With the ongoing societal development and changes in lifestyle, the incidence of cardiovascular diseases continues to rise. Although the most effective means of preventing atherosclerotic cardiovascular...
Application status of traditional computational methods and machine learning in cancer drug repositioning
December 2024
The escalating global burden of cancer has spurred extensive research and development efforts aimed at discovering effective anti-cancer agents. However, the prohibitively high costs associated with...
Quality evaluation of the guidelines for vericiguat treatment of heart failure with reduced ejection fraction
June 2025
Heart failure (HF) bears a heavy disease burden, and vericiguat is the only guanylate cyclase stimulator proved to improve its prognosis. However, its clinical use needs a further improvement....
A bibliometric analysis of mechanisms and linkage studies on neurological disorders and statins over the past 20 years
September 2025
Neurological disorders are one of the major contributors to the burden of disease, affecting the quality of life of the global population.Statins, known for their cholesterol-lowering properties, have...
Establishment and evaluation of a risk prediction model for venlafaxine plasma concentration exceeding alert levels
March 2025
To investigate the factors influencing venlafaxine blood concentration exceeding the alert threshold in patients with depression and to develop a risk prediction model for elevated venlafaxine concentrations,...
Predictive potential of five genes of cuproptosis for survival in LGG
December 2025
Low-grade glioma (LGG) is a common primary tumor in the central nervous system. The function of several types of cell death has been proved in tumorigenesis of low-grade glioma (LGG). Cuproptosis, a...
Current status and prospects of nucleic acid mass spectrometry in clinical pharmacogenomics
November 2024
Pharmacogenomics is an essential means to achieve personalized medicine. Multi-gene and multi-loci panel testing is an inevitable trend in its development, comprehensively analyzing the impact of genes...
Study on administration timing and combination therapy of NSAIDs for preventing post-ERCP pancreatitis
March 2025
To determine the optimal timing, dosage, and efficacy of combination NSAID therapy in preventing post-ERCP pancreatitis....