Beyond the tooth: Cross-talk between oral and gut/brain organoids
January 2026
•Oral organoids are reframed as hubs along the oral-gut-brain axis.•Engineered biomaterials support long-term oral organoid culture.•AI tools enhance analysis and translation of oral organoids....
Compression training enhanced tough hydrogel as Ca-P reservoir for tooth extraction socket
January 2026
To develop a customized hydrogel scaffold that unifies toughness and calcium-phosphorus (Ca-P) ion reservoir through compression training for the tooth extraction socket, and to evaluate its efficacy...
Bioinformatics and AI in dental biomaterials: Applications in drug delivery for tissue engineering
January 2026
Dental biomaterials play a vital role in restorative dentistry and tissue regeneration, but their design and clinical translation remain challenging due to complex material–tissue interactions, patient-specific...
Harnessing plasma for peri-implantitis: Technical and clinical insights into its application on dental implants and abutments
January 2026
Dental implants have become an increasingly popular solution for the replacement of missing teeth in partially or fully edentulous patients. However, one of the most common causes of implant failure...
A digital translational framework for biomaterials validation: From evidence- to model-based dentistry
January 2026
Traditional evidence-based workflows, progressing sequentially from laboratory testing to animal studies and clinical trials, have ensured safety and standardization but remain slow, costly, and only...
Platelet-rich plasma driven quiescence–activation reprogramming primes dental pulp stem cells for translational bone regeneration
Available online 28 January 2026
Dental pulp stem cells (DPSCs) are multipotent cells widely used in tissue repair and regeneration, making effective preconditioning strategies essential to maximize their therapeutic potential. Here,...
The Neonatal Line in Primary Teeth: A Systematic Review and Meta-analysis of Its Forensic, Clinical, Anthropological, and Archaeological Applications
Available online 28 January 2026
The neonatal line (NNL) is an accentuated histological feature of dental enamel formed around the time of birth. It provides a permanent marker of parturition and has been linked to maternal, perinatal,...
Inhibition of hyaluronic acid synthesis alleviates periodontitis through relieving periodontal inflammatory microenvironment
Available online 28 January 2026
Hyaluronic acid (HA) is one of the major components of the extracellular matrix (ECM), and hyaluronic acid synthase 2 (HAS2) is a key enzyme regulating its production. It has been reported that HA and...
Perspective Opportunities and challenges in translating dental materials into clinical practice
Available online 21 November 2025
The clinical translation of dental materials presents significant opportunities, driven by increasing market demand, supportive regulatory frameworks, and advancements in digital and additive manufacturing...
Accuracy of rest seat prepared by rigid constraint template for removable partial denture: An in vitro study
October 2025
To establish a design and fabrication method for a rigid constraint guiding template for preparing rest seats for removable partial dentures (RPDs) and to verify the feasibility and accuracy of template-guided...
Opportunities and challenges in wearable ultrasound for oral health
October 2025
•Oral health.•Wearable ultrasound.•Continuous monitoring....
Antimicrobial peptides in oral medicine: From mechanisms to clinical translation
October 2025
Oral diseases pose significant threats to global public health, while conventional antibiotic therapies face increasing challenges from bacterial resistance. Antimicrobial peptides (AMPs) have emerged...
A digital cone beam computed tomography scan-based approach to transfer the preoperative maxillomandibular relation for immediate complete-arch interim restoration fabrication
October 2025
Achieving an accurate and stable maxillomandibular relation registration immediately following complete-arch implant placement surgery for interim restoration fabrication remains a significant clinical...
Ethical issues and coping strategies for artificial intelligence in medical research
October 2025
With the rapid development of artificial intelligence (AI) technologies, their applications in medical research have become increasingly widespread. However, the extensive use of AI has also raised...
Quantum dot-engineered extracellular vesicles derived from human exfoliated deciduous teeth stem cells for the dynamic monitoring and synergistic therapy of ischemic stroke
October 2025
Ischemic stroke, marked by oxidative stress and neuroinflammation in the long-term injury process after reperfusion, remains a leading global cause of disability and mortality, urging the need for innovative...
Clinical evaluation of 3D-printed templates for accurate and safe mini-screw implantation
October 2025
To develop mini-screw templates using three-dimensional (3D) printing technology to prevent root damage during implantation, and to evaluate the accuracy and safety of the implantation process....
Oral and maxillofacial surgery in the digital age: Current practice and perspective
October 2025
•Systematically reviewing the development and application of digital technology in Oral and maxillofacial surgery.•Timely and informative.•Prospecting development and limitation of digital technology...
Wearable technologies for dental medicine: From flexible sensors to the metaverse
July 2025
•Revisits wearable mechanical and chemical sensors in stomatology.•Presents advancements in flexible electronics in dental care.•Discusses the metaverse's potential in translational dental research...
Emerging roles of apoptotic bodies in immune homeostasis and oral disease therapeutics
July 2025
Oral diseases represent a global health challenge, affecting billions worldwide and imposing substantial health and economic burdens while significantly compromising the quality of life for those affected....
Senescence and oral cancer: From mechanisms to therapeutic opportunities
July 2025
Cellular senescence, characterized by stable cell cycle arrest, plays a multifaceted role in the development of oral cancer, attracting growing attention for its influence on cancer progression and...
SHED aggregate derived exosomes-shuttled miR-222 promotes the angiogenic properties of periodontal ligament stem cells and enhances periodontal regeneration
July 2025
Periodontal ligament stem cells (PDLSCs) aggregate is still limited in clinical application due to a lack of angiogenesis. This study aimed to investigate the effects and underlying mechanism of exosomes...
Artificial intelligence unlocks the future of oral organoid research
July 2025
Oral organoids, emerging as a powerful method for modeling oral development and diseases, show potential in fundamental research and clinical applications. However, their translational application in...
Fabrication of nano-structured biphasic calcium phosphate bioceramics to promote bone regeneration
July 2025
In recent years, inorganic non-metallic bone graft materials have attracted growing attention in bone defect repair. Among these, biphasic calcium phosphate (BCP) bioceramics, consisting of hydroxyapatite...
Modeling the laser irradiation induced carbonate loss in dental enamel for dental caries prevention
July 2025
The substitution of carbonate ions with phosphate ions in dental enamel results in an acid-soluble mineral. Laser irradiation-induced carbonate loss in enamel has been correlated with a reduction in...