Genetic and familial high-risk assessment in cervical cancer
June 2026
Cervical cancer remains a major public health concern worldwide, despite the well-established causal role of high-risk human papillomavirus (HPV) infection in its pathogenesis. HPV infection is necessary...
Functionalized carbon dots: A novel strategy for healing of diabetic wounds
December 2026
The latest data released by the International Diabetes Federation indicates that there are currently 589 million people aged 20‐79 living with diabetes worldwide. Diabetic wounds are one of the most...
GALNTs in cancer: Driving tumor progression and opening a new therapeutic frontier
June 2026
The human GALNT family consists of 20 isoenzymes that initiate mucin-type O-glycosylation. These enzymes catalyze the transfer of N-acetylgalactosamine to serine or threonine residues on protein substrates....
From signal amplification to inflammatory resolution: The NF-κB-inflammasome-SPM axis as an integrated regulatory network
September 2026
Inflammation is a fundamental biological process essential for host defense, tissue repair and maintenance of homeostasis. However, dysregulated inflammatory responses contribute to the pathogenesis...
New insights into microbiome metabolic mechanisms for pancreatic cancer therapy
September 2026
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with a dismal 5-year survival rate, largely due to pervasive chemoresistance. Emerging evidence suggests that microbiome-metabolism...
Role of gut microbiota in regulating host cell metabolism in digestive system diseases
September 2026
The impact of gut microbiota on disease pathogenesis and progression is receiving increasing attention, particularly in the field of digestive system disorders. Previous reviews have predominantly focused...
Sepsis-induced PICS: Immunometabolic mechanisms, emerging biomarkers, and precision management
June 2026
Sepsis, a life-threatening organ dysfunction caused by infection, casts a lingering shadow over its survivors. Many develop persistent inflammation, immunosuppression, and catabolism syndrome (PICS),...
Gut microbiota as master regulators: Mapping gut-organ axes that orchestrate systemic health
December 2026
The intestine engages in communication with various distant organs through neural, immune, and endocrine pathways. This systemic interconnection mechanism is referred to as the gut-organ axis, in which...
In situ-forming turkish galls polyphenol/CMCS hydrogel powder for the treatment of radiation-induced oral mucositis
June 2026
Radiation-induced oral mucositis (RIOM) is a debilitating complication in head and neck cancer patients undergoing radiotherapy. The severe ulcerative lesions often necessitate treatment interruptions,...
Potential and recent advances of stem cell exosomes in the repair of lung injury
September 2026
The repair of lung injury is one of the challenges faced by physicians. Exosomes are nano-sized vesicles that can assist in mediating intercellular communication. Their applications in cell-to-cell...
Unlocking new horizons in immunity: The roles and mechanisms of immune checkpoints in inflammation regulation
September 2026
Immune checkpoints (ICs) are receptors that regulate immune responses through both activating and inhibitory mechanisms. Key pathways, including programmed death 1, cytotoxic T-lymphocyte antigen 4,...
The promise and potential of liver organoids: Development, classification and application
June 2026
Liver diseases are a leading cause of mortality worldwide. While liver transplantation remains the gold standard for end-stage liver disease, its application is severely constrained by donor shortages,...
Tailoring nanomaterials for cancer therapy: A comprehensive insight into theranostics and limitations
December 2026
Nanotheranostics has emerged as a promising approach in cancer therapy. It enables the diagnosis of cancer cells and targeted drug delivery on a single platform. Due to their small size, unique surface...
Single-cell encapsulation of Agathobacter rectalis in Aloe vera gel alleviates DSS-induced colitis by remodeling the gut microbiota-metabolite axis
June 2026
Gut microbiota dysbiosis and metabolic disturbances are implicated in inflammatory bowel disease (IBD). Current probiotic therapies are limited by poor bioavailability and inadequate colonic colonization....
Cianidanol suppresses M1 macrophage polarization via JAK2/STAT1 to ameliorate DNCB-induced atopic dermatitis
December 2026
Cianidanol (Cian), also known as (+)-catechin, is a naturally occurring flavonoid found in medicinal plants including Camellia sinensis and Violae herba. Its role in inflammatory skin disease has not...
Necroptosis-driven immunoregulatory vicious cycle in periodontitis: Mechanisms and therapeutic insights
September 2026
Recent advances in cell death research have highlighted necroptosis, a form of regulated cell death crucial for tissue development and homeostasis. Periodontitis, affecting over one billion people globally,...
The gut-organ axis: A 25-year bibliometric analysis of 10327 publications on global research landscape and future directions
December 2026
The gut interacts with multiple organs through neural, immune, and endocrine pathways, a relationship termed the gut-organ axis. Gut microbes play a key role in this axis. This review systematically...
Engineering energy metabolism boosts therapeutic protein production via the E. coli hemolysin A system
September 2026
Escherichia coli currently serves as a widely tool for therapeutic proteins production, however, the high accumulation of heterologous proteins in the cytoplasm poses a risk of degradation by proteases...
Nanocarrier-induced inflammation: mechanisms, immunometabolic impacts and strategies for safer design
June 2026
Nanocarriers have emerged as indispensable platforms for drug delivery, molecular imaging and precision diagnostics. Their rapidly expanding global application has intensified concerns regarding inflammation-driven...
Molecular basis of graphene-induced oxidative stress and mitochondrial signaling in target cells: Consequences for therapeutic window and design of redox-responsive payloads
June 2026
Graphene nanomaterials (GNMs) have emerged as a unique class of bioactive interfaces capable of directly modulating cellular redox homeostasis and mitochondrial function through their distinctive physicochemical...
Receptor-guided therapeutic targeting of the inflammation-cancer axis: Molecular mechanisms and emerging drug discovery strategies
December 2026
Chronic inflammation is a key driver of carcinogenesis, promoting tumour initiation, progression, metastasis and therapeutic resistance through receptor-mediated signalling networks. Chemokine receptors,...
An analysis of research on healthy lifestyle and digestive system cancers using bibliometric methods over the last two decades
June 2026
Digestive system cancers remain major contributors to global cancer-related morbidity and mortality, and increasing evidence suggests that modifiable lifestyle factors are closely associated with their...
miR-503 in solid tumors: Context-dependent regulation, strand specificity, and translational implications
Available online 24 August 2026
MicroRNA-503 (miR-503) is encoded within the X-linked MIR503HG locus and the miR-424/503 cluster, where its output is shaped by guide-strand identity, target availability, competing endogenous RNA (ceRNA)...