Genetic and familial high-risk assessment in cervical cancer
June 2026
Cervical cancer remains a major public health concern worldwide, despite the well-established causal role of high-risk human papillomavirus (HPV) infection in its pathogenesis. HPV infection is necessary...
Sepsis-induced PICS: Immunometabolic mechanisms, emerging biomarkers, and precision management
June 2026
Sepsis, a life-threatening organ dysfunction caused by infection, casts a lingering shadow over its survivors. Many develop persistent inflammation, immunosuppression, and catabolism syndrome (PICS),...
Nanocarrier-induced inflammation: mechanisms, immunometabolic impacts and strategies for safer design
June 2026
Nanocarriers have emerged as indispensable platforms for drug delivery, molecular imaging and precision diagnostics. Their rapidly expanding global application has intensified concerns regarding inflammation-driven...
In situ-forming turkish galls polyphenol/CMCS hydrogel powder for the treatment of radiation-induced oral mucositis
June 2026
Radiation-induced oral mucositis (RIOM) is a debilitating complication in head and neck cancer patients undergoing radiotherapy. The severe ulcerative lesions often necessitate treatment interruptions,...
The promise and potential of liver organoids: Development, classification and application
June 2026
Liver diseases are a leading cause of mortality worldwide. While liver transplantation remains the gold standard for end-stage liver disease, its application is severely constrained by donor shortages,...
Single-cell encapsulation of Agathobacter rectalis in Aloe vera gel alleviates DSS-induced colitis by remodeling the gut microbiota-metabolite axis
June 2026
Gut microbiota dysbiosis and metabolic disturbances are implicated in inflammatory bowel disease (IBD). Current probiotic therapies are limited by poor bioavailability and inadequate colonic colonization....
Engineering energy metabolism boosts therapeutic protein production via the E. coli hemolysin A system
September 2026
Escherichia coli currently serves as a widely tool for therapeutic proteins production, however, the high accumulation of heterologous proteins in the cytoplasm poses a risk of degradation by proteases...
Molecular basis of graphene-induced oxidative stress and mitochondrial signaling in target cells: Consequences for therapeutic window and design of redox-responsive payloads
June 2026
Graphene nanomaterials (GNMs) have emerged as a unique class of bioactive interfaces capable of directly modulating cellular redox homeostasis and mitochondrial function through their distinctive physicochemical...
Circulating cfDNA promoter methylation: An emerging biomarker for early detection of advanced adenoma and colorectal cancer
June 2026
Cell-free DNA (cfDNA) methylation has emerged as a promising avenue for the early detection of various cancers. However, specific biomarkers for advanced adenoma (AA) and colorectal cancer (CRC) are...
GALNTs in cancer: Driving tumor progression and opening a new therapeutic frontier
June 2026
The human GALNT family consists of 20 isoenzymes that initiate mucin-type O-glycosylation. These enzymes catalyze the transfer of N-acetylgalactosamine to serine or threonine residues on protein substrates....
Assessing the accuracy of a handheld real-time fluorescence microscope for rapid intraoperative diagnosis of prostate biopsies
June 2026
Standard hematoxylin and eosin staining for prostate cancer diagnosis is time-consuming, delaying clinical workflows and intraoperative decisions. We evaluated EndoSCell (ES), a handheld real-time fluorescence...
An analysis of research on healthy lifestyle and digestive system cancers using bibliometric methods over the last two decades
June 2026
Digestive system cancers remain major contributors to global cancer-related morbidity and mortality, and increasing evidence suggests that modifiable lifestyle factors are closely associated with their...
Exosome/vancomycin enable targeted therapeutics of liver abscess with enhanced anti-inflammation performance
June 2026
Current clinical management for pyogenic liver abscess primarily relies on broad-spectrum antibiotics, necessitating excessive dosing due to targeting limitations, which would lead to severe drug resistance...
BFAR facilitates gastric cancer progression via SPRR3 activating PI3K/AKT/mTOR signal pathway
June 2026
Gastric cancer remains a major global health challenge with limited advances in targeted therapy. While the overexpression of bifunctional apoptosis regulator in gastric cancer has been previously documented,...
Bibliometric and visualization analysis of aconitine toxicity research
September 2026
Aconitine is the main toxic alkaloid in Aconitum, responsible for frequent adverse reactions and poisoning incidents. This study presents a comprehensive bibliometric and visual analysis of global research...
Adhesion G protein-coupled receptor ADGRF1 promotes pancreatic ductal adenocarcinoma progression by modulating YY1/CTSD signaling axis
June 2026
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate of merely 10%, underscoring the urgent need for new therapeutic targets. In this study, we investigated...
Role of gut microbiota in regulating host cell metabolism in digestive system diseases
September 2026
The impact of gut microbiota on disease pathogenesis and progression is receiving increasing attention, particularly in the field of digestive system disorders. Previous reviews have predominantly focused...
Unlocking new horizons in immunity: The roles and mechanisms of immune checkpoints in inflammation regulation
September 2026
Immune checkpoints (ICs) are receptors that regulate immune responses through both activating and inhibitory mechanisms. Key pathways, including programmed death 1, cytotoxic T-lymphocyte antigen 4,...
National burden of age-related macular degeneration in China: Findings from the global burden of disease study
September 2026
This study analyzed the burden of age-related macular degeneration (AMD) in China from 1990 to 2023 using data from the Global Burden of Disease 2023 (GBD 2023), focusing on temporal trends, gender-...
Temporal trends and sociodemographic disparities in osteoarthritis prevalence among U.S. adults
June 2026
New insights into microbiome metabolic mechanisms for pancreatic cancer therapy
September 2026
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with a dismal 5-year survival rate, largely due to pervasive chemoresistance. Emerging evidence suggests that microbiome-metabolism...
Short-chain fatty acids as molecular bridges between the gut microbiota and systemic inflammation: Mechanisms, organ-specific axes, and therapeutic opportunities
Available online 5 June 2026
Association of heavy metal exposure with comorbid diabetes and coronary heart disease: An exploratory analysis of NHANES and GBD data
Available online 6 June 2026
Potential and recent advances of stem cell exosomes in the repair of lung injury
September 2026
The repair of lung injury is one of the challenges faced by physicians. Exosomes are nano-sized vesicles that can assist in mediating intercellular communication. Their applications in cell-to-cell...
Necroptosis-driven immunoregulatory vicious cycle in periodontitis: Mechanisms and therapeutic insights
September 2026
Recent advances in cell death research have highlighted necroptosis, a form of regulated cell death crucial for tissue development and homeostasis. Periodontitis, affecting over one billion people globally,...