Cervical cancer diagnosis: Fundamental theories, clinical practice and future perspectives
February 2027
Cervical cancer remains the fourth most commonly diagnosed cancer among women worldwide, but its diagnostic landscape is becoming increasingly diverse. High income settings are moving toward risk stratification...
Hydrogel-based multifunctional biomaterials for glaucoma therapy: Emerging strategies in sustained delivery, anti-fibrotic regulation, and retinal neuroprotection
February 2027
Glaucoma is a leading cause of irreversible blindness worldwide, characterized by progressive retinal ganglion cell (RGC) degeneration and visual field impairment. Although current therapeutic approaches...
Functionalized carbon dots: A novel strategy for healing of diabetic wounds
December 2026
The latest data released by the International Diabetes Federation indicates that there are currently 589 million people aged 20‐79 living with diabetes worldwide. Diabetic wounds are one of the most...
Tailoring nanomaterials for cancer therapy: A comprehensive insight into theranostics and limitations
December 2026
Nanotheranostics has emerged as a promising approach in cancer therapy. It enables the diagnosis of cancer cells and targeted drug delivery on a single platform. Due to their small size, unique surface...
Cianidanol suppresses M1 macrophage polarization via JAK2/STAT1 to ameliorate DNCB-induced atopic dermatitis
December 2026
Cianidanol (Cian), also known as (+)-catechin, is a naturally occurring flavonoid found in medicinal plants including Camellia sinensis and Violae herba. Its role in inflammatory skin disease has not...
Receptor-guided therapeutic targeting of the inflammation-cancer axis: Molecular mechanisms and emerging drug discovery strategies
December 2026
Chronic inflammation is a key driver of carcinogenesis, promoting tumour initiation, progression, metastasis and therapeutic resistance through receptor-mediated signalling networks. Chemokine receptors,...
Gut microbiota as master regulators: Mapping gut-organ axes that orchestrate systemic health
December 2026
The intestine engages in communication with various distant organs through neural, immune, and endocrine pathways. This systemic interconnection mechanism is referred to as the gut-organ axis, in which...
The gut-organ axis: A 25-year bibliometric analysis of 10327 publications on global research landscape and future directions
December 2026
The gut interacts with multiple organs through neural, immune, and endocrine pathways, a relationship termed the gut-organ axis. Gut microbes play a key role in this axis. This review systematically...
Biomaterials regulate cellular senescence for the treatment of H. pylori-related gastric cancer
December 2026
Helicobacter pylori (H. pylori) infection is a primary risk factor for gastric cancer, whose core pathogenicity lies in driving gastric mucosal cells into an irreversible senescent state and establishing...
Pharmacovigilance in perioperative malignant hyperthermia: strengths, caveats, and the path forward
December 2026
Deubiquitinating enzymes at the crossroads of temozolomide resistance in gliomas: mechanisms, regulatory networks, and therapeutic opportunities
December 2026
Temozolomide (TMZ) is the standard chemotherapy agent used to treat malignant gliomas. However, intrinsic and acquired resistance significantly limit its clinical efficacy. Recent studies have revealed...
Global Adverse Drug Reaction Databases: Current Landscape, Challenges, and Future Directions for Enhancing Drug Safety
Available online 12 October 2026
The global adverse drug reaction database is the core of drug vigilance signal management and development. It collects and analyzes data on adverse drug reaction events and serves as a supplement to...
PANoptosis in diabetic wound repair and regeneration: current evidence and mechanistic perspectives
Available online 9 October 2026
Diabetic wound (DW) is a major complication of diabetes characterized by persistent inflammation, oxidative stress, vascular dysfunction, impaired angiogenesis, and abnormal extracellular matrix remodeling....
Gout burden and socioeconomic inequalities in the global working-age population from the Global Burden of Disease Study
Available online 8 October 2026
Using Global Burden of Disease Study estimates, we assessed gout burden among adults aged 15–64 years across 204 countries and territories over a 32-year observation period. Analyses covered temporal...
Engineering energy metabolism boosts therapeutic protein production via the E. coli hemolysin A system
September 2026
Escherichia coli currently serves as a widely tool for therapeutic proteins production, however, the high accumulation of heterologous proteins in the cytoplasm poses a risk of degradation by proteases...
National burden of age-related macular degeneration in China: Findings from the global burden of disease study
September 2026
This study analyzed the burden of age-related macular degeneration (AMD) in China from 1990 to 2023 using data from the Global Burden of Disease 2023 (GBD 2023), focusing on temporal trends, gender-...
Bibliometric and visualization analysis of aconitine toxicity research
September 2026
Aconitine is the main toxic alkaloid in Aconitum, responsible for frequent adverse reactions and poisoning incidents. This study presents a comprehensive bibliometric and visual analysis of global research...
Role of gut microbiota in regulating host cell metabolism in digestive system diseases
September 2026
The impact of gut microbiota on disease pathogenesis and progression is receiving increasing attention, particularly in the field of digestive system disorders. Previous reviews have predominantly focused...
Unlocking new horizons in immunity: The roles and mechanisms of immune checkpoints in inflammation regulation
September 2026
Immune checkpoints (ICs) are receptors that regulate immune responses through both activating and inhibitory mechanisms. Key pathways, including programmed death 1, cytotoxic T-lymphocyte antigen 4,...
New insights into microbiome metabolic mechanisms for pancreatic cancer therapy
September 2026
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with a dismal 5-year survival rate, largely due to pervasive chemoresistance. Emerging evidence suggests that microbiome-metabolism...