Engineering energy metabolism boosts therapeutic protein production via the E. coli hemolysin A system
Available online 22 April 2026
Escherichia coli (E. coli) currently serves as a widely tool for therapeutic proteins production, however, the high accumulation of heterologous proteins in the cytoplasm poses a risk of degradation...
Genetic and familial high-risk assessment in cervical cancer
March 2026
Cervical cancer remains a major public health concern worldwide, despite the well-established causal role of high-risk human papillomavirus (HPV) infection in its pathogenesis. HPV infection is necessary...
Nanocarrier-induced inflammation: mechanisms, immunometabolic impacts and strategies for safer design
March 2026
Nanocarriers have emerged as indispensable platforms for drug delivery, molecular imaging and precision diagnostics. Their rapidly expanding global application has intensified concerns regarding inflammation-driven...
The promise and potential of liver organoids: Development, classification and application
March 2026
Liver diseases are a leading cause of mortality worldwide. While liver transplantation remains the gold standard for end-stage liver disease, its application is severely constrained by donor shortages,...
Circulating cfDNA promoter methylation: An emerging biomarker for early detection of advanced adenoma and colorectal cancer
March 2026
Cell-free DNA (cfDNA) methylation has emerged as a promising avenue for the early detection of various cancers. However, specific biomarkers for advanced adenoma (AA) and colorectal cancer (CRC) are...
Adhesion G protein-coupled receptor ADGRF1 promotes pancreatic ductal adenocarcinoma progression by modulating YY1/CTSD signaling axis
March 2026
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate of merely 10%, underscoring the urgent need for new therapeutic targets. In this study, we investigated...
BFAR facilitates gastric cancer progression via SPRR3 activating PI3K/AKT/mTOR signal pathway
March 2026
Gastric cancer remains a major global health challenge with limited advances in targeted therapy. While the overexpression of bifunctional apoptosis regulator in gastric cancer has been previously documented,...
Assessing the accuracy of a handheld real-time fluorescence microscope for rapid intraoperative diagnosis of prostate biopsies
March 2026
Standard hematoxylin and eosin staining for prostate cancer diagnosis is time-consuming, delaying clinical workflows and intraoperative decisions. We evaluated EndoSCell (ES), a handheld real-time fluorescence...
Sepsis-induced PICS: Immunometabolic mechanisms, emerging biomarkers, and precision management
March 2026
Sepsis, a life-threatening organ dysfunction caused by infection, casts a lingering shadow over its survivors. Many develop persistent inflammation, immunosuppression, and catabolism syndrome (PICS),...
Molecular basis of graphene-induced oxidative stress and mitochondrial signaling in target cells: Consequences for therapeutic window and design of redox-responsive payloads
March 2026
Graphene nanomaterials (GNMs) have emerged as a unique class of bioactive interfaces capable of directly modulating cellular redox homeostasis and mitochondrial function through their distinctive physicochemical...
Exosome/vancomycin enable targeted therapeutics of liver abscess with enhanced anti-inflammation performance
March 2026
Current clinical management for pyogenic liver abscess primarily relies on broad-spectrum antibiotics, necessitating excessive dosing due to targeting limitations, which would lead to severe drug resistance...
GALNTs in cancer: Driving tumor progression and opening a new therapeutic frontier
March 2026
The human GALNT family consists of 20 isoenzymes that initiate mucin-type O-glycosylation. These enzymes catalyze the transfer of N-acetylgalactosamine to serine or threonine residues on protein substrates....
An analysis of research on healthy lifestyle and digestive system cancers using bibliometric methods over the last two decades
March 2026
Digestive system cancers remain major contributors to global cancer-related morbidity and mortality, and increasing evidence suggests that modifiable lifestyle factors are closely associated with their...
In situ-forming turkish galls polyphenol/CMCS hydrogel powder for the treatment of radiation-induced oral mucositis
March 2026
Radiation-induced oral mucositis (RIOM) is a debilitating complication in head and neck cancer patients undergoing radiotherapy. The severe ulcerative lesions often necessitate treatment interruptions,...