Functionalized carbon dots: A novel strategy for healing of diabetic wounds
December 2026
The latest data released by the International Diabetes Federation indicates that there are currently 589 million people aged 20‐79 living with diabetes worldwide. Diabetic wounds are one of the most...
Tailoring nanomaterials for cancer therapy: A comprehensive insight into theranostics and limitations
December 2026
Nanotheranostics has emerged as a promising approach in cancer therapy. It enables the diagnosis of cancer cells and targeted drug delivery on a single platform. Due to their small size, unique surface...
Cianidanol suppresses M1 macrophage polarization via JAK2/STAT1 to ameliorate DNCB-induced atopic dermatitis
December 2026
Cianidanol (Cian), also known as (+)-catechin, is a naturally occurring flavonoid found in medicinal plants including Camellia sinensis and Violae herba. Its role in inflammatory skin disease has not...
Engineering energy metabolism boosts therapeutic protein production via the E. coli hemolysin A system
September 2026
Escherichia coli currently serves as a widely tool for therapeutic proteins production, however, the high accumulation of heterologous proteins in the cytoplasm poses a risk of degradation by proteases...
National burden of age-related macular degeneration in China: Findings from the global burden of disease study
September 2026
This study analyzed the burden of age-related macular degeneration (AMD) in China from 1990 to 2023 using data from the Global Burden of Disease 2023 (GBD 2023), focusing on temporal trends, gender-...
Bibliometric and visualization analysis of aconitine toxicity research
September 2026
Aconitine is the main toxic alkaloid in Aconitum, responsible for frequent adverse reactions and poisoning incidents. This study presents a comprehensive bibliometric and visual analysis of global research...
Role of gut microbiota in regulating host cell metabolism in digestive system diseases
September 2026
The impact of gut microbiota on disease pathogenesis and progression is receiving increasing attention, particularly in the field of digestive system disorders. Previous reviews have predominantly focused...
Unlocking new horizons in immunity: The roles and mechanisms of immune checkpoints in inflammation regulation
September 2026
Immune checkpoints (ICs) are receptors that regulate immune responses through both activating and inhibitory mechanisms. Key pathways, including programmed death 1, cytotoxic T-lymphocyte antigen 4,...
New insights into microbiome metabolic mechanisms for pancreatic cancer therapy
September 2026
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with a dismal 5-year survival rate, largely due to pervasive chemoresistance. Emerging evidence suggests that microbiome-metabolism...
Necroptosis-driven immunoregulatory vicious cycle in periodontitis: Mechanisms and therapeutic insights
September 2026
Recent advances in cell death research have highlighted necroptosis, a form of regulated cell death crucial for tissue development and homeostasis. Periodontitis, affecting over one billion people globally,...
Potential and recent advances of stem cell exosomes in the repair of lung injury
September 2026
The repair of lung injury is one of the challenges faced by physicians. Exosomes are nano-sized vesicles that can assist in mediating intercellular communication. Their applications in cell-to-cell...
From signal amplification to inflammatory resolution: The NF-κB-inflammasome-SPM axis as an integrated regulatory network
September 2026
Inflammation is a fundamental biological process essential for host defense, tissue repair and maintenance of homeostasis. However, dysregulated inflammatory responses contribute to the pathogenesis...
Receptor-Guided Therapeutic Targeting of the Inflammation-Cancer Axis: Molecular Mechanisms and Emerging Drug Discovery Strategies
Available online 12 August 2026
Chronic inflammation is a key driver of carcinogenesis, promoting tumour initiation, progression, metastasis and therapeutic resistance through receptor-mediated signalling networks. Chemokine receptors,...
Gut microbiota as master regulators: mapping gut-organ axes that orchestrate systemic health
Available online 12 August 2026
The intestine engages in communication with various distant organs through neural, immune, and endocrine pathways. This systemic interconnection mechanism is referred to as the gut-organ axis, in which...
Genetic and familial high-risk assessment in cervical cancer
June 2026
Cervical cancer remains a major public health concern worldwide, despite the well-established causal role of high-risk human papillomavirus (HPV) infection in its pathogenesis. HPV infection is necessary...
Nanocarrier-induced inflammation: mechanisms, immunometabolic impacts and strategies for safer design
June 2026
Nanocarriers have emerged as indispensable platforms for drug delivery, molecular imaging and precision diagnostics. Their rapidly expanding global application has intensified concerns regarding inflammation-driven...
The promise and potential of liver organoids: Development, classification and application
June 2026
Liver diseases are a leading cause of mortality worldwide. While liver transplantation remains the gold standard for end-stage liver disease, its application is severely constrained by donor shortages,...
Circulating cfDNA promoter methylation: An emerging biomarker for early detection of advanced adenoma and colorectal cancer
June 2026
Cell-free DNA (cfDNA) methylation has emerged as a promising avenue for the early detection of various cancers. However, specific biomarkers for advanced adenoma (AA) and colorectal cancer (CRC) are...
Adhesion G protein-coupled receptor ADGRF1 promotes pancreatic ductal adenocarcinoma progression by modulating YY1/CTSD signaling axis
June 2026
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate of merely 10%, underscoring the urgent need for new therapeutic targets. In this study, we investigated...
BFAR facilitates gastric cancer progression via SPRR3 activating PI3K/AKT/mTOR signal pathway
June 2026
Gastric cancer remains a major global health challenge with limited advances in targeted therapy. While the overexpression of bifunctional apoptosis regulator in gastric cancer has been previously documented,...
Assessing the accuracy of a handheld real-time fluorescence microscope for rapid intraoperative diagnosis of prostate biopsies
June 2026
Standard hematoxylin and eosin staining for prostate cancer diagnosis is time-consuming, delaying clinical workflows and intraoperative decisions. We evaluated EndoSCell (ES), a handheld real-time fluorescence...