Genetic and familial high-risk assessment in cervical cancer
March 2026
Cervical cancer remains a major public health concern worldwide, despite the well-established causal role of high-risk human papillomavirus (HPV) infection in its pathogenesis. HPV infection is necessary...
Nanocarrier-induced inflammation: mechanisms, immunometabolic impacts and strategies for safer design
March 2026
Nanocarriers have emerged as indispensable platforms for drug delivery, molecular imaging and precision diagnostics. Their rapidly expanding global application has intensified concerns regarding inflammation-driven...
The promise and potential of liver organoids: Development, classification and application
March 2026
Liver diseases are a leading cause of mortality worldwide. While liver transplantation remains the gold standard for end-stage liver disease, its application is severely constrained by donor shortages,...
Circulating cfDNA promoter methylation: An emerging biomarker for early detection of advanced adenoma and colorectal cancer
March 2026
Cell-free DNA (cfDNA) methylation has emerged as a promising avenue for the early detection of various cancers. However, specific biomarkers for advanced adenoma (AA) and colorectal cancer (CRC) are...
Assessing the Accuracy of a Handheld Real-Time Fluorescence Microscope for Rapid Intraoperative Diagnosis of Prostate Biopsies
Available online 17 March 2026
Standard hematoxylin and eosin (H&E) staining for prostate cancer diagnosis is time-consuming, delaying clinical workflows and intraoperative decisions. We evaluated EndoSCell (ES), a handheld real-time...
Adhesion G protein-coupled receptor ADGRF1 promotes pancreatic ductal adenocarcinoma progression by modulating YY1/CTSD signaling axis
Available online 14 March 2026
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate of merely 10%, underscoring the urgent need for new therapeutic targets. In this study, we investigated...
BFAR facilitates gastric cancer progression via SPRR3 activating PI3K/AKT/mTOR signal pathway
Available online 14 March 2026
Gastric cancer remains a major global health challenge with limited advances in targeted therapy. While the overexpression of bifunctional apoptosis regulator in gastric cancer has been previously documented,...