Current status of dengue fever epidemics and vaccine development
February 2026
Dengue fever, an acute mosquito-borne infectious disease caused by dengue virus (DENV), is primarily endemic in tropical and subtropical regions. In recent years, the global incidence of dengue has...
Crimean-Congo hemorrhagic fever: An emerging threat in Europe
June 2026
Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is endemic in Africa, Asia, and Europe. However, CCHF epidemiology and epizootiology have been poorly...
Antiviral agents for dengue virus
December 2025
Dengue virus (DENV) is a mosquito-borne pathogen responsible for a spectrum of illnesses, including dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Nearly half of the global population...
The epidemiology and disease burden of enterovirus infections among hospitalized children in China: An 8-year national cross-sectional study
June 2026
Enterovirus (EV) infections represent a significant global and national health concern in children, leading to various complications. Although most children with EV infections generally have a favorable...
Metagenomic and serological evidence of emerging tick-borne viruses in livestock, humans, and rats in Pakistan
June 2026
Tick-borne viruses (TBVs) pose significant emerging threats to public and veterinary health worldwide. In Pakistan, the potential threats posed by TBVs extend far beyond Crimean-Congo hemorrhagic fever...
Therapeutic efficacy of a K1-specific bacteriophage against hypervirulent Klebsiella pneumoniae in a mouse infection model
June 2026
Klebsiella pneumoniae is an important opportunistic pathogen in both humans and animals. Controlling it has become increasingly difficult due to the rapid spread of antimicrobial resistance. In this...
The role of T cells in influenza infection and vaccination
February 2026
Influenza virus infections cause significant illness or death every year, becoming a serious health risk. Currently, influenza vaccines mainly induce responses to antibodies against specific strains,...
Bruton's tyrosine kinase inhibitor BTKi-2 inhibits mpox virus and vaccinia virus infection
June 2026
The recent global outbreak of mpox virus (MPXV) infections underscores the urgent need for antiviral therapies against orthopoxviruses. In this study, using a high-content screening (HCS) platform based...
Dominant HA motif 131/132-NT shapes the phenotype of avian H9N2 influenza virus by modulating agglutination property, receptor specificity and infectivity in animals
June 2026
H9N2 avian influenza viruses (AIVs), which are enzootic in poultry and possess spillover potential to humans, represent a considerable global public health threat. Since 2021, we have observed an unprecedented...
Degradation of ACSL3 by influenza A virus shifts unfolded protein response from antiviral defense to viral evasion
June 2026
Host restriction factors and viral evasion strategies involved in the virus-host arms races remain to be discovered. Through an initial membrane protein-targeted CRISPR-Cas9 screening, we identified...
Structural vaccinology expedites rational design of next-generation vaccines for influenza and respiratory syncytial virus
April 2026
Vaccination stands as the single most effective and cost-efficient public health intervention in human history, serving as a cornerstone of modern medicine that profoundly transforms global health outcomes....
Nanobody targeting glycan cap confers broad orthoebolavirus neutralization
April 2026
The Zaire Ebola virus (EBOV) and Bundibugyo virus (BDBV) cause severe hemorrhagic fever with high mortality, highlighting the urgent need for broad-spectrum antiviral therapies. Neutralizing nanobodies,...
Breaking barriers and beyond: Mechanisms and pathological implications of Zika virus traversal across blood-tissue interfaces
April 2026
Blood-tissue barriers are specialized interfaces that safeguard organ homeostasis by restricting pathogen dissemination. Zika virus (ZIKV), an emerging flavivirus of global concern, exhibits an exceptional...
Recent progress in anti-Chikungunya virus drug discovery: Focus on the viral life cycle and direct-acting antivirals
August 2026
Chikungunya virus (CHIKV) belongs to the genus Alphavirus of the family Togaviridae. CHIKV infection generally causes severe clinical symptoms, including debilitating arthralgia, fever, hemorrhage and...
Current antiviral therapies and promising drug candidates against respiratory syncytial virus infection
April 2025
Respiratory syncytial virus (RSV) is one of the most common viruses leading to lower respiratory tract infections (LRTIs) in children and elderly individuals worldwide. Although significant progress...
Stabilization of prefusion hMPV F improves manufacturability and protective immunity across hMPV lineages
August 2026
Human metapneumovirus (hMPV) is a major cause of pediatric acute lower respiratory tract infections (ALRTIs), yet vaccine development has been hindered by the intrinsic metastability of the prefusion...
Antiviral activity of Saponin C from Liriope muscari against influenza A virus and SARS-CoV-2
June 2026
Saponin C (also known as DT-13) is the dominant ingredient extracted from the tuber of Liriope muscari (Decne.) L. H. Bailey, which exhibits multiple pharmacological activities, including anti-tumor,...
A comprehensive RNA virome from molluscan transcriptomes reveals extensive diversity and modular genome evolution
June 2026
Mollusca, the second-largest animal phylum, includes many aquaculture species used as important food resources for humans. While DNA viruses that threaten molluscan aquaculture have received much attention,...
Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway
June 2026
Mitochondrial homeostasis is intricately linked to the pathogenesis of many viral infections. The maintenance of mitochondrial homeostasis and normal cellular functions relies heavily on the delicate...
ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly
June 2026
African swine fever (ASF), caused by the African swine fever virus (ASFV), is characterized by high mortality in infected pigs. ASFV infection triggers severe inflammatory response in the host, which...
HVT-based multiepitope vaccine administered subcutaneously or in ovo boosts protection of inactivated H9N2 vaccine against heterologous virus
April 2026
H9N2 avian influenza virus (AIV) poses a persistent threat as inactivated vaccines (InV) often fail to prevent viral shedding. To address this, we developed a recombinant turkey herpesvirus (HVT-BNT)...
HBV and host metabolic crosstalk: Reprogramming pathways for viral replication and pathogenesis
October 2025
Hepatitis B virus (HBV) establishes chronic infection through strategic manipulation of host metabolic networks, driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular...
The guanosine nucleotide analog bemnifosbuvir inhibits hepatitis E virus infection in cell and organoid models
June 2026
•The nucleotide analog bemnifosbuvir (AT-527) inhibits hepatitis E virus (HEV) infection in cell and organoid models.•Supplementation with guanosine largely reversed the anti-HEV activity of AT-527.•Combining...
Retinoic acid is a translation inhibitor against chikungunya virus both in vitro and invivo
August 2026
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes debilitating febrile and arthritic disease and remains a persistent public health threat in tropical and subtropical regions, with no clinically...
Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease
June 2025
Dengue viruses (DENV) have spread throughout the world and pose a huge threat to human life. The most widespread serotype is type 2 DENV (DENV 2), which has no specific treatment. NS2B-NS3 protease...