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ISSN: 1995-820X
CN: 42-1760/Q
p-ISSN: 1674-0769

PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor

Cap-dependent endonuclease (CEN) in the polymerase acidic protein (PA) of influenza A virus (IAV) represents a promising drug target due to its critical role in viral gene transcription. The CEN inhibitor,...

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Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread

•Cells infected with HSV-2 release migrasomes containing HSV-2 virions.•HSV-2 in the isolated migrasomes can be transmitted to uninfected cells and cause productive infection. 3. It is the first time...

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A visual assay panel for the identification of monkeypox virus DNA belonging to the clades I and II

•The newly developed visual assay panel is a rapid and reliable tool to differentiate the clade I and clade II MPXV within 25 min.•The panel combines recombinase-aid amplification and immunochromatography,...

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In vitro and in vivo efficacy of Molnupiravir against Zika virus infections

•Molnupiravir exhibits effective antiviral activity against ZIKV in vitro.•Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge.•Molnupiravir might act on the replication...

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Construction of coxsackievirus B5 viruses with luciferase reporters and their applications in vitro and in vivo

Coxsackievirus belongs to the Picornaviridae family and is one of the major pathogens that cause hand, foot and mouth disease (HFMD) in infants and children with potential serious complications and...

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Delta (B.1.617.2) inactivated vaccine candidate elicited neutralizing antibodies to SARS-CoV-2 and circulating variants in rhesus macaques

•The Delta inactivated vaccine constructed in this study has high immunogenicity and good safety.•The inactivated vaccine has good cross-protection against SARS-CoV-2 variants.•The vaccine exhibited...

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Development of PREDAC-H1pdm to model the antigenic evolution of influenza A/(H1N1) pdm09 viruses

The Influenza A (H1N1) pdm09 virus caused a global pandemic in 2009 and has circulated seasonally ever since. As the continual genetic evolution of hemagglutinin in this virus leads to antigenic drift,...

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Elucidating cellular interactome of chikungunya virus identifies host dependency factors

Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. To better understand how CHIKV rewires the host cell and usurps host cell functions, we generated...

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Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport (ESCRT) protein

Human immunodeficiency virus-1 (HIV-1) encodes simply 15 proteins and thus depends on multiple host cellular factors for virus reproduction. Spastin, a microtubule severing protein, is an identified...

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Vagal-mAChR4 signaling promotes Friend virus complex (FV)-induced acute erythroleukemia

Erythroleukemia belongs to acute myeloid leukemia (AML) type 6 (M6), and treatment remains difficult due to the poor prognosis of the disease. Friend virus (FV) is a complex of two viruses: Friend murine...

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Integrated interactome and transcriptome analysis reveals key host factors critical for SARS-CoV-2 infection

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has seriously threatened global public health and caused huge economic losses....

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SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria

Autophagy plays an important role in the interaction between viruses and host cells. SARS-CoV-2 infection can disrupt the autophagy process in target cells. However, the precise molecular mechanism...

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Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding

The Dicistroviridae is a virus family that includes many insect pathogens. These viruses contain a positive-sense RNA genome that is replicated by the virally encoded RNA-dependent RNA polymerase (RdRP)...

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Prevalence, variation, and transmission patterns of human respiratory syncytial virus from pediatric patients in Hubei, China during 2020–2021

Human respiratory syncytial virus (RSV) is a severe threat to children and a main cause of acute lower respiratory tract infections. Nevertheless, the intra-host evolution and inter-regional diffusion...

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A novel bat coronavirus with a polybasic furin-like cleavage site

The current pandemic of COVID-19 caused by a novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), threatens human health around the world. Of particular concern is that bats...

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Optimization and applications of an in vivo bioluminescence imaging model of influenza A virus infections

•The in vivo BLI model of IAV infections can simplify the determination of viral load in living animals.•The in vivo BLI model of IAV infections allow longitudinal measurements of virus infection/spread...

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Antibiotic-induced gut bacteria depletion has no effect on HBV replication in HBV immune tolerance mouse model

Commensal microbiota is closely related to Hepatitis B virus (HBV) infection. Gut bacteria maturation accelerates HBV immune clearance in hydrodynamic injection (HDI) HBV mouse model. However, the effect...

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Temperature-regulated type II grass carp reovirus establishes latent infection in Ctenopharyngodon idella brain

Grass carp reovirus (GCRV) causes extensive infection and death in grass carp and black carp fingerlings, with a highly seasonal prevalence. Previous studies suggested that GCRV can become latent after...

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Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo

Neutralizing monoclonal antibodies (mAb) are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The continuous emergence of new...

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Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Homologous booster, heterologous booster, and Omicron variants breakthrough infection (OBI) could improve the humoral immunity against Omicron variants. Questions concerning about memory B cells (MBCs)...

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Discovery and characterization of novel paramyxoviruses from bat samples in China

Many paramyxoviruses are responsible for a variety of mild to severe human and animal diseases. Based on the novel discoveries over the past several decades, the family Paramyxoviridae infecting various...

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Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells invivo

HIV-specific chimeric antigen receptor (CAR) T-cells have been developed to target HIV-1 infected CD4+ T-cells that express HIV Env proteins. However, T cell exhaustion and the patient-specific autologous...

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Crimean-Congo hemorrhagic fever virus in Central, Eastern, and South-eastern Asia

Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is endemic in Africa, Asia, and Europe, but CCHF epidemiology and epizootiology is only rudimentarily...

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PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling

Enterovirus 71 (EV71) poses a serious threat to human health, with scattered outbreaks worldwide. There are several vaccines against a few EV71 strains but no efficient drug for the treatment of EV71...

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Natural co-infection of fowl adenovirus type E-8b and avian hepatitis E virus in parental layer breeders in Hebei, China

•Co-infection of fowl adenovirus (FAdV) and avian hepatitis E virus (aHEV) was observed in layer breeders.•All three main genes of FAdV isolate share high homology with the E-8b type.•ORF2 from aHEV...

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