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ISSN: 1995-820X
CN: 42-1760/Q
p-ISSN: 1674-0769

Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

Next-generation sequencing (NGS) has significantly improved the accuracy and efficiency of pathogen diagnosis for a wide range of diseases. In this study, viral metagenomics analysis was conducted on...

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Continued Evolution of H10N3 Influenza Virus with Adaptive Mutations Poses an Increased Threat to Mammals

The H10 subtype of avian influenza virus (AIV) poses an ongoing threat to both birds and humans. Notably, fatal human cases of H10N3 and H10N8 infections have drawn public attention. In 2022, we isolated...

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The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses

Foxes are susceptible to SARS-CoV-2 in laboratory settings, and there have also been reports of natural infections of both SARS-CoV and SARS-CoV-2 in foxes. In this study, we assessed the binding capacities...

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Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy

The landscape of hepatitis B virus (HBV) integration in the plasma cell-free DNA (cfDNA) of HBV-infected patients with different stages of liver diseases [chronic hepatitis B (CHB), liver cirrhosis...

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Correlation between Circulating T Follicular Helper Cell Levels after Infection and a Decreased Risk of COVID-19 Re-infection

•Our study conducted a retrospective analysis of individuals with differing susceptibilities to COVID-19.•The correlation between cTfh cells and neutralizing antibody generation contributes to enhanced...

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Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

Lassa virus (LASV) is an enveloped, negative-sense RNA virus that causes Lassa hemorrhagic fever. Successful entry of LASV requires the viral glycoprotein 1 (GP1) to undergo a receptor switch from its...

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Diverse genotypes of norovirus genogroup I and II contamination in environmental water in Thailand during the COVID-19 outbreak from 2020 to 2022

Noroviruses (NoVs) are the most significant viral pathogens associated with waterborne and foodborne outbreaks of nonbacterial acute gastroenteritis in humans worldwide. This study aimed to investigate...

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Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation

Herpesviruses antagonize host antiviral responses through a myriad of molecular strategies culminating in the death of the host cells. Pseudorabies virus (PRV) is a significant veterinary pathogen in...

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Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai, China, 2022

•The first report of serological characteristics of HFMD associated enteroviruses in Shanghai after the COVID-19 epidemic.•The seroprevalence of protective NtAbs against Coxsackieviruses was low within...

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Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response

The infection caused by porcine epidemic diarrhea virus (PEDV) is associated with high mortality in piglets worldwide. Host factors involved in the efficient replication of PEDV, however, remain largely...

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Function investigation of p11.5 in ASFV infection

Virus replication relies on complex interactions between viral proteins. In the case of African swine fever virus (ASFV), only a few such interactions have been identified so far. In this study, we...

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Development of a Měnglà virus minigenome and comparison of its polymerase complexes with those of other filoviruses

Ebola virus (EBOV) and Marburg virus (MARV), members of the Filoviridae family, are highly pathogenic and can cause hemorrhagic fevers, significantly impacting human society. Bats are considered reservoirs...

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Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023

•H1N1 strains were collected from Hunan and Jiangsu provinces in early 2023 following the optimized COVID-19 strategy.•Phylogenic analysis revealed that the epidemic H1N1 viruses fell into different...

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First complete genomic sequence analysis of canine distemper virus in wild boar

•The first complete genomic sequence of canine distemper virus from wild boar in northeast China was obtained.•Phylogenetic analysis showed that this wild boar CDV strain belongs to the Arctic lineage.•Wild...

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NSUN2 mediates distinct pathways to regulate enterovirus 71 replication

Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function...

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DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice

As of December 2022, 2603 laboratory-identified Middle East respiratory syndrome coronavirus (MERS-CoV) infections and 935 associated deaths, with a mortality rate of 36%, had been reported to the World...

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Design of antiviral AGO2-dependent short hairpin RNAs

The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals. RNA interference (RNAi) is a sequence-specific gene silencing mechanism that...

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Ten computational challenges in human virome studies

In recent years, substantial advancements have been achieved in understanding the diversity of the human virome and its intricate roles in human health and diseases. Despite this progress, the field...

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Joint deletion of multifunctional MGF505-7R and H240R genes generates a safe and effective African swine fever virus attenuated live vaccine candidate

•MGF505-7R and H240R are virulence-related genes.•ASFV-ΔMGF505-7R-ΔH240R is attenuated.•The candidate vaccine is safe and protective....

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Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection

Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered a lower expression of antiviral factors, such as IFN-β, STING and IFI16, in the brain tissues...

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Isolation and characterization of mpox virus from the first mpox case in Shenzhen, China

•We reported the first MPXV strain hMpxV/China/SZ-SZTH42/2023 isolated in southern China.•The isolate SZTH42 belongs to C.1 lineage of clade IIb, representing the currently prevalent IIb branch strain...

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C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus

Influenza A virus (IAV) binds sialic acid receptors on the cell surface to enter the host cells, which is the key step in initiating infection, transmission and pathogenesis. Understanding the factors...

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PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major economically devastating pathogen that has evolved various strategies to evade innate immunity. Downregulation of antiviral interferon...

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Cross-species transmission and host range genes in poxviruses

The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread of MPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and...

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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

•Full-length genome sequences of reassortant swine influenza A(H1N2) virus from domestic pigs in Hong Kong SAR.•These swine influenza A(H1N2) viruses are closely related with those circulating in Taiwan.•Swine...

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