Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication
Available online 16 April 2024
The pseudorabies virus (PRV) is identified as a double-helical DNA virus responsible for causing Aujeszky's disease, which results in considerable economic impacts globally. The enzyme tryptophanyl-tRNA...
Share article
Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence
Available online 8 April 2024
Infectious diseases caused by arboviruses are a public health concern in Pakistan. However, the studies on data prevalence and threats posed by arboviruses are limited. This study investigated the seroprevalence...
Share article
Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies
Available online 6 April 2024
African swine fever virus (ASFV) poses a significant threat to the global swine industry. Currently, there are no effective vaccines or treatments available to combat ASFV infection in pigs. The primary...
Share article
Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory
Available online 29 March 2024
The Ebola virus (EBOV) is a member of the Orthoebolavirus genus, Filoviridae family, which causes severe hemorrhagic diseases in humans and non-human primates (NHPs), with a case fatality rate of up...
Share article
An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo
Available online 26 March 2024
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still epidemic around the world. The manipulation of SARS-CoV-2 is restricted to biosafety level 3 laboratories (BSL-3). In this study,...
Share article
A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation
Available online 24 March 2024
•The recombinant VSV-EBOV is highly lethal to IFNα/β/γ R−/− mice.•The infected mice exhibit hyperviremia and distinct splenohepatic lesions.•Virus replicon particle vaccine can protect all IFNα/β/γ...
Share article
Crucial role played by CK8+ cells in mediating alveolar injury remodeling for patients with COVID-19
Available online 21 March 2024
The high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after...
Share article
Severe fever with thrombocytopenia syndrome virus infection attributed to cat contact: A case report in Beijing, China
Available online 20 March 2024
•SFTSV is detected in host-seeking ticks in rural–urban fringe areas in Beijing.•SFTSV RNA, IgM, and neutralizing antibodies are detected in stray cats in Beijing.•Multiple SFTSV genotypes naturally...
Share article
Integration of HiBiT into enteroviruses: A universal tool for advancing enterovirus virology research
Available online 16 March 2024
The utilization of enteroviruses engineered with reporter genes serves as a valuable tool for advancing our understanding of enterovirus biology and its applications, enabling the development of effective...
Share article
KIF5B-mediated internalization of FMDV promotes virus infection
Available online 16 March 2024
Foot-and-mouth disease (FMD) is a highly contagious and economically important disease, that is caused by the FMD virus (FMDV). Although the cell receptor for FMDV has been identified, the specific...
Share article
Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients
Available online 14 March 2024
Naturally occurred precore (PC, G1896A) and/or basal core promoter (BCP, A1762T/G1764A) mutations are prevalent in chronic HBV-infected patients, especially those under HBeAg-negative status. However,...
Share article
The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes
Available online 8 March 2024
Guaico Culex virus (GCXV) is a newly identified segmented Jingmenvirus from Culex spp. mosquitoes in Central and South America. The genome of GCXV is composed of four or five single-stranded positive...
Share article
Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury
Available online 6 March 2024
SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of COVID-19. Our research, along with others', has demonstrated that mast cells (MCs) play a vital role in the initiation of...
Share article
Identification of fangchinoline as a broad-spectrum enterovirus inhibitor through reporter virus based high-content screening
Available online 5 March 2024
Hand, foot, and mouth disease (HFMD) is a common pediatric illness mainly caused by enteroviruses, which are important human pathogens. Currently, there are no available antiviral agents for the therapy...
Share article
Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication
February 2024
Avian H9N2 viruses have wide host range among the influenza A viruses. However, knowledge of H9N2 mammalian adaptation is limited. To explore the molecular basis of the adaptation to mammals, we performed...
Share article
Naturally occurring PAE206K point mutation in 2009 H1N1 pandemic influenza viruses impairs viral replication at high temperatures
February 2024
The emergence of influenza virus A pandemic H1N1 in April 2009 marked the first pandemic of the 21st century. In this study, we observed significant differences in the polymerase activities of two clinical...
Share article
Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions
February 2024
Hepatitis E virus (HEV) infection can cause severe complications and high mortality, particularly in pregnant women, organ transplant recipients, individuals with pre-existing liver disease and immunosuppressed...
Share article
SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants
February 2024
•Inactivated vaccine breakthrough infection with ancestral variants induced nearly undetectable nAbs against XBB variants.•Inactivated vaccine breakthrough infection with Omicron BA.1 or BA.5 evoked...
Share article
Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virus
February 2024
Severe fever with thrombocytopenia syndrome (SFTS) caused by the SFTS virus (SFTSV) is an emerging disease in East Asia with a fatality rate of up to 30%. However, the viral-host interaction of SFTSV...
Share article
Single-cell RNA sequencing to understand host-virus interactions
February 2024
Single-cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell resolution. This review summarizes the existing scRNA-seq...
Share article
HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming
February 2024
The mortality of patients with severe pneumonia caused by H1N1 infection is closely related to viral replication and cytokine storm. However, the specific mechanisms triggering virus replication and...
Share article
Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing
February 2024
The monkeypox virus (MPXV) has triggered a current outbreak globally. Genome sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and control. It is a significant...
Share article
Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice
February 2024
Influenza A virus (IAV) continues to pose a pandemic threat to public health, resulting a high mortality rate annually and during pandemic years. Posttranslational modification of viral protein plays...
Share article
Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation
February 2024
Ferroptosis is a newly discovered prototype of programmed cell death (PCD) driven by iron-dependent phospholipid peroxidation accumulation, and it has been linked to numerous organ injuries and degenerative...
Share article
Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics
February 2024
The achievement of a functional cure for chronic hepatitis B (CHB) remains limited to a minority of patients treated with currently approved drugs. The primary objective in developing new anti-HBV drugs...
Share article