Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A
Available online 16 July 2024
Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy. Group B coxsackievirus (CVB) is one of the leading causative pathogens of viral...
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A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice
Available online 10 July 2024
Norovirus (NoV) infection is a major cause of gastroenteritis worldwide. The virus poses great challenges in developing vaccines with broad immune protection due to its genetic and antigenic diversity....
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Structural and functional insights into the 2'-O-methyltransferase of SARS-CoV-2
Available online 3 July 2024
A unique feature of coronaviruses is their utilization of self-encoded nonstructural protein 16 (nsp16), 2'-O-methyltransferase (2'-O-MTase), to cap their RNAs through ribose 2'-O-methylation modification....
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June 2024
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A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation
June 2024
•The recombinant VSV-EBOV is highly lethal to IFNα/β/γ R−/− mice.•The infected mice exhibit hyperviremia and distinct splenohepatic lesions.•Virus replicon particle vaccine can protect all IFNα/β/γ...
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Crucial role played by CK8+ cells in mediating alveolar injury remodeling for patients with COVID-19
June 2024
The high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after...
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Integration of HiBiT into enteroviruses: A universal tool for advancing enterovirus virology research
June 2024
The utilization of enteroviruses engineered with reporter genes serves as a valuable tool for advancing our understanding of enterovirus biology and its applications, enabling the development of effective...
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Development of a Měnglà virus minigenome and comparison of its polymerase complexes with those of other filoviruses
June 2024
Ebola virus (EBOV) and Marburg virus (MARV), members of the Filoviridae family, are highly pathogenic and can cause hemorrhagic fevers, significantly impacting human society. Bats are considered reservoirs...
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Severe fever with thrombocytopenia syndrome virus infection attributed to cat contact: A case report in Beijing, China
June 2024
•SFTSV is detected in host-seeking ticks in rural–urban fringe areas in Beijing.•SFTSV RNA, IgM, and neutralizing antibodies are detected in stray cats in Beijing.•Multiple SFTSV genotypes naturally...
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Function investigation of p11.5 in ASFV infection
June 2024
Virus replication relies on complex interactions between viral proteins. In the case of African swine fever virus (ASFV), only a few such interactions have been identified so far. In this study, we...
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Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication
June 2024
The pseudorabies virus (PRV) is identified as a double-helical DNA virus responsible for causing Aujeszky's disease, which results in considerable economic impacts globally. The enzyme tryptophanyl-tRNA...
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Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses, China, 2021–2022
June 2024
The recent concurrent emergence of H5N1, H5N6, and H5N8 avian influenza viruses (AIVs) has led to significant avian mortality globally. Since 2020, frequent human-animal interactions have been documented....
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Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies
June 2024
African swine fever virus (ASFV) poses a significant threat to the global swine industry. Currently, there are no effective vaccines or treatments available to combat ASFV infection in pigs. The primary...
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Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence
June 2024
Infectious diseases caused by arboviruses are a public health concern in Pakistan. However, studies on data prevalence and threats posed by arboviruses are limited. This study investigated the seroprevalence...
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Characterization of humoral immune responses against SARS-CoV-2 accessory proteins in infected patients and mouse model
June 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, encodes several accessory proteins that have been shown to play crucial roles in regulating the innate...
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Joint deletion of multifunctional MGF505-7R and H240R genes generates a safe and effective African swine fever virus attenuated live vaccine candidate
June 2024
•MGF505-7R and H240R are virulence-related genes.•ASFV-ΔMGF505-7R-ΔH240R is attenuated.•The candidate vaccine is safe and protective....
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Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response
June 2024
The infection caused by porcine epidemic diarrhea virus (PEDV) is associated with high mortality in piglets worldwide. Host factors involved in the efficient replication of PEDV, however, remain largely...
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Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory
June 2024
The Ebola virus (EBOV) is a member of the Orthoebolavirus genus, Filoviridae family, which causes severe hemorrhagic diseases in humans and non-human primates (NHPs), with a case fatality rate of up...
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KIF5B-mediated internalization of FMDV promotes virus infection
June 2024
Foot-and-mouth disease (FMD) is a highly contagious and economically important disease, which is caused by the FMD virus (FMDV). Although the cell receptor for FMDV has been identified, the specific...
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Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023
June 2024
•H1N1 strains were collected from Hunan and Jiangsu provinces in early 2023 following the optimized COVID-19 strategy.•Phylogenic analysis revealed that the epidemic H1N1 viruses fell into different...
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DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice
June 2024
As of December 2022, 2603 laboratory-identified Middle East respiratory syndrome coronavirus (MERS-CoV) infections and 935 associated deaths, with a mortality rate of 36%, had been reported to the World...
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An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo
June 2024
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still epidemic around the world. The manipulation of SARS-CoV-2 is restricted to biosafety level 3 laboratories (BSL-3). In this study,...
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Measures of insulin resistance and beta cell function before and after treatment of HCV infection
Available online 29 June 2024
The association between chronic HCV infection and type 2 diabetes mellitus (T2DM) has been established; however, there is limited research on β-cell function particularly in the pre-diabetic population....
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Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats
Available online 28 June 2024
Bats are the natural reservoir hosts for SARS-related coronavirus (SARSr-CoV) and other highly pathogenic microorganisms. Therefore, it is conceivable that an individual bat may harbor multiple microbes....
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AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase
Available online 28 June 2024
Hand, foot and mouth disease (HFMD), mainly caused by enterovirus 71 (EV71), has frequently occurred in the Asia-Pacific region, posing a significant threat to the health of infants and young children....
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