Isolation and phylogenetic analysis of swinepox virus from pigs in China
Available online 11 July 2025
•This study presents the first characterization and analysis of key host genes of SWPV from the Chinese lineage.•A SWPV strain (SWPV/AH/China/2024) was successfully isolated.•Genetic evolution analysis...
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Thermal tolerance and inactivation of Ebola virus
Available online 9 July 2025
•The investigation demonstrated a high level of tolerance of EBOV to thermal disinfection.•A water-bath is recommended and the tubes should be fully submerged during the process.•The established inactivation...
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SNX10 enhances HCoV-OC43 infection by facilitating viral entry and inhibiting virus-triggered autophagy
Available online 9 July 2025
The ongoing coronavirus epidemic, including the novel coronavirus (COVID-19), continues to pose a significant threat to global public health. Host targets address multiple stages of the viral life cycle...
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The Coronavirus 3CL protease: Unveiling Its Complex Host Interactions and Central Role in Viral Pathogenesis
Available online 7 July 2025
The 3CL protease, a highly conserved enzyme in the coronavirus, plays a crucial role in the viral life cycle by facilitating viral replication through precise cleavage of polyproteins. Beyond its proteolytic...
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Identification of a novel ectromelia virus from rodent: Implications for use as an in vivo infection model for vaccine and antiviral research
Available online 7 July 2025
Ectromelia virus (ECTV), a member of the Orthopoxvirus genus, serves as both a causative agent of mousepox and a pivotal surrogate model for studying highly pathogenic orthopoxviruses. While genomic...
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STAT5-c-Myc-axis regulates B cell metabolism in vaccinated individuals and COVID-19 recovered patients
Available online 7 July 2025
SARS-CoV-2 infection and vaccination both trigger immune responses. The former leads to naturally acquired immunity, while the latter induces active immunity through artificial means. However, the distinct...
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Single-cycle Rift Valley fever virus particles from stable replicon cells enable discovery of antiviral CNX-1351 for multiple RNA viruses
Available online 4 July 2025
Rift Valley fever virus (RVFV) is a high-containment pathogen that causes severe diseases in humans, with no approved therapeutics available. Its classification as a biosafety level 3 (BSL-3) agent...
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Clinical outcomes after HBsAg clearance in chronic hepatitis B patients treated with Peg-IFN α:A study with an 11- to 173-month follow-up
Available online 4 July 2025
To investigate the risk and influencing factors of long-term liver adverse events in chronic hepatitis B patients achieving hepatitis B surface antigen (HBsAg) clearance after pegylated interferon α...
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Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification
Available online 1 July 2025
Rapid and accurate detection of infectious virus particles, not just viral nucleic acid, is essential to avoid unnecessary quarantine and effectively control the spread of viral diseases such as coronavirus...
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SARS-CoV-2-encoded miR-nsp3-3p promotes pulmonary fibrosis by inhibiting expression of ALCAM
Available online 1 July 2025
microRNAs (miRNAs) derived from viruses, have been detected in body fluids and are known to regulate the expression of host genes. Recent evidence indicates that SARS-CoV-2-encoded miRNAs could contribute...
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Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic lassa virus
June 2025
•A new strain of Lassa virus (LASV) was successfully isolated and characterized.•The combination of ribavirin and LHF-535 has been demonstrated to exhibit synergistic effects in inhibiting LASV.•The...
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A noninfectious pseudovirus system for an emerging orthoflavivirus
June 2025
•A trans-complementation system for Usutu virus (USUV) recapitulates authentic viral replication.•High yield of TMN-ΔNS1 virus was obtained with no recombination into replication competent viruses.•TMN-ΔNS1...
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A mouse model of Crimean-Congo hemorrhagic fever virus-induced coagulopathy
June 2025
•A mouse model for CCHFV-induced coagulopathy was developed and characterized using STAT1 knockout mice.•High doses of CCHFV resulted in delayed tail bleeding time, shortened PT and APTT, and prolonged...
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Nucleophosmin 1 inhibits the replication of influenza A virus by competitively binding viral RNA with viral proteins
June 2025
Influenza A viruses (IAVs) are single-stranded negative-sense RNA viruses that continually challenge animal and human health. In IAV-infected cells, host RNA-binding proteins play key roles in the life...
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Characterization of a SARS-CoV-2 infection model in golden hamsters with diabetes mellitus
June 2025
Being widespread across the globe, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and generating new variants and continuously poses threat to public health, especially...
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Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc
June 2025
Crimean-Congo hemorrhagic fever (CCHF) is a hemorrhagic fever caused by infection with the CCHF virus (CCHFV) and has a mortality rate of up to 30 %. Thrombocytopenia is a hallmark of CCHF; however,...
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Mutational landscapes of NITD008-resistant EV71 variants revealed through population sequencing
June 2025
•The mutation spectra between WT population and NITD008-resistant populations during replication are compared.•The 2C protein may be a new target of NITD008 as a nucleotide analogue against EV71 infection.•Antiviral...
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Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription
June 2025
The persistence of covalently closed circular DNA (cccDNA) in hepatitis B virus (HBV)-infected hepatocytes remains a major obstacle to effective antiviral treatment. Understanding the molecular mechanisms...
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Compromised efferocytosis during aging is related to COVID-19 severity in mice
June 2025
Aging is one of the greatest risk factors for morbidity caused by the coronavirus disease 2019 (COVID-19). In older individuals, a dysregulated immune response to severe acute respiratory syndrome coronavirus...
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Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia
June 2025
The human endogenous retrovirus type W envelope glycoprotein (ERVWE1), located at chromosome 7q21–22, has been implicated in the pathophysiology of schizophrenia. Our previous studies have shown elevated...
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Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease
June 2025
Dengue viruses (DENV) have spread throughout the world and pose a huge threat to human life. The most widespread serotype is type 2 DENV (DENV 2), which has no specific treatment. NS2B-NS3 protease...
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Severe enterovirus A71 infection is associated with dysfunction of T cell immune response and alleviated by Astragaloside A
June 2025
Enterovirus A71 (EV-A71) is the major causative pathogen for severe hand-foot-mouth disease (HFMD), a predominantly childhood-associated communicable disease. The mechanisms that children manifest severe...
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Decoding the virome reveals diverse novel viruses in tree shrews (Tupaia belangeri) in Yunnan Province
June 2025
Viruses circulating in small mammals possess the potential to infect humans. Tree shrews are a group of small mammals inhabiting widely in forests and plantations, but studies on viruses in tree shrews...
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Clofazimine targeting the spike protein and RdRp exhibits highly efficient antiviral activity against porcine epidemic diarrhea virus in vitro
June 2025
Porcine epidemic diarrhea virus (PEDV) infection causes acute watery diarrhea in neonatal piglets, leading to substantial economic losses within the pig farming industry. This study demonstrates that...
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Scutellaria barbata D. Don extracts alleviate SARS-CoV-2 induced acute lung injury by inhibiting virus replication and bi-directional immune modulation
June 2025
The emergence of SARS-CoV-2 variants and drug-resistant mutants emphasizes the urgent need to develop novel antiviral agents. In the present study, we examined the therapeutic effect of the Chinese...
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