Classical swine fever virus NS5A protein antagonizes innate immune response by inhibiting the NF-κB signaling
Available online 14 September 2023
The NS5A non-structural protein of classical swine fever virus (CSFV) is a multifunctional protein involved in viral genomic replication, protein translation, assembly of infectious virus particles,...
Share article
Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia
Available online 9 September 2023
Human endogenous retroviruses (HERVs) are remnants of retroviral infections in human germline cells from millions of years ago. Among these, ERVW-1 (also known as HERV-W-ENV, ERVWE1, or ENVW) encodes...
Share article
African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction
Available online 1 September 2023
African swine fever (ASF) is originally reported in East Africa as an acute hemorrhagic fever. African swine fever virus (ASFV) is a giant and complex DNA virus with icosahedral structure and encodes...
Share article
Genomic similarity and antibody-dependent enhancement of immune serum may be two potential factors affecting the protective efficacy of commercial MLV vaccines against NADC30-like PRRSV
Available online 1 September 2023
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important diseases endangering the global pig industry. The mutation rate of PRRSV is the highest among RNA viruses. At present,...
Share article
Epizootiological surveillance of porcine circoviruses in free-ranging wild boars in China
Available online 1 September 2023
Four species of porcine circoviruses (PCV1–4) have been reported to circulate in Chinese domestic pigs, while the epizootiology of these viruses in free-ranging wild boars in China remains unknown....
Share article
Optimization and applications of an in vivo bioluminescence imaging model of influenza A virus infections
August 2023
•The in vivo BLI model of IAV infections can simplify the determination of viral load in living animals.•The in vivo BLI model of IAV infections allow longitudinal measurements of virus infection/spread...
Share article
SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria
August 2023
Autophagy plays an important role in the interaction between viruses and host cells. SARS-CoV-2 infection can disrupt the autophagy process in target cells. However, the precise molecular mechanism...
Share article
Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding
August 2023
The Dicistroviridae is a virus family that includes many insect pathogens. These viruses contain a positive-sense RNA genome that is replicated by the virally encoded RNA-dependent RNA polymerase (RdRP)...
Share article
Integrated interactome and transcriptome analysis reveals key host factors critical for SARS-CoV-2 infection
August 2023
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has seriously threatened global public health and caused huge economic losses....
Share article
Elucidating cellular interactome of chikungunya virus identifies host dependency factors
August 2023
Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. To better understand how CHIKV rewires the host cell and usurps host cell functions, we generated...
Share article
Development of PREDAC-H1pdm to model the antigenic evolution of influenza A/(H1N1) pdm09 viruses
August 2023
The Influenza A (H1N1) pdm09 virus caused a global pandemic in 2009 and has circulated seasonally ever since. As the continual genetic evolution of hemagglutinin in this virus leads to antigenic drift,...
Share article
Delta (B.1.617.2) inactivated vaccine candidate elicited neutralizing antibodies to SARS-CoV-2 and circulating variants in rhesus macaques
August 2023
•The Delta inactivated vaccine constructed in this study has high immunogenicity and good safety.•The inactivated vaccine has good cross-protection against SARS-CoV-2 variants.•The vaccine exhibited...
Share article
Construction of coxsackievirus B5 viruses with luciferase reporters and their applications in vitro and in vivo
August 2023
Coxsackievirus belongs to the Picornaviridae family and is one of the major pathogens that cause hand, foot and mouth disease (HFMD) in infants and children with potential serious complications and...
Share article
In vitro and in vivo efficacy of Molnupiravir against Zika virus infections
August 2023
•Molnupiravir exhibits effective antiviral activity against ZIKV in vitro.•Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge.•Molnupiravir might act on the replication...
Share article
A visual assay panel for the identification of monkeypox virus DNA belonging to the clades I and II
August 2023
•A MPXV visual assay panel is a rapid and reliable tool to differentiate the clades I and II within 25 min.•This panel combines RAA and immunochromatography, and detects as low as 1 copy/μL recombinant...
Share article
PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor
August 2023
Cap-dependent endonuclease (CEN) in the polymerase acidic protein (PA) of influenza A virus (IAV) represents a promising drug target due to its critical role in viral gene transcription. The CEN inhibitor,...
Share article
Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread
August 2023
•Cells infected with HSV-2 release migrasomes containing HSV-2 virions.•HSV-2 in the isolated migrasomes can be transmitted to uninfected cells and cause productive infection.•It is the first time that...
Share article
Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry
August 2023
SARS-CoV-2 variants are constantly emerging, hampering public health measures in controlling the number of infections. While it is well established that mutations in spike proteins observed for the...
Share article
STING strengthens host anti-hantaviral immunity through an interferon-independent pathway
August 2023
Hantaan virus (HTNV), the prototype virus of hantavirus, could escape innate immunity by restraining type I interferon (IFN) responses. It is largely unknown whether there existed other efficient anti-hantaviral...
Share article
A high throughput antiviral screening platform for alphaviruses based on Semliki Forest virus expressing eGFP reporter gene
August 2023
Alphaviruses, which contain a variety of mosquito-borne pathogens, are important pathogens of emerging/re-emerging infectious diseases and potential biological weapons. Currently, no specific antiviral...
Share article
Genetic characterization of rarely reported GII.3[P25] norovirus strain detected in patients with acute gastroenteritis in Huzhou, China, 2021
August 2023
•The first genome of GII.3 [P25] strain isolated in China was determined by NGS.•About 19 unique amino acid substitutions were identified in the VP1 region of GII.3 [P25].•Antigenic variation may have...
Share article
Multicenter evaluation of a simple and sensitive nucleic acid self-testing for SARS-CoV-2
August 2023
A rapid and accurate COVID-19 diagnosis is a prerequisite for blocking the source of infection as soon as possible and taking the appropriate medical action. Herein, we developed GeneClick, a device...
Share article
SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
August 2023
A key question in the coronavirus disease 2019 (COVID-19) pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) post primary...
Share article
Host cell restriction factors of equine infectious anemia virus
August 2023
Equine infectious anemia virus (EIAV) is a member of the lentivirus genus in the Retroviridae family and is considered an animal model for HIV/AIDS research. An attenuated EIAV vaccine, which was successfully...
Share article
Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host
Available online 30 August 2023
Enterovirus D68 (EV-D68) can cause respiratory diseases and acute flaccid paralysis, posing a great threat to public health. Interferons are cytokines secreted by host cells that have broad-spectrum...
Share article
