Single-cell RNA Sequencing Reveals the Diversity of the Immunological Landscape Response to Genital Herpes
Available online 18 October 2024
Genital herpes (GH) is a common sexually transmitted disease, which is primarily caused by herpes simplex virus type 2 (HSV-2), and continues to be a global health concern. Although our understanding...
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Viral load dynamics in asymptomatic and symptomatic patients during Omicron BA.2 outbreak in Shanghai, China, 2022: a longitudinal cohort study
Available online 11 October 2024
The SARS-CoV-2 virus, particularly the Omicron BA.2 variant, led to a significant surge in Shanghai, 2022. However, the viral load dynamic in Omicron infections with varying clinical severities remain...
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Generation and characterization of a novel ovariole cell line derived from Spodoptera frugiperda in China with sensitivity to both SfMNPV and AcMNPV
Available online 11 October 2024
Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), belonging to the species Alphabaculovirus spofrugiperdae, has been recently registered as an insecticide in China. This virus has a specific...
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Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening
Available online 29 September 2024
Unveiling the molecular mechanisms underlying rotavirus replication and pathogenesis has been hampered by the lack of a reverse genetics (RG) system in the past. Since 2017, multiple plasmid-based RG...
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A G3P[3] bat rotavirus can infect cultured human cholangiocytes and cause biliary atresia symptom in suckling mice
Available online 24 September 2024
•Bat rotavirus strain MSLH14 (G3P[3]) can infect human cholangiocytes in vitro.•MSLH14 can cause suckling mice biliary atresia symptom, indicating potential public health risks.•MSLH14 have the potential...
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Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71
Available online 19 September 2024
Human Enterovirus 71 (EV71) has emerged as one of the predominant causative agents of hand, foot and mouth disease (HFMD) with global impact. Despite the inactivated vaccine being licensed, other vaccine...
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A novel vesicular stomatitis virus armed with IL-2 mimic for oncolytic therapy
Available online 17 September 2024
Oncolytic virus (OV) is increasingly being recognized as a novel vector in cancer immunotherapy. Increasing evidence suggests that OV has the ability to change the immune status of tumor microenvironment,...
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Phylogenetic analyses and antigenic characterization of foot-and-mouth disease virus PanAsia lineage circulating in China between 1999 and 2023
Available online 16 September 2024
Foot-and-mouth disease (FMD) is one of the most important transboundary animal diseases caused by foot-and-mouth disease virus (FMDV), leading to significant economic losses worldwide. The first report...
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Virome-wide analysis of histone modification mimicry motifs carried by viral proteins
Available online 16 September 2024
Histone mimicry (HM) refers to the presence of short linear motifs in viral proteins that mimic critical regions of host histone proteins. These motifs have the potential to interfere with host cell...
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Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters
Available online 16 September 2024
Nipah virus (NiV) is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia. NiV leads to severe respiratory disease and encephalitis in humans and animals, with a mortality...
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A multi-center study on genetic variations in the fusion protein of respiratory syncytial virus from children with Acute Lower Respiratory Tract Infections in China during 2017–2021
Available online 13 September 2024
Respiratory syncytial virus (RSV) is a significant cause of acute lower respiratory tract infection (ALRTI) in children under five years of age. Between 2017 and 2021, 396 complete sequences of the...
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The spatiotemporal analysis of SARS-CoV-2 transmission in China since the termination of the dynamic zero-COVID policy
Available online 11 September 2024
China's dynamic zero-COVID policy has effectively curbed the spread of SARS-CoV-2, while inadvertently creating immunity gaps within its population. Subsequent surges in COVID-19 cases linked to various...
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Bis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy
Available online 7 September 2024
Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), represent a substantial public health challenge as there are currently no approved treatments available....
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Antigenic analysis of the influenza B virus hemagglutinin protein
Available online 2 September 2024
Influenza B viruses (IBVs) primarily infect humans and are a common cause of respiratory infections in humans. Here, to systematically analyze the antigenicity of the IBVs Hemagglutinin (HA) protein,...
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Structural and functional insights into the 2′-O-methyltransferase of SARS-CoV-2
August 2024
A unique feature of coronaviruses is their utilization of self-encoded nonstructural protein 16 (nsp16), 2′-O-methyltransferase (2′-O-MTase), to cap their RNAs through ribose 2′-O-methylation modification....
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Measures of insulin resistance and beta cell function before and after treatment of HCV infection
August 2024
The association between chronic HCV infection and type 2 diabetes mellitus (T2DM) has been established; however, there is limited research on β-cell function particularly in the pre-diabetic population....
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Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats
August 2024
Bats are the natural reservoir hosts for SARS-related coronavirus (SARSr-CoV) and other highly pathogenic microorganisms. Therefore, it is conceivable that an individual bat may harbor multiple microbes....
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AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase
August 2024
Hand, foot and mouth disease (HFMD), mainly caused by enterovirus 71 (EV71), has frequently occurred in the Asia-Pacific region, posing a significant threat to the health of infants and young children....
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Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual
August 2024
•Viral metagenomics analysis was conducted on samples from an HSCT recipient experiencing severe lingual papillomatosis.•Coexistence of AAV2 with AdV18 in fecal and HSV-1 in tissue samples was detected.•A...
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Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals
August 2024
The H10 subtype avian influenza virus (AIV) poses an ongoing threat to both birds and humans. Notably, fatal human cases of H10N3 and H10N8 infections have drawn public attention. In 2022, we isolated...
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The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses
August 2024
Foxes are susceptible to SARS-CoV-2 in laboratory settings, and there have also been reports of natural infections of both SARS-CoV and SARS-CoV-2 in foxes. In this study, we assessed the binding capacities...
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Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy
August 2024
The landscape of hepatitis B virus (HBV) integration in the plasma cell-free DNA (cfDNA) of HBV-infected patients with different stages of liver diseases [chronic hepatitis B (CHB), liver cirrhosis...
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Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection
August 2024
•Our study conducted a retrospective analysis of individuals with differing susceptibilities to COVID-19.•The correlation between cTfh cells and neutralizing antibodies enhances protection against SARS-CoV-2.•cTfh...
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Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch
August 2024
Lassa virus (LASV) is an enveloped, negative-sense RNA virus that causes Lassa hemorrhagic fever. Successful entry of LASV requires the viral glycoprotein 1 (GP1) to undergo a receptor switch from its...
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Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation
August 2024
Herpesviruses antagonize host antiviral responses through a myriad of molecular strategies culminating in the death of the host cells. Pseudorabies virus (PRV) is a significant veterinary pathogen in...
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