Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein
April 2025
•A neutralizing monoclonal antibody against the capsid protein of PAstV5 was prepared for the first time.•The B cell epitope of PAstV5 capsid protein was identified for the first time.•The monoclonal...
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In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs
April 2025
Porcine reproductive and respiratory syndrome (PRRS), a highly infectious immunosuppressive disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), has led to significant economic...
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Virus profiling of bronchoalveolar lavage fluid in hospitalized non-COVID-19 adult patients with pulmonary infection from November 2020 to November 2021
April 2025
Identifying the cause of respiratory tract infections is important for reducing the burden of diagnosis and treatment. To assess viral etiologies of hospitalized patients with pulmonary infection, bronchoalveolar...
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Epidemiological and molecular characteristics of human parainfluenza virus in southern China during 2016–2020
April 2025
Human parainfluenza viruses (HPIV) are common viral pathogens in acute respiratory infection (ARI). We aimed to describe the epidemiological and molecular characteristics of HPIV from ARI patients....
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Qingqi Guxue Decoction induces S cell cycle arrest to inhibit replication of severe fever with thrombocytopenia syndrome virus
April 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging acute infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), characterized by high fever and thrombocytopenia....
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Development of a reporter HBoV1 strain for antiviral drug screening and life cycle studies
April 2025
Human bocavirus 1 (HBoV1; family: Parvoviridae) causes a wide spectrum of respiratory diseases in children and gastroenteritis in adults. A lack of sensitive cell lines and efficient animal models hinders...
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Host factor Naf1 restricts HIV-1 infection of myeloid cells and compromises the capacity of dendritic cell to prime CD4+ T cell
April 2025
Naf1 (Nef-associated factor 1) is a host protein that interacts with human immunodeficiency virus type 1 (HIV-1) Nef protein. We and others have previously demonstrated that Naf1 restricts HIV-1 infection...
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The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission
April 2025
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in mutations not only in the spike protein, aiding immune evasion, but also in the NSP3/4/6 proteins, crucial...
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Structure-function insights into the dual role of African swine fever virus pB318L: A typical geranylgeranyl-diphosphate synthase and a nuclear import protein
April 2025
African swine fever virus (ASFV) pB318L is an important protein for viral replication that acts as a membrane-bound trans-geranylgeranyl-diphosphate synthase (GGPPS) catalyzing the condensation of isopentenyl...
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April 2025
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A noninfectious pseudovirus system for an emerging orthoflavivirus
Available online 23 April 2025
•A trans-complementation system for Usutu virus (USUV) recapitulates authentic viral replication.•High yield of TMN-ΔNS1 virus was obtained with no recombination into replication competent viruses.•TMN-ΔNS1...
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Coadministration of ribavirin and arenaviral entry inhibitor LHF-535 enhances antiviral benefit against authentic lassa virus
Available online 12 April 2025
•A new strain of Lassa virus (LASV) was successfully isolated and characterized.•The combination of ribavirin and LHF-535 has been demonstrated to exhibit synergistic effects in inhibiting LASV.•The...
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Scutellaria barbata D. Don extracts alleviate SARS-CoV-2 induced acute lung injury by inhibiting virus replication and bi-directional immune modulation
Available online 12 April 2025
The emergence of SARS-CoV-2 variants and drug-resistant mutants emphasizes the urgent need to develop novel antiviral agents. In the present study, we examined the therapeutic effect of the Chinese...
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Viral pseudo-enzyme facilitates KSHV lytic replication via suppressing PFAS-mediated RTA deamidation
Available online 12 April 2025
Deamidation, a type of post-translational modification commonly considered a hallmark of protein “aging” and function decay, is increasingly recognized for its pivotal role in regulating biological...
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Differential susceptibility of immunodeficient mice to MPXV infection and the impact of various inoculation routes
Available online 7 April 2025
Monkeypox virus (MPXV), a member of the Orthopoxvirus genus, caused a large-scale global outbreak in 2022. Developing mouse models for MPXV infection is crucial for advancing research on vaccines and...
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Insights into cross-species infection: Porcine epidemic diarrhea virus infections in the rodent
Available online 27 March 2025
The cross-species infection of coronaviruses has resulted in several major epidemics since 2003. Porcine epidemic diarrhea virus (PEDV) is a devastating swine enteric coronavirus, which targets pigs...
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Development and immunoprotection assessment of novel vaccines for avian infectious bronchitis virus
Available online 25 March 2025
Infectious bronchitis (IB), a highly contagious acute respiratory disease affecting avian species, poses significant challenges to poultry production. The causative agent, Infectious Bronchitis Virus...
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The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D
Available online 19 March 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of novel coronavirus disease 2019, can cause acute respiratory symptoms and even death globally. However, the immune...
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Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China
February 2025
On January 30, 2024, China announced the first human case of H10N5 influenza infection. Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution...
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The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses
February 2025
Traditional Chinese medicine has unique advantages in preventing and treating COVID-19, and Fuzheng Jiedu decoction (FZJDD) was reported to be effective against COVID-19 in clinical trials. To investigate...
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Zika virus infections and associated risk factors among pregnant women in Gombe, Nigeria
February 2025
In-utero exposure to Zika virus (ZIKV) could lead to miscarriage, preterm birth and congenital Zika syndrome. This study aimed at estimating the burden of ZIKV and Dengue virus (DENV) infections among...
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Distinct tropisms of HCMV and SARS-CoV-2 in lung tissue of a patient with advanced HIV disease
February 2025
•This report presents a rare case of co-infection with SARS-CoV-2 and HCMV in a patient with severe AIDS.•Despite suppression of SARS-CoV-2, HCMV pneumonia contributed to the patient's death.•Distinct...
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