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ISSN: 1995-820X
CN: 42-1760/Q
p-ISSN: 1674-0769

Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

Next-generation sequencing (NGS) has significantly improved the accuracy and efficiency of pathogen diagnosis for a wide range of diseases. In this study, viral metagenomics analysis was conducted on...

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Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals

The H10 subtype avian influenza virus (AIV) poses an ongoing threat to both birds and humans. Notably, fatal human cases of H10N3 and H10N8 infections have drawn public attention. In 2022, we isolated...

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The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses

Foxes are susceptible to SARS-CoV-2 in laboratory settings, and there have also been reports of natural infections of both SARS-CoV and SARS-CoV-2 in foxes. In this study, we assessed the binding capacities...

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Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy

The landscape of hepatitis B virus (HBV) integration in the plasma cell-free DNA (cfDNA) of HBV-infected patients with different stages of liver diseases [chronic hepatitis B (CHB), liver cirrhosis...

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Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection

•Our study conducted a retrospective analysis of individuals with differing susceptibilities to COVID-19.•The correlation between cTfh cells and neutralizing antibodies enhances protection against SARS-CoV-2.•cTfh...

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Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

Lassa virus (LASV) is an enveloped, negative-sense RNA virus that causes Lassa hemorrhagic fever. Successful entry of LASV requires the viral glycoprotein 1 (GP1) to undergo a receptor switch from its...

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Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation

Herpesviruses antagonize host antiviral responses through a myriad of molecular strategies culminating in the death of the host cells. Pseudorabies virus (PRV) is a significant veterinary pathogen in...

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Diverse genotypes of norovirus genogroup I and II contamination in environmental water in Thailand during the COVID-19 outbreak from 2020 to 2022

Noroviruses (NoVs) are the most significant viral pathogens associated with waterborne and foodborne outbreaks of nonbacterial acute gastroenteritis in humans worldwide. This study aimed to investigate...

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Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai, China, 2022

•The first report of serological characteristics of HFMD associated enteroviruses in Shanghai after the COVID-19 epidemic.•The seroprevalence of protective NtAbs against Coxsackieviruses was low within...

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First complete genomic sequence analysis of canine distemper virus in wild boar

•The first complete genomic sequence of canine distemper virus from wild boar in northeast China was obtained.•Phylogenetic analysis showed that this wild boar CDV strain belongs to the Arctic lineage.•Wild...

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NSUN2 mediates distinct pathways to regulate enterovirus 71 replication

Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function...

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Design of antiviral AGO2-dependent short hairpin RNAs

The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals. RNA interference (RNAi) is a sequence-specific gene silencing mechanism that...

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Coxsackievirus B3 HFMD animal models in Syrian hamster and rhesus monkey

Coxsackievirus B3 (CVB3) is the pathogen causing hand, foot and mouth disease (HFMD), which manifests across a spectrum of clinical severity from mild to severe. However, CVB3-infected mouse models...

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Viromes of Haemaphysalis longicornis reveal different viral abundance and diversity in free and engorged ticks

Haemaphysalis longicornis ticks, commonly found in East Asia, can transmit various pathogenic viruses, including the severe fever with thrombocytopenia syndrome virus (SFTSV) that has caused febrile...

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Isolation and characterization of mpox virus from the first mpox case in Shenzhen, China

•We reported the first MPXV strain hMpxV/China/SZ-SZTH42/2023 isolated in southern China.•The isolate SZTH42 belongs to C.1 lineage of clade IIb, representing the currently prevalent IIb branch strain...

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Non-proteolytic ubiquitination of HBx controls HBV replication

•The expression level of TRIM21 in patients is negatively correlated with the replication and integration of HBV.•TRIM21 was found to trigger non-proteolytic ubiquitination of X protein of HBV.•This...

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Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population

•Single-nucleotide polymorphisms in critical patients with COVID-19 conducted worldwide are validated in Chinese population.•Variants in DPP9 and near RNU2-47P and TYRP1 show the strongest associated...

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Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection

Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered a lower expression of antiviral factors, such as IFN-β, STING and IFI16, in the brain tissues...

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The evolution, pathogenicity and transmissibility of quadruple reassortant H1N2 swine influenza virus in China: A potential threat to public health

Swine are regarded as “intermediate hosts” or “mixing vessels” of influenza viruses, capable of generating strains with pandemic potential. From 2020 to 2021, we conducted surveillance on swine H1N2...

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Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of COVID-19. Our research, along with others', has demonstrated that mast cells (MCs) play a vital role in the initiation of...

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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

•Full-length genome sequences of reassortant swine influenza A(H1N2) virus from domestic pigs in Hong Kong SAR.•These swine influenza A(H1N2) viruses are closely related with those circulating in Taiwan.•Swine...

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C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus

Influenza A virus (IAV) binds sialic acid receptors on the cell surface to enter the host cells, which is the key step in initiating infection, transmission and pathogenesis. Understanding the factors...

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