Thermal tolerance and inactivation of Ebola virus
August 2025
•The investigation demonstrated a high level of tolerance of EBOV to thermal disinfection.•A water-bath is recommended and the tubes should be fully submerged during the process.•The established inactivation...
Isolation and phylogenetic analysis of swinepox virus from pigs in China
August 2025
•This study presents the first characterization and analysis of key host genes of SWPV from the Chinese lineage.•A SWPV strain (SWPV/AH/China/2024) was successfully isolated.•Genetic analysis shows...
Quercetin inhibits herpes simplex virus 1 replication in corneal epithelium and suppresses keratitis progression
August 2025
Quercetin is a natural compound with potent antiviral effects; however, its role in the treatment of herpes simplex keratitis (HSK) remains underexplored. Here, we investigated the antiviral effects...
ARRDC3 promotes lysosome-mediated YAP degradation to inhibit enterovirus replication
August 2025
Enterovirus D68 (EV-D68) and enterovirus A71 (EV-A71) are two major types of enteroviruses that pose emerging challenges to public health and have the potential to cause outbreaks, yet their pathogenic...
Co-circulation of all four DENV serotypes during 2016 outbreak in Sinaloa, Mexico: First report of DENV-4 in patients
August 2025
•The serotype with the highest incidence during the 2016 dengue outbreak in Sinaloa was DENV-2, followed by DENV-4.•This study represents the first report of the DENV-4 serotype in Sinaloa, Mexico,...
Epidemiological and genomic surveillance of influenza A virus (pdm09 H1N1 and H3N2) strains from 2017 to 2025 in Tianjin, China
August 2025
Influenza A virus (IAV) remains a global public health concern, causing influenza-like illness and severe respiratory tract infections. Two major subtypes, A/pdm09 H1N1 and A/H3N2, circulate globally,...
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August 2025
The 16th national virology symposium concludes: Sustaining academic exchanges and innovations in China's virology
Available online 29 August 2025
Bibliometric analysis of global research output on viral vaccines and antivirals in the 21st century
Available online 26 August 2025
•A total of over 190,000 SCIE-indexed research papers focusing on viral vaccines and antiviral drugs were systematically retrieved for the period 2000–2024.•Article counts show a steady annual growth...
Adaptor protein complex 1 gamma 1 subunit is an important host factor involved in both Zika virus and dengue virus infections
Available online 5 August 2025
Mosquito-borne flaviviruses, such as Zika virus (ZIKV) and dengue virus (DENV), cause diverse severe clinical manifestations including fever, rash, hepatitis, arthralgia, and congenital anomalies. Here,...
Black swans as sentinel species for the emergence of clade 2.3.4.4b highly pathogenic avian influenza (H5N1) in Shanghai, China, 2024
Available online 19 July 2025
•A novel reassortant H5N1 virus detected in 15 sick black swans in Shanghai, China.•Novel H5N1 virus in black swans suggests wild-domestic bird reassortant from East Asia.•Susceptible black swans could...
SNX10 enhances HCoV-OC43 infection by facilitating viral entry and inhibiting virus-triggered autophagy
Available online 9 July 2025
The ongoing coronavirus epidemic, including the novel coronavirus (SARS-CoV-2), continues to pose a significant threat to global public health. Host targets address multiple stages of the viral life...
Characterization of a SARS-CoV-2 infection model in golden hamsters with diabetes mellitus
June 2025
Being widespread across the globe, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and generating new variants and continuously poses threat to public health, especially...
Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc
June 2025
Crimean-Congo hemorrhagic fever (CCHF) is a hemorrhagic fever caused by infection with the CCHF virus (CCHFV) and has a mortality rate of up to 30 %. Thrombocytopenia is a hallmark of CCHF; however,...
Mutational landscapes of NITD008-resistant EV71 variants revealed through population sequencing
June 2025
•The mutation spectra between WT population and NITD008-resistant populations during replication are compared.•The 2C protein may be a new target of NITD008 as a nucleotide analogue against EV71 infection.•Antiviral...
Compromised efferocytosis during aging is related to COVID-19 severity in mice
June 2025
Aging is one of the greatest risk factors for morbidity caused by the coronavirus disease 2019 (COVID-19). In older individuals, a dysregulated immune response to severe acute respiratory syndrome coronavirus...
Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia
June 2025
The human endogenous retrovirus type W envelope glycoprotein (ERVWE1), located at chromosome 7q21–22, has been implicated in the pathophysiology of schizophrenia. Our previous studies have shown elevated...
Severe enterovirus A71 infection is associated with dysfunction of T cell immune response and alleviated by Astragaloside A
June 2025
Enterovirus A71 (EV-A71) is the major causative pathogen for severe hand-foot-mouth disease (HFMD), a predominantly childhood-associated communicable disease. The mechanisms that children manifest severe...
Differential susceptibility of immunodeficient mice to MPXV infection and the impact of various inoculation routes
June 2025
Monkeypox virus (MPXV), a member of the Orthopoxvirus genus, caused a large-scale global outbreak in 2022. Developing mouse models for MPXV infection is crucial for advancing research on vaccines and...
Insights into cross-species infection: Porcine epidemic diarrhea virus infections in the rodent
June 2025
The cross-species infection of coronaviruses has resulted in several major epidemics since 2003. Porcine epidemic diarrhea virus (PEDV) is a devastating swine enteric coronavirus, which targets pigs...
The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D
June 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of novel coronavirus disease 2019, can cause acute respiratory symptoms and even death globally. However, the immune...
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June 2025