Metatranscriptomics profiling reveals rodent- and shrew-borne viral diversity and evolutionary relationships in Guangzhou, China
Available online 17 December 2025
Emerging zoonotic infectious diseases, predominantly caused by viruses, pose increasing public health threats globally. Rodents and shrews are natural hosts for a variety of zoonotic viruses. Guangzhou...
Crimean-Congo hemorrhagic fever: An emerging threat in Europe
Available online 15 December 2025
Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is endemic in Africa, Asia, and Europe. However, CCHF epidemiology and epizootiology have been poorly...
Genomic assembly, rescue, and characterization of a functional pseudorabies virus
Available online 28 November 2025
With recent advances in synthetic biology methods, the genomes of several large DNA viruses have been de novo synthesized and assembled, leading to the functional rescue of the respective viruses. Pseudorabies...
SNX10 enhances HCoV-OC43 infection by facilitating viral entry and inhibiting virus-triggered autophagy
October 2025
The ongoing coronavirus epidemic, including the novel coronavirus (SARS-CoV-2), continues to pose a significant threat to global public health. Host targets address multiple stages of the viral life...
Black swans as sentinel species for the emergence of clade 2.3.4.4b highly pathogenic avian influenza (H5N1) in Shanghai, China, 2024
October 2025
•A novel reassortant H5N1 virus detected in 15 sick black swans in Shanghai, China.•Novel H5N1 virus in black swans suggests wild-domestic bird reassortant from East Asia.•Susceptible black swans could...
The 16th national virology symposium concludes: Sustaining academic exchanges and innovations in China's virology
October 2025
Ubiquitously expressed transcript isoform 2 (UXT-V2) restricts HSV-2 replication by targeting glycoprotein B for degradation through ubiquitin-proteasome pathway
October 2025
Herpes simplex virus 2 (HSV-2) is a major pathogen causing neonatal herpes and increasing the risk of human immunodeficiency virus 1 (HIV-1) infection. However, the mechanisms underlying host restriction...
Antigenic and structural insights into Langya henipavirus attachment glycoprotein
October 2025
The invasion of host cells by the henipavirus is facilitated through the interaction between viral attachment (G) and fusion (F) glycoproteins with receptors on the cell surface. Langya henipavirus...
A safe and broad-spectrum SARS-CoV-2 mRNA vaccine with a new delivery system for in-situ expression
October 2025
Since the outbreak of COVID-19 in late 2019, the cumulative number of confirmed cases worldwide has surpassed 778 million, and the number of deaths has exceeded 7 million, posing a significant threat...
Antisera and antivirals targeting the conserved domains in SARS-CoV-2 S2 subunit are effective against ACE2-using MERSr-CoVs with spillover potential
October 2025
•S2 subunit remains high conserved throughout coronavirus evolution.•BA.5/BF.7-infection induces weak cross-immune response against MERS-related coronaviruses (MERSr-CoVs) in humans.•HR1LS based on...
Genetic analysis of human adenovirus type 108 circulating in China during 2014–2024
October 2025
Human adenovirus type 108 (HAdV-108) has been detected in multiple countries, including China, and is associated with severe acute respiratory infection (ARI) in children, with reported fatalities....
Long-term surveillance of avian avulavirus in wild birds in China from 2003 to 2020
October 2025
Avian avulavirus (AAVV) is a significant pathogen affecting avian species, but research on its prevalence in wild birds in China has been relatively limited. In this study, active surveillance for AAVV...
First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation
October 2025
•This is the first identification of Tusavirus in calf tissue in China, expanding its host species and geographical range.•Genomic analysis reveals conservation, with nucleotide insertions in the VP1...
The pathogenic role and genomic characteristics of Epstein-Barr virus in vitreoretinal lymphoma
October 2025
Epstein-Barr virus (EBV) infection is well-known for its association with lymphoproliferative disorders and various lymphomas, causing significant global morbidity and mortality. EBV-positive vitreoretinal...
HBV and host metabolic crosstalk: Reprogramming pathways for viral replication and pathogenesis
October 2025
Hepatitis B virus (HBV) establishes chronic infection through strategic manipulation of host metabolic networks, driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular...
Phylogenomics and structural modelling feature accelerated evolution of Oropouche virus: 1955 to 2024
October 2025
A large multi-country outbreak of Oropouche virus (OROV), a segmented negative-sense RNA virus, is emerging in Latin America. By analyzing publicly available whole-genome sequences spanning 1955 to...
Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening
October 2025
Tick-borne encephalitis virus (TBEV) is a re-emerging pathogen in Kazakhstan, where the increasing risk of its spread underscores the need for improved healthcare preparedness, including the development...
African swine fever virus MGF360-9L degrades DDX20 through the Rab1A-dependent autophagy pathway to antagonize its antiviral effect
October 2025
African swine fever (ASF) is an acute, hemorrhagic, and highly contagious disease in pigs caused by the African swine fever virus (ASFV). Our previous studies have demonstrated that deletion of the...
Seasonal dynamics of hedgehog-borne ticks and severe fever with thrombocytopenia syndrome virus in Beijing's urban parks
October 2025
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne pathogen, has caused a rising number of human cases in the urban-rural fringe of Beijing since 2021. This study explores...
Efficacy and safety of switching from lopinavir/ritonavir-based regimens to bictegravir/emtricitabine/tenofovir alafenamide in people living with HIV: A multicenter retrospective study
October 2025
In China, approximately 13% of people living with human immunodeficiency virus (HIV) (PLWH) are receiving lopinavir/ritonavir (LPV/r)-based regimens. These PLWH typically have a history of either treatment...
Oncolytic Newcastle disease virus promotes tumor cell death via the anoikis effector Bit1 translocation
October 2025
Anoikis is a specialized form of programmed cell death triggered by the detachment of cells from the extracellular matrix (ECM). Tumor cells that develop resistance to anoikis acquire the ability to...
Issue Cover
October 2025