Evidence of human exposure to tick-borne viruses based on viromes of ticks and presence of specific antibodies among patients in Hainan Island, southern China
February 2026
Hainan Island, located in the South China Sea, is known as an area with diseases related to Rickettsia spp. or spirochete infection; however, the potential threat there from infection with tick-borne...
GlycoRNAs: Biological functions and novel antiviral targets
February 2026
•GlycoRNAs on host cell surfaces serve as adhesive molecules for viral internalization.•GlycoRNAs may interact with immunomodulatory receptors and facilitate immune recognition and responses.•Targeting...
Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus
February 2026
Swine enteric coronaviruses (SECoVs) cause severe watery diarrhea and high mortality in piglets, resulting in significant economic losses to the global pig industry. However, frequent mutations in SECoVs...
Genomic assembly, rescue, and characterization of a functional pseudorabies virus
February 2026
With recent advances in synthetic biology methods, the genomes of several large DNA viruses have been de novo synthesized and assembled, leading to the functional rescue of the respective viruses. Pseudorabies...
Issue Cover
February 2026
The effectiveness of two doses of Hecolin vaccine in response to outbreaks in resource-limited settings
December 2025
•The use of Hecolin vaccine with a 2-dose schedule can replace the 3-dose schedule during campaigns in HEV outbreak settings.•Vaccination against hepatitis E during pregnancy may be feasible.•A single...
Topoisomerase IIα orchestrates secretion of IL-6 and IL-8 with human papillomavirus replication
December 2025
High-risk human papillomavirus (HPV) replication requires deregulation of host DNA damage response (DDR) and inflammatory pathways. DNA topoisomerase 2β (Top2β) was previously shown to promote HPV replication....
Structural polymorphism of two-dimensional lattices assembled from baculoviral capsid proteins
December 2025
Protein nanotubes (PNTs) can be regarded as two-dimensional (2D) lattices with p1 or p2 symmetry rolled into tubes. However, attempts to re-assemble their building blocks into stable 2D nanomaterials...
A dual monoclonal antibody-based sandwich ELISA for detection of potent vaccine immunogen against Coxsackievirus B1
December 2025
•The developed quantitative double-antibody sandwich ELISA supports the vaccine development, production, and quality control of CVB1 vaccine.•This method enables real-time monitoring of mature virion...
Thapsigargin suppresses porcine hemagglutinating encephalomyelitis virus replication by disrupting host energy metabolism
December 2025
Coronaviruses (CoVs) are a large family of human and animal pathogens that cause significant health and economic burdens worldwide. Thapsigargin (Tg) is a plant-derived sesquiterpene lactone with potent...
Improvement in UV resistance of entomopathogenic viruses by coating silica nanoparticles on occlusion bodies surface
December 2025
Entomopathogenic viruses, such as baculoviruses and cypoviruses, have been employed as biological pesticides against agricultural and forestry pests. However, their susceptibility to inactivation under...
Antiviral agents for dengue virus
December 2025
Dengue virus (DENV) is a mosquito-borne pathogen responsible for a spectrum of illnesses, including dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Nearly half of the global population...
Specific and visual detection of EBOV based on a one-pot RT-RAA-CRISPR/Cas12a assay
December 2025
•The one-pot RT-RAA-CRISPR/Cas12a assay for EBOV has single-copy resolution within 40 min.•This assay targeting the VP40 gene has high specificity for EBOV and no cross-reaction with SUDV.•This one-pot...
Neutralization of Crimean-Congo hemorrhagic fever pseudotyped virions with heavy chain antibodies
December 2025
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus that causes severe hemorrhagic fever with high mortality rates in humans. No licensed vaccines or efficacious antiviral...
Ubiquitin-specific protease 5 promotes EV-A71 replication by de-ubiquitinating MAVS and IRF3
December 2025
Human enterovirus A71 (EV-A71) is a major causative agent of hand, foot and mouth disease (HFMD), which poses a significant public health threat, particularly among young children. Mitochondrial antiviral...
Predicting mortality risk of severe fever with thrombocytopenia syndrome: A multi-center retrospective cohort study
December 2025
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with high mortality, and clinical practice lacks dynamic tools to assess its rapidly evolving course. This study...
An adenovirus-vectored recombinant vaccine confers passive immunity protection from swine acute diarrhea syndrome coronavirus challenge in neonatal mice
December 2025
Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging bat-origin Alphacoronavirus with demonstrated zoonotic potential, poses a significant threat to swine health and has considerable economic...
Deep data-independent acquisition-based plasma proteomic profiling unveils distinct molecular features in dengue fever with neutropenia
December 2025
Dengue virus (DENV) remains a pervasive global health threat, further complicated by the occurrence of neutropenia—a distinct clinical feature indicative of an altered host immune response, closely...
Meta-transcriptomic analysis of tick virome diversity and ecological characteristics in Yunnan Province, southwestern China
December 2025
Emerging tick-borne viruses are posing an increasing health concern. However, there is limited knowledge about the distribution characteristics of tick virome in Yunnan Province, southwestern China,...
Adaptor protein complex 1 gamma 1 subunit is an important host factor involved in both Zika virus and dengue virus infections
December 2025
Mosquito-borne flaviviruses, such as Zika virus (ZIKV) and dengue virus (DENV), cause diverse severe clinical manifestations including fever, rash, hepatitis, arthralgia, and congenital anomalies. Here,...
Bibliometric analysis of global research output on viral vaccines and antivirals in the 21st century
December 2025
•A total of over 190,000 SCIE-indexed research papers focusing on viral vaccines and antiviral drugs were systematically retrieved for the period 2000–2024.•Article counts show a steady annual growth...
2025 Reviewer Acknowledgment
December 2025