Differential susceptibility of immunodeficient mice to MPXV infection and the impact of various inoculation routes
June 2025
Monkeypox virus (MPXV), a member of the Orthopoxvirus genus, caused a large-scale global outbreak in 2022. Developing mouse models for MPXV infection is crucial for advancing research on vaccines and...
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Insights into cross-species infection: Porcine epidemic diarrhea virus infections in the rodent
June 2025
The cross-species infection of coronaviruses has resulted in several major epidemics since 2003. Porcine epidemic diarrhea virus (PEDV) is a devastating swine enteric coronavirus, which targets pigs...
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The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D
June 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of novel coronavirus disease 2019, can cause acute respiratory symptoms and even death globally. However, the immune...
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Viral pseudo-enzyme facilitates KSHV lytic replication via suppressing PFAS-mediated RTA deamidation
June 2025
Deamidation, a type of post-translational modification commonly considered a hallmark of protein “aging” and function decay, is increasingly recognized for its pivotal role in regulating biological...
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Development and immunoprotection assessment of novel vaccines for avian infectious bronchitis virus
June 2025
Infectious bronchitis (IB), a highly contagious acute respiratory disease affecting avian species, poses significant challenges to poultry production. The causative agent, infectious bronchitis virus...
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Isolation and identification of a newly discovered broad-spectrum Acinetobacter baumannii phage and therapeutic validation against pan-resistant Acinetobacter baumannii
Available online 27 June 2025
The treatment of Acinetobacter baumannii (A. baumannii) poses significant clinical challenges due to its multidrug/pan-drug resistance. In this study, we isolated a broad-spectrum lytic A. baumannii...
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First isolation and genomic characterization of a novel inter-genotype recombinant feline calicivirus from domestic cats: implications for viral evolution
Available online 27 June 2025
•Two strains of FCV with distinct genotypes were successfully isolated and identified.•First identification of recombination between GI and GII.•Significant antigenic cross-reactivity with traditional...
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Identification of PEDV inhibitors targeting 3CL protease
Available online 27 June 2025
Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is a highly contagious gastrointestinal disease characterized by vomiting, diarrhea, and dehydration, with mortality...
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Virome diversity in small mammals from south China: insights into virus evolution, transmission, and ecology
Available online 27 June 2025
Mammals are critical reservoirs of human infectious diseases and the spillover of viruses is related to climate conditions. We conducted meta-transcriptomic sequencing of 226 mammals (bats, rodents,...
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The slow progression of Japanese encephalitis in aged mice is likely associated to B cell recruitment in the brain
Available online 3 June 2025
The Japanese encephalitis virus (JEV) causes Japanese encephalitis (JE), a severe disease that primarily affects children and induces significant central nervous system complications. With the widespread...
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Evaluating the performance of the PREDAC method in flu vaccine recommendations over the past decade (2013–2023)
April 2025
•PREDAC is a semi-automated and user-friendly method for flu vaccine recommendations based on HA protein sequences.•PREDAC performed comparably to the WHO in recommending vaccines of influenza A(H3N2)...
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Zika virus transmission in Aedes aegypti: A systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically
April 2025
Zika virus (ZIKV) is a mosquito-borne virus belonging to the genus Orthoflavivirus, and the family Flaviviridae. It commonly presents with febrile-like symptoms, neurological issues, and pregnancy complications...
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Phylogenitc analysis and immunogenicity comparison of porcine genotype G9 rotavirus in China from 2020–2023
April 2025
As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, and have been reported in many countries and regions in the recent years. Moreover, porcine G9 strains...
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Identification and genetic analysis of new ephemeroviruses in wild boars in China
April 2025
Ephemeroviruses (EVs) are arthropod-borne rhabdoviruses and were isolated exclusively from cattle and haematophagous arthropods until two new ephemeroviruses were first identified from domestic pigs...
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Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription
April 2025
•SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level.•SMPD3 knockdown enhances HBV replication in various cell models, increasing...
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Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein
April 2025
•A neutralizing monoclonal antibody against the capsid protein of PAstV5 was prepared for the first time.•The B cell epitope of PAstV5 capsid protein was identified for the first time.•The monoclonal...
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Virus profiling of bronchoalveolar lavage fluid in hospitalized non-COVID-19 adult patients with pulmonary infection from November 2020 to November 2021
April 2025
Identifying the cause of respiratory tract infections is important for reducing the burden of diagnosis and treatment. To assess viral etiologies of hospitalized patients with pulmonary infection, bronchoalveolar...
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Qingqi Guxue Decoction induces S cell cycle arrest to inhibit replication of severe fever with thrombocytopenia syndrome virus
April 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging acute infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), characterized by high fever and thrombocytopenia....
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Development of a reporter HBoV1 strain for antiviral drug screening and life cycle studies
April 2025
Human bocavirus 1 (HBoV1; family: Parvoviridae) causes a wide spectrum of respiratory diseases in children and gastroenteritis in adults. A lack of sensitive cell lines and efficient animal models hinders...
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Host factor Naf1 restricts HIV-1 infection of myeloid cells and compromises the capacity of dendritic cell to prime CD4+ T cell
April 2025
Naf1 (Nef-associated factor 1) is a host protein that interacts with human immunodeficiency virus type 1 (HIV-1) Nef protein. We and others have previously demonstrated that Naf1 restricts HIV-1 infection...
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The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission
April 2025
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in mutations not only in the spike protein, aiding immune evasion, but also in the NSP3/4/6 proteins, crucial...
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Structure-function insights into the dual role of African swine fever virus pB318L: A typical geranylgeranyl-diphosphate synthase and a nuclear import protein
April 2025
African swine fever virus (ASFV) pB318L is an important protein for viral replication that acts as a membrane-bound trans-geranylgeranyl-diphosphate synthase (GGPPS) catalyzing the condensation of isopentenyl...
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April 2025
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