Comparative analysis between genotypes of adenovirus isolates from hospitalized children with acute respiratory tract infections and clinical manifestations in Wuhan, China, from June 2022 to September 2023
February 2025
Acute respiratory tract infections (ARTIs) are among the leading causes of morbidity and mortality in children worldwide. Human adenovirus (HAdV) infections are estimated to account for at least 5%...
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The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses
February 2025
Traditional Chinese medicine has unique advantages in preventing and treating COVID-19, and Fuzheng Jiedu decoction (FZJDD) was reported to be effective against COVID-19 in clinical trials. To investigate...
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CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB
February 2025
Virus-encoding RNA-dependent RNA polymerase (RdRp) is essential for genome replication and gene transcription of human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus...
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A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity
February 2025
Influenza, a highly contagious respiratory infectious disease caused by an influenza virus, is a threat to public health worldwide. Avian influenza viruses (AIVs) have the potential to cause the next...
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Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus
February 2025
A switch from avian-type α-2,3 to human-type α-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus. Some H9N2 viruses exhibit a preference for binding...
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Patterns of liver fibrosis evolution in Chinese HIV/HBV co-infected adults following 5-year antiretroviral treatment: A longitudinal study using non-invasive APRI and Fib-4 scores
February 2025
The long-term effects of combined antiretroviral therapy (ART) on liver fibrosis patterns in adults living with human immunodeficiency virus (HIV) and chronic hepatitis B virus (HBV) are not well understood....
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Zika virus infections and associated risk factors among pregnant women in Gombe, Nigeria
February 2025
In-utero exposure to Zika virus (ZIKV) could lead to miscarriage, preterm birth and congenital Zika syndrome. This study aimed at estimating the burden of ZIKV and Dengue virus (DENV) infections among...
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Geographical distribution and characterization of Jingmen tick virus in wild boars in China
February 2025
•JMTV RNA was identified in 9 out of 26 provinces with an average wild boar infection rate of 5.45% (25/459).•Phylogenetic analysis indicated that JMTV strains could be divided into two groups, but...
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Distinct tropisms of HCMV and SARS-CoV-2 in lung tissue of a patient with advanced HIV disease
February 2025
•This report presents a rare case of co-infection with SARS-CoV-2 and HCMV in a patient with severe AIDS.•Despite suppression of SARS-CoV-2, HCMV pneumonia contributed to the patient's death.•Distinct...
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February 2025
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Antigenic analysis of the influenza B virus hemagglutinin protein
February 2025
Influenza B viruses (IBVs) primarily infect humans and are a common cause of respiratory infections in humans. Here, to systematically analyze the antigenicity of the IBVs Hemagglutinin (HA) protein,...
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Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription
Available online 27 February 2025
•SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level.•SMPD3 knockdown enhances HBV replication in various cell models, increasing...
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Phylogenitc analysis and immunogenicity comparison of porcine genotype G9 rotavirus in China from 2020–2023
Available online 21 February 2025
As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, and have been reported in many countries and regions in the recent years. Moreover, porcine G9 strains...
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Identification and genetic analysis of new ephemeroviruses in wild boars in China
Available online 15 February 2025
Ephemeroviruses (EVs) are arthropod-borne rhabdoviruses and were isolated exclusively from cattle and haematophagous arthropods until two new ephemeroviruses were first identified from domestic pigs...
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Zika virus transmission in Aedes aegypti: A systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically
Available online 11 February 2025
Zika virus (ZIKV) is a mosquito-borne virus belonging to the genus Orthoflavivirus, and the family Flaviviridae. It commonly presents with febrile-like symptoms, neurological issues, and pregnancy complications...
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Evaluating the performance of the PREDAC method in flu vaccine recommendations over the past decade (2013–2023)
Available online 28 January 2025
•PREDAC is a semi-automated and user-friendly method for flu vaccine recommendations based on HA protein sequences.•PREDAC performed comparably to the WHO in recommending vaccines of influenza A(H3N2)...
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Current antiviral therapies and promising drug candidates against respiratory syncytial virus infection
Available online 28 January 2025
Respiratory syncytial virus (RSV) is one of the most common viruses leading to lower respiratory tract infections (LRTIs) in children and elderly individuals worldwide. Although significant progress...
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Characterization of novel highly pathogenic avian influenza A(H5N6) clade 2.3.4.4b virus in wild birds, East China, 2024
Available online 21 January 2025
•We reported a novel H5N6 HPAIV belonging to clade 2.3.4.4b in wild birds in eastern China.•The novel H5N6 HPAIV most likely descended from clade 2.3.4.4b H5N1 virus in Japan.•The novel H5N6 HPAIV evolved...
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A G3P[3] bat rotavirus can infect cultured human cholangiocytes and cause biliary atresia symptom in suckling mice
December 2024
•Bat rotavirus strain MSLH14 (G3P[3]) can infect human cholangiocytes in vitro.•MSLH14 can cause suckling mice biliary atresia symptom, indicating potential public health risks.•MSLH14 have the potential...
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Viral load dynamics in asymptomatic and symptomatic patients during Omicron BA.2 outbreak in Shanghai, China, 2022: A longitudinal cohort study
December 2024
The SARS-CoV-2 virus, particularly the Omicron BA.2 variant, led to a significant surge in Shanghai, 2022. However, the viral load dynamic in Omicron infections with varying clinical severities remain...
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Generation and characterization of a novel ovariole cell line derived from Spodoptera frugiperda in China with sensitivity to both SfMNPV and AcMNPV
December 2024
Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), belonging to the species Alphabaculovirus spofrugiperdae, has been recently registered as an insecticide in China. This virus has a specific...
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Modulation of the unfolded protein response by white spot syndrome virus via wsv406 targeting BiP to facilitate viral replication
December 2024
Outbreaks of diseases are often linked to environmental stress, which can lead to endoplasmic reticulum (ER) stress and subsequently trigger the unfolded protein response (UPR). The replication of the...
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December 2024
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