SFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication
October 2026
SFTSV (Severe fever with thrombocytopenia syndrome virus) causes severe febrile illness with high case fatality rates and poses a growing public health threat, while the molecular basis by which it...
Epidemiology-guided discovery of a K1-specific lytic phage with therapeutic potential against ST23-K1 multidrug-resistant hypervirulent Klebsiella pneumoniae
October 2026
Phage therapy has emerged as a promising alternative for combating multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) infections. Recent advances suggest that tailoring phage cocktails...
SwiVirScan, a high-throughput platform for profiling antibodies to swine-associated viruses, reveals extensive viral exposure histories in pigs
October 2026
Pigs are crucial as food sources, biomedical models, and reservoirs of some zoonotic viruses, yet their comprehensive viral exposure history remains poorly understood. Here, we developed SwiVirScan,...
Multiomics reveals alterations in the gut microbiome, host proteins, and host metabolites correlating with SADS-CoV pathogenicity and the immune response in piglets
October 2026
Swine acute diarrhea syndrome coronavirus (SADS-CoV) infection causes severe acute diarrhea, vomiting, and lethality in piglets. To explore the molecular mechanisms by which intestinal flora regulate...
Recurrent intrahost G-gene haplotype structures suggest potential co-transmission in RSV-A
October 2026
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization worldwide. Its molecular epidemiology rests on consensus G-gene sequences, which capture only the dominant virus in each...
Monocyte-associated C1q upregulation and complement activation contribute to vascular endothelial and multi-organ injury in severe dengue
October 2026
Dengue virus (DENV) infection causes a broad spectrum of clinical manifestations, ranging from self-limiting dengue fever (DF) to life-threatening severe dengue (SD). Increased vascular permeability...
A dual-glycoprotein-targeting bispecific nanoantibody confers potent neutralization against Nipah virus
October 2026
Nipah virus (NiV) is a biosafety level 4 pathogen that has consistently posed a significant threat to public health. The two envelope proteins on the viral surface, the receptor-binding protein (RBP)...
Ferritin nanoparticle-based vaccine enhances mucosal immunity by promoting antigen uptake and activation of alveolar macrophages
October 2026
•Ferritin nanoparticle-displayed mosaic tandem-RBD enhances respiratory mucosal immunity.•Intranasal immunization induces broad neutralizing antibodies and tissue-resident immune populations.•Nanoparticles...
ZNF598 enhances FAT10-mediated non-covalent stabilization of Tat to promote HIV-1 transcription and replication
October 2026
Human immunodeficiency virus type 1 (HIV-1) Tat is essential for efficient viral transcription and replication, and its stability is tightly controlled by host factors. In our previous study, we showed...
Issue Cover
October 2026
The HSV-1 US1 gene product targets the histone chaperone ASF1 to suppress H3K9 acetylation
Available online 31 October 2026
It is commonly known that the Herpes simplex virus type 1 (HSV-1) manipulates host gene expression to facilitate its reproduction. HSV-1 regulates host and viral transcription through coordinated effects...
Establishment of a tandem dimeric replication system for torque teno virus in vitro
Available online 23 September 2026
•Successfully constructed tandem dimeric recombinant plasmids of Torque teno virus (TTV).•TTV dimeric clone possesses robust transcriptional and translational activity and supports viral capsid assembly.•TTV...
Update on BA.3.2 epidemiology: Evidence for co-circulation and preferential infection of children
Available online 11 September 2026
•BA.3.2 preferentially infects children.•BA.3.2 cocirculates rather than dominating.•Inactivation of ORF7a is unlikely to account for the preferential infection of children....
Retinoic acid is a translation inhibitor against chikungunya virus both in vitro and invivo
August 2026
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes debilitating febrile and arthritic disease and remains a persistent public health threat in tropical and subtropical regions, with no clinically...
Recent progress in anti-Chikungunya virus drug discovery: Focus on the viral life cycle and direct-acting antivirals
August 2026
Chikungunya virus (CHIKV) belongs to the genus Alphavirus of the family Togaviridae. CHIKV infection generally causes severe clinical symptoms, including debilitating arthralgia, fever, hemorrhage and...
The C-terminal T234 residue of VP3 is required for KREMEN1 receptor-dependent infectivity and pathogenesis of coxsackieviruses A10 and A8
August 2026
Coxsackievirus A10 (CVA10) is a major causative agent of hand, foot and mouth disease and utilizes KREMEN1 (KRM1) as its cellular receptor. While our previous work identifies VP2 residue K140 as a universal...
Effectiveness of lignans against severe fever with thrombocytopenia syndrome virus infection
August 2026
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes a life-threatening infectious disease with high mortality. Currently, there are no approved...
Whole-genome evolutionary dynamics of human parainfluenza virus type 3 in Shanghai, China, 2016–2024
August 2026
•Fifty whole-genome sequencing revealed co-circulating HPIV-3 C3 sub-lineages C3f and C3a in Shanghai, China.•Whole-genome phylogeny dated the HPIV-3 tMRCA to ∼1925.6 and revealed two post-1990 demographic...
Hidden diversity of coronaviruses in high-altitude plateau mammals
August 2026
•Pikas and marmots from plateaus host divergent α- and β-CoVs, including the candidate subgenera Pibecovirus and Mabecovirus.•The plateau CoVs show distinctive genomic features (relocated HE gene, variable...
The antiviral role of TRIM25 in mammalian embryonic stem cells
August 2026
Mammalian embryonic stem cells (ESCs), despite lacking functional interferon (IFN) signaling, are remarkably resistant to viral infection. However, the mechanistic basis of their antiviral defenses...
Genetic heterogeneity and pathogenic potential of historical Crimean-Congo hemorrhagic fever virus isolates in China
August 2026
The Crimean-Congo hemorrhagic fever virus (CCHFV) poses a significant public health threat. In China, CCHFV has been circulating for decades, yet the genomic diversity and pathogenic potential of the...
Pre-existing hemagglutinin-specific antibody levels are associated with B-cell repertoire maturation and antibody breadth after influenza vaccination
August 2026
Repeated influenza exposures generate complex antibody landscapes, yet how pre-existing antibodies are associated with subsequent vaccine responses remains unclear. We longitudinally tracked 21 adults...
Hijacking the host heparan sulfate-cell-surface ribonucleoproteins (RNPs) scaffold pathway for viral immune evasion
August 2026
•Viral nucleocapsid proteins may co-opt this host scaffold for cell-surface display.•Surface-displayed viral proteins can bind chemokines, suppressing immune cell recruitment....
Issue Cover
August 2026
