Diverse genotypes of norovirus genogroup I and II contamination in environmental water in Thailand during the COVID-19 outbreak from 2020 to 2022
August 2024
Noroviruses (NoVs) are the most significant viral pathogens associated with waterborne and foodborne outbreaks of nonbacterial acute gastroenteritis in humans worldwide. This study aimed to investigate...
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Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai, China, 2022
August 2024
•The first report of serological characteristics of HFMD associated enteroviruses in Shanghai after the COVID-19 epidemic.•The seroprevalence of protective NtAbs against Coxsackieviruses was low within...
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First complete genomic sequence analysis of canine distemper virus in wild boar
August 2024
•The first complete genomic sequence of canine distemper virus from wild boar in northeast China was obtained.•Phylogenetic analysis showed that this wild boar CDV strain belongs to the Arctic lineage.•Wild...
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NSUN2 mediates distinct pathways to regulate enterovirus 71 replication
August 2024
Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function...
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Design of antiviral AGO2-dependent short hairpin RNAs
August 2024
The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals. RNA interference (RNAi) is a sequence-specific gene silencing mechanism that...
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A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice
August 2024
Norovirus (NoV) infection is a major cause of gastroenteritis worldwide. The virus poses great challenges in developing vaccines with broad immune protection due to its genetic and antigenic diversity....
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Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A
August 2024
Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy. Group B coxsackievirus (CVB) is one of the leading causative pathogens of viral...
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Transmission restriction and genomic evolution co-shape the genetic diversity patterns of influenza A virus
August 2024
Influenza A virus (IAV) shows an extensive host range and rapid genomic variations, leading to continuous emergence of novel viruses with significant antigenic variations and the potential for cross-species...
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RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qīnghăi Province, China
August 2024
Ticks are a major parasite on the Qīnghăi-Tibet Plateau, western China, and represent an economic burden to agriculture and animal husbandry. Despite research on tick-borne pathogens that threaten humans...
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August 2024
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The 2024 National Symposium on Insect Virology held in Qingdao
Available online 30 August 2024
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Rapid diagnosis of a fox's death case using nanopore sequencing reveals the infection with an Artic-like rabies virus
Available online 27 August 2024
•We detected a rabies virus (RABV) in a fox's death case within 6 h upon sample receipt using nanopore direct sequencing.•The virus belongs to AL2 sub-lineage, suggesting a high risk of fox-related...
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Bibliometric analysis of virology advancements in the 21st century
Available online 23 August 2024
•Databases of Web of Science, Essential Science Indicators, and Nature Index are utilized in the analysis.•More than one million publications, including 900,000 research articles are identified.•Annual...
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Trivalent SARS-CoV-2 virus-like particle vaccines exhibit broad-spectrum neutralization and protection against XBB.1 and BA.2.86 variants
Available online 22 August 2024
•RBDs of the WT, BQ.1.1 and XBB.1 variants were genetically fused and displayed on the VLP to create RBDV14 M.•RBDV14 M can induce superior antibody responses against the newly emerged SARS-CoV-2...
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The unique immune evasion mechanisms of the mpox virus and their implication for developing new vaccines and immunotherapies
Available online 22 August 2024
Mpox is an infectious and contagious zoonotic disease caused by the mpox virus (MPXV), which belongs to the genus Orthopoxvirus. Since 2022, MPXV has posed a significant threat to global public health....
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Antiviral activity of vitamin D derivatives against severe fever with thrombocytopenia syndrome virus in vitro and in vivo
Available online 20 August 2024
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus that causes the severe fever thrombocytopenia syndrome, which manifests as fever and haemorrhage, accompanied by severe...
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Single-cell RNA-sequencing reveals a profound immune cell response in human cytomegalovirus-infected humanized mice
Available online 15 August 2024
Human cytomegalovirus (HCMV) is a common herpesvirus that persistently infects a large portion of the world's population. Despite the robust host immune response, HCMV is able to replicate, evade host...
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Identification of mutations in viral proteins involved in cell adaptation using a reverse genetic system of the live attenuated hepatitis A virus vaccine H2 strain
Available online 14 August 2024
The live attenuated hepatitis A virus vaccine H2 strain was developed by passaging a wild-type H2w isolate in cell cultures. Currently, the mechanism underlying its attenuation phenotype remain largely...
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A bivalent Delta/BA.5 mRNA vaccine elicits broad immune responses against various lineages of SARS-CoV-2 including JN.1
Available online 8 August 2024
•A bivalent Delta/BA.5 mRNA vaccine provides protection against BA.5 in K18-ACE2 mice.•The vaccine protects hamsters from both Delta and BA.5 infections.•The animal immune sera neutralizes various lineages...
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Identification of a novel caspase cleavage motif AEAD
Available online 3 August 2024
Infections of many viruses induce caspase activation to regulate multiple cellular pathways, including programmed cell death, immune signaling and etc. Characterizations of caspase cleavage sites and...
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Antibacterial activity evaluation of a novel K3-specific phage against Acinetobacter baumannii and evidence for receptor-binding domain transfer across morphologies
Available online 3 August 2024
Acinetobacter baumannii (A. baumannii) poses a serious public health challenge due to its notorious antimicrobial resistance, particularly carbapenem-resistant A. baumannii (CRAB). In this study, we...
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Circulation patterns and molecular characteristics of respiratory syncytial virus among hospitalized children in Tianjin, China, before and during the COVID-19 pandemic (2017–2022)
Available online 26 July 2024
Respiratory syncytial virus (RSV) is the main pathogen that causes hospitalization for acute lower respiratory tract infections (ALRIs) in children. With the reopening of communities and schools, the...
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June 2024
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