Accelerated corrosion of 316L stainless steel in a simulated oral environment via extracellular electron transfer and acid metabolites of subgingival microbiota
May 2024
316L stainless steel (SS) is widely applied as microimplant anchorage (MIA) due to its excellent mechanical properties. However, the risk that the oral microorganisms can corrode 316L SS is fully neglected....
Artificial Intelligence Virtual Organoids (AIVOs)
May 2026
Organoid platforms have reshaped in vitro human biology yet remain constrained by batch variability, sparse longitudinal readouts and barriers to scale. This review introduces Artificial Intelligence...
A safe and anti-inflammatory plant-derived nanovesicle platform for targeted delivery in acute lung injury
August 2026
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening pulmonary disorders with extremely high mortality rates, for which effective and safe...
Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics
June 2026
The integration of artificial intelligence, protein engineering, and sustainable nanomedicine is driving a paradigm shift in theranostics by enabling highly precise disease diagnosis and targeted therapy....
Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review
January 2025
This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead...
Activating the cellular scavenger: A bioactive hydrogel promotes diabetic wounds via plant exosome-like nanovesicles enhanced macrophage efferocytosis
August 2026
The core pathological process of impaired diabetic wound healing is closely associated with macrophage homeostasis imbalance and defective efferocytosis. To address this clinical challenge, this study...
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
October 2021
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive...
Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy
August 2026
Mitophagy is a self-protection mechanism for cells to eliminate dysfunctional mitochondria, and maintain mitochondrial homeostasis. Thus, precisely inducing mitophagy represents a promising strategy...
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
April 2026
Skin aging is characterized by a progressive decline in regenerative capacity, primarily driven by fibroblast senescence, oxidative stress, chronic inflammation, and the degradation of type I/III collagen,...
Bone grafts and biomaterials substitutes for bone defect repair: A review
December 2017
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft...
Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
September 2023
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading...
Advances in orthodontic clear aligner materials
April 2023
Rapid technological improvements in biomaterials, computer-aided design (CAD) and manufacturing (CAM) have endorsed clear aligner therapy (CAT) as a mainstay of orthodontic treatment, and the materials...
Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair
August 2026
The healing of diabetic foot ulcers (DFU) is severely hindered by dysregulated immune microenvironment, recurrent infections, and insufficient angiogenesis. The persistent and resistant nature, coupled...
Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
December 2023
In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing...
Dynamic compliance penis enlargement patch
December 2024
Men are particularly sensitive to penis size, especially those with a deformed or injured penis. This can lead to a strong desire for penis enlargement surgery. Given the ethical sensitivities of the...
Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms
January 2026
The extracellular matrix (ECM) serves as a dynamic biomechanical regulator of cellular behavior, yet conventional 3D culture systems, such as Matrigel, lack the spatiotemporal control required to dissect...
Local periodontal injection, systemic heart repair: A dual-functional hydrogel for non-invasive concurrent treatment of periodontitis and myocardial infarction
August 2026
Periodontitis and myocardial infarction (MI), the leading cause of mortality worldwide, represent globally prevalent inflammatory diseases with bidirectional pathophysiological links. Despite the urgent...
AI-enabled organoids: Construction, analysis, and application
January 2024
Organoids, miniature and simplified in vitro model systems that mimic the structure and function of organs, have attracted considerable interest due to their promising applications in disease modeling,...
Smart microenvironment-adaptive nanocatalytic hydrogel for sequential antibacterial, anti-inflammatory, and regenerative therapy of biofilm-infected wounds
August 2026
Biofilm-infected wounds remain a major clinical challenge, as biofilm infections and persistent inflammation hinder conventional therapies from dynamically adapting to the evolving wound microenvironment....
Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing
July 2026
Diabetic wound healing is a complex spatiotemporal process that requires stage-specific interventions to address disrupted neuro-immune interactions and impaired angiogenesis. However, achieving such...
Programmable next-generation supramolecular self-assembled materials as drug delivery systems
June 2026
Supramolecular self-assembly, driven by noncovalent interactions, serves as a fundamental principle for constructing complex functional systems (biological membranes, proteins, and DNA). Inspired by...
Artificial intelligence virtual extracellular vesicles (AIVEVs)
July 2026
Recent progress in artificial intelligence (AI) has given rise to AI virtual cells (AIVCs), which are digital twins of predictable or dynamic biological cells. This model can simulate, predict and replicate...
Photo-curing 3D printing technique and its challenges
March 2020
In recent ten years, 3D printing technology has been developed rapidly. As an advanced technology, 3D printing has been used to fabricate complex and high-precision objects in many fields. 3D printing...
AI-driven 3D bioprinting for regenerative medicine: From bench to bedside
March 2025
In recent decades, 3D bioprinting has garnered significant research attention due to its ability to manipulate biomaterials and cells to create complex structures precisely. However, due to technological...
Biomedical titanium-tantalum alloys for orthopedic implant applications: From manufacturing to biological performance
July 2026
An ideal biomedical material for orthopedic implant applications is characterized by being biologically compatible with the human body, mechanically matching human cortical or cancellous bones, and...
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