Accelerated corrosion of 316L stainless steel in a simulated oral environment via extracellular electron transfer and acid metabolites of subgingival microbiota
May 2024
316L stainless steel (SS) is widely applied as microimplant anchorage (MIA) due to its excellent mechanical properties. However, the risk that the oral microorganisms can corrode 316L SS is fully neglected....
Artificial Intelligence Virtual Organoids (AIVOs)
May 2026
Organoid platforms have reshaped in vitro human biology yet remain constrained by batch variability, sparse longitudinal readouts and barriers to scale. This review introduces Artificial Intelligence...
Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics
June 2026
The integration of artificial intelligence, protein engineering, and sustainable nanomedicine is driving a paradigm shift in theranostics by enabling highly precise disease diagnosis and targeted therapy....
Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review
January 2025
This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead...
A safe and anti-inflammatory plant-derived nanovesicle platform for targeted delivery in acute lung injury
August 2026
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening pulmonary disorders with extremely high mortality rates, for which effective and safe...
Dynamic compliance penis enlargement patch
December 2024
Men are particularly sensitive to penis size, especially those with a deformed or injured penis. This can lead to a strong desire for penis enlargement surgery. Given the ethical sensitivities of the...
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
April 2026
Skin aging is characterized by a progressive decline in regenerative capacity, primarily driven by fibroblast senescence, oxidative stress, chronic inflammation, and the degradation of type I/III collagen,...
Advances in orthodontic clear aligner materials
April 2023
Rapid technological improvements in biomaterials, computer-aided design (CAD) and manufacturing (CAM) have endorsed clear aligner therapy (CAT) as a mainstay of orthodontic treatment, and the materials...
Artificial intelligence virtual extracellular vesicles (AIVEVs)
July 2026
Recent progress in artificial intelligence (AI) has given rise to AI virtual cells (AIVCs), which are digital twins of predictable or dynamic biological cells. This model can simulate, predict and replicate...
Bone grafts and biomaterials substitutes for bone defect repair: A review
December 2017
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft...
Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
September 2023
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading...
Programmable next-generation supramolecular self-assembled materials as drug delivery systems
June 2026
Supramolecular self-assembly, driven by noncovalent interactions, serves as a fundamental principle for constructing complex functional systems (biological membranes, proteins, and DNA). Inspired by...
Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy
August 2026
Mitophagy is a self-protection mechanism for cells to eliminate dysfunctional mitochondria, and maintain mitochondrial homeostasis. Thus, precisely inducing mitophagy represents a promising strategy...
Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms
January 2026
The extracellular matrix (ECM) serves as a dynamic biomechanical regulator of cellular behavior, yet conventional 3D culture systems, such as Matrigel, lack the spatiotemporal control required to dissect...
AI-enabled organoids: Construction, analysis, and application
January 2024
Organoids, miniature and simplified in vitro model systems that mimic the structure and function of organs, have attracted considerable interest due to their promising applications in disease modeling,...
Exosome-functionalized photocrosslinked GelMA/HAMA hydrogel promotes facial nerve recovery via inflammatory microenvironment regulation
June 2026
Facial nerve crush injuries frequently lead to incomplete functional restoration owing to constrained regenerative approaches and suboptimal treatment methods. While hydrogel-based systems have emerged...
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
October 2021
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive...
Spermidine-functionalized Janus hydrogel microneedles inhibit ferroptosis and promote healing of oral ulcers
June 2026
Oral ulceration is a prevalent mucosal disorder, and its healing process is frequently hampered by poor local drug retention and inadequate mucosal adhesion. However, the underlying pathological mechanisms...
Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
December 2023
In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing...
Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal
September 2021
Sterilization is the process of killing all microorganisms, while disinfection is the process of killing or removing all kinds of pathogenic microorganisms except bacterial spores. Biomaterials involved...
AI-driven 3D bioprinting for regenerative medicine: From bench to bedside
March 2025
In recent decades, 3D bioprinting has garnered significant research attention due to its ability to manipulate biomaterials and cells to create complex structures precisely. However, due to technological...
Photo-curing 3D printing technique and its challenges
March 2020
In recent ten years, 3D printing technology has been developed rapidly. As an advanced technology, 3D printing has been used to fabricate complex and high-precision objects in many fields. 3D printing...
Injectable living hydrogel as engineered biotherapeutic to promote tooth-extraction wound healing and alveolar bone regeneration
May 2026
Effective wound healing and functional bone regeneration following tooth extraction remain clinical challenges, underscoring the significant need for multifunctional strategies that address the complex,...
Local periodontal injection, systemic heart repair: A dual-functional hydrogel for non-invasive concurrent treatment of periodontitis and myocardial infarction
August 2026
Periodontitis and myocardial infarction (MI), the leading cause of mortality worldwide, represent globally prevalent inflammatory diseases with bidirectional pathophysiological links. Despite the urgent...
An inhalable gallium-polyphenol nanoparticle blocks bacterial electron transport chain and signal transduction for anti-biofilm therapy
March 2026
Bacterial biofilms have become an escalating global health threat due to their persistent infections and antimicrobial resistance. Conventional antibacterial approaches often fail to eliminate biofilms...
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