Phenomics of traditional Chinese medicine 2.0: the integration with digital medicine
September 2025
Modern western medicine typically focuses on treating specific symptoms or diseases, and traditional Chinese medicine (TCM) emphasizes the interconnections of the body’s various systems under external...
Bone protective potential of Nelumbo nucifera Gaertn. seed hydroalcoholic extract on ovariectomy-induced osteoporosis in Wistar rats via ER/OPG/RANKL signaling pathway
September 2025
To investigate the bone-protective potential of Nelumbo nucifera Gaertn. seed hydroalcoholic extract (NNHE) in an ovariectomized (OVX) rat model by modulating the estrogen receptor/osteoprotegerin/receptor...
A lung cancer early-warning risk model based on facial diagnosis image features
September 2025
To explore the feasibility of constructing a lung cancer early-warning risk model based on facial image features, providing novel insights into the early screening of lung cancer....
Effects of Zuogui Jiangtang Yishen Formula in regulating the NLRP3/caspase-1/GSDMD signaling axis on pyroptosis in rats with diabetic kidney disease
September 2025
To investigate the effects of Zuogui Jiangtang Yishen Formula (左归降糖益肾方, ZGJTYSF) in regulating the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/caspase-1/gasdermin D (GSDMD)...
In silico evaluation of hsa-miR-125a-5p and hsa-miR-125b-5p as potential biomarkers for monitoring acupuncture treatment in rheumatoid arthritis
September 2025
To perform an in silico bioinformatics analysis to identify differentially expressed microRNAs (miRNAs) implicated in rheumatoid arthritis (RA) pathogenesis and evaluate their potential as biomarkers...
Reviving classical Bawl (urine) diagnostics in Unani medicine via artificial intelligence and digital tools: toward integrative informatics for traditional systems
September 2025
In Unani medicine, Bawl (urine) is recognized as a key diagnostic tool, with humoural imbalances assessed via parameters like color, consistency, sediment, clarity, froth, odor, and volume. This conceptual...
Traditional Chinese medicine in lupus nephritis: mechanistic insights and integrative therapeutic strategies
September 2025
To review and synthesize preclinical and clinical evidence regarding traditional Chinese medicine (TCM) formulations and bioactive herbal compounds in lupus nephritis (LN), and to identify direction...
Efficacy and safety of the tonifying spleen and reinforcing Qi therapy combined with thyroid hormone in Hashimoto’s hypothyroidism: a systematic review and meta-analysis
September 2025
To evaluate the effectiveness and safety of the tonifying spleen and reinforcing Qi (TSRQ) therapy combined with thyroid hormone replacement therapy (THRT) for treating Hashimoto’s hypothyroidism....
Effects of moxibustion at Huantiao (GB30) acupoint on nerve regeneration in rats with sciatic nerve injury
September 2025
To observe the effects of moxibustion at Huantiao (GB30) acupoint on nerve repair, regeneration, and function in rats with sciatic nerve injury (SNI), and explore the possible mechanism of SNI improvement...
Shanxiangyuanye (Turpiniae Folium) for diabetic complications: chemical constituents and therapeutic potential
September 2025
To analyze the chemical constituents of Shanxiangyuanye (Turpiniae Folium) through liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, and to evaluate their anti-oxidant, hypoglycemic,...
Advances and prospects of the integration of multi-omics and artificial intelligence in traditional Chinese medicine research
September 2025
To map the research hotspots, developmental trends, and existing challenges in the integration of artificial intelligence (AI) with multi-omics in traditional Chinese medicine (TCM) through comprehensive...
Clinical efficacy of fecal microbiota transplantation based on syndrome element differentiation principle in the treatment of type 2 diabetes mellitus
September 2025
To investigate the therapeutic efficacy and potential mechanisms of fecal microbiota transplantation (FMT) in patients with type 2 diabetes mellitus (T2DM), and to preliminarily identify the traditional...
Development and validation of a quality appraisal tool for case reports in traditional Chinese medicine using the Delphi method
June 2025
To develop a quality appraisal tool for case reports in traditional Chinese medicine (TCM) based on their characteristics....
Correlation analysis between facial feature-based traditional Chinese medicine inspection of spirit classification and Beck Depression Inventory score
June 2025
To determine the correlation between traditional Chinese medicine (TCM) inspection of spirit classification and the severity grade of depression based on facial features, offering insights for intelligent...
Lantana camara alleviating TNBS-induced ulcerative colitis in rats: regulating TNF-α/EGFR/STAT3/Bcl-2 signaling pathways
June 2025
To investigate the therapeutic potential and underlying mechanism of Lantana camara ethanolic extract (LCEE) in ulcerative colitis (UC)....
Herbal remedies for Alzheimer’s disease: neuroprotective mechanisms and cognitive enhancement potential
June 2025
Alzheimer’s disease (AD) is a progressive neurodegenerative condition characterized by memory loss and cognitive decline. Current drugs offer limited benefits and often cause side effects. Recently,...
Validating the pathogenic mechanism of chronic obstructive pulmonary disease induced by negative emotions via Mendelian randomization and traditional Chinese medicine theory of emotions
June 2025
We employed Mendelian randomization (MR) to test the traditional Chinese medicine (TCM) theory of emotional pathogenesis concept and explore the causal relationship between negative emotions and chronic...
Development and validation of a nomogram model for predicting the risk of H-type hypertension with pulse diagram parameters
June 2025
To develop an onset risk prediction nomogram for patients with homocysteine-type (H-type) hypertension (HTH) based on pulse diagram parameters to assist early clinical prediction and diagnosis of H...
Clinical research report on Chinese patent medicines and classic traditional Chinese medicine prescriptions (2023)
June 2025
Randomized controlled trials (RCTs) of Chinese patent medicines and classic traditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in...
Integrated plasma and synovial membrane lipidomic profiling revealing the therapeutic effects of moxibustion in collagen-induced arthritis rat models
June 2025
To reveal the therapeutic effects of moxibustion in collagen-induced arthritis (CIA) rat models using the combined analysis of plasma and synovial membrane lipidomic profiling and to enhance the understanding...
Mechanism of electroacupuncture treating detrusor-bladder neck dyssynergia after suprasacral spinal cord injury by proteomics
June 2025
To elucidate the potential mechanisms of electroacupuncture (EA) in restoring detrusor-bladder neck dyssynergia (DBND) following suprasacral spinal cord injury (SSCI)....
TCMHTI: a Transformer-based herb-target interaction prediction model for Qingfu Juanbi Decoction in rheumatoid arthritis
June 2025
To predict the potential targets of Qingfu Juanbi Decoction (青附蠲痹汤, QFJBD) in treating rheumatoid arthritis (RA) using an improved Transformer model and investigate the network pharmacological mechanisms...
Construction and evaluation of a predictive model for the degree of coronary artery occlusion based on adaptive weighted multi-modal fusion of traditional Chinese and western medicine data
June 2025
To develop a non-invasive predictive model for coronary artery stenosis severity based on adaptive multi-modal integration of traditional Chinese and western medicine data....
Evaluating the in vitro anti-diabetic activity of Bryonia dioica root extracts supported by molecular docking analysis
June 2025
To evaluate the in vitro anti-diabetic effects of Bryonia dioica roots extracts, including water-acetone extracts and their ethyl acetate and butanol fractions, and chloroform-methanol extracts....
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