A theory-constrained digital framework of the traditional Chinese medicine Jing-Shen-Mei theory for mammalian lifespan modeling
September 2026
To construct a theory-constrained mathematical framework for the traditional Chinese medicine (TCM) Jing (精, essence)-Shen (神, spirit)-Mei (寐, sleep) theory and to evaluate the applicability of a pre-specified...
Developing a diagnostic model for spleen-stomach damp-heat syndrome in chronic gastritis patients using hyperspectral tongue imaging
September 2026
To construct a diagnostic model for spleen-stomach damp-heat syndrome in patients with chronic gastritis (CG) based on hyperspectral tongue imaging data, and to investigate the diagnostic value of hyperspectral...
Protective effects of Bushen Huoxue Formula on intervertebral disc degeneration and endplate microcirculation in rats via the SIRT1/CXCL12/CXCR4/CXCR7 axis in endothelial progenitor cells
September 2026
To investigate the efficacy of the Bushen Huoxue Formula (补肾活血方, BSHXF) in alleviating intervertebral disc degeneration (IVDD), improving endplate microcirculation, and enhancing endothelial progenitor...
Study on the dose-efficacy relationship of Dahuang (Rhei Radix et Rhizoma) based on fuzzy association rules
September 2026
To investigate the dose-efficacy relationship of Dahuang (Rhei Radix et Rhizoma) using fuzzy association rules, provide scientific evidence for its precise clinical application, and establish a novel...
Task-oriented compression of resampled pulse waves for lightweight blood pressure prediction
September 2026
This study proposes a task-oriented signal compression paradigm for non-invasive blood pressure (BP) prediction, eliminating manual feature engineering through resampling to achieve a high-performance...
TCM-HyperRAG: higher-order knowledge hypergraphs for disease diagnosis and prescription recommendation in traditional Chinese medicine
September 2026
To address the limitations of knowledge graphs in modeling higher-order associations in traditional Chinese medicine (TCM) knowledge and distinguishing the importance of different entities, we propose...
Regulation of oocyte meiosis and reproductive function by Bushen Tiaojing Decoction through the APC/C-CDC20 signaling pathway in aged mice
September 2026
To investigate the effects of Bushen Tiaojing Decoction (补肾调经汤, BSTJD) on oocyte meiotic progression and reproductive function in aged mice, and to explore the potential involvement of the anaphase-promoting...
Formalization, structural representation, and construction of equivalent mathematical expressions for basic theories of traditional Chinese medicine
September 2026
To construct a formalized, structured, and equivalent mathematical representation framework for the basic theories of traditional Chinese medicine (TCM), and to illustrate the mathematical expression...
Algorithmic consistency and feature-leakage assessment of machine learning models for traditional Chinese medicine syndrome differentiation in herpes zoster: a cross-sectional study
September 2026
To evaluate whether standardized traditional Chinese medicine (TCM) syndrome labels in patients with herpes zoster can be reproduced from structured clinical variables and to determine how model performance...
Potential mechanisms of Lycium barbarum polysaccharides in optic nerve regeneration based on network pharmacology, single-cell transcriptomic analysis, and molecular docking
September 2026
To identify the potential molecular mechanisms mediating the role of Lycium barbarum polysaccharides (LBPs) in optic nerve regeneration (ONR) through an integrated approach that combines network pharmacology,...
The molecular mechanisms of Liuwei Dihuang Decoction in improving cognitive dysfunction in D-galactose-induced aged mice revealed by an lncRNA‒miRNA‒mRNA network analysis
September 2026
To elucidate the potential mechanisms by which Liuwei Dihuang Decoction (六味地黄汤, LWDHD) ameliorates D-galactose (D-gal)-induced cognitive impairment in aged mice through a long noncoding RNA (lncRNA)-micro...
Effects of Liangxue Xiaofeng Powder on inflammatory responses and gut microbiota in atopic dermatitis rats with wind-dampness-heat syndrome
September 2026
To investigate the potential therapeutic effects of Liangxue Xiaofeng Powder (凉血消风散, LXXFP) on atopic dermatitis (AD) rats with wind-dampness-heat syndrome, and to explore the potential mechanisms associated...
Attenuation of oxidative injury in retinal photoreceptor cells by Gouqizi (Lycii Fructus) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) through modulation of ANGPTL4
June 2026
To investigate the protective effects of Gouqizi (Lycii Fructus, GQZ)-Danshen (Salviae Miltiorrhizae Radix et Rhizoma, DS) against hydrogen peroxide (H2O2)-induced oxidative injury in 661W retinal photoreceptor...
Clinical efficacy and pharmacological basis of Mongolian medicine Manggari hot compress therapy for cervical spondylotic radiculopathy: a randomized controlled trial and serum pharmacochemistry study
June 2026
To systematically evaluate the clinical efficacy of topical preparations of Mongolian medicine Manggari hot compress therapy (hereafter referred to as Manggari hot compress therapy) in treating cervical...
HerbGL: a network propagation and graph regularization-based framework for herb pairs prediction in traditional Chinese medicine
June 2026
To address the challenges of systematically identifying herb pairs in traditional Chinese medicine (TCM), we proposed HerbGL, a framework for predicting potential herb pairs that integrates network...
Construction of the clinical diagnosis and treatment model during the “pre-disease to disease” window period in traditional Chinese medicine: integration of objective multimodal data from the perspective of traditional Chinese medicine stateology
June 2026
The philosophy of “treating disease before its onset” is a fundamental concept of traditional Chinese medicine (TCM), permeating its diagnostic and therapeutic framework, and is central to clinical...
Visualization analysis and clinical interpretability evaluation of artificial intelligence-assisted tongue diagnosis
June 2026
To map the research landscape of artificial intelligence (AI)-assisted tongue diagnosis through bibliometric analysis and to quantify its diagnostic accuracy and clinical interpretability through a...
Molecular features of traditional Chinese medicine syndrome evolution in chronic liver diseases: a dynamic network biomarker analysis
June 2026
To elucidate the biological basis of traditional Chinese medicine (TCM) syndromes from the perspective of “same syndrome, different diseases” in patients with chronic hepatitis B (CHB), liver cirrhosis...
From pulse to pixel: artificial intelligence-enhanced pulse diagnosis for cardiovascular diseases
June 2026
Traditional Chinese medicine (TCM) pulse diagnosis is a non-invasive approach used to infer cardiovascular status, but its interpretation is relatively subjective, limiting reproducibility and diagnostic...
The macro, meso, and micro dimensions of Yin-Yang theory in traditional Chinese medicine: a three-level analysis of Yin and Yang
June 2026
Yin-Yang theory is one of the core components of the foundational theory of traditional Chinese medicine (TCM), yet its classification as philosophical or scientific has long been controversial. To...
Deep learning for subtype recognition of Yang deficiency tongue images in traditional Chinese medicine
June 2026
To address the lack of fine-grained clinical recognition for specific Yang deficiency syndrome subtypes and the limitations of conventional object detection models in extracting irregular, low-contrast...
Facial and tongue features in traditional Chinese medicine for coronary artery stenosis warning and their association chain with cardiac biomarkers
June 2026
To explore whether digital facial and tongue diagnostic technologies can support the assessment of coronary heart disease (CHD) patients for coronary artery stenosis severity, and examine potential...
Comparative evaluation of Mamdani and Takagi-Sugeno fuzzy systems for predicting peripheral vascular resistance from photoplethysmogram signals using Persian medicine pulsology
June 2026
To perform a comparative evaluation of Mamdani and Takagi-Sugeno (TS) fuzzy inference systems for predicting peripheral vascular resistance from photoplethysmogram (PPG) signals, incorporating diagnostic...
CMM-EmbedCluster: a clustering framework for Chinese materia medica based on large language model and Chinese materia medica property theory
June 2026
This study proposes a clustering framework for Chinese materia medica (CMM) based on a large language model (LLM), aiming to explore potential compatibility patterns among CMMs from the semantic perspective...
Interdisciplinary integration and development trends of intelligent diagnosis in traditional Chinese medicine: a topic evolution analysis
March 2026
To systematically characterize the developmental trajectory and interdisciplinary integration of intelligent diagnosis in traditional Chinese medicine (TCM) through quantitative topic evolution analysis,...
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