Most Downloaded Articles

ISSN: 2589-3777

CN: 43-1540/R

p-ISSN: 2096-479X

Recommended Medicinal Plants as Source of Natural Products: A Review

June 2018

Natural product is one of the sources of drugs in pharmaceutical industry, and one of the notable origin of natural product is the medicinal plants. Medicinal plants tend to cure some certain diseases...

Herbal remedies for Alzheimer’s disease: neuroprotective mechanisms and cognitive enhancement potential

June 2025

Dharmalingam Kirubakaran

Alzheimer’s disease (AD) is a progressive neurodegenerative condition characterized by memory loss and cognitive decline. Current drugs offer limited benefits and often cause side effects. Recently,...

Medicinal properties and anti-inflammatory components of Phytolacca (Shanglu)

October 2021

Christian Bailly

(Shanglu) is a well-known traditional herbal medicine that has been used for thousands of years in China. Phytolacca is also used worldwide in different traditional phyto-medicines and homeopathic preparations....

Quantum theory-based physical model of the human body in TCM

December 2022

Shuna SONG | Zhensu SHE

In the study, a quantum resonant cavity model based on wave-particle duality was proposed for the explanation of the dynamic processes of essence, vigor, and spirit in the human body in traditional...

Correlation Between Helicobacter pylori Infection and Tongue Manifestations: A Meta-analysis

June 2018

Objective To analyze the relationship between Helicobacter pylori (H. pylori) infection and the manifestations of the tongue....

Research status and prospect of tongue image diagnosis analysis based on machine learning

March 2024

X.U. Jiatuo | J.I.A.N.G. Tao | L.I.U. Shi

Image-based intelligent diagnosis represents a trending research direction in the field of tongue diagnosis in traditional Chinese medicine (TCM). In recent years, machine learning techniques, including...

TCMLLM-PR: evaluation of large language models for prescription recommendation in traditional Chinese medicine

December 2024

To develop and evaluate a fine-tuned large language model (LLM) for traditional Chinese medicine (TCM) prescription recommendation named TCMLLM-PR....

A new interpretation of TCM pulse diagnosis based on quantum physical model of the human body

December 2022

Shuna SONG | Zhensu SHE

Following the quantum theory-based physical model of the human body, a new interpretation of the traditional Chinese medicine (TCM) principle of “Cunkou reads viscera” is presented. Then, a Gaussian...

From digits towards digitization: the past, present, and future of traditional Chinese medicine

March 2025

Qi Wang

Digitization is the inevitable path for the natural development of traditional Chinese medicine (TCM) in the context of the Fourth Industrial Revolution. The goal of TCM digitization is to generate...

Advances and prospects of the integration of multi-omics and artificial intelligence in traditional Chinese medicine research

September 2025

L.I.U. Guicheng | L.O.N.G. Xi | P.E.N.G. Qinghua | T.I.A.N. Sainan | H.U. Shujuan

To map the research hotspots, developmental trends, and existing challenges in the integration of artificial intelligence (AI) with multi-omics in traditional Chinese medicine (TCM) through comprehensive...

Quantitative research on tongue diagnosis in traditional Chinese medicine for obstructive coronary artery disease: a computational analysis based on multimodal feature fusion

December 2025

Yanyun ZHANG | Dongsheng WEI | Yue ZHANG | Yanshu LIU | Zhe ZHANG

To investigate morphological differences between obstructive and non-obstructive coronary artery disease (CAD) patients using computer-aided image analysis, and identify color and texture features for...

Harnessing traditional herbal medicine: molecular insights into diabetic wound healing for modern therapeutics

December 2024

Pavithra Bharathy | Punniyakoti Veeraveedu Thanikachalam

This study aims to explore the molecular aspects of the wound-healing potential of medicinal plants through preclinical and clinical research. This review focuses on the theoretical support and therapeutic...

Artificial intelligence meets traditional Chinese medicine: a bridge to opening the magic box of sphygmopalpation for pulse pattern recognition

March 2021

Artificial intelligence (AI) aims to mimic human cognitive functions and execute intellectual activities like that performed by humans dealing with an uncertain environment. The rapid development...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S258937772500151X" target="_blank" rel="noreferrer" > The study of traditional Chinese medicine five-element music therapy for depression: a bibliometric analysis </a> </h2> <p class="article-date">December 2025</p> <p class="article-authors"> Hui XIAO | Cong CHEN</p> <p class="article-abstract">To systematically analyze the research status, highlights, and advancements of five-element music therapy (FEMT) in intervening depression with bibliometric methods....</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377722000490" target="_blank" rel="noreferrer" > Tongue image segmentation and tongue color classification based on deep learning </a> </h2> <p class="article-date">September 2022</p> <p class="article-authors"> L.I.U. Wei | C.H.E.N. Jinming | L.I.U. Bo | H.U. Wei | W.U. Xingjin | Z.H.O.U. Hui</p> <p class="article-abstract">To propose two novel methods based on deep learning for computer-aided tongue diagnosis, including tongue image segmentation and tongue color classification, improving their diagnostic accuracy....</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377725001508" target="_blank" rel="noreferrer" > Traditional Chinese medicine-based phytotherapeutics for junk food-induced obesity and metabolic dysfunction </a> </h2> <p class="article-date">December 2025</p> <p class="article-authors"> Kirubakaran Dharmalingam | Nagaraj Durga | Poongavanam Senthamil Selvi | Murugan Pachaiyappan | Sethuraman Veeran</p> <p class="article-abstract">Obesity driven by high-sugar and high-fat dietary patterns has become a major global health challenge and is closely associated with metabolic syndrome, diabetes, and cardiovascular disorders. Growing...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377725000977" target="_blank" rel="noreferrer" > Phenomics of traditional Chinese medicine 2.0: the integration with digital medicine </a> </h2> <p class="article-date">September 2025</p> <p class="article-authors"> X.U. Min | S.H.A.O. Xinyi | G.U.O. Donggeng | Y.A.N. Xiaojing | W.A.N.G. Lei | Y.A.N.G. Tao | L.I.A.N.G. Hao | P.E.N.G. Qinghua | YE Lingyu Linda | C.H.E.N.G. Haibo | DUAN Dayue Darrel</p> <p class="article-abstract">Modern western medicine typically focuses on treating specific symptoms or diseases, and traditional Chinese medicine (TCM) emphasizes the interconnections of the body’s various systems under external...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377726000121" target="_blank" rel="noreferrer" > QingNangTCM: a parameter-efficient fine-tuning large language model for traditional Chinese medicine </a> </h2> <p class="article-date">March 2026</p> <p class="article-authors"> Tong Xuming | Liu Liyan | Yuan Yanhong | Ding Xiaozheng | Jia Huiru | Yang Xu | Im Sio Kei | Wang Mini Han | Xiong Zhang | Wang Yapeng</p> <p class="article-abstract">To develop QingNangTCM, a specialized large language model (LLM) tailored for expert-level traditional Chinese medicine (TCM) question-answering and clinical reasoning, addressing the scarcity of domain-specific...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377724000090" target="_blank" rel="noreferrer" > Efficacy and safety of Jiuhua hemorrhoid suppository plus diosmin for the treatment of hemorrhoid hemorrhage: a multicenter, randomized, and controlled trial </a> </h2> <p class="article-date">December 2023</p> <p class="article-authors"> Rong Xinqi | Wu Mingsheng | Xin Xuezhi | Zhang Bo | Liu Dianwen | Xiao Huirong | Wang Zhenyi | Cui Junhui | Wang Jianping | Wang Zhongcheng | Fan Xiaohua | Hu Ying | Rong Yisheng | Li Ying</p> <p class="article-abstract">To compare the efficacy and safety of combining diosmin with Jiuhua hemorrhoid suppository versus diosmin alone for the treatment of hemorrhoid hemorrhage....</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377725001004" target="_blank" rel="noreferrer" > Traditional Chinese medicine in lupus nephritis: mechanistic insights and integrative therapeutic strategies </a> </h2> <p class="article-date">September 2025</p> <p class="article-authors"> Elizabethrani Edwin | Karthikeyan Elumalai | Nandhini Jayaprakash</p> <p class="article-abstract">To review and synthesize preclinical and clinical evidence regarding traditional Chinese medicine (TCM) formulations and bioactive herbal compounds in lupus nephritis (LN), and to identify direction...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S258937772100046X" target="_blank" rel="noreferrer" > Systematic review of robust experimental models of rheumatoid arthritis for basic research </a> </h2> <p class="article-date">December 2021</p> <p class="article-authors"> Lin Ye | Hu Mingyue | Zhang Feng | Dai Zongshun | Xie Ying | Cai Xiong | Liu Liang</p> <p class="article-abstract">Rheumatoid arthritis (RA) is a common autoimmune disease characterized by progressive joint inflammation and destruction, deformity, loss of mobility, and permanent disability. Although the cellular...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377726000133" target="_blank" rel="noreferrer" > Clinical decision and prescription generation for diarrhea in traditional Chinese medicine based on large language model </a> </h2> <p class="article-date">March 2026</p> <p class="article-authors"> Wu Jiaze | Liang Hao | Dai Haoran | Rui Hongliang | Liu Baoli</p> <p class="article-abstract">To develop a clinical decision and prescription generation system (CDPGS) specifically for diarrhea in traditional Chinese medicine (TCM), utilizing a specialized large language model (LLM), Qwen-TCM-Dia,...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S258937772200074X" target="_blank" rel="noreferrer" > Data-driven based four examinations in TCM: a survey </a> </h2> <p class="article-date">December 2022</p> <p class="article-authors"> Dong SUI | Lei ZHANG | Fei YANG</p> <p class="article-abstract">Traditional Chinese medicine (TCM) diagnosis is a unique disease diagnosis method with thousands of years of TCM theory and effective experience. Its thinking mode in the process is different from that...</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377724000582" target="_blank" rel="noreferrer" > Effects of needling at Sanyinjiao (SP6) acupuncture point on blood glucose levels and cardiovascular functions in patients with type 2 diabetes mellitus: a randomized placebo-controlled study </a> </h2> <p class="article-date">September 2024</p> <p class="article-authors"> S. Priyadharshini | A. Mooventhan | Venkatalakshmi Saravanan | N. Mangaiarkarasi</p> <p class="article-abstract">To determine the effect of needling at Sanyinjiao (SP6) on random blood glucose (RBG) levels and cardiovascular function in patients with type 2 diabetes mellitus (T2DM)....</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> <div class="panel"> <div class="article-listing" > <h2 class="h5 article-title"> <a href="http://www.sciencedirect.com/science/article/pii/S2589377724000594" target="_blank" rel="noreferrer" > The gas discharge visualization (GDV) order parameter model based on the principle of mastering both permanence and change </a> </h2> <p class="article-date">September 2024</p> <p class="article-authors"> Yu Xin | Lei Zhang | Qiancheng Zhao | Yurong She | Zhensu She | Shuna Song</p> <p class="article-abstract">To investigate the human body’s complex system, and classify and characterize the human body’s health states with “a comprehensive integrated method from qualitative to quantitative”....</p> </div> <div class="d-sm-flex align-items-sm-center justify-content-sm-between justify-content-md-start"> </div> </div> </section> </div> <div class="col-12 col-xl-3"> <div class="d-grid gap-3 mb-3 journalCTAs"> <a href="https://www.editorialmanager.com/dcmed/Default.aspx" class="btn btn-primary btn-lg" target="_blank" rel="noreferrer"> Submit your paper </a> <a href="https://www.sciencedirect.com/journal/digital-chinese-medicine" class="btn btn-outline-primary btn-lg" target="_blank" rel="noreferrer"> View articles </a> </div> <ul class="list-group list-group-flush"> <li class="list-group-item"> <a class="action-link text-wrap" href="/en/journals/digital-chinese-medicine/guide-for-authors/" > <i class="bi bi-chevron-right"></i>Guide for Authors </a> </li> <li class="list-group-item"> <a class="action-link text-wrap" href="/en/journals/digital-chinese-medicine/abstracting-and-indexing/" > <i class="bi bi-chevron-right"></i>Abstracting and Indexing </a> </li> </ul> <div class="d-grid gap-3 mb-3"> <a class="btn btn-outline-primary btn-lg text-wrap" href="/en/journals/digital-chinese-medicine/recent-articles/" > Recent Articles </a> <a class="btn btn-outline-primary btn-lg text-wrap" href="/en/journals/digital-chinese-medicine/most-downloaded-articles/" > Most Downloaded Articles </a> <a class="btn btn-outline-primary btn-lg text-wrap" href="/en/journals/digital-chinese-medicine/most-cited-articles/" > Most Cited Articles </a> <a class="btn btn-outline-primary btn-lg text-wrap" href="/en/journals/digital-chinese-medicine/news/" > News </a> </div> <div class="panelled-container"> <div class="panel"> <div id="umbraco_form_def4c6c89a9e44038daddb19fca065ba" class="umbraco-forms-form stayinformed umbraco-forms-floating"> <form action="/en/journals/digital-chinese-medicine/most-downloaded-articles/" enctype="multipart/form-data" id="formf13fc2722f2147adbde395fda40d3888" method="post"><input data-val="true" data-val-required="The FormId field is required." name="FormId" type="hidden" value="def4c6c8-9a9e-4403-8dad-db19fca065ba" /><input data-val="true" data-val-required="The FormName field is required." name="FormName" type="hidden" value="#Stay informed" /><input data-val="true" data-val-required="The RecordId field is required." name="RecordId" type="hidden" value="00000000-0000-0000-0000-000000000000" /><input name="PreviousClicked" type="hidden" value="" /><input name="Theme" type="hidden" value="floating" /><input name="RedirectToPageId" type="hidden" value="" /> <input type="hidden" name="FormStep" value="0" /> <input type="hidden" name="RecordState" value="Q2ZESjhFa3BveFdJUlZ0Q2o4NjJqeUlHdFBfR0FzZHgtUE44OGtLNkpYVFFFU09Jck1xZkRtX0NYXzhTNkJPT1E4MUFOR19XQU10UXAwV05ZeEpXXzZYLXJPVFM2LWEzZUNDblk5dWdMcEpINFZCdXRTcURDZlJFVGZnSWQwWHZ5YnFTVXc=" /> <div id="7c4e12e0-e26b-4af2-a312-6649ca7b5e4c"> <fieldset id="d83df139-0d23-4e0d-a2f3-df7411256907"> <div class=" umbraco-forms-field intro titleanddescription" > <div id="9323e01d-3126-4ab8-bbe1-6237a21abfda" data-umb="9323e01d-3126-4ab8-bbe1-6237a21abfda"> <h2>Stay Informed</h2> <p>Register your interest and receive email alerts tailored to your needs. 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