Development of a primary hepatocyte-based preclinical spheroid model system for the analysis of Phase I and Phase II enzyme activity in vitro
2026
•This study highlights a method to improve hepatic spheroids by incorporating Matrigel, which enhances cell-extracellular matrix (ECM) interactions, crucial for liver function.•Hepatic spheroids with...
Harnessing the interplay between tendon stem/progenitor cell and microenvironment boosts tendon tissue regeneration
2026
•TSPC subpopulations-niche interaction is vital for tendon biology.•The degeneration loop is a key factor leading to tendon diseases.•Remodel Niche - Disrupt Degeneration Loop - Tendon Healing.•Artificial...
Synergistic interplay of dECM and exosomes in shaping the cartilage matrix microenvironment: A new paradigm for regenerative medicine
2026
•dECM-exosome integration mimics the native cartilage microenvironment for regeneration.•Exosomes deliver bioactive signals to enhance chondrogenesis and immune modulation.•dECM scaffolds retain exosomes,...
Cell electrowriting: An advanced biofabrication approach for micrometre-scale living tissue fabrication
2026
•Cell electrowriting (CEW) places living cells with near single-cell precision.•Delivers finer detail than melt electrowriting and extrusion bioprinting.•Prints aligned, organised cells directly—no...
Multi-modal therapeutic action of gallium-containing bioactive glass against osteosarcoma and bacterial pathogens
2026
•Multifunctional materials are required for optimised bone tumour therapy.•Ga-containing bioactive glasses (Ga-BGs) were manufactured and characterised.•Gallium Nitrate was used to demonstrate Ga therapeutic...
Rational molecular design to elicit biological functions for modulating cellular and tissue responses
2026
•Reviews molecular engineering to manipulate cell signaling pathways.•Summarizes molecular recognition and active molecule modifications.•Details mechanisms for precise intervention in cellular behaviors.•Explores...
Granular materials for biomedical applications: structural design, functional properties, advanced manufacturing and clinical application
2026
●Covers structure, properties, advanced manufacturing, and clinical applications.●Focuses on the structure–property relationship to guide design and fabrication.●Integrates fundamentals and advances...
Dynamic 4D-Bioprinted Duct-Like Microenvironments for Triple-Negative Breast Cancer Modeling and Drug Response
Available online 15 July 2026
•4D-bioprinted self-folding tubes mimic mammary duct geometry.•Tunable bioink and design enable robust duct-like tubular formation.•Mechanical gradients and flow enhance viability and aggregation.•Dynamic...
Asini Corii Colla exhibits anti-photoaging efficacy via activating collagen synthesis and maintaining redox & extracellular matrix homeostasis
Available online 14 July 2026
•Systematically elucidates ACO's multi-mechanistic anti-photoaging effects, including promoting keratinocyte proliferation/migration, inhibiting fibroblast senescence, regulating collagen/elastin synthesis,...
Comparison of two hemostatic skin adhesive dressings, incorporating multi-metal bioactive glass
2025
•Multi-element bioactive glass nanoparticles (BG) were successfully synthesized.•Two skin adhesives, with GelMA back bone, based on adhesive molecules of DOPA and TA, integrating BG were developed.•Both...
Targeted drug delivery system for Golgi apparatus's diseases
2025
•Snapshot of Golgi apparatus.•Design scheme for targeting Golgi apparatus.•Typical application of Golgi targeting in disease surveillance and therapy....
ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration
2025
•ORM1 was expressed in AIS bone tissues.•ORM1-positive AIS patient-derived osteoblasts, there was an increased expression of RANKL, decreased expression of OPG.•Osteoclasts overexpressing ORM1 promoted...
Bioactive scaffolds integrated with micro-precise spatiotemporal delivery and in vivo degradation tracking for complex tissue regeneration
2025
•This study we report groundbreaking preclinical outcomes in the functional regeneration of temporomandibular joint (TMJ) discs of mini-pigs using anatomically correct bioactive 3D-printed scaffolds.•The...
Integrating bioprinted oral epithelium with millifluidics for fluorouracil perfusion and Fusobacterium infection to bioengineer oral mucositis-on-a-chip
2025
•Magnetic 3D bioassembly or bioprinting can promptly produce physiologically relevant multi-layered oral epithelial sheets from human oral keratinocytes.•Our dynamic millifluidic system can generate...
Ultrasonic manipulation in tissue engineering
2025
•This review systematically explores the application of ultrasonic waves in tissue engineering, emphasizing their safe, contactless, and precise capabilities for cell manipulation and tissue morphogenesis.•It...
Advances in smart hybrid scaffolds: A strategic approach for regenerative clinical applications
2025
•3D hybrid scaffolds improve biocompatibility and biomechanical properties.•Nano-topography enhances cellular interactions and scaffold performance.•4D printing enables dynamic, stimuli-responsive tissue...
Transcript-activated collagen matrix for enhanced bone marrow stem cell differentiation and osteochondral repair
2025
•Transcript-activated collagen matrix delivers TGF-β3 mRNA for enhanced osteochondral repair.•Localized and sustained delivery of TGF-β3 promotes BMSC differentiation into chondrocytes.•Chemically modified...
MicroRNAs and mRNAs: A comparative analysis in translation and commercialization
2025
•Examines the potential of microRNAs as next-generation therapeutics.•Compares microRNAs and mRNAs in translation and commercialization prospects.•Highlights microRNAs’ unique gene-regulatory roles...
Novel microsphere scaffold-based islet organoids for rescuing type 1 diabetes and reversing hyperglycemia
2025
•Three-dimensional porous microsphere scaffolds are constructed based on microfluidic technology to form a multi-stage pore network through controlled stacking to promote cell infiltration and material...
Engineering neuroblastoma models for clinical translation
2025
•Children diagnosed with high-risk neuroblastoma exhibit limited significant therapeutic benefits from the administration of chemotherapy and immunotherapy.•The heterogeneity observed in neuroblastoma...
Force induces axon growth in inhibitory conditions
2025
•Nano-pulling is a technology that utilizes magnetic nanoparticles and magnetic fields to mechanically stimulate neurons.•Nano-pulling induces axon growth in hippocampal neurons in the presence of repulsive...
Bioactive diamond scaffolds support neuronal survival and axonal growth
2025
•Bare diamond scaffold was unable to adhere human embryonic stem cell-derived interneurons.•Interestingly, protein-coated (called as bioactive) diamond scaffolds supported the survival and elongation...
The microenvironment in atherosclerosis: molecular regulation mechanism and immunotherapy
2025
•Exploration of the role of immune cells in atherosclerosis and their potential as therapeutic targets.•Discuss the importance of understanding immune cell crosstalk and signaling pathways for developing...
Injectable elastin-like recombinamer hydrogels with layered degradation rates for osteochondral regeneration in a rabbit model
2025
•Injectable bioactive elastin-like recombinamer (ELR) hydrogels were designed with distinct degradation kinetics tailored for osteochondral regeneration.•Bilayer hydrogels, containing distinct degradation...
Current advances and prospects in biomaterials-guided tools for liver organoids research
2025
•This review emphasizes the significance of utilizing biomaterials for liver organoid development.•The limitations and controversies surrounding the use of Matrigel in clinical studies are critically...