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ISSN: 2666-1381

Heterogenous glucose-stimulated insulin secretion at single islet level

•Using single-islet-on-a-chip platform, three types of islets have been identified based on their dynamic GSIS.•High expression of Atp5pb is anti-correlated with the first phase of insulin secretion.•Diabetic...

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Persuasive factors on the bioink printability and cell viability in the extrusion-based 3D bioprinting for tissue regeneration applications

•The effect of the biopolymer concentration, rheological and physiochemical parameters on the biological and mechanical properties of the printed tissues.•The optimal composition for the various biopolymers...

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Driving modes and characteristics of biomedical micro-robots

•Overview of driving mechanisms for micro-robots.•The autonomous micro-robots are mainly divided into chemically actuated micro-robots and biohybrid micro-robots.•The responsive micro-robots are controlled...

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Biomimetic extracellular vesicles for the tumor targeted treatment

•In this review, we have summarized the relevant articles of the recent new cell follicular peritonium medicine for disease and gave our own opinions.•Through the introduction of different kinds of...

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Strategies for engineering neural cell alignment and their biomedical applications

•Proper alignment is essential for neural cells.•A variety of bioengineering methods have been employed to promote neural cell alignment.•Proper alignment of neural cells benefit nerve injury regen...

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Engineered artificial skins: Current construction strategies and applications

•Give a detailed introduction of the cellular components, scaffold materials and bio-fabrication techniques involved in the construction of artificial skin.•Highlight the application for chronic wound...

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Instability-Driven 3D bioprinting for engineering composite bio-inks

•Extrusion-based 3D printing techniques are advancing bioengineering with the innovative electric-assisted coil-write technology, enabling high-resolution and fast fabrication of intricate microstructures.•This...

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Heparinized PGA host-guest hydrogel loaded with paracrine products from electrically stimulated adipose-derived mesenchymal stem cells for enhanced wound repair

•Appropriate electrical stimulation could boost the paracrine function of adipose derived stem cells.•Heparinized host-guest PGA hydrogel loaded with paracrine factors could effectively benefit the...

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Autophagy mediates osteoporotic bone regeneration induced by micro-/nano-structured modification on hydroxyapatite bioceramics

•Micro-/nano-structured surface played biophysical cues to regulate osteoporotic osteogenesis.•Micro-/nano-structured surface stimulated osteogenesis mediated by autophagy approach.•The mnHA scaffold...

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One-step and wash-free multiplexed immunoassay platform based on bioinspired photonic barcodes

•A novel wash-free immunoassay platform based bioinspired PhC barcodes was developed.•This platform realized multiplexed virus quantification in one tube.•This method exhibited high-sensitivity and...

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Accelerated neutral atom beam (ANAB) and gas clustered ion beam (GCIB) treatment of implantable device polymers leads to decreased bacterial attachment in vitro and decreased inflammation in vivo

•Reduced bacterial attachment to medical device polymers without antibiotics.•Attenuation of polymer foreign body response to implanted medical devices.•Non-chemical, physical modification of polymer...

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Novel metal nanomaterials to promote angiogenesis in tissue regeneration

•The review highlights proangiogenic inorganic nanomaterials in two categories: metal oxide and graphene oxides.•This review discusses novel technologies for the delivery of proangiogenic inorganic...

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Engineering of electrospun nanofiber scaffolds for repairing brain injury

•We introduce the main pathological mechanisms of current brain injuries, pointing out the prospect for the application of electrospun nanofiber scaffolds compared to current clinical treatment strategies.•We...

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Understanding the interplay between cell force and cell adhesion processes

•The activation of cell adhesion and the subsequent molecular biological effects are reviewed.•How mechanics tune cell adhesions are detailed.•An overview of the methods for measuring cell adhesive...

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Rassf2 overexpression mediated by AAV promotes the supporting cell-to-hair cell transformation in the cochlea

•It is a promising way to promote hair cell regeneration by AAV-mediated foreign genes.•Rassf2 overexpression mediated by AAV-ie could enhance organoids production and supporting cells trans-differentiation...

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Developing hierarchical microneedles for biomedical applications

•A broad range of researches about hierarchical microneedles were reviewed, and were categorized according to their structure and materials.•The fabrication strategies and research progress of hierarchical...

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The overexpression of Rps14 in Lgr5+ progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea

•We first constructed Rps14 knock-in floxed mice and explored the role of Rps14 in sensory HC regeneration in vivo.•Overexpression of Rps14 specifically in Lgr5+ progenitor cells significantly promoted...

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Recent advances in small incision lenticule extraction (SMILE)-derived refractive lenticule preservation and clinical reuse

•SMILE-derived lenticules, which used to be the byproduct of SMILE surgery, have now become a huge potential biomaterial in treating various eye diseases, such as refractive error, keratoconus, and...

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Biomimetic selenium nanosystems for infectious wound healing

•The red blood cell membrane-encapsulated selenium nanoparticles (SeNPs) were spherical with a uniform core-shell structure.•The encapsulation of red blood cell membrane enables the nanoparticles with...

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Emerging microfluidic technologies for sperm sorting

•A broad range of researches about sperm sorting with microfluidics were reviewed, and were classified into three types according to the sorting principle.•The properties of sperm and female reproductive...

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Supplemental mineral ions for bone regeneration and osteoporosis treatment

•Summary on all the potentially beneficial nutrition elements for bone regeneration.•Daily supplementation suggestions and dose guidance of these nutrition elements.•In vitro and in vivo models and...

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Treatment of Alzheimer's disease by microcapsule regulates neurotransmitter release via microfluidic technology

•The microfludics electrospray technologies were recruited to overcome limitations associated with variability during microcapsule production and generate functional microcapsules.•In vivo and in vitro...

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Structure and mechanics of native and decellularized porcine cranial dura mater

•Dura mater is decellularized using the SDS decellularization protocol.•There are significant differences in the DNA content of native and decellularized tissues.•There is a sustained tissue thickness,...

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Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells

•The conductive and anisotropic inverse opal substrate is fabricated by modifying polystyrene inverse opal films with carbon nanotubes and then stretching them to varying degrees.•The conductive and...

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