Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects
Available online 9 April 2024
•Asymmetric porous composite hydrogel patch (cCS/PVA@BAC) is developed by a simple and efficient stepwise phase-conversion strategy.•cCS/PVA@BAC offers antibacteria, anti-adhesion, pro-healing and durable...
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Modelling the development of biological structures displaying longitudinal geometries in vitro: culturing pluripotent stem cells on plasma-treated, growth factor-coupled polycaprolactone fibres
March 2024
•We have taken a biomimicry approach to generate complex longitudinal structures in vitro using pluripotent stem cells cultured on plasma-immersion ion implantation (PIII)-treated polycaprolactone (PCL)...
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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency
March 2024
•Simplified process: The AgSNP@CD was prepared through a simplified process, making it amenable to large-scale production.•Portable and stroage: AgSNP@CD maintains structural integrity after compression,...
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Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis
March 2024
•It is a huge challenge to one-step repair the load-bearing large segmental bone defects due to the insufficient structural stability of Ca-phosphate bioceramics.•Customized magnesium-doped wollastonite/β-TCP...
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PETG: Applications in Modern Medicine
March 2024
•PETG is a miscible, transparent thermoplastic with strong tensile properties, high ductility, and favorable resistance to heat and chemical insults.•PETG is an inexpensive and versatile biomaterial.•3D...
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Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering
March 2024
•This review outlined hierarchical structures of bone matrix spanning from nanoscale to macroscale.•This study discussed materialistic components of scaffolds and featured scaffold strategies.•This...
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Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure
March 2024
•The fully human tissue-derived adhesive materials enable significant suppression of inflammatory cytokine storms, which breaks the limitations of existing strategies for organ repair based on the molecular...
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Microenvironment-responsive nanosystems for osteoarthritis therapy
March 2024
•This review underscores the intricate nature of OA, and emphasizes the challenge of comprehending its pathogenesis which have hindered the development of targeted therapies and precision medicine for...
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Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour
March 2024
•Tanycte-derived stem/progenitor cells cultured in vitro spontaneously differentiate.•Fiber properties can be controlled during manufacture to introduce aligned fibers.•Tanycyte-derived neurospheres...
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Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages
March 2024
•We applied pulsed electromagnetic field (PEMF) stimulation on nerve cells.•We screened different parameters and found the optimal ones to improve neurite outgrowth.•The same parameters had anti-inflammatory...
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Applications of silk-based biomaterials in biomedicine and biotechnology
March 2024
•Here, we reported the various unique properties of silk and commercially available silk-based biomaterials.•This review focused on highlighting various biomedical applications of silk-based biomaterials...
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Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
Available online 5 March 2024
•We have developed Bis-5HT-modified paris saponins II (designated as PLGA-5HT-PSII-Ce6) to target neutrophil-specific myeloperoxidase with high availability and bioactivity.•Our verification, using...
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Heterogenous glucose-stimulated insulin secretion at single islet level
December 2023
•Using single-islet-on-a-chip platform, three types of islets have been identified based on their dynamic GSIS.•High expression of Atp5pb is anti-correlated with the first phase of insulin secretion.•Diabetic...
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Strategies for engineering neural cell alignment and their biomedical applications
December 2023
•Proper alignment is essential for neural cells.•A variety of bioengineering methods have been employed to promote neural cell alignment.•Proper alignment of neural cells benefit nerve injury regen...
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Engineered artificial skins: Current construction strategies and applications
December 2023
•Give a detailed introduction of the cellular components, scaffold materials and bio-fabrication techniques involved in the construction of artificial skin.•Highlight the application for chronic wound...
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Driving modes and characteristics of biomedical micro-robots
December 2023
•Overview of driving mechanisms for micro-robots.•The autonomous micro-robots are mainly divided into chemically actuated micro-robots and biohybrid micro-robots.•The responsive micro-robots are controlled...
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Biomimetic extracellular vesicles for the tumor targeted treatment
December 2023
•In this review, we have summarized the relevant articles of the recent new cell follicular peritonium medicine for disease and gave our own opinions.•Through the introduction of different kinds of...
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Decellularized extracellular matrix: A promising strategy for skin repair and regeneration
December 2023
•The commonly utilized decellularization methods and the evaluation methods for cellular residues and bioactive molecules of dECM were introduced.•dECM derived from different sources, including humans,...
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In inflammatory bowel disease and extraintestinal manifestations: What role does microbiome play?
December 2023
•This review aims at conveying the roles of microbiome in inflammatory bowel disease and extraintestinal manifestations.•A critical analysis of current development and challenges is presented.•A comprehensive...
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Development of modified PMMA cement in spine surgery
December 2023
•This paper summarizes the research progress of modified PMMA bone.•Cement in spinal surgery for the first time....
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Mesoporous magnetic nanoparticles conjugated aptamers for exosomes capture and detection of Alzheimer's disease
December 2023
•The magnetic nanoparticles were synthesized by hydrothermal are composed of a core of Fe3O4 and coupled with gold nanoparticles gives it a large specific surface area to effectively capture exosomes.•We...
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Persuasive factors on the bioink printability and cell viability in the extrusion-based 3D bioprinting for tissue regeneration applications
December 2023
•The effect of the biopolymer concentration, rheological and physiochemical parameters on the biological and mechanical properties of the printed tissues.•The optimal composition for the various biopolymers...
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Rassf2 overexpression mediated by AAV promotes the supporting cell-to-hair cell transformation in the cochlea
September 2023
•It is a promising way to promote hair cell regeneration by AAV-mediated foreign genes.•Rassf2 overexpression mediated by AAV-ie could enhance organoids production and supporting cells trans-differentiation...
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One-step and wash-free multiplexed immunoassay platform based on bioinspired photonic barcodes
September 2023
•A novel wash-free immunoassay platform based bioinspired PhC barcodes was developed.•This platform realized multiplexed virus quantification in one tube.•This method exhibited high-sensitivity and...
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