Transcript-activated collagen matrix for enhanced bone marrow stem cell differentiation and osteochondral repair
2025
•Transcript-activated collagen matrix delivers TGF-β3 mRNA for enhanced osteochondral repair.•Localized and sustained delivery of TGF-β3 promotes BMSC differentiation into chondrocytes.•Chemically modified...
MicroRNAs and mRNAs: A comparative analysis in translation and commercialization
2025
•Examines the potential of microRNAs as next-generation therapeutics.•Compares microRNAs and mRNAs in translation and commercialization prospects.•Highlights microRNAs’ unique gene-regulatory roles...
Novel microsphere scaffold-based islet organoids for rescuing type 1 diabetes and reversing hyperglycemia
2025
•Three-dimensional porous microsphere scaffolds are constructed based on microfluidic technology to form a multi-stage pore network through controlled stacking to promote cell infiltration and material...
Engineering neuroblastoma models for clinical translation
2025
•Children diagnosed with high-risk neuroblastoma exhibit limited significant therapeutic benefits from the administration of chemotherapy and immunotherapy.•The heterogeneity observed in neuroblastoma...
Force induces axon growth in inhibitory conditions
2025
•Nano-pulling is a technology that utilizes magnetic nanoparticles and magnetic fields to mechanically stimulate neurons.•Nano-pulling induces axon growth in hippocampal neurons in the presence of repulsive...
Bioactive diamond scaffolds support neuronal survival and axonal growth
2025
•Bare diamond scaffold was unable to adhere human embryonic stem cell-derived interneurons.•Interestingly, protein-coated (called as bioactive) diamond scaffolds supported the survival and elongation...
The microenvironment in atherosclerosis: molecular regulation mechanism and immunotherapy
2025
•Exploration of the role of immune cells in atherosclerosis and their potential as therapeutic targets.•Discuss the importance of understanding immune cell crosstalk and signaling pathways for developing...
Injectable elastin-like recombinamer hydrogels with layered degradation rates for osteochondral regeneration in a rabbit model
2025
•Injectable bioactive elastin-like recombinamer (ELR) hydrogels were designed with distinct degradation kinetics tailored for osteochondral regeneration.•Bilayer hydrogels, containing distinct degradation...
Current advances and prospects in biomaterials-guided tools for liver organoids research
2025
•This review emphasizes the significance of utilizing biomaterials for liver organoid development.•The limitations and controversies surrounding the use of Matrigel in clinical studies are critically...
Immunomodulating red blood cell coating for mitigation of foreign body reactions
2025
•A living RBCs coating was fabricated upon PDMS substrate by using HA as a bridging polymer.•PDMS-HA-RBC implant revealed the minimum fibrosis formation compared to pristine PDMS and PDMS-HA implants.•PDMS-HA-RBC...
Mapping the trajectory of organoid research: Insights into complex models and advanced technologies
2025
•In recent years, organoid models have become invaluable tools for studying organ development, disease progression, and drug interactions, offering significant advantages over traditional animal models....
Molecular pathogenesis of acne and their microneedle treatments
2025
•Acne is a chronic inflammatory skin disorder driven by genetics, hormones, immune dysregulation, follicular hyperkeratosis, and C. acnes proliferation.•Microneedle-based therapies provide innovative...
Decellularized tissue-specific hydrogels support an engineered salivary gland within a microfluidic platform
2025
•dSMG hydrogel retains key ECM components, exhibits a nanofibrous structure, and possesses a thermo-responsive gelation.•dSMG hydrogel ensures consistent biological effects with minimal batch-to-batch...
Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing
December 2024
•A sprayable, efficient and convenient TACo nanozyme was designed via one-pot method.•TACo nanozyme exhibit pH-responsive and photothermal antibacterial properties.•TACo nanozyme can effectively relieve...
Bone improvement in osteoporotic rabbits using CoCrMo implants
December 2024
•Metallic biomaterial helps to improve osteoporotic cortical bone.•The experience performed in animals reflected an increase in bone quality.•After 8 weeks, there was marked osteogenesis with both apposition...
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
December 2024
•Highly bioactive ECM microfibers serve as reinforce phase to strengthen CSH/CP@ECM-Deno mechanical property similar to cancellous bone.•Long-term release of denosumab regulates osteoclastogenesis by...
Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects
December 2024
•Asymmetric porous composite hydrogel patch (cCS/PVA@BAC) is developed by a simple and efficient stepwise phase-conversion strategy.•cCS/PVA@BAC offers antibacteria, anti-adhesion, pro-healing and durable...
Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
December 2024
•We have developed Bis-5HT-modified paris saponins II (designated as PLGA-5HT-PSII-Ce6) to target neutrophil-specific myeloperoxidase with high availability and bioactivity.•Our verification, using...
Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons
December 2024
•Cochlear implant/MXene-based electricacoustic stimulation system is proposed and constructed.•Low-frequency electroacoustic stimulation promotes the growth and development of SGNs.•Low-frequency electroacoustic...
