The microenvironment in atherosclerosis: molecular regulation mechanism and immunotherapy
2025
•Exploration of the role of immune cells in atherosclerosis and their potential as therapeutic targets.•Discuss the importance of understanding immune cell crosstalk and signaling pathways for developing...
Injectable elastin-like recombinamer hydrogels with layered degradation rates for osteochondral regeneration in a rabbit model
2025
•Injectable bioactive elastin-like recombinamer (ELR) hydrogels were designed with distinct degradation kinetics tailored for osteochondral regeneration.•Bilayer hydrogels, containing distinct degradation...
Current advances and prospects in biomaterials-guided tools for liver organoids research
2025
•This review emphasizes the significance of utilizing biomaterials for liver organoid development.•The limitations and controversies surrounding the use of Matrigel in clinical studies are critically...
Immunomodulating red blood cell coating for mitigation of foreign body reactions
2025
•A living RBCs coating was fabricated upon PDMS substrate by using HA as a bridging polymer.•PDMS-HA-RBC implant revealed the minimum fibrosis formation compared to pristine PDMS and PDMS-HA implants.•PDMS-HA-RBC...
Mapping the trajectory of organoid research: Insights into complex models and advanced technologies
2025
•In recent years, organoid models have become invaluable tools for studying organ development, disease progression, and drug interactions, offering significant advantages over traditional animal models....
Molecular pathogenesis of acne and their microneedle treatments
2025
•Acne is a chronic inflammatory skin disorder driven by genetics, hormones, immune dysregulation, follicular hyperkeratosis, and C. acnes proliferation.•Microneedle-based therapies provide innovative...
Decellularized tissue-specific hydrogels support an engineered salivary gland within a microfluidic platform
2025
•dSMG hydrogel retains key ECM components, exhibits a nanofibrous structure, and possesses a thermo-responsive gelation.•dSMG hydrogel ensures consistent biological effects with minimal batch-to-batch...
Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing
December 2024
•A sprayable, efficient and convenient TACo nanozyme was designed via one-pot method.•TACo nanozyme exhibit pH-responsive and photothermal antibacterial properties.•TACo nanozyme can effectively relieve...
Bone improvement in osteoporotic rabbits using CoCrMo implants
December 2024
•Metallic biomaterial helps to improve osteoporotic cortical bone.•The experience performed in animals reflected an increase in bone quality.•After 8 weeks, there was marked osteogenesis with both apposition...
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
December 2024
•Highly bioactive ECM microfibers serve as reinforce phase to strengthen CSH/CP@ECM-Deno mechanical property similar to cancellous bone.•Long-term release of denosumab regulates osteoclastogenesis by...
Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects
December 2024
•Asymmetric porous composite hydrogel patch (cCS/PVA@BAC) is developed by a simple and efficient stepwise phase-conversion strategy.•cCS/PVA@BAC offers antibacteria, anti-adhesion, pro-healing and durable...
Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
December 2024
•We have developed Bis-5HT-modified paris saponins II (designated as PLGA-5HT-PSII-Ce6) to target neutrophil-specific myeloperoxidase with high availability and bioactivity.•Our verification, using...
A patch comprising human umbilical cord-derived hydrogel and mesenchymal stem cells promotes pressure ulcer wound healing
December 2024
•Patch of MSCs/dECM accelerated wound healing and enhanced re-epithelialization of PU in mice.•This effect can be attributed to the promotion of tissue re-epithelialization, collagen deposition, angiogenesis,...
Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons
December 2024
•Cochlear implant/MXene-based electricacoustic stimulation system is proposed and constructed.•Low-frequency electroacoustic stimulation promotes the growth and development of SGNs.•Low-frequency electroacoustic...
Ginsenoside Rb1 improves human nonalcoholic fatty liver disease with liver organoids-on-a-chip
September 2024
•The liver organoids-on-a-chip platform could recapitulate key features of human liver physiology.•Free fatty acid-induced liver organoids displayed typical pathological characteristics similar to those...
Intelligent hydrogels for treating malignant melanoma
September 2024
•Potential options for treatment of malignant melanoma (MM) are being presented by emerging therapies like immunotherapy, photodynamic therapy and photothermal therapy due to their effective and secure...
Advances in nano silver-based biomaterials and their biomedical applications
September 2024
•We report the various physical, chemical and biological methods for AgNP synthesis.•Antimicrobial effect of AgNPs allows effective use in wound healing and dentistry.•Unique optical properties of AgNPs...
Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles
September 2024
•Green synthesized silver nanoparticles have shown promising results in wound healing, promoting faster healing and reducing infection risk.•These environmentally friendly nanoparticles offer a sustainable...
Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres
September 2024
•The effect of strain on muscle tendon junction formation was investigated for the first time.•10 % cyclic strain induced the cell morphology changes and the gene expression and production of proteins...
Instability-Driven 3D bioprinting for engineering composite bio-inks
September 2024
•Extrusion-based 3D printing techniques are advancing bioengineering with the innovative electric-assisted coil-write technology, enabling high-resolution and fast fabrication of intricate microstructures.•This...