In inflammatory bowel disease and extraintestinal manifestations: What role does microbiome play?
December 2023
•This review aims at conveying the roles of microbiome in inflammatory bowel disease and extraintestinal manifestations.•A critical analysis of current development and challenges is presented.•A comprehensive...
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Mesoporous magnetic nanoparticles conjugated aptamers for exosomes capture and detection of Alzheimer's disease
December 2023
•The magnetic nanoparticles were synthesized by hydrothermal are composed of a core of Fe3O4 and coupled with gold nanoparticles gives it a large specific surface area to effectively capture exosomes.•We...
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Decellularized extracellular matrix: A promising strategy for skin repair and regeneration
December 2023
•The commonly utilized decellularization methods and the evaluation methods for cellular residues and bioactive molecules of dECM were introduced.•dECM derived from different sources, including humans,...
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Development of modified PMMA cement in spine surgery
December 2023
•This paper summarizes the research progress of modified PMMA bone.•Cement in spinal surgery for the first time....
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Heterogenous glucose-stimulated insulin secretion at single islet level
December 2023
•Using single-islet-on-a-chip platform, three types of islets have been identified based on their dynamic GSIS.•High expression of Atp5pb is anti-correlated with the first phase of insulin secretion.•Diabetic...
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Persuasive factors on the bioink printability and cell viability in the extrusion-based 3D bioprinting for tissue regeneration applications
December 2023
•The effect of the biopolymer concentration, rheological and physiochemical parameters on the biological and mechanical properties of the printed tissues.•The optimal composition for the various biopolymers...
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Driving modes and characteristics of biomedical micro-robots
December 2023
•Overview of driving mechanisms for micro-robots.•The autonomous micro-robots are mainly divided into chemically actuated micro-robots and biohybrid micro-robots.•The responsive micro-robots are controlled...
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Biomimetic extracellular vesicles for the tumor targeted treatment
December 2023
•In this review, we have summarized the relevant articles of the recent new cell follicular peritonium medicine for disease and gave our own opinions.•Through the introduction of different kinds of...
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Strategies for engineering neural cell alignment and their biomedical applications
December 2023
•Proper alignment is essential for neural cells.•A variety of bioengineering methods have been employed to promote neural cell alignment.•Proper alignment of neural cells benefit nerve injury regen...
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Engineered artificial skins: Current construction strategies and applications
December 2023
•Give a detailed introduction of the cellular components, scaffold materials and bio-fabrication techniques involved in the construction of artificial skin.•Highlight the application for chronic wound...
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Instability-Driven 3D bioprinting for engineering composite bio-inks
Available online 30 December 2023
•Extrusion-based 3D printing techniques are advancing bioengineering with the innovative electric-assisted coil-write technology, enabling high-resolution and fast fabrication of intricate microstructures.•This...
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Heparinized PGA host-guest hydrogel loaded with paracrine products from electrically stimulated adipose-derived mesenchymal stem cells for enhanced wound repair
September 2023
•Appropriate electrical stimulation could boost the paracrine function of adipose derived stem cells.•Heparinized host-guest PGA hydrogel loaded with paracrine factors could effectively benefit the...
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Autophagy mediates osteoporotic bone regeneration induced by micro-/nano-structured modification on hydroxyapatite bioceramics
September 2023
•Micro-/nano-structured surface played biophysical cues to regulate osteoporotic osteogenesis.•Micro-/nano-structured surface stimulated osteogenesis mediated by autophagy approach.•The mnHA scaffold...
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One-step and wash-free multiplexed immunoassay platform based on bioinspired photonic barcodes
September 2023
•A novel wash-free immunoassay platform based bioinspired PhC barcodes was developed.•This platform realized multiplexed virus quantification in one tube.•This method exhibited high-sensitivity and...
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Accelerated neutral atom beam (ANAB) and gas clustered ion beam (GCIB) treatment of implantable device polymers leads to decreased bacterial attachment in vitro and decreased inflammation in vivo
September 2023
•Reduced bacterial attachment to medical device polymers without antibiotics.•Attenuation of polymer foreign body response to implanted medical devices.•Non-chemical, physical modification of polymer...
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Novel metal nanomaterials to promote angiogenesis in tissue regeneration
September 2023
•The review highlights proangiogenic inorganic nanomaterials in two categories: metal oxide and graphene oxides.•This review discusses novel technologies for the delivery of proangiogenic inorganic...
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Engineering of electrospun nanofiber scaffolds for repairing brain injury
September 2023
•We introduce the main pathological mechanisms of current brain injuries, pointing out the prospect for the application of electrospun nanofiber scaffolds compared to current clinical treatment strategies.•We...
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Understanding the interplay between cell force and cell adhesion processes
September 2023
•The activation of cell adhesion and the subsequent molecular biological effects are reviewed.•How mechanics tune cell adhesions are detailed.•An overview of the methods for measuring cell adhesive...
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Rassf2 overexpression mediated by AAV promotes the supporting cell-to-hair cell transformation in the cochlea
September 2023
•It is a promising way to promote hair cell regeneration by AAV-mediated foreign genes.•Rassf2 overexpression mediated by AAV-ie could enhance organoids production and supporting cells trans-differentiation...
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Developing hierarchical microneedles for biomedical applications
September 2023
•A broad range of researches about hierarchical microneedles were reviewed, and were categorized according to their structure and materials.•The fabrication strategies and research progress of hierarchical...
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The overexpression of Rps14 in Lgr5+ progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea
September 2023
•We first constructed Rps14 knock-in floxed mice and explored the role of Rps14 in sensory HC regeneration in vivo.•Overexpression of Rps14 specifically in Lgr5+ progenitor cells significantly promoted...
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Emerging microfluidic technologies for sperm sorting
June 2023
•A broad range of researches about sperm sorting with microfluidics were reviewed, and were classified into three types according to the sorting principle.•The properties of sperm and female reproductive...
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Structure and mechanics of native and decellularized porcine cranial dura mater
June 2023
•Dura mater is decellularized using the SDS decellularization protocol.•There are significant differences in the DNA content of native and decellularized tissues.•There is a sustained tissue thickness,...
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Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells
June 2023
•The conductive and anisotropic inverse opal substrate is fabricated by modifying polystyrene inverse opal films with carbon nanotubes and then stretching them to varying degrees.•The conductive and...
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