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ISSN: 2666-1381

In inflammatory bowel disease and extraintestinal manifestations: What role does microbiome play?

•This review aims at conveying the roles of microbiome in inflammatory bowel disease and extraintestinal manifestations.•A critical analysis of current development and challenges is presented.•A comprehensive...

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Mesoporous magnetic nanoparticles conjugated aptamers for exosomes capture and detection of Alzheimer's disease

•The magnetic nanoparticles were synthesized by hydrothermal are composed of a core of Fe3O4 and coupled with gold nanoparticles gives it a large specific surface area to effectively capture exosomes.•We...

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Decellularized extracellular matrix: A promising strategy for skin repair and regeneration

•The commonly utilized decellularization methods and the evaluation methods for cellular residues and bioactive molecules of dECM were introduced.•dECM derived from different sources, including humans,...

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Heparinized PGA host-guest hydrogel loaded with paracrine products from electrically stimulated adipose-derived mesenchymal stem cells for enhanced wound repair

•Appropriate electrical stimulation could boost the paracrine function of adipose derived stem cells.•Heparinized host-guest PGA hydrogel loaded with paracrine factors could effectively benefit the...

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Autophagy mediates osteoporotic bone regeneration induced by micro-/nano-structured modification on hydroxyapatite bioceramics

•Micro-/nano-structured surface played biophysical cues to regulate osteoporotic osteogenesis.•Micro-/nano-structured surface stimulated osteogenesis mediated by autophagy approach.•The mnHA scaffold...

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One-step and wash-free multiplexed immunoassay platform based on bioinspired photonic barcodes

•A novel wash-free immunoassay platform based bioinspired PhC barcodes was developed.•This platform realized multiplexed virus quantification in one tube.•This method exhibited high-sensitivity and...

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Accelerated neutral atom beam (ANAB) and gas clustered ion beam (GCIB) treatment of implantable device polymers leads to decreased bacterial attachment in vitro and decreased inflammation in vivo

•Reduced bacterial attachment to medical device polymers without antibiotics.•Attenuation of polymer foreign body response to implanted medical devices.•Non-chemical, physical modification of polymer...

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Novel metal nanomaterials to promote angiogenesis in tissue regeneration

•The review highlights proangiogenic inorganic nanomaterials in two categories: metal oxide and graphene oxides.•This review discusses novel technologies for the delivery of proangiogenic inorganic...

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Engineering of electrospun nanofiber scaffolds for repairing brain injury

•We introduce the main pathological mechanisms of current brain injuries, pointing out the prospect for the application of electrospun nanofiber scaffolds compared to current clinical treatment strategies.•We...

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Understanding the interplay between cell force and cell adhesion processes

•The activation of cell adhesion and the subsequent molecular biological effects are reviewed.•How mechanics tune cell adhesions are detailed.•An overview of the methods for measuring cell adhesive...

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Rassf2 overexpression mediated by AAV promotes the supporting cell-to-hair cell transformation in the cochlea

•It is a promising way to promote hair cell regeneration by AAV-mediated foreign genes.•Rassf2 overexpression mediated by AAV-ie could enhance organoids production and supporting cells trans-differentiation...

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Developing hierarchical microneedles for biomedical applications

•A broad range of researches about hierarchical microneedles were reviewed, and were categorized according to their structure and materials.•The fabrication strategies and research progress of hierarchical...

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The overexpression of Rps14 in Lgr5+ progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea

•We first constructed Rps14 knock-in floxed mice and explored the role of Rps14 in sensory HC regeneration in vivo.•Overexpression of Rps14 specifically in Lgr5+ progenitor cells significantly promoted...

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Natural Biopolymers for Bone Tissue Engineering: A Brief Review

•The review emphasizes the critical characteristics such as structure, degradability, and, the biocompatibility of natural biopolymers for bone tissue engineering.•The document embraces the information...

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Recent advances in small incision lenticule extraction (SMILE)-derived refractive lenticule preservation and clinical reuse

•SMILE-derived lenticules, which used to be the byproduct of SMILE surgery, have now become a huge potential biomaterial in treating various eye diseases, such as refractive error, keratoconus, and...

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Engineering strategies of islet products for endocrine regeneration

•Providing a general understanding of engineering challenges in islet transplantation.•Summarizing the cutting edge of engineering technologies for islet-related products.•Brief introduction of human...

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Biomimetic selenium nanosystems for infectious wound healing

•The red blood cell membrane-encapsulated selenium nanoparticles (SeNPs) were spherical with a uniform core-shell structure.•The encapsulation of red blood cell membrane enables the nanoparticles with...

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X-reality for phantom limb management for amputees: A systematic review and meta-analysis

•This review included 16 articles that managed phantom limb using X-reality interventions.•Virtual (11), augmented (4), and mixed reality (1) were applied for phantom limb management.•X-reality can...

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Emerging microfluidic technologies for sperm sorting

•A broad range of researches about sperm sorting with microfluidics were reviewed, and were classified into three types according to the sorting principle.•The properties of sperm and female reproductive...

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Supplemental mineral ions for bone regeneration and osteoporosis treatment

•Summary on all the potentially beneficial nutrition elements for bone regeneration.•Daily supplementation suggestions and dose guidance of these nutrition elements.•In vitro and in vivo models and...

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Treatment of Alzheimer's disease by microcapsule regulates neurotransmitter release via microfluidic technology

•The microfludics electrospray technologies were recruited to overcome limitations associated with variability during microcapsule production and generate functional microcapsules.•In vivo and in vitro...

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Structure and mechanics of native and decellularized porcine cranial dura mater

•Dura mater is decellularized using the SDS decellularization protocol.•There are significant differences in the DNA content of native and decellularized tissues.•There is a sustained tissue thickness,...

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Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells

•The conductive and anisotropic inverse opal substrate is fabricated by modifying polystyrene inverse opal films with carbon nanotubes and then stretching them to varying degrees.•The conductive and...

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Bioactive 3D-printed chitosan-based scaffolds for personalized craniofacial bone tissue engineering

•3D-printing of chitosan-based hydrogel.•Increase in pore size and porosity was observed in the 3D-printed scaffolds containing hydroxyapatite.•Hydroxyapatite incorporation increased apatite formation...

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Orthotopic implantable liver decellularized scaffold for acute liver failure

•The natural morphology of the decellularized constructs is preserved by whole liver perfusion decellularization technique.•The whole liver perfused decellularized scaffold exhibit a superior bio-mechanical...

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