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ISSN: 2666-1381

Development of fish collagen in tissue regeneration and drug delivery

•Marine-based collagen as a resealable replacement for mammal-based collagen.•Potential advantages of MC thanks to its amenable chemical properties.•Methods for preparation of collagen from different...

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Engineered microneedles arrays for wound healing

•The advances of engineered microneedles arrays for wound healing were reviewed.•The design strategies, advanced applications and advantages of engineered microneedles arrays were summarized.•The challenges,...

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Osteoblastic microRNAs in skeletal diseases: Biological functions and therapeutic implications

•The role of microRNAs in skeletal diseases is summarized.•The regulatory effects of microRNAs in biological process during osteogenesis are systematically presented.•The potential application of microRNA-based...

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Programmable microfluidic manipulations for biomedical applications

•Programable fluid manipulation plays an important role in biomedical applications such as biochemical assays, medical diagnostics, and drug development.•In this paper, we summarize some latest studies...

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Ellipsoidal porous patch with anisotropic cell inducing ability for inhibiting skin scar formation

•An ellipsoidal porous patch is fabricated for inhibiting skin scar formation.•The anisotropic surface microstructure of patch showed dramatic capability in guiding cell growth and arrangement by reconstructing...

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Engineered extracellular vesicles: Regulating the crosstalk between the skeleton and immune system

•Extracellular vesicles of natural origin mediate the crosstalk between immune system and skeleton.•Bioengineering techniques are used to tailor extracellular vesicles for enhanced targeting ability...

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Living cell for drug delivery

•The development of living cell as drug delivery systems were reviewed.•The drug loading methods, applications and advantages were listed.•The mechanisms of action, therapeutic applications, and features...

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Virtual reality based multiple life skill training for intellectual disability: A multicenter randomized controlled trial

•A VR based life skill training was developed, including shopping, cooking, and cleaning tasks.•VR training can improve cooking and cleaning performance.•VR training had better improvement on memory...

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Extracellular matrix and nitric oxide based functional coatings for vascular stents

•Intravascular stents face perpetuating shortcomings, including thrombogenecity, poor re-endothelialization, and in-stent restenosis.•Extracellular matrix-based coatings improve stent performance by...

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Wound dressing products: A translational investigation from the bench to the market

•Designing advanced cost-effective wound dressings is an urgent need worldwide.•Promising in vitro and in vivo results are not often confirmed by Clinical Trials.•The use of personalized treatments...

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Scaffolds with anisotropic structure for neural tissue engineering

•Scaffolds with anisotropic structures biomimicking the native extracellular matrix (ECM) can effectively guide neural orientation and reconnection.•The advancements of scaffolds with anisotropic structures...

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Development and challenges of cells- and materials-based tooth regeneration

•The common dental diseases and their treatment methods are introduced.•Various cells and materials used to realize tooth regeneration are summarized.•The mechanisms of tooth regeneration were also...

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Biomimetic epithelium/endothelium on chips

•Epithelium/endothelium on chips provides a novel and effective in vitro approach for interrogating human epithelium or endothelium pathophysiology.•Epithelium/endothelium on chips will promote the...

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Microfluidic bioscaffolds for regenerative engineering

•Microfluidic bioscaffolds is a hotspot sprung up in recent years, which refers to biological scaffold prepared from biological materials through microfluidic technology.•Microfluidic bioscaffolds typically...

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Polyhydroxyalkanoates in tissue repair and regeneration

•PHA is widely used in biomedical engineering due to its flexible mechanical properties, biocompatibility, and biodegradability.•A systematic report on the performance advantages and application value...

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Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration

•PU/PLCL composite membranes with different proportions were prepared via electrospinning.•Bonding joints in PU/PLCL composite electrospun membranes could result in a transfer of force on the fibers.•The...

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Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

•Photosensitizers with Aggregation-Induced emission characteristics (AIEgens) are introduced with their excellent biocompatibility, biodegradability, and moldability.•Recent progress of photosensitizers...

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3D Printing of Ceramic Biomaterials

•Five additive manufacturing strategies for printing bioceramics are described herein.•Printing bioceramics lead to highly porous, bioactive microstructures as favored by tissue-engineered scaffolds,...

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Conductive ionic liquid/chitosan hydrogels for neuronal cell differentiation

•The aim was to regulate cell behavior and promote nerve function recovery.•An artificial conductive pCM@IL hydrogel was employed to maintain cell viability and increase cell growth.•The pCM@IL conductive...

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Applications of 3D printed chimeric DNA biomaterials

•3D bioprinting techniques suitable for chimeric biomaterials are discussed.•Current research conducted with chimeric biomaterials, e.g. tissue engineering and cancer treatment, are reviewed.•Major...

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A novel core-shell rifampicin/isoniazid electrospun nanofiber membrane for long time drug dissolution

•RIF/INH core-shell nanofibers were successfully prepared by coaxial electrospinning.•RIF and INH had no chemical reaction with PLLA during the preparation process.•RIF/INH core-shell nanofibers have...

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Multifunctional building elements for the construction of peptide drug conjugates

•This review presents special attention to the role and importance of structural characteristics of self-assembling peptides, transformable peptide-drug conjugates, targeting peptides and cell-penetrating...

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Developing tissue engineering strategies for liver regeneration

•Liver tissue engineering is considered to be the most promising alternative for mimicking liver microstructure, maintaining hepatic function or implanting whole liver.•The most common and novel strategies...

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In silico analysis of RNA and small RNA sequencing data from human BM-MSCs and differentiated osteocytes, chondrocytes and tenocytes

•Identification of transcriptomic changes in human bone marrow stem cells and their differentiation lineages.•Young adult's stem cells are more active and rapidly differentiate to their lineages.•Very...

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Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy

Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the tumor. The outcome of antigen-specific T-cells responses relies...

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