Ginsenoside Rb1 improves human nonalcoholic fatty liver disease with liver organoids-on-a-chip
September 2024
•The liver organoids-on-a-chip platform could recapitulate key features of human liver physiology.•Free fatty acid-induced liver organoids displayed typical pathological characteristics similar to those...
Share article
Intelligent hydrogels for treating malignant melanoma
September 2024
•Potential options for treatment of malignant melanoma (MM) are being presented by emerging therapies like immunotherapy, photodynamic therapy and photothermal therapy due to their effective and secure...
Share article
Advances in nano silver-based biomaterials and their biomedical applications
September 2024
•We report the various physical, chemical and biological methods for AgNP synthesis.•Antimicrobial effect of AgNPs allows effective use in wound healing and dentistry.•Unique optical properties of AgNPs...
Share article
Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles
September 2024
•Green synthesized silver nanoparticles have shown promising results in wound healing, promoting faster healing and reducing infection risk.•These environmentally friendly nanoparticles offer a sustainable...
Share article
Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression
September 2024
•3-Dimensional matrix fabricated from poly-l-lactide acid (PLLA) with collagen coating (PLLA/CC) displayed great biocompatibility and biodegradability properties.•Immobilization of conditioned medium...
Share article
Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption
September 2024
•The mechanism of osteoclastogenesis induced by rankl is very important.•Oleandin can inhibit RANKL-induced osteoclast formation and bone resorption in vitro.•Oleandrin effectively inhibited lipopolysaccharide-induced...
Share article
Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres
September 2024
•The effect of strain on muscle tendon junction formation was investigated for the first time.•10 % cyclic strain induced the cell morphology changes and the gene expression and production of proteins...
Share article
Cross-talk between biometal ions and immune cells for bone repair
September 2024
•The interplay between bioactive factors, bone-related cells, and immune system involved in bone repair continues to be of great scientific interest in the field of bone tissue regeneration.•In this...
Share article
Microalgae-based drug delivery systems in biomedical applications
September 2024
•Applications of microalgae biomass as drug carrier.•Microalgae drug delivery systems based on simple preparation and surface modifying.•Applications of photosynthesis in microalgae as an oxygenator.•Applications...
Share article
Instability-Driven 3D bioprinting for engineering composite bio-inks
September 2024
•Extrusion-based 3D printing techniques are advancing bioengineering with the innovative electric-assisted coil-write technology, enabling high-resolution and fast fabrication of intricate microstructures.•This...
Share article
Comparison of two hemostatic skin adhesive dressings, incorporating multi-metal bioactive glass
Available online 2 July 2024
•Multi-element bioactive glass nanoparticles (BG) were successfully synthesized.•Two skin adhesives, with GelMA back bone, based on adhesive molecules of DOPA and TA, integrating BG were developed.•Both...
Share article
Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells
June 2024
•Sustained adenosine release achieved using S/O/W method in polymeric microparticles.•Controlled release of adenosine boosts mineralization & osteogenic differentiation.•Novel exploration of adenosine's...
Share article
Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair
June 2024
•Developed a magnetic-responsive aligned nanofiber fibrin hydrogel (MAFG), integrating material structure with magnetic stimulation for spinal cord regeneration.•Demonstrated that medium-intensity magnetic...
Share article
The Artificial Disc Nucleus and Other Strategies for Replacement of the Nucleus Pulposus: Past, Present and Future Designs for an Emerging Surgical Solution
June 2024
•Nucleus pulposus replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs (IVDs).•Review of pathologies treated with this technology,...
Share article
Microalgae-based drug delivery system for tumor microenvironment photo-modulating and synergistic chemo-photodynamic therapy of osteosarcoma
June 2024
•A natural photosynthetic microalgae (C. vulgaris) was used as drug carriers loaded with chemotherapeutic doxorubicin to develop a multifunctional therapeutic platform (CV@DOX) for tumor microenvironment...
Share article
Flexible wearable sensors: An emerging platform for monitoring of bacterial infection in skin wounds
June 2024
•We introduced the distribution of bacteria in wound infections.•We summarized current methods for bacterial detection in wounds.•We discussed three kinds of flexible wearable sensors for bacterial...
Share article
Emerging microfluidics for the modeling and treatment of arthritis
June 2024
•Arthritis is a general term for a variety of joint diseases, seriously affecting people's physical and mental health.•Microfluidic is a technology that allows the precise control of fluid in a micro-channel.•In...
Share article
LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma
June 2024
•High mobility group box 1(HMGB1) high expressed in laryngeal cancer tissues.•Knockdown of HMGB1 expression in laryngeal squamous cell carcinoma (LSCC) cells significantly suppressed the malignant phenotype...
Share article
The role of gut microbiota associated metabolites in digestive disorders
June 2024
•Gut microbiota is closely linked to the body through its metabolites.•Gut microbiota metabolites participate in digestive system stabilization.•Gut microbiota metabolites affect the inflammatory bowel...
Share article
The role of Piezo1 and Piezo2 proteins in tissue engineering: A Comprehensive review
June 2024
•Piezo1 and Piezo2 are the two novel mechanosensitive ion channels found in humans.•Piezo's are a sizeable trimeric protein with a three-bladed, propeller-like structure.•Two models- ‘Force from filament’...
Share article
Targeted delivery of factors and cells for improving cardiac tissue regeneration and heart function following myocardial infarction
June 2024
•Sequential delivery of cytokines, growth factors and cells improved cardiac tissue repair.•IL-10, TGF-β/VEGF-A, FGF-2 loaded into a chitosan-based cryogel exerted a synergistic effect.•Cryo/GF/Cells...
Share article
Targeted drug delivery system for Golgi apparatus's diseases
Available online 8 June 2024
•Snapshot of Golgi apparatus•Design scheme for targeting Golgi apparatus•Typical application of Golgi targeting in disease surveillance and therapy...
Share article
Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing
Available online 8 June 2024
•A sprayable, efficient and convenient TACo nanozyme was designed via one-pot method.•TACo nanozyme exhibit pH-responsive and photothermal antibacterial properties.•TACo nanozyme can effectively relieve...
Share article
Bone improvement in osteoporotic rabbits using CoCrMo implants
Available online 18 May 2024
•Metallic biomaterial helps to improve osteoporotic cortical bone.•The experience performed in animals reflected an increase in bone quality.•After 8 weeks, there was marked osteogenesis with both apposition...
Share article
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
Available online 11 May 2024
•Highly bioactive ECM microfibers serve as reinforce phase to strengthen CSH/CP@ECM-Deno mechanical property similar to cancellous bone.•Long-term release of denosumab regulates osteoclastogenesis by...
Share article
