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ISSN: 2666-1381

Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair

•Developed a magnetic-responsive aligned nanofiber fibrin hydrogel (MAFG), integrating material structure with magnetic stimulation for spinal cord regeneration.•Demonstrated that medium-intensity magnetic...

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The role of Piezo1 and Piezo2 proteins in tissue engineering: A Comprehensive review

•Piezo1 and Piezo2 are the two novel mechanosensitive ion channels found in humans.•Piezo's are a sizeable trimeric protein with a three-bladed, propeller-like structure.•Two models- ‘Force from filament’...

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Emerging microfluidics for the modeling and treatment of arthritis

•Arthritis is a general term for a variety of joint diseases, seriously affecting people's physical and mental health.•Microfluidic is a technology that allows the precise control of fluid in a micro-channel.•In...

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Microalgae-based drug delivery system for tumor microenvironment photo-modulating and synergistic chemo-photodynamic therapy of osteosarcoma

•A natural photosynthetic microalgae (C. vulgaris) was used as drug carriers loaded with chemotherapeutic doxorubicin to develop a multifunctional therapeutic platform (CV@DOX) for tumor microenvironment...

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Flexible wearable sensors: An emerging platform for monitoring of bacterial infection in skin wounds

•We introduced the distribution of bacteria in wound infections.•We summarized current methods for bacterial detection in wounds.•We discussed three kinds of flexible wearable sensors for bacterial...

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Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects

•Asymmetric porous composite hydrogel patch (cCS/PVA@BAC) is developed by a simple and efficient stepwise phase-conversion strategy.•cCS/PVA@BAC offers antibacteria, anti-adhesion, pro-healing and durable...

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Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis

•It is a huge challenge to one-step repair the load-bearing large segmental bone defects due to the insufficient structural stability of Ca-phosphate bioceramics.•Customized magnesium-doped wollastonite/β-TCP...

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Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering

•This review outlined hierarchical structures of bone matrix spanning from nanoscale to macroscale.•This study discussed materialistic components of scaffolds and featured scaffold strategies.•This...

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Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour

•Tanycte-derived stem/progenitor cells cultured in vitro spontaneously differentiate.•Fiber properties can be controlled during manufacture to introduce aligned fibers.•Tanycyte-derived neurospheres...

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PETG: Applications in Modern Medicine

•PETG is a miscible, transparent thermoplastic with strong tensile properties, high ductility, and favorable resistance to heat and chemical insults.•PETG is an inexpensive and versatile biomaterial.•3D...

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Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure

•The fully human tissue-derived adhesive materials enable significant suppression of inflammatory cytokine storms, which breaks the limitations of existing strategies for organ repair based on the molecular...

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Applications of silk-based biomaterials in biomedicine and biotechnology

•Here, we reported the various unique properties of silk and commercially available silk-based biomaterials.•This review focused on highlighting various biomedical applications of silk-based biomaterials...

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Microenvironment-responsive nanosystems for osteoarthritis therapy

•This review underscores the intricate nature of OA, and emphasizes the challenge of comprehending its pathogenesis which have hindered the development of targeted therapies and precision medicine for...

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Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages

•We applied pulsed electromagnetic field (PEMF) stimulation on nerve cells.•We screened different parameters and found the optimal ones to improve neurite outgrowth.•The same parameters had anti-inflammatory...

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Modelling the development of biological structures displaying longitudinal geometries in vitro: culturing pluripotent stem cells on plasma-treated, growth factor-coupled polycaprolactone fibres

•We have taken a biomimicry approach to generate complex longitudinal structures in vitro using pluripotent stem cells cultured on plasma-immersion ion implantation (PIII)-treated polycaprolactone (PCL)...

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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency

•Simplified process: The AgSNP@CD was prepared through a simplified process, making it amenable to large-scale production.•Portable and stroage: AgSNP@CD maintains structural integrity after compression,...

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Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway

•Our previous studies have demonstrated the potential of paris saponins II in mitigating neutrophil infiltration in the nasal mucosa of AR mice. However, its clinical applicability has been hampered...

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Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption

•The mechanism of osteoclastogenesis induced by rankl is very important.•Oleandin can inhibit RANKL-induced osteoclast formation and bone resorption in vitro•Oleandrin effectively inhibited lipopolysaccharide-induced...

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Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres

•The effect of strain on muscle tendon junction formation was investigated for the first time.•10 % cyclic strain induced the cell morphology changes and the gene expression and production of proteins...

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Cross-talk between biometal ions and immune cells for bone repair

•The interplay between bioactive factors, bone-related cells, and immune system involved in bone repair continues to be of great scientific interest in the field of bone tissue regeneration.•In this...

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Microalgae-based drug delivery systems in biomedical applications

•Applications of microalgae biomass as drug carrier.•Microalgae drug delivery systems based on simple preparation and surface modifying.•Applications of photosynthesis in microalgae as an oxygenator.•Applications...

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In inflammatory bowel disease and extraintestinal manifestations: What role does microbiome play?

•This review aims at conveying the roles of microbiome in inflammatory bowel disease and extraintestinal manifestations.•A critical analysis of current development and challenges is presented.•A comprehensive...

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Mesoporous magnetic nanoparticles conjugated aptamers for exosomes capture and detection of Alzheimer's disease

•The magnetic nanoparticles were synthesized by hydrothermal are composed of a core of Fe3O4 and coupled with gold nanoparticles gives it a large specific surface area to effectively capture exosomes.•We...

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Decellularized extracellular matrix: A promising strategy for skin repair and regeneration

•The commonly utilized decellularization methods and the evaluation methods for cellular residues and bioactive molecules of dECM were introduced.•dECM derived from different sources, including humans,...

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Development of modified PMMA cement in spine surgery

•This paper summarizes the research progress of modified PMMA bone.•Cement in spinal surgery for the first time....

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