Development of a primary hepatocyte-based preclinical spheroid model system for the analysis of Phase I and Phase II enzyme activity in vitro
2026
•This study highlights a method to improve hepatic spheroids by incorporating Matrigel, which enhances cell-extracellular matrix (ECM) interactions, crucial for liver function.•Hepatic spheroids with...
Harnessing the interplay between tendon stem/progenitor cell and microenvironment boosts tendon tissue regeneration
2026
•TSPC subpopulations-niche interaction is vital for tendon biology.•The degeneration loop is a key factor leading to tendon diseases.•Remodel Niche - Disrupt Degeneration Loop - Tendon Healing.•Artificial...
Synergistic interplay of dECM and exosomes in shaping the cartilage matrix microenvironment: A new paradigm for regenerative medicine
2026
•dECM-exosome integration mimics the native cartilage microenvironment for regeneration.•Exosomes deliver bioactive signals to enhance chondrogenesis and immune modulation.•dECM scaffolds retain exosomes,...
Cell electrowriting: An advanced biofabrication approach for micrometre-scale living tissue fabrication
2026
•Cell electrowriting (CEW) places living cells with near single-cell precision.•Delivers finer detail than melt electrowriting and extrusion bioprinting.•Prints aligned, organised cells directly—no...
Multi-modal therapeutic action of gallium-containing bioactive glass against osteosarcoma and bacterial pathogens
2026
•Multifunctional materials are required for optimised bone tumour therapy.•Ga-containing bioactive glasses (Ga-BGs) were manufactured and characterised.•Gallium Nitrate was used to demonstrate Ga therapeutic...
Rational molecular design to elicit biological functions for modulating cellular and tissue responses
2026
•Reviews molecular engineering to manipulate cell signaling pathways.•Summarizes molecular recognition and active molecule modifications.•Details mechanisms for precise intervention in cellular behaviors.•Explores...
Granular materials for biomedical applications: structural design, functional properties, advanced manufacturing and clinical application
2026
●Covers structure, properties, advanced manufacturing, and clinical applications.●Focuses on the structure–property relationship to guide design and fabrication.●Integrates fundamentals and advances...
Asini Corii Colla exhibits anti-photoaging efficacy via activating collagen synthesis and maintaining redox & extracellular matrix homeostasis
2026
•Systematically elucidates ACO's multi-mechanistic anti-photoaging effects, including promoting keratinocyte proliferation/migration, inhibiting fibroblast senescence, regulating collagen/elastin synthesis,...
Dynamic 4D-bioprinted duct-like microenvironments for triple-negative breast cancer modeling and drug response
2026
•4D-bioprinted self-folding tubes mimic mammary duct geometry.•Tunable bioink and design enable robust duct-like tubular formation.•Mechanical gradients and flow enhance viability and aggregation.•Dynamic...
State-of-the-art molecular compounds in artificial salivary substitutes tackling xerostomia and oral mucositis
2026
•Reviews molecular compounds for managing xerostomia and oral mucositis.•Analyzes biochemical barrier disruptions caused by head and neck cancer therapies.•Bridges molecular design with in vitro, in...
Reframing hair follicle development through Tissue Engineering Triad for hair organoid construction
2026
•A Tissue Engineering Triad framework is proposed to guide the rational design of hair follicle organoids.•Spatiotemporal regulation of cells, signalling cues, and extracellular matrix governs hair...
On-chip hydrogel microfibers for biomedical sensing applications
2026
•Stimulus-triggered mechanisms in hydrogel microfibers.•Microfluidic strategies to generate hydrogel microfibers.•Recent progress of hydrogel microfibers for biomedical sensing.•AI, synthetic biology,...
Dual-crosslinked thermosensitive hydrogel for spatiotemporally sequential drug delivery in 3D-bioprinted diabetic wound dressings
2026
•Dynamic Schiff-base pre-crosslinking and thermoresponsive crosslinking create a robust chemical–physical double-network hydrogel.•Bioprinted dual-layer architecture enables spatiotemporally controlled...
Polydopamine nanoparticles integrated microneedle patch for near-infrared-II light triggered thrombolysis
2026
•Polydopamine nanoparticles integrated microneedle patch showed good near-infrared-II photothermal conversion performance.•Polydopamine nanoparticles integrated microneedle patch induced the blood clot...
Physical properties of scaffold materials promote tissue repair and regeneration by influencing the paracrine action of mesenchymal stem cells
2026
•MSC secretome, rather than differentiation, orchestrates tissue repair.•Multiple mechanisms mediate MSC secretome-driven regeneration.•Mechanotransduction links physical cues to specific secretome...
Nanogrooved plasma-activated PDMS functionalized with Argiope modesta spider silk extract enhances hWJ-MSC adhesion and chondrogenic differentiation
2026
•Plasma-treated PDMS functionalized with Argiope modesta spider silk extract exhibited increased wettability and supported hWJ-MSC attachment.•SSE-coated nanogrooved PDMS increased protein adsorption...
Injectable borate/borosilicate bioactive glass systems for the regeneration of hard tissue – A critical review of the literature
2026
•Injectable B-BG/BS-BG enable minimally invasive, ion-releasing bone repair.•SrO moderates’ boron release; Cu/VEGF strategies enhance angiogenic repair.•Vancomycin/gentamicin cements and magnetic heat...
Self-assembling peptide amphiphiles inhibit inflammation in a murine model of colitis
2026
•AIF-PAs are a biocompatible, comprehensive therapeutic for ulcerative colitis (UC).•Lesion numbers and pathological severity scores decreased upon delivery of AIF-PAs.•In particular, AIF-PA1 reduced...
Comparison of two hemostatic skin adhesive dressings, incorporating multi-metal bioactive glass
2025
•Multi-element bioactive glass nanoparticles (BG) were successfully synthesized.•Two skin adhesives, with GelMA back bone, based on adhesive molecules of DOPA and TA, integrating BG were developed.•Both...
Targeted drug delivery system for Golgi apparatus's diseases
2025
•Snapshot of Golgi apparatus.•Design scheme for targeting Golgi apparatus.•Typical application of Golgi targeting in disease surveillance and therapy....
ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration
2025
•ORM1 was expressed in AIS bone tissues.•ORM1-positive AIS patient-derived osteoblasts, there was an increased expression of RANKL, decreased expression of OPG.•Osteoclasts overexpressing ORM1 promoted...
Bioactive scaffolds integrated with micro-precise spatiotemporal delivery and in vivo degradation tracking for complex tissue regeneration
2025
•This study we report groundbreaking preclinical outcomes in the functional regeneration of temporomandibular joint (TMJ) discs of mini-pigs using anatomically correct bioactive 3D-printed scaffolds.•The...
Integrating bioprinted oral epithelium with millifluidics for fluorouracil perfusion and Fusobacterium infection to bioengineer oral mucositis-on-a-chip
2025
•Magnetic 3D bioassembly or bioprinting can promptly produce physiologically relevant multi-layered oral epithelial sheets from human oral keratinocytes.•Our dynamic millifluidic system can generate...
Ultrasonic manipulation in tissue engineering
2025
•This review systematically explores the application of ultrasonic waves in tissue engineering, emphasizing their safe, contactless, and precise capabilities for cell manipulation and tissue morphogenesis.•It...
Advances in smart hybrid scaffolds: A strategic approach for regenerative clinical applications
2025
•3D hybrid scaffolds improve biocompatibility and biomechanical properties.•Nano-topography enhances cellular interactions and scaffold performance.•4D printing enables dynamic, stimuli-responsive tissue...
