Alcohol-associated liver disease: A review
April 2025
Alcohol-associated Liver Disease (ALD) is a collection of liver disorders caused by prolonged and excessive alcohol consumption, ranging from fatty liver alterations to fibrosis and cirrhosis. This...
Liver lobes and cirrhosis: Diagnostic insights from lobar ratios
January 2025
Liver cirrhosis is the formation of abnormal nodular structure and fibrosis. Globally it accounts for 4 % of all deaths. Alcohol, viral hepatitis, and non-alcoholic fatty liver disease are the most...
Impact of COVID-19 vaccines on liver function: A state of the art and challenges for healthcare providers
January 2024
COVID-19 vaccines have significantly reduced the virus's spread, but they may impact liver function. Although most individuals tolerate the vaccines well, rare cases of liver injury have been reported....
When the gut Speaks: The hidden toll of irritable bowel syndrome on body and mind
July 2025
Irritable bowel syndrome (IBS) is a multifaceted gastrointestinal disorder that transcends the gut, affecting the physical, psychological, and social well-being of millions worldwide. Despite its prevalence,...
Use of ‘Diarrhea Stool Card’ in acute diarrhea management in under 5 Years children in resource constraints country
April 2024
Antibiotics are often overused in the management of diarrhea, despite few indications. Lack of confidence regarding the causative organism and limited access to diagnostic facilities contribute to the...
Ilaprazole: Distinctive pharmacokinetic and pharmacodynamic properties among proton pump inhibitors
July 2025
Ilaprazole is a new proton pump inhibitor (PPI) that provides effective and sustained intragastric acid suppression. As PPIs are foundational medications in the treatment of acid-related disorders,...
Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies
April 2025
Colorectal cancer (CRC) has an incidence rate of 10 % and is the third most common cause of mortality worldwide, following breast and lung cancer. The clinical symptoms of CRC appear in the last phases...
Liver cirrhosis: epidemiology, risk factors, potential complications, and possible treatment strategies
April 2026
In 2025, liver cirrhosis, characterized by hepatic fibrosis and regenerating nodules, with over 185 million individuals infected globally (>3% of the world population), represented a significant global...
Drug-induced liver injury: An overview and update
April 2023
Drug-induced liver injury (DILI) is a relatively rare but important adverse event for a variety of commonly used drugs, herbal and dietary supplements, illegal drugs and novel agents. The actual epidemiology...
Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia
January 2025
Peptic ulcer disease's (PUD) global significance, emphasizing its health burdens and associations with factors like Helicobacter pylori infection and lifestyle habits. The need for comprehensive approaches...
Bacillus coagulans as a potent intervention for treating irritable bowel syndrome: A systematic review and meta-analysis of randomized control trials
January 2024
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal tract disorder. Bacillus coagulans (BC) is a potent spore-forming probiotic that has been proposed as a potent supplement...
Effective non-surgical treatment of hemorrhoids with sclerosing foam and novel injection device
October 2024
To determine the effectiveness of a novel protocol to treat patients with hemorrhoidal disease....
The impact of Ramadan fasting on the health of cirrhosis patients: A systematic review of available evidences
January 2026
Ramadan fasting is an annual obligation practiced by millions of Muslims worldwide. This practice is generally safe for healthy individuals, but the metabolic burden of this all-day fasting could cause...
Exploring the effects of reflexology on gastrointestinal symptoms in Type-2 diabetic patients: A quasi-experimental study
January 2026
Type 2 diabetes is a growing global health concern, often leading to gastrointestinal complications that impact quality of life. Reflexology, a non-invasive therapy, may help alleviate these symptoms,...
The gut-brain connection in inflammatory bowel disease: Mechanisms, mental health, and therapeutic horizons
April 2026
Inflammatory Bowel Disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory condition that extends beyond the gut, affecting systemic and psychological health. The...
The digestive system under microgravity environment: Changes, mechanisms and the prospects of the future
April 2025
In recent years, the space industry has continued to improve and develop, and human beings have been staying in space for longer periods while facing the challenges of microgravity to human life. The...
Current evidence and emerging role of endoscopic bariatric and metabolic therapies in gastrointestinal endoscopy
April 2026
Obesity and related metabolic disorders, such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease(NAFLD) and dyslipidemia, are rising global health concerns. Traditional management...
Refractory gastroesophageal reflux disease (GERD): A clinical, endoscopic, and histopathological perspective –a single centre cross-sectional study
July 2024
Gastroesophageal reflux disease (GERD) manifests as the regurgitation of stomach contents into the esophagus, causing symptoms and potential complications. Proton Pump Inhibitors (PPIs) stand as the...
Monosodium glutamate-induced alterations in MMR protein expression: A potential mechanism linking diet and colorectal cancer
April 2026
Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been...
Subcutaneous panniculitis as complication of valproate-induced pancreatitis
January 2025
Medications and drugs constitute a well-known etiology of pancreatitis. Rare signs and symptoms of the disease can occur. We present a case of pancreatitis caused by valproic acid and that was complicated...
Chronic anal fissures treated with Unani formulation – A series of case reports
January 2024
Chronic anal fissure is recognized for its profound impact on quality of life and the propensity for treatment relapse, underscoring the need to explore safe and alternative clinical interventions....
Chronic alcohol and liver health: The gut-liver axis as a therapeutic target
January 2026
Chronic alcohol use has a substantial effect on liver health and general morbidity, making it one of the world's main causes of liver disease. Recent studies highlight the pivotal role of the gut-liver...
CRISPR-Cas-enabled nanocarriers in hepatocellular carcinoma: Emerging gene-editing strategies for precision liver therapy
April 2026
Hepatocellular carcinoma (HCC) remains a highly deadly global malignancy with limited curative treatments, frequent recurrence, and delayed diagnosis. Gene editing systems using CRISPR-Cas offer great...
Prospects of clinical trials for novel therapeutic approaches in celiac disease
July 2025
Celiac disease (CD) is a chronic a multifactorial immune-mediated systemic inflammatory disease of the small intestine caused by genetic and environmental factors, elicited by the ingestion of dietary...
Prevalence and association of small intestinal bacterial overgrowth with functional gastrointestinal disorders in children: A systematic review and meta-analysis
January 2026
Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathophysiology of functional gastrointestinal disorders (FGIDs), yet its prevalence and clinical relevance in children remain...