Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
Available online 9 December 2025
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
Skeletal editing of pyridine for ring transformations
Available online 28 October 2025
The pyridine ring, functioning as a vital framework in numerous bioactive molecules, has recently witnessed significant advancements in precise skeletal editing, which has brought about a revolutionary...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
Available online 7 April 2025
The catalytic conversion of carbon dioxide toward methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
Available online 29 December 2025
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
Visible-light-driven multicomponent reactions: Concurrent pyridylation and alkylation of styrenes
Available online 28 November 2025
Given the prevalence of pyridines in pharmaceuticals, methods for regioselectively introducing functional groups to the pyridine ring offer a categorical yet sustainable challenge strategy for expanding...
Photocatalyzed site-selective aryl C–H sulfinamidation via thianthracene salts
Available online 7 January 2026
Benzenesulfinamides are a critical class of S(IV) compounds that serve as important entry points to an array of emerging pharmaceutical molecules and bioactive substances. However, the widespread application...
Recent advances in C–B bond formation by borylation with NHC–boranes
Available online 25 September 2025
Organoboron compounds play a pivotal role in synthetic, pharmaceutical, and material chemistry due to their distinctive properties. Developing efficient, regioselective methods for C–B bond construction...
Advances of Ugi reaction in natural product synthesis
August 2025
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
Recent advances in electrochemically driven deoxygenation/deoxygenative coupling of C−O and C=O bonds
Available online 30 September 2025
Alcohols, aldehydes and ketones, which contain oxygen-containing functional groups such as C−O and C=O, are widely present in drugs, fine chemicals, and biomass. These compounds provide diverse carbon...
TBADT/nickel co-catalyzed three-component radical acylarylation of alkenes with aldehydes and aryl iodides
Available online 17 October 2025
Here we report a photo/nickel co-catalyzed three-component acylarylation of alkenes using aldehydes and aryl iodides. Tetrabutylammonium decatungstate (TBADT) serves as a hydrogen-atom-transfer (HAT)...
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
November 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst
November 2025
We have developed a chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes. It offers several advantages, including the use of an environmentally friendly catalyst (5 mol%...
Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications
Available online 9 December 2025
Benzaldehyde lyase (BAL), a thiamine diphosphate (ThDP)-dependent enzyme requiring divalent cations (e.g., Mg2+), mediates enantioselective C-C bond formation and cleavage to exclusively produce (R)-configured...
A small molecule EnT photocatalyst for rapid [2+2] cycloaddition
Available online 15 December 2025
Identifying novel catalysts for light-induced energy transfer (EnT) processes is crucial for advancing EnT-based chemical reactions. This work demonstrates that the readily available acylsilane, 1-(tert-butyldimethylsilyl)ethan-1-one,...
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
Available online 16 May 2025
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Recent advances in photocatalytic C-H amination to nitrogenous structures
February 2026
Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity, surpassing non-nitrogen architectures. Given the vast array of nitrogen-containing compounds...
Nickel-catalyzed construction of C(sp3)-C(sp3) bonds with alkyl halides and diazo compounds for accessing all-carbon quaternary centers
Available online 14 November 2025
Transition-metal catalyzed formation of C–C bonds has emerged as an effective strategy for constructing all-carbon quaternary centers, which represent a persistent synthetic challenge in organic synthesis....
Unsaturated C2 synthons in photocatalysis: Taming and directing acetylene and ethylene in radical reactions
Available online 28 January 2026
The conversion of the simplest unsaturated C2 molecular building units (C2H2 and C2H4) to high-value-added fine chemicals has been a pivotal domain in modern synthetic chemistry. Because of the inherent...
Continuous-flow harnesses the synergy of nitrogen dioxide and ozone for safe, catalyst-free and ultrafast arene nitration
Available online 10 December 2025
Green and scalable nitration of aromatic compounds remains a challenge in chemical synthesis. While acid-free nitration using simple nitrogen oxides is highly attractive, it is often plagued by poor...