TsOH-assisted photocatalytic aerobic upcycling of polystyrene waste
Available online 9 July 2025
The persistent environmental challenge posed by polystyrene (PS) waste calls for efficient and sustainable recycling strategies. Herein, we report a TsOH-assisted, metal-free photocatalytic system for...
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Recent advances in electrochemical transformations of p-substituted phenols
Available online 9 July 2025
At present, the electrochemical transformations of p-substituted phenols have achieved plentiful applications in organic synthesis. The efficient functionalization of two key anodically generated intermediates—p-quinone...
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Oxocarbenium Lewis Acid Complex: A Neutral Thiol-Specific Bioconjugation Reagent
Available online 4 July 2025
Oxocarbenium ions are pivotal intermediates in organic synthesis, driving key transformations like glycosylation, rearrangement and cyclization. However, their generation typically requires Lewis or...
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Pd@POPs-catalyzed carbonylative transformations of aryl bromides: efficient synthesis of esters, amides, and topramezone
Available online 4 July 2025
In this study, we thoroughly investigated the performance of Pd@POPs in the heterogeneous catalytic carbonylation of aryl bromides. A variety of phenols and amines could be efficiently converted into...
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Palladium/copper-catalyzed 1,2-arylboration of styrenes with b2pin2 and indoles
Available online 4 July 2025
Boryldifunctionalization of alkenes has emerged as a valuable synthetic tool for constructing complex organoboron compounds. While significant advances have been achieved in carboboration reactions...
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A greener approach to Buchwald-Hartwig coupling. A sustainable Pd/C-catalyzed Csp2–N bond formation under microwave irradiation and bio-based solvent.
Available online 27 June 2025
The Buchwald-Hartwig coupling enables the grafting of nitrogen-containing functionalities onto molecules, facilitating the synthesis of a wide variety of molecular structures. However, several challenges...
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Modular synthetic platform for diverse substituted benzylamines through selective amide-aldehyde-aldehyde cross-cyclization reaction
Available online 18 June 2025
Substituted benzylamines constitute an important structural motif in numerous natural products and pharmaceutical intermediates. Consequently, developing a straightforward and step-economical strategy...
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Solvent-polarity-controlled stereoselective synthesis of cis-acyclic indoline via photocatalytic dearomatization of indole
Available online 14 June 2025
Indolines, a privileged scaffold in natural products and bioactive molecules, hold immense potential in drug discovery and organic synthesis. Herein, we report a photocatalytic dearomatization strategy...
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Recent advances in the electrochemical synthesis of oligosaccharides and glycosides
Available online 13 June 2025
Sugars are fundamental building blocks in biological molecules such as oligosaccharides, glycoproteins, and glycosylated natural products. The construction of glycosidic bonds in a diastereoselective...
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One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases
Available online 11 June 2025
Chiral vicinal diols and their derivatives play pivotal roles in pharmaceutical chemistry and organic synthesis. However, their synthesis remains challenging due to the presence of adjacent chiral centers....
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Pd/Ag dual-catalyzed asymmetric synthesis of sulfur-stereogenic sulfoximines via enantioselective intramolecular C−H arylation
Available online 10 June 2025
Sulfoximines, which often show significant bioactivity, are important motifs in pharmaceutical and agricultural chemicals. However, asymmetric synthesis of sulfoximines bearing S(VI) stereogenic centers...
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Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones
Available online 9 June 2025
Quinolinones have been prepared by an intramolecular radical annulation of α-EWG (electron-withdrawing group) substituted amides and alkynes involving an electrochemical oxidation enabled hydrogen atom...
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Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
Available online 7 June 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
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New avenues for asymmetric synthesis: N–H (+)-sparteine and analogues
Available online 7 June 2025
Sparteine, a naturally occurring chiral N-centered diamine, has been employed as a useful chiral ligand in numerous synthetic transformations, but due to a shortage of accessible intermediates, its...
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Distance-driving host-guest recognition with boron-based molecular tweezers and its applications in catalysis
Available online 7 June 2025
Understanding the influence of structural variations on host-guest interactions is crucial for developing selective molecular recognition systems and efficient catalysts for chemical transformations....
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Recent advances in the asymmetric catalytic synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their derivatives
Available online 6 June 2025
This review summarizes the progress achieved in the asymmetric catalytic synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their oxidized forms. To aid understanding, mechanistic...
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Heterogeneous difunctional organic polymers with 2,2,6,6-tetramethylpiperidinyloxy and N-methylimidazole for selective oxidation of alcohols
Available online 5 June 2025
Highly selective transformation of biomass-derived platform chemicals into value-added chemicals is of great significance. Herein, a heterogeneous polymer catalyst was developed for the selective oxidation...
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CO2-promoted hydrosulfonylation of electron-deficient alkenes with sulfinates
Available online 3 June 2025
Herein, we report a method for direct C–sulfonyl bond formation, which represents a significant advancement in sustainable catalysis and green chemistry. By using carbon dioxide (CO2) as a renewable...
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Engineering galactose oxidase for biocatalytic synthesis of 2-(furan-2-yl)-2-oxoacetic acid, a critical precursor of cefuroxime
Available online 2 June 2025
2-(Furan-2-yl)-2-oxoacetic acid (2-FOA) is a critical building block for the C7 side chain of cefuroxime, a second-generation antibiotic. Traditional chemical synthesis of 2-FOA involves harsh conditions...
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Electrochemical cascade pyrazole annulation and C-H halogenation for the synthesis of 4-halopyrazoles
May 2025
The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between N,N-dimethyl enaminones and proper hydrazine reagents in the presence of a halogen source is realized at...
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Water-controlled skeletal editing or peripheral modification of ortho-chalcone-substituted organophosphines
May 2025
Skeletal editing of organophosphines is highly challenging owing to the high P-C bond dissociation energy. Herein, we report an efficient catalyst- and additive-free skeletal editing strategy to transform...
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Facile synthesis of asymmetric tetrablock copolymer by dual thermal and photochemical initiator
May 2025
Vesicles obtained by the self-assembly of asymmetric tetrablock copolymers are a class of materials with fascinating properties. However, simple strategies to synthesize asymmetric tetrablock copolymers...
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Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles
May 2025
Indoles are essential heterocycles in natural products, biological chemistry, and medicinal chemistry. Efficient approaches to their synthesis, therefore, remain in demand. Herein is reported a novel...
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Carbonyl group-assisted 1,3-amine addition to α,β-unsaturated aldehydes
May 2025
An unusual 1,3-addition products were obtained when amines were reacted with α,β-unsaturated aldehydes compounds in the presence of iodine and an oxidant. The versatile unsaturated α-amino acetals are...
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Efficient toluene degradation using Bacillus subtilis biofilm-supported Mn–Ce/zeolite catalysts
May 2025
This study investigated a new approach for synthesizing Bacillus subtilis biofilm-supported Mn–Ce/zeolite catalysts for the degradation of gaseous toluene. Four different metal oxide nano-catalysts...
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