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ISSN: 2666-5549

1,3-Indanedione: An versatile building block

Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...

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Pd-catalyzed functionalization of 1,3-enynes via alkylene-π-allylpalladium intermediates

In recent years, the concept of transition metal-catalyzed functionalization of unsaturated hydrocarbons has emerged as a promising strategy for developing new and valuable reactions, and has attracted...

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Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization

C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past...

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Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

An iron-catalyzed [4 ​+ ​2] annulation of amidines with α,β-unsaturated ketoxime acetates is described. This strategy employs amidines as CN units and provides a new protocol for the construction of...

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Waste-minimized continuous flow copper-catalyzed azide-alkyne cycloaddition with low metal contamination

Metal contamination is a waste-generating and serious issue in the synthesis of chemicals, in particular in the case of products with biological activity. The appropriate selection of operating conditions...

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Recent trends and developments in the asymmetric synthesis of profens

The profens belong to a class of nonsteroidal anti-inflammatory drugs (NSAIDs), which exert significant anti-inflammatory, analgesic, antipyretic and other pharmacological effects. A considerable number...

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Book review of “Enzyme engineering: Selective catalysts for applications in biotechnology, organic chemistry, and life science”

An authoritative and up-to-date discussion of enzyme engineering, methodology development and its applications.Image 1...

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Immobilized iron functionalised imidazolium-based ionic liquid: Solvent-free and recoverable heterogeneous catalytic application for the synthesis of amines under green conditions

We reported solvent-free and recoverable heterogeneous iron functionalised imidazolium-based ionic liquid for the reduction of nitroarene derivatives in the presence of formic acid under greener conditions....

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Base-controlled annulation of tryptamine-derived isocyanides with nitrile imines for access to polycyclic spiroindoline derivatives

An annulation reaction of tryptamine-derived isocyanides with hydrazonyl chlorides in the presence of bases was developed. Controlled by different bases, [1+ ​2+3] annulation and [1+ ​2+3]/[2 ​+ ​3]...

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Parallel photoreactor development with enhanced photon efficiency and reproducibility based on laws of optics

A lab-scale parallel photoreactor model has been developed for broad applications in organic chemistry. Position, angle, and distance in the reactor are systematically optimized for achieving high reproducibility...

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Heating-induced decarboxylative cyclization for the synthesis of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides and α-oxocarboxylic acids

A simple metal and additive-free approach for the assembly of 5-trifluoromethyl-1,2,4-triazoles via only heating-induced decarboxylative cyclization of readily available trifluoroacetimidohydrazides...

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Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions

Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides. With the aid of AgOTf,...

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Organophosphorus catalytic reaction based on reduction of phosphine oxide

The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...

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Photocatalytic generation of 1,4-disubstituted 1,2,3-triazoles under metal, oxidant and azide-free conditions

Available online A mild and efficient photocatalytic-induced radical method has been developed for [4 ​+ ​1] cycloaddition reaction of 1,4-disubstituted 1,2,3-triazoles with N-tosylhydrazides and primary...

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Photoredox/Ti dual-catalyzed dehydroxylative ring-opening Giese reaction of cyclobutanone oximes

A dehydroxylative ring-opening Giese reaction of cyclobutanone oximes enabled by photoredox/Ti dual catalysis has been reported in this work. This protocol avoids the prefunctionalization of oximes...

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A sustainable synthesis of 3,3-disubstituted oxindoles via CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile

We herein reported a sustainable synthesis of 3,3-disubstituted oxindoles via a Michael-type reaction based on the CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile....

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Rh(II) catalyzed efficient sigmatropic rearrangement reaction of pyridotriazoles and sulfides

The [2,3]- and [1,2]-sigmatropic rearrangement reactions between pyridotriazoles and sulfides catalyzed by rhodium(II) were investigated. The utilization of pyridotriazoles as the carbene precursors...

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Polymer-supported chiral palladium-based complexes as efficient heterogeneous catalysts for asymmetric reductive Heck reaction

Heterogeneous asymmetric catalysis is an important strategy for the industrial production of chiral compounds. Herein, we reported a polymer-bound Xu-Phos-derived palladium catalyst that shows good...

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Metal- and light-free approach to polyheterocycles via a quinone-Cs2CO3 couple promoted regioselective cascade radical cyclization

A highly efficient, transition-metal- and light-free approach to polyheterocycles via regioselective cascade radical cyclization is developed. The redox-neutral protocol has a broad substrate scope...

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Metal-free and water-compatible nanocatalysts for green photocatalytic dehydrogenation in aqueous medium

Two types of poly-porphyrin-based heterogeneous photocatalysts including insoluble polymer and water-soluble nanoparticles exhibited excellent photocatalytic activity in visible-light-induced dehydrogenation...

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Visible-light-induced selective alkylsulfonylation of unactivated alkenes via remote heteroaryl migrations

Photocatalyzed alkylsulfonylation of unactivated alkenes using DABCO. (SO2)2 and thianthrenium salts via a distal heteroaryl migration process has been developed, which provides a new means of synthesizing...

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Self-assembled hexameric capsule: A highly β-selective O-glycosylation reaction enabled via proton wire mechanism

A simple methodology has been developed for the synthesis of highly β-selective O-glycosylation scaffolds of wider substrate scope under mild conditions using a self-assembled hexameric capsule. The...

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Emerging radical rearrangement reactions: The 1,2-boron shift

As the cross-coupling needs of chemists continue to grow for accessing increasingly complex targets, radical-based transformations have become mainstay methodologies for the discovery of new reactivity...

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Enantioselective [3 + 2] cycloadditions of terminal allenoates with β-sulfonyl-α,β-unsaturated ketones

A highly efficient and mild method for [3 ​+ ​2] cycloaddition of β-sulfonyl-α,β-unsaturated ketones with terminal allenoates was well-explored and developed. The reactions were successfully performed...

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Electrochemically mediated three-component synthesis of isothioureas using thiols as sulfur source

The simultaneous binding/dissociation of multiple bonds in a one-pot manner by multicomponent reactions provide an important approach for developing novel and sustainable pathway in the drug discovery...

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