Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
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Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
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Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
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The roles of computer-aided drug synthesis in drug development
February 2022
With the improvements in computer computing ability, data accumulation and rapid algorithm development, the integration of artificial intelligence (AI) and drug synthesis has been accelerated, significantly...
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Synthesis of dydrogesterone by aromatization-dearomatization strategy
Available online 15 December 2023
Dydrogesterone as an agonist of the progesterone receptor is an important and selective synthetic progesterone used for the treatment of a variety of conditions associated with progesterone deficiency...
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Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones
Available online 6 January 2024
With reusable sodium decatungstate (NaDT) as the photocatalyst, hydrocarbons (alkanes, ethers and ketones) as the alkylating agents, a wide range of alkylated fused N-heterocycles were obtained in high...
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Controlled generation of ortho-quinone methides and (4+3) cyclization with 2-indolylalcohols by dual photoredox/Brønsted acid relay catalysis
Available online 9 January 2024
Given the significance of oxacyclic frameworks in molecular scaffolds and drug discovery, it is intriguing to precisely construct and manipulate such ring systems in chemical research. In this area,...
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Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis
June 2020
Asymmetric catalytic hydrogenations of imines and enamines with chiral transition-metal complexes bearing chiral ligands are among the most green and powerful approaches for the elaboration of chiral...
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Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization
May 2023
C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past...
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Recent advances in (4 + 3) cycloaddition of allenes
Available online 2 December 2023
Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 + 3) cycloaddition reaction...
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Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
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1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
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Recent advances in visible-light photoredox-catalyzed nitrogen radical cyclization
June 2020
Visible-light photoredox catalysis is a powerful and attractive strategy for organic molecule activation and new reaction design owing to its environmental-friendly characteristics and unique catalytic...
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Stereoselective construction of atropisomers featuring a C–N chiral axis
May 2022
Atropisomeric C–N compounds belong to an important class of axially chiral compounds. However, whereas the asymmetric synthesis of biaryl atropisomers have been well established, general and efficient...
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Synthesis of indoles, indolines, and carbazoles via palladium-catalyzed C–H activation
May 2021
The construction of indole, indoline and carbazole heterocycles has been of significant interest in the synthetic community over the last century due to their prevalence in natural products and other...
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Radical azidation as a means of constructing C(sp3)-N3 bonds
November 2020
The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...
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Synthesis of 5-hydroxymethylfurfural from dehydration of biomass-derived glucose and fructose using supported metal catalysts
May 2021
The global energy shortage has become more and more serious, which promotes the urgent need to shift to sustainable development. The value-added 5-hydroxymethylfurfural (HMF) can be derived from biomass...
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Brønsted acid-promoted synthesis of polysubstituted pyrroles from enamines/imines and diazopyruvates: A metal-free cascade approach
Available online 13 December 2023
A Brønsted acid-promoted, metal-free cascade reaction of easily available enamines/imines with diazopyruvates has been demonstrated. With triflic acid as the promoter, the reaction proceeds smoothly...
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Synthesis of tetraarylmethanes: 1897–2022
November 2023
Tetraarylmethanes (TAMs) contain a carbon atom bound to four aryl groups. They have found diverse applications in chemistry, materials science, chemical biology and medicinal chemistry because of their...
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Carbon dioxide cycle via electrocatalysis: Electrochemical carboxylation of CO2 and decarboxylative functionalization of carboxylic acids
February 2021
As one of the most important biogeochemical cycles, the carbon dioxide (CO2) cycle between atmosphere and biosphere has a profound impact on the life on earth. Therefore, the search for sustainable...
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Alternating current electrolysis: A photoredox catalysis mimic and beyond
February 2022
Alternating current electrolysis (ACE) is an emerging powerful synthetic tool, which principally resembles photoredox catalysis strategies. Its periodically alternating polarity feature allows oxidation...
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Recent advances in transition-metal-free C–H functionalization of imidazo[1,2-a]pyridines
August 2022
Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharmaceuticals, natural products, material science and organometallics. Due to their significant biological...
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Transition-metal-catalyzed aromatic C–H functionalization assisted by the phosphorus-containing directing groups
August 2023
Transition-metal-catalyzed C–H bond functionalization has attracted tremendous attention as an increasingly important protocol for the construction of C–C and C–X bonds. In particular, C–H bond functionalization...
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