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ISSN: 2666-5549

Advanced green synthesis: Solvent-free and catalyst-free reaction

The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...

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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients

Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...

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Green polyurethanes from bio-based building blocks: Recent advances and applications

Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...

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Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis

C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...

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Flow chemistry in the multi-step synthesis of natural products

The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...

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1,3-Indanedione: An versatile building block

Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...

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Recent advances in the syntheses of pyrroles

The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...

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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts

Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...

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CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity

The catalytic conversion of carbon dioxide toward methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...

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Advances of Ugi reaction in natural product synthesis

The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...

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Mechanochemical syntheses of N-acyl sulfinamidines via iron-nitrenoids and their conversions to sulfur(VI) derivatives

Herein, we present an iron-catalyzed mechanochemical synthesis of N-acyl sulfinamidines via nitrenoids generated from dioxazolones. Various substituents on both sulfenamides and thiols are well tolerated,...

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Recent progress in selective liquid-phase hydrogenation of furfural on heterogeneous Ni-containing catalysts

Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural...

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Enantioselective synthesis of chiral N-arylpyrroles through photoinduced desymmetrization

The C–N axial chirality is widely present in natural products, bioactive molecules, and chiral ligands. Catalytic asymmetric construction of C–N axially chiral compounds is a challenging task due to...

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Electrochemical generation of nitrogen-centered radicals for organic synthesis

There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...

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Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients

The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...

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Recent advances in transition-metal-free conversion of aldehydes to ketones

The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....

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Spirooxindoles: Recent report of green synthesis approach

Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...

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Radical azidation as a means of constructing C(sp3)-N3 bonds

The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...

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Recent advances in transition-metal-free C–H functionalization of imidazo[1,2-a]pyridines

Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharmaceuticals, natural products, material science and organometallics. Due to their significant biological...

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Copper-catalyzed aerobic photodecarboxylation of carboxylic acids to aldehydes and ketones

Base-metal-catalyzed decarboxylative transformations provide an economic pathway to the efficient functionalization of carboxylic acids. Herein, a copper-catalyzed aerobic photodecarboxylation of carboxylic...

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Benzaldehyde lyase-catalyzed enantioselective C–C bond formation and cleavage: A review

Benzaldehyde lyase (BAL) is an enzyme which was originally found from Pseudomonas fluorescens biovar I. It has long been used in the formation of a C–C bond. BAL can exclusively yield (R)-enantioselective...

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Perspectives on green synthesis and catalysis

Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...

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Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones

Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...

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Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: Current status, challenges and future perspectives

Deoxynivalenol (DON) has received considerable attention due to its toxicity and widespread presence in food and feed. This review summarizes the DON contamination in commonly consumed commercially...

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N-aryl/-alkenyl difluoroketenimines: Transient intermediates for the general synthesis of difluoroalkylated heterocycles

Fluorinated ketenimines not only have unique reactivities but also can be used as fluorinated building blocks, however, the research on their synthesis and application remains in its infancy. We herein...

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