Transformation of ambient CO2 in air into cyclic carbonates mediated by a phosphorus-nitrogen PN3-pincer iron complex
November 2025
The atom-economical reaction of carbon dioxide (CO2) with epoxides possesses the potential to utilize captured CO₂ for synthesizing useful chemicals. Among a wide range of metal complexes employed for...
Selective cleavage of Csp3–N bonds in aliphatic tertiary amines enabled by difluorocarbene to access esters and thioethers
November 2025
Presented herein is a series of C–X (X = O, S) couplings for the synthesis of esters and thioethers via difluorocarbene-promoted selective Csp3–N bond cleavage between tertiary amines and carboxylic...
A water-soluble supermolecular cage for artificial light-harvesting nanoreactors
November 2025
Two discrete octahedral metallo-supramolecular cages were designed and constructed by using truxene-based pyridine L with enPd(NO3)2 or enPt(NO3)2, followed by detailed NMR, MS, UV absorption, and fluorescence...
Chiral bis(imidazoline) NCN pincer iridium(III)-catalyzed enantioselective alkynylation of trifluoropyruvates with terminal alkynes
November 2025
Readily prepared chiral bis(imidazoline) NCN pincer iridium(III) complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes...
Iron-catalyzed carbonylative synthesis of tert-alkyl thioesters
November 2025
In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic...
Palladium-catalyzed halosulfonylation of alkynes with ionic liquid as the green solvent and halide sources
November 2025
The first palladium-catalyzed halosulfonylation of alkynes with arylsulfonic acid under aerobic conditions was accomplished. This catalytic protocol provides a straightforward and effective synthetic...
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
November 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
Direct C(sp3)-H functionalization with thiosulfonates via photoredox catalysis
November 2025
While C(sp3)-S bonds exist in many biologically active compounds, the direct catalytic C(sp3)-H thiolation remains elusive. Herein, we report a convenient and green C(sp3)-H thiolation approach mediated...
Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst
November 2025
We have developed a chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes. It offers several advantages, including the use of an environmentally friendly catalyst (5 mol%...
Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
November 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
Synthesis of bridged bicyclic thiazine-2-thione and thiazole-2-thiones through DBU-promoted regioselective annulation of quinone monoacetals under mild conditions
November 2025
The first regioselective [4 + 2] annulation reactions of quinone monoacetals with isothiocyanates and Na2S have been accomplished. This convenient and novel protocol involves the synthesis of valuable...
Recent progress in selective liquid-phase hydrogenation of furfural on heterogeneous Ni-containing catalysts
November 2025
Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural...
Electrochemical selective deuterium labelling of N-heteroarenes
November 2025
Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an electrochemical selective...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Synthesis of naphtho[1,2-b]furan-2-carbaldehydes and naphtho[2,1-b]furan-2-carbaldehydes via electrocatalytic 3,3-rearrangement/cyclization of propargylic aryl ethers under mild conditions
November 2025
An electrocatalytic 3,3-rearrangement/cyclization approach has been developed for the transformation of aryl-substituted propargylic aryl ethers to naphtho[1,2-b]furan-2-carbaldehyde and naphtho[2,1-b]furan-2-carbaldehyde...
Visible-light-driven multicomponent reactions: concurrent pyridylation and alkylation of styrenes
Available online 28 November 2025
Given the prevalence of pyridines in pharmaceuticals, methods for regioselectively introducing functional groups to the pyridine ring offer a categorical yet sustainable challenge strategy for expanding...
Electrochemical amino- or methoxymethylation of weak nucleophiles with methoxamine hydrochloride
Available online 28 November 2025
The in-situ generation of iminium ions from amines and aldehyde compounds, followed by nucleophilic attack (Mannich reaction), represents a powerful strategy for the formation of Mannich bases. However,...
A study on the synthesis of racemic Baloxavir Marboxil
Available online 25 November 2025
A novel four-step procedure for the synthesis of fragment A is described, starting with a cheaper starting material 2,3-difluorotoluene. Compared with the previous methods, this is a relatively reasonable...
From amines to complex lactams: a unified photocatalysis strategy for γ-amino acids and bridged bicyclic scaffolds via amino radicals
Available online 24 November 2025
A procedure for the synthesis of bridged bicyclic lactams has been developed via an unprecedented cascade of C‒C and C‒N bond formations, utilizing readily available amines. The intermolecular cyclization...
Shape-controlled palladium nanoparticles on polyaniline nanohelices with chirality continuum for tuneable photothermal response and enantioselective catalysis
Available online 20 November 2025
The integration of chiral catalysts with circularly polarized light (CPL) for enantioselective catalysis is an emerging research direction. Herein, a series of cubic and icosahedral Pd nanoparticles...
Nickel-catalyzed construction of C(sp3)-C(sp3) bonds with alkyl halides and diazo compounds for accessing all-carbon quaternary centers
Available online 14 November 2025
Transition-metal catalyzed formation of C–C bonds has emerged as an effective strategy for constructing all-carbon quaternary centers, which represent a persistent synthetic challenge in organic synthesis....
Skeletal editing of pyridine for ring transformations
Available online 28 October 2025
The pyridine ring, functioning as a vital framework in numerous bioactive molecules, has recently witnessed significant advancements in precise skeletal editing, which has brought about a revolutionary...
Catalysis-free green synthesis of thiophenes and thioketones by one-pot method based on the resource utilization of SO2 in flue gas
Available online 18 October 2025
Thiophenes and thioketones possess significant synthetic value due to their extensive pharmacological activities. However, the sulfur sources used in traditional methods for synthesizing these compounds...
TBADT/nickel co-catalyzed three-component radical acylarylation of alkenes with aldehydes and aryl iodides
Available online 17 October 2025
Here we report a photo/nickel co-catalyzed three-component acylarylation of alkenes using aldehydes and aryl iodides. Tetrabutylammonium decatungstate (TBADT) serves as a hydrogen-atom-transfer (HAT)...
Practical access to axially chiral triazole phosphine oxides via enantioselective CuAAC reaction
Available online 30 September 2025
The construction and application of axially biaryl N,P-ligands is of great importance in asymmetric catalysis. Herein, an enantioselective copper-catalyzed azide-alkyne cycloaddition (CuAAC) of prochiral...