Transition-metal-free defluorinative cyclization of perfluoroalkyl alkenyl iodides with C,N-dinucleophiles: Synthesis of (E)-perfluoroalkenyl pyrroles
August 2026
Functionalization of the C-F bond in perfluoroalkyl substances represents an emerging focus in organic chemistry. We report here a transition-metal-free intermolecular defluorinative cyclization of...
Organocatalytic asymmetric cyclization of aminochalcones and azlactones: Synthesis of 3,4-dihydroquinolinones
August 2026
A novel and efficient reaction of aminochalcones and azlactones has been developed under the catalysis of bifunctional organocatalysts. The corresponding enantioenriched 3,4-dihydroquinolinones were...
Electrochemical late-stage modification of hydralazine an antihypertensive drug. A green strategy for the synthesis of nano-structured new sulfonylhydrazine derivatives
August 2026
This work is focused on the electrochemical late-stage modification of hydralazine (1-hydrazinylphthalazine) (HYD), a common antihypertensive drug, and the synthesis of its new sulfonylhydrazine derivatives....
Copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes
August 2026
Hydrophosphination of α,β-unsaturated carbonyl compounds is one of the most common methods to prepare chiral phosphines. Herein, a copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes...
Engineering Clostridium ljungdahlii for efficient 3-hydroxybutyrate production from one-carbon gases
August 2026
3-Hydroxybutyrate (3-HB) has attracted great attention due to its importance as a building block in the production of high-value chemicals and polymers. Autotrophic Clostridium species have the potential...
Oxidative halogenation enabled by 2-haloethanol and aqueous H2O2 under metal-free conditions
August 2026
Electrophilic halogenation reactions have been recognized as robust approaches to accessing synthetically useful organohalides. Herein, we disclose an exclusive oxidative halogenation pathway, which...
Photo-catalyzed dearomative coupling of benzylmalonates and alkynes with CO2, leading to spiro-1,4-cyclohexadiene carboxylic acids
August 2026
A dearomative coupling reaction of benzylmalonates and alkynes with CO2via visible-light catalysis is developed, leading to a series of spiro-1,4-cyclohexadiene carboxylic acids. This three-component...
Recent advances in the catalytic asymmetric synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines, and their derivatives
August 2026
Spirocyclic tetrahydroquinolines (spiro-THQs) and tetrahydroisoquinolines (spiro-iTHQs), along with their derivatives, constitute a prominent class of natural products that exhibit a broad spectrum...
Dichloromethane-promoted photo-induced aerobic oxidation of methylarenes
Available online 29 August 2026
We present a novel, efficient, and sustainable strategy for the aerobic oxidation of methylarenes to valuable carbonyl products using dichloromethane (DCM) as both solvent and promoter under photo-irradiation....
Catalytic conversion of furfural to 2-methylfuran: Regulating the synergy between hydrogenation and C–O bond cleavage
Available online 2 August 2026
The selective hydrogenolysis of furfural (FUR) to 2-methylfuran (2-MF) has attracted substantial attention as a representative biomass-upgrading approach. Despite the development of numerous catalytic...
“Control from root design”: A proactive strategy for green and sustainable API process research and development
Available online 21 July 2026
We detail the concept, implementation, and illustrative applications of the “control from root design” (CRD) strategy for developing safe, environmentally benign, simple, health-protective, quality-assured,...
Recent advances in para-selective C–H bond functionalization of aniline derivatives
Available online 17 July 2026
Positional selectivity control in the C–H bond functionalization of aniline derivatives remains a formidable challenge in synthetic organic chemistry. Owing to the broad utility of these compounds across...
Visible-light induced site-selective C(sp3) –H epoxidation of amides
Available online 11 July 2026
Oxiranes are among the most valuable reagents in the chemical sciences, with applications that span pharmaceuticals, agrochemicals, and functional materials. Although remarkable progress has been achieved...
Electrophilic aryl spiroannulation induced by diaryliodonium salts: efficient synthesis of [5,5]-spiro lactone-lactam scaffolds from α-cyanocarboxylates
June 2026
Spirocyclic architectures represent one of the privileged three-dimensional scaffolds in pharmaceutical chemistry and drug discovery, while the new-skeletal synthesis of spiromolecules from simple starting...
Electrochemical C-H thiocyanation of BODIPYs: Two birds with one stone of KSCN
June 2026
An efficient electrochemical C–H thiocyanation of BODIPYs was developed by using potassium thiocyanide as the source of thiocyanation. The straightforward C–H thiocyanation protocol possesses many advantages:...
Efficient templating synthesis of [12]cyclo-meta-phenylenes: A novel strategy for capturing fullerene
June 2026
The resorcin[4]arene-templated synthesis of the structure with [12]cyclo-meta-phenylene ([12]CMP), achieves a remarkable 53% overall yield in its key steps, overcoming the thermodynamic instability...
Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: Current status, challenges, and future perspectives
June 2026
Deoxynivalenol (DON) has received considerable attention due to its toxicity and widespread presence in food and feed. This review summarizes the DON contamination in commonly consumed commercially...
Synthesis of 1,4-oxathiins via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides
June 2026
A straightforward and valuable approach for the synthesis of 1,4-oxathiins has been developed via [3+3] annulation of pyridinium 1,4-zwitterionic thiolates with iodonium ylides. C–S and C–O bonds were...
Accelerating rational organoborazine discovery: Predicted by machine learning, synthesized under continuous flow
June 2026
Substituting a benzene ring with a borazine ring in π-conjugated systems has garnered significant interest in recent years, particularly for its potential in enhancing optoelectronic device performance....
CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
June 2026
The catalytic conversion of carbon dioxide to methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
Light-driven enzymatic conversion of mevastatin into pravastatin by coupling P450sca-2 with the cyanobacterial photosynthetic system
June 2026
Cytochrome P450 enzymes (P450s) are highly attractive green biocatalysts with application potential in the fields of synthetic chemistry and synthetic biology. However, most P450 enzymatic reactions...
Accelerated flow synthesis of aripiprazole and brexpiprazole in environmentally benign solvents
June 2026
Aripiprazole and brexpiprazole are both second-generation atypical antipsychotic medications to treat a wide range of psychiatric disorders, the retail sales of which reached $1.35 billion and $2.07...
Recent advances in the electrochemical synthesis of oligosaccharides and glycosides
June 2026
Sugars are fundamental building blocks in biological molecules such as oligosaccharides, glycoproteins, and glycosylated natural products. The construction of glycosidic bonds in a diastereoselective...