Iridium-catalyzed C(sp3)-H activation using imidazopyridine and pyridine as directing groups for selective silylation
Available online 17 February 2026
A general and practically applicable strategy for chelation-assisted, iridium-catalyzed intermolecular silylation of C(sp3)-H bonds in 8-methylimidazo[1,2-a]pyridines has been developed. This protocol...
Streamlined synthesis of E-selective oxaboracycles with tunable solid-state emission via sequential amine-click/arylation process
Available online 6 February 2026
Selective aminoarylation of internal alkynes under transition metal-free conditions provides a sustainable route to fully substituted enamines. However, existing aminoarylation strategies rely on ambiphilic...
Metal-free electrochemical synthesis of sulfinamides via alkyl radical addition to sulfinylamines
Available online 6 February 2026
Sulfinamides are important sulfur-containing motifs with broad applications in pharmaceuticals, agrochemicals, and materials. Traditional alkyl sulfinamide synthesis often requires prefunctionalized...
Microwave-assisted pyrolysis synthesis: Atomic-scale regulation for green and efficient catalyst preparation
Available online 5 February 2026
This perspective article systematically elaborates on the research progress of microwave-assisted pyrolysis synthesis (MAPS) for atomic-scale, precise regulation of catalysts, a green, energy-efficient...
Recent advances in parallel kinetic resolution with organocatalysis
Available online 31 January 2026
Parallel kinetic resolution (PKR) is an important strategy for obtaining chiral functional molecules. PKR processes can be classified into three types, including chemo-, regio- and stereodivergent PKRs...
Unsaturated C2 synthons in photocatalysis: Taming and directing acetylene and ethylene in radical reactions
Available online 28 January 2026
The conversion of the simplest unsaturated C2 molecular building units (C2H2 and C2H4) to high-value-added fine chemicals has been a pivotal domain in modern synthetic chemistry. Because of the inherent...
Chemoenzymatic synthesis of ADP-d-glycero-β-d-manno-heptose using a bifunctional kinase/nucleotidyltransferase
Available online 21 January 2026
Adenosine-diphosphate-d-glycero-β-d-manno-heptose (ADP-d,d-heptose) and adenosine-diphosphate-l-glycero-β-d-manno-heptose (ADP-l,d-heptose) are potent agonists of innate immunity. They also serve as...
Cobalt-catalyzed enantioselective hydroalkylation of oxanorbornene for the construction of chiral bridged oxabicyclic structures
Available online 19 January 2026
Available online Oxanorbornene is a versatile building block in natural product and pharmaceutical synthesis, yet its enantioselective hydroalkylation with bridged ring retention remains underdeveloped....
Radical-mediated selective cascade addition/annulation of ((2-isocyanophenyl)methylene)dibenzenes for the divergent synthesis of 3H-indoles and indolines
Available online 17 January 2026
A radical-mediated selective cascade addition/annulation of ((2-isocyanophenyl)methylene)dibenzenes for the divergent synthesis of 3,3-diaryl-3H-indoles and 2-alkyl-3,3-diarylindolines under transition...
Porous materials for photo-enzyme-coupled catalysis: Bridging the gap between light-driven and enzymatic process
Available online 14 January 2026
Porous materials bridge the gap between light-driven and enzymatic process in photo-enzyme-coupled catalytic systems (PECS), which integrate the energy conversion of photocatalysis with the high selectivity...
Photocatalyzed site-selective aryl C–H sulfinamidation via thianthracene salts
Available online 7 January 2026
Benzenesulfinamides are a critical class of S(IV) compounds that serve as important entry points to an array of emerging pharmaceutical molecules and bioactive substances. However, the widespread application...
Accessing tetrasubstituted CF2H 1-pyrrolines via electrochemical hydrodefluorination and [3+2] cascade cyclization
Available online 30 December 2025
Tetrasubstituted difluoromethyl 1-pyrrolines are scarcely reported compared to trifluoromethyl 1-pyrrolines. Herein, we present a novel access to difluoromethyl 1-pyrrolines through electrochemical...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
Available online 29 December 2025
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Harnessing N-nitroamines for direct deaminative coupling
Available online 29 December 2025
A novel deaminative strategy for aryl amines via N-nitroamines intermediates has been successfully developed, which substitutes the traditional diazo chemistry and directly converts the aryl C-N bond...
Time-dependent chemoselectivity in a single glycosyltransferase drives O- to C-glycosylation
Available online 26 December 2025
The inherent chemoselectivity of glycosyltransferases (GTs) toward specific acceptors is well established, yet the capacity of a single GT to achieve time-dependent chemoselective glycosylation has...
Phenoxazinone synthase-like activity of rationally designed heme enzymes based on cytochrome P450BM3
Available online 26 December 2025
The development of functional metalloenzymes provides a promising strategy for the sustainable synthesis of heterocyclic compounds such as phenazines and phenoxazinones. Here, we establish an H2O2-driven...
Visible-light-driven photocatalyst-free multicomponent reaction for synthesis of C3-alkylated isoindolinones
Available online 23 December 2025
A photocatalyst- and transition-metal-free three-component reaction of readily available 2-carboxybenzaldehydes, primary amines and 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) for the synthesis of C3-alkylated...
Activation of diterpene hydrocarbon skeletons by microbial natural P450 oxidases
Available online 15 December 2025
Diterpenoids represent invaluable resources for novel drug discovery and development. The high inertness of diterpene hydrocarbon skeletons, coupled with their multiple chiral centers, makes oxidative...
A small molecule EnT photocatalyst for rapid [2+2] cycloaddition
Available online 15 December 2025
Identifying novel catalysts for light-induced energy transfer (EnT) processes is crucial for advancing EnT-based chemical reactions. This work demonstrates that the readily available acylsilane, 1-(tert-butyldimethylsilyl)ethan-1-one,...
A membrane-mediated modulation for chemoenzymatic redox deracemization of secondary alcohols and applications
Available online 11 December 2025
The exploration of a chemoenzymatic dual catalysis system can bridge the methodological gap between chemical and biological catalysis under mild reaction conditions for the preparation of chiral molecules....
Continuous-flow harnesses the synergy of nitrogen dioxide and ozone for safe, catalyst-free and ultrafast arene nitration
Available online 10 December 2025
Green and scalable nitration of aromatic compounds remains a challenge in chemical synthesis. While acid-free nitration using simple nitrogen oxides is highly attractive, it is often plagued by poor...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
Available online 9 December 2025
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Visible-light-induced cascade radical sulfonation/annulation/isomerization reactions of propargyl chalcones with sodium sulfinates: Regioselective synthesis of sulfonyl 2H-chromene and 2H-quinoline derivatives
Available online 9 December 2025
A cascade approach has been developed for the one-pot three-step synthesis of sulfonyl-containing 2H-chromenes and 2H-quinoline derivatives from propargyl chalcones and sodium sulfinates. This protocol...
Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications
Available online 9 December 2025
Benzaldehyde lyase (BAL), a thiamine diphosphate (ThDP)-dependent enzyme requiring divalent cations (e.g., Mg2+), mediates enantioselective C-C bond formation and cleavage to exclusively produce (R)-configured...
Transformation of ambient CO2 in air into cyclic carbonates mediated by a phosphorus-nitrogen PN3-pincer iron complex
November 2025
The atom-economical reaction of carbon dioxide (CO2) with epoxides possesses the potential to utilize captured CO₂ for synthesizing useful chemicals. Among a wide range of metal complexes employed for...