Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst
Available online 13 February 2024
We have developed a chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes. It offers several advantages, including the use of an environmentally friendly catalyst (5 mol%...
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Metal-free and visible-light-mediated method enables the synthesis of olefins from ketones
Available online 10 February 2024
Direct synthesis of olefins continues to attract stellar attention due to the high importance of olefins. In this context, due to the wide availability of ketones, the synthesis of olefins directly...
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1,7-Hydride transfer-involved dearomatization of quinolines to access C3-spiro hydroquinolines
Available online 6 February 2024
1,7-Hydride transfer-involved dearomatization of quinolines toward C3-spiro hydroquinoline derivatives has been developed. This method offers a protocol to achieve the dearomatization of electron-deficient...
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Efficient toluene degradation using Bacillus subtilis biofilm-supported Mn–Ce/zeolite catalysts
Available online 5 February 2024
This study investigated a new approach for synthesizing Bacillus subtilis biofilm-supported Mn–Ce/zeolite catalysts for the degradation of gaseous toluene. Four different metal oxide nano-catalysts...
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A water-soluble supermolecular cage for artificial light-harvesting nanoreactors
Available online 1 February 2024
Two discrete octahedral metallo-supramolecular cages were designed and constructed by using truxene-based pyridine L with enPd(NO3)2 or enPt(NO3)2, followed by detailed NMR, MS, UV absorption, and fluorescence...
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Photoinduced radical cascade brominative addition/spirocyclization of N-arylpropiolamides and CBr4 with O2 as oxidant
Available online 15 January 2024
A visible-light-induced brominated spirocyclization of N-arylpropiolamides and CBr4 for the synthesis of 3-bromo-azaspiro[4,5]trienones is reported here. This process allows the formation of C–Br, C–C,...
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Directed evolution of stereoselective enzymes meets click reactions: Asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase
Available online 12 January 2024
We report for the first time the combination of directed evolution focused on enhancing and reversing the stereoselectivity of an enzyme with Cu(I)-mediated click chemistry (CuAAC), providing an asymmetric...
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Electrochemical N-olefination for the regio- and stereo-selective synthesis of vinyl azoles
Available online 12 January 2024
A selenium-catalyzed electrosynthesis involving regio- and stereo-selective N-olefination of azoles was developed. The room-temperature reaction was efficient (up to 97 % yield) and compatible with...
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Controlled generation of ortho-quinone methides and (4+3) cyclization with 2-indolylalcohols by dual photoredox/Brønsted acid relay catalysis
Available online 9 January 2024
Given the significance of oxacyclic frameworks in molecular scaffolds and drug discovery, it is intriguing to precisely construct and manipulate such ring systems in chemical research. In this area,...
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Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones
Available online 6 January 2024
With reusable sodium decatungstate (NaDT) as the photocatalyst, hydrocarbons (alkanes, ethers and ketones) as the alkylating agents, a wide range of alkylated fused N-heterocycles were obtained in high...
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Water-controlled skeletal editing or peripheral modification of ortho-chalcone-substituted organophosphines
Available online 5 January 2024
Skeletal editing of organophosphines is highly challenging owing to the high P-C bond dissociation energy. Herein, we report an efficient catalyst- and additive-free skeletal editing strategy to transform...
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Facile synthesis of asymmetric tetrablock copolymer by dual thermal and photochemical initiator
Available online 18 December 2023
Vesicles obtained by the self-assembly of asymmetric tetrablock copolymers are a class of materials with fascinating properties. However, simple strategies to synthesize asymmetric tetrablock copolymers...
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Synthesis of dydrogesterone by aromatization-dearomatization strategy
Available online 15 December 2023
Dydrogesterone as an agonist of the progesterone receptor is an important and selective synthetic progesterone used for the treatment of a variety of conditions associated with progesterone deficiency...
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Brønsted acid-promoted synthesis of polysubstituted pyrroles from enamines/imines and diazopyruvates: A metal-free cascade approach
Available online 13 December 2023
A Brønsted acid-promoted, metal-free cascade reaction of easily available enamines/imines with diazopyruvates has been demonstrated. With triflic acid as the promoter, the reaction proceeds smoothly...
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Recent advances in (4 + 3) cycloaddition of allenes
Available online 2 December 2023
Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 + 3) cycloaddition reaction...
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Palladium-catalyzed intramolecular C–H arylation of ferrocenyl-sulfides, sulfoxide and its application in metal ion recognition
Available online 1 December 2023
An intramolecular C–H arylation of ferrocenyl ortho-bromophenyl sulfide and sulfoxide has been developed with a palladium/non-chiral monophosphine ligand. Under mild reaction conditions, a wide range...
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Visible-light-driven intramolecular xanthylation of remote unactivated C(sp3)-H bonds
November 2023
Visible light-mediated site-specific C(sp3)-H xanthylation of amides has been accomplished using N-xanthylamides. The N-centered radicals generated by light initiation of N-xanthylamide substrates undergo...
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Diastereo-selective synthesis of CF3-substituted epoxide viain situ generated trifluoroethylideneiodonium ylide
November 2023
The first example for the generation of 2,2,2-trifluoroethylidene ylide from corresponding iodonium salt is reported, which has been successfully applied in the epoxidation of aldehydes, achieving the...
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Electrochemical synthesis of 3-halogenated spiro [4,5]trienones based on dearomative spirocyclization strategy
November 2023
A novel and green route have been developed for the electrochemical synthesis of 3-halogenated spiro[4.5]trienones based on dearomative spirocyclization of alkynes with NaX (Br, I) as the halogen source....
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Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides
November 2023
Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds. However, modification of 2-oxyl...
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Metal, iodine and oxidant-free electrosynthesis of substituted indoles from 1-(2-aminophenyl)alcohols
November 2023
A green and straightforward electrosynthesis of substituted indoles has been developed through dehydration and intramolecular dehydrogenative C–N bond-forming radical cross-coupling from 1-(2-aminophenyl)alcohols...
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Protecting-group-free ortho-C–H borylation of anilines enabled by mesoionic carbene-Ir complex
November 2023
We describe an iridium-catalyzed ortho-selective C–H borylation of unprotected anilines. The employing strong σ-donating cyclometalated mesoionic carbene as C^C bidentate ligand is crucial for the high...
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Zwitterionic cellular polymer enabled reductive fixation of CO2 for N-methylation of amines
November 2023
Using heterogeneous catalysts to promote the construction of the C–N bond between amines and CO2 under mild conditions is a challenge yet. Herein, we synthesized a novel zwitterionic polymer (PDDC)...
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A H2O2 generation-detection-regulation integrated platform for boosting the efficiency of peroxygenase-catalysed C–H oxidative hydroxylation
Available online 30 November 2023
The peroxygenases are ideal biocatalysts for the selective oxyfunctionalisation of stable C–H bonds. However, the catalytic efficiency of this approach is limited due to enzyme lability toward oxidant...
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Ferric nitrate-catalyzed aerobic oxidative ring-opening of substituted furans for the stereoselective synthesis of (Z)-1,4-enediones
Available online 30 November 2023
A simple and highly efficient catalytic system for the selective aerobic oxidative ring-opening of substituted furans has been achieved using Fe(NO3)3·9H2O as a catalyst and air as an oxidant under...
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