Photoinduced radical cascade brominative addition/spirocyclization of N-arylpropiolamides and CBr4 with O2 as oxidant
May 2025
A visible-light-induced brominated spirocyclization of N-arylpropiolamides and CBr4 for the synthesis of 3-bromo-azaspiro[4,5]trienones is reported here. This process allows the formation of C–Br, C–C,...
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Enhancement of CO2 hydrogenation to formate using formate dehydrogenase immobilized on UiO66 and its derivatives
May 2025
In the present work, a highly stable zirconium-based metal-organic framework (MOF), UiO66, and its derivative, UiO66-NH2, were tested as support materials to immobilize Formate dehydrogenase (FDH) for...
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Ferric nitrate-catalyzed aerobic oxidative ring-opening of substituted furans for the stereoselective synthesis of (Z)-1,4-enediones
May 2025
A simple and highly efficient catalytic system for the selective aerobic oxidative ring-opening of substituted furans has been achieved using Fe(NO3)3·9H2O as a catalyst and air as an oxidant under...
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Thioamide construction via sulfur interrupted Brook rearrangement
May 2025
Thioamide was straightforwardly constructed via a chemoselective one-pot synthesis, employing acylsilanes in conjunction with diverse amines and elemental sulfur. The driving force of thioamidation...
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1,7-Hydride transfer-involved dearomatization of quinolines to access C3-spiro hydroquinolines
May 2025
1,7-Hydride transfer-involved dearomatization of quinolines toward C3-spiro hydroquinoline derivatives has been developed. This method offers a protocol to achieve the dearomatization of electron-deficient...
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Enantioselective synthesis of planar chiral ferrocenes via gold(I)-catalyzed hydroarylation of N-ferrocenyl propiolamides
May 2025
Herein, we report an intramolecular 6-endo-dig cyclization of N-ferrocenyl propiolamides for the synthesis of planar chiral ferrocenes enabled by gold(I)-catalyzed hydroarylation. By using this protocol,...
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Asymmetric synthesis of allylic sulfonamides with axially and central chirality via palladium-catalyzed of atroposelective N-allylic alkylation
May 2025
Axially chiral anilide compounds are an emerging but scarcely investigated class of stereogenic molecules with potential applications as chiral catalysts, biologically active scaffolds and functional...
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Electrochemical N-olefination for the regio- and stereo-selective synthesis of vinyl azoles
May 2025
A selenium-catalyzed electrosynthesis involving regio- and stereo-selective N-olefination of azoles was developed. The room-temperature reaction was efficient (up to 97 % yield) and compatible with...
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Iron-catalyzed formation of six-membered rings from alkyne
Available online 29 May 2025
Iron compounds, exhibiting high catalytic behavior and excellent compatibility, have been considered as low-toxic, cheap, efficient and green catalysts for many important organic transformations. Organic...
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Photoinduced α-addition and hydrogenation of carbazole-based alkenes
Available online 27 May 2025
The conjugate addition of nucleophiles to electron-deficient alkenes is the fundamental reaction in organic synthesis. However, the regio-inversed α-addition reaction remains largely underexplored at...
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Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients
Available online 27 May 2025
The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...
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Visible-light-induced cascade radical cyclization of aryl alkynoates with fluoroalkyl carboxylic anhydrides to construct fluoroalkylated coumarins
Available online 27 May 2025
We herein described an efficient and practical protocol for radical cyclization of aryl alkynoates to access 3-fluoroalkyl-substituted coumarins using readily available, easy-to-handle and low-cost...
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Hydrogenation of organic carbonates and formate derivatives to formaldehyde under one atmosphere of H2 by an unsymmetrical phosphorus-nitrogen PN3P-pincer Mn complex
Available online 23 May 2025
A well-defined unsymmetrical phosphorus-nitrogen PN3P-Mn(I) complex catalyzed hydrogenation of organic carbonates and formate derivatives with 1 atm of H2 was developed, which could be applied in the...
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Four-component modular synthesis of sulfonylated indolo[2,1-a]isoquinolines via SO2 insertion/Smiles rearrangement radical relay strategy
Available online 20 May 2025
A multicomponent reaction of 1,8-enynes, aromatic amines, DABCO·(SO2)2 and tBuONO is achieved, affording diverse sulfonylated indolo[2,1-a]isoquinolines in moderate to good yields via SO2 insertion/Smiles...
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Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
Available online 16 May 2025
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
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Copper camphorate based MOFs: Efficient and recyclable catalysts for synthesis of propargylamines, oxazolidinones and cyclic carbonates
Available online 14 May 2025
We report the first application of copper camphorate based MOFs ([Cu2camph2dabco] – Cu-MOF-1 and [Cu2camph2bipy] - Cu-MOF-2) as catalysts in three-component A3-coupling of alkynes, aldehydes and amines....
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Rh(III)-catalyzed C2-arylation/lactonization of cyclic 1,3-dicarbonyls and ortho-borylbenzoic acid esters to access 3,4-fused isocoumarins
Available online 13 May 2025
A Rh-catalyzed C2-arylation/lactonization cascade of cyclic 1,3-dicarbonyls and ortho-borylbenzoic acid esters is described. Key to success is that nucleophilic cyclic 1,3-dicarbonyls can be converted...
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The cascade annulation approach to quinoxalines by radical NHC catalysis
Available online 7 May 2025
A wide range of functionalized quinoxalines were rapidly constructed by novel NHC-catalyzed cascade annulation of acyl oximes and isonitriles. The developed protocol characterized good functional group...
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Efficient bioproduction of 3-(4-thiazolyl)-l-alanine, an unnatural amino acid of pharmaceutical importance, by an enzymatic relay process
Available online 6 May 2025
As an l-histidine analog, 3-(4-thiazolyl)-l-alanine (TAla) has been attracting increasing biotechnological interest because it can serve as a key building block in the development of many novel therapeutic...
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Accelerating rational organoborazine discovery: Predicted by machine learning, synthesized under continuous flow
Available online 24 April 2025
Substituting a benzene ring with a borazine ring in π-conjugated systems has garnered significant interest in recent years, particularly for its potential in enhancing optoelectronic device performance....
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Contamination and biotransformation of deoxynivalenol (DON) in common commercial foods: Current status, challenges and future perspectives
Available online 22 April 2025
Deoxynivalenol (DON) has received considerable attention due to its toxicity and widespread presence in food and feed. This review summarizes the DON contamination in commonly consumed commercially...
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Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
Available online 17 April 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
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Green and sustainable site- and cross-selective C-H reductive coupling of para-quinone methides with quinoxaline-2(1H)-ones
Available online 15 April 2025
We herein disclose a novel activation mode for quinoxaline-2(1H)-ones via selective hydrogen atom transfer (HAT) of the N=Csp2-H bonds by synergistic photoredox catalysis and bromine radical catalysis,...
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Recent progress in selective liquid-phase hydrogenation of furfural on heterogeneous Ni-containing catalysts
Available online 9 April 2025
Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural...
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Mechanochemical syntheses of N-acyl sulfinamidines via iron-nitrenoids and their conversions to sulfur(VI) derivatives
Available online 7 April 2025
Herein, we present an iron-catalyzed mechanochemical synthesis of N-acyl sulfinamidines via nitrenoids generated from dioxazolones. Various substituents on both sulfenamides and thiols are well tolerated,...
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