Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Sulfone as traceless activating group: Divergent synthesis of α-fluoroamides with C–F quaternary stereocenters
February 2025
A novel approach to α-fluoroamides bearing a C–F quaternary stereocenter is reported herein. With sulfone installed as the activating group, an alkyl group as well as a fluorine atom was introduced...
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Chemo- and diastereoselective four-component reactions with Rh carbynoids
February 2025
Multi-component reactions (MCRs) provide an efficient method for constructing multiple chemical bonds by combining three or more starting materials in a single operational step, enabling rapid and cost-effective...
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Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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One-pot access to indazole fused-phenanthridinones via Rh(III)-catalyzed [4+2] annulation
February 2025
An efficient synthesis of indazole fused phenanthridinones via Rh(III)-catalyzed inert C(sp2)-H activation/[4 + 2] annulation of 3-aryl-1H-indazoles with iodonium ylides has been developed, providing...
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Palladium-catalyzed intramolecular C–H arylation of ferrocenyl-sulfides, sulfoxide and its application in metal ion recognition
February 2025
An intramolecular C–H arylation of ferrocenyl ortho-bromophenyl sulfide and sulfoxide has been developed with a palladium/non-chiral monophosphine ligand. Under mild reaction conditions, a wide range...
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Highly efficient palladacycle-catalyzed carboxylation of benzyl alcohols
February 2025
A general and practical carboxylation of benzyl alcohols using the air- and moisture-stable Herrmann-Beller palladacycle was developed. With this novel methodology, numerous carboxylated products were...
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Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation
February 2025
The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities....
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Photo-mediated para-selective C(sp2)−H difluoroalkylations
February 2025
Photo-mediated ruthenium-catalyzed para-C−H difluoroalkylation has been disclosed under extremely mild conditions. This photochemical ruthenium catalyst system is characterized by good functional group...
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Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones
February 2025
With reusable sodium decatungstate (NaDT) as the photocatalyst, hydrocarbons (alkanes, ethers and ketones) as the alkylating agents, a wide range of alkylated fused N-heterocycles were obtained in high...
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Brønsted acid-promoted synthesis of polysubstituted pyrroles from enamines/imines and diazopyruvates: A metal-free cascade approach
February 2025
A Brønsted acid-promoted, metal-free cascade reaction of easily available enamines/imines with diazopyruvates has been demonstrated. With triflic acid as the promoter, the reaction proceeds smoothly...
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Light-induced perfluoroalkylative carbonylation of unactivated alkenes with a recyclable photocatalyst
February 2025
The development of heterogeneous catalysis difunctionalization of olefins is of great significance because it can save costs in the industry. Here, we report the perfluoroalkyl carbonylation reaction...
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Divergent synthesis of new naphtho-fused 2-aminoindolines and naphthoxindoles based on straightforward construction of phenanthrene
February 2025
An environmentally friendly, highly atom-economical and operationally simple approach toward the synthesis of naphtho-fused 2-aminoindolines and naphthoxindoles starting from biaryl aldehydes and secondary...
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Accelerated flow synthesis of aripiprazole and brexpiprazole in environmentally benign solvents
Available online 22 February 2025
Aripiprazole and Brexpiprazole are both second-generation atypical antipsychotic medications to treat a wide range of psychiatric disorders, the retail sales of which reached $1.35 billion and $2.07...
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Enantioselective epimerizations of meso-diols via asymmetric hydrogen atom abstraction catalysis
Available online 29 January 2025
A new type of asymmetric hydrogen atom abstraction catalysts, originated from the cinchona alkaloid family of natural products, has been successfully developed to access enantioselective epimerizations...
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Copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes
Available online 10 January 2025
Hydrophosphination of α,β-unsaturated carbonyl compounds is one of the most common methods to prepare chiral phosphines. Herein, a copper(I)-catalyzed asymmetric hydrophosphination of alkenyl azaarenes...
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Engineering Clostridium ljungdahlii for efficient 3-hydroxybutyrate production from one-carbon gases
Available online 7 January 2025
3-Hydroxybutyrate (3-HB) has attracted great attention due to its importance as a building block in the production of high-value chemicals and polymers. Autotrophic Clostridium species have the potential...
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Copper-catalyzed deuterodehalogenation of aryl halides
Available online 4 January 2025
There is growing potential and interest in the development of precise and practical deuterium labelling methodologies using an easy-handling deuterated source for alkylarenes and methylarenes. Here...
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Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
Available online 19 December 2024
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
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Regioselectively electrochemical Csp3-H alkoxylation for functionalized indanone
Available online 13 December 2024
An electrochemical regioselective Csp3-H alkoxylation has been developed to synthesize functionalized 1-indanone. In this process, electricity serves as the formal terminal oxidant, while the molecular...
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The synthesis of multi-substituted benzazepine derivatives via Mn(III)-promoted oxidative annulation of isocyanides with boronic acids
Available online 10 December 2024
Seven-membered nitrogen-containing heterocyclic rings are important cores of anti-cancer, anti-antimicrobial, anti-malaria and other drugs. Therefore, efficient and expedient strategies for the synthesis...
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Modular trifluoromethylselenolation and fluoroalkylselenolation via Ag(I)-mediated selenium nitrogen exchange reaction of benzothiaselenazole-1-oxides
Available online 6 December 2024
By virtue of benzothiaselenazole-1-oxides as versatile building blocks and masked sulfoximines, we present a novel and practical trifluoromethylselenolation/fluoroalkylselenolation strategy via Ag(I)-mediated...
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Recent advances in (4 + 3) cycloaddition of allenes
November 2024
Allenes are a class of unsaturated compounds containing a propadiene structural moiety, exhibiting essential physiological, pharmacological, and various reactivities. Their (4 + 3) cycloaddition reaction...
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Carbonylative transformation of aryl halides and strong bonds via cheap metal catalysts and sustainable technologies
November 2024
The development of catalytic carbonylation reactions has increased considerably. Although many reviews/chapters/books on carbonylation reactions have been published, summaries on cheap metal-catalyzed...
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Electrocatalytic regio- and stereoselective carboxylation of terminal alkynes with CO2
Available online 30 November 2024
Carboxylation with CO2 is a practical and streamlined way to construct a variety of sophisticated carboxylic acids and their derivatives. However, a series of elegant methods focus mainly on C(sp3)–...
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