Electrochemical selective deuterium labelling of N-heteroarenes
November 2025
Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an electrochemical selective...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Synthesis of naphtho[1,2-b]furan-2-carbaldehydes and naphtho[2,1-b]furan-2-carbaldehydes via electrocatalytic 3,3-rearrangement/cyclization of propargylic aryl ethers under mild conditions
November 2025
An electrocatalytic 3,3-rearrangement/cyclization approach has been developed for the transformation of aryl-substituted propargylic aryl ethers to naphtho[1,2-b]furan-2-carbaldehyde and naphtho[2,1-b]furan-2-carbaldehyde...
Visible-light-driven multicomponent reactions: Concurrent pyridylation and alkylation of styrenes
Available online 28 November 2025
Given the prevalence of pyridines in pharmaceuticals, methods for regioselectively introducing functional groups to the pyridine ring offer a categorical yet sustainable challenge strategy for expanding...
Electrochemical amino- or methoxymethylation of weak nucleophiles with methoxamine hydrochloride
Available online 28 November 2025
The in-situ generation of iminium ions from amines and aldehyde compounds, followed by nucleophilic attack (Mannich reaction), represents a powerful strategy for the formation of Mannich bases. However,...
A study on the synthesis of racemic Baloxavir Marboxil
Available online 25 November 2025
A novel four-step procedure for the synthesis of fragment A is described, starting with a cheaper starting material 2,3-difluorotoluene. Compared with the previous methods, this is a relatively reasonable...
From amines to complex lactams: A unified photocatalysis strategy for γ-amino acids and bridged bicyclic scaffolds via amino radicals
Available online 24 November 2025
A procedure for the synthesis of bridged bicyclic lactams has been developed via an unprecedented cascade of C‒C and C‒N bond formations, utilizing readily available amines. The intermolecular cyclization...
Shape-controlled palladium nanoparticles on polyaniline nanohelices with chirality continuum for tuneable photothermal response and enantioselective catalysis
Available online 20 November 2025
The integration of chiral catalysts with circularly polarized light (CPL) for enantioselective catalysis is an emerging research direction. Herein, a series of cubic and icosahedral Pd nanoparticles...
Nickel-catalyzed construction of C(sp3)-C(sp3) bonds with alkyl halides and diazo compounds for accessing all-carbon quaternary centers
Available online 14 November 2025
Transition-metal catalyzed formation of C–C bonds has emerged as an effective strategy for constructing all-carbon quaternary centers, which represent a persistent synthetic challenge in organic synthesis....
Skeletal editing of pyridine for ring transformations
Available online 28 October 2025
The pyridine ring, functioning as a vital framework in numerous bioactive molecules, has recently witnessed significant advancements in precise skeletal editing, which has brought about a revolutionary...
Catalysis-free green synthesis of thiophenes and thioketones by one-pot method based on the resource utilization of SO2 in flue gas
Available online 18 October 2025
Thiophenes and thioketones possess significant synthetic value due to their extensive pharmacological activities. However, the sulfur sources used in traditional methods for synthesizing these compounds...
TBADT/nickel co-catalyzed three-component radical acylarylation of alkenes with aldehydes and aryl iodides
Available online 17 October 2025
Here we report a photo/nickel co-catalyzed three-component acylarylation of alkenes using aldehydes and aryl iodides. Tetrabutylammonium decatungstate (TBADT) serves as a hydrogen-atom-transfer (HAT)...
Practical access to axially chiral triazole phosphine oxides via enantioselective CuAAC reaction
Available online 30 September 2025
The construction and application of axially biaryl N,P-ligands is of great importance in asymmetric catalysis. Herein, an enantioselective copper-catalyzed azide-alkyne cycloaddition (CuAAC) of prochiral...
Recent advances in electrochemically driven deoxygenation/deoxygenative coupling of C−O and C=O bonds
Available online 30 September 2025
Alcohols, aldehydes and ketones, which contain oxygen-containing functional groups such as C−O and C=O, are widely present in drugs, fine chemicals, and biomass. These compounds provide diverse carbon...
Efficient templating synthesis of [12]cyclo-meta-phenylenes: A novel strategy for capturing fullerene
Available online 27 September 2025
The resorcin[4]arene-templated synthesis of the structure with [12]cyclo-meta-phenylene ([12]CMP), achieves a remarkable 53% overall yield in its key steps, overcoming the thermodynamic instability...
Recent advances in C–B bond formation by borylation with NHC–boranes
Available online 25 September 2025
Organoboron compounds play a pivotal role in synthetic, pharmaceutical, and material chemistry due to their distinctive properties. Developing efficient, regioselective methods for C–B bond construction...
Additive-controlled divergent annulation of ynamide-ynes: Selective synthesis of benzo[b]carbazoles and furo[3,4-b]indoles
Available online 22 September 2025
An additive-controlled divergent annulation strategy enables the selective synthesis of benzo[b]carbazoles and furo[3,4-b]indoles from ynamide-ynes. The reaction pathway is modulated by additive selection...
Enantio- and diastereoselective cyclopropanation of CF3-imidoyl sulfoxonium ylides by chiral-at-metal Rh(III) complex
Available online 6 September 2025
An enantio- and diastereoselective cyclopropanation of CF3-imidoyl sulfoxonium ylides with α,β-unsaturated 2-acyl imidazoles catalyzed by chiral-at-metal Rh(III) complex has been demonstrated for the...
Visible-light-induced cascade radical cyclization of aryl alkynoates with fluoroalkyl carboxylic anhydrides to construct fluoroalkylated coumarins
August 2025
We herein described an efficient and practical protocol for radical cyclization of aryl alkynoates to access 3-fluoroalkyl-substituted coumarins using readily available, easy-to-handle and low-cost...
Unraveling chemical glycosylation: DFT insights into factors imparting stereoselectivity
August 2025
Stereoselective chemical glycosylation reactions are pivotal for preparing manifold biologically and medically important compounds, while mechanisms of chemical glycosylation reactions remain obscure...
Synthesis of dydrogesterone by aromatization-dearomatization strategy
August 2025
Dydrogesterone as an agonist of the progesterone receptor is an important and selective synthetic progesterone used for the treatment of a variety of conditions associated with progesterone deficiency...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
Palladium-catalyzed tandem aza-Heck reaction of alkene-tethered oxime esters with cyclopropanols
August 2025
Aza-Heck cyclization of alkene-tethered oxime esters has received considerable attention as an effective strategy for synthesizing 1-pyrroline derivatives. However, the achievement of tandem aza-Heck...
α-Chloroketones enabled Rh(III)-catalyzed enantioselective C–H [4+2] annulation of sulfoximines under mild and redox-neutral conditions
August 2025
Taking advantage of facilely available α-chloroketones as C(sp3)-based electrophilic partners and oxidized alkyne equivalents, we here present a novel CpxRh(III)-catalyzed enantioselective C–H [4 +...
Harnessing redox-inactive rare-earth metals for photocatalytic reductive coupling of benzyl bromides
August 2025
Compared with rare and expensive late-transition metals, rare-earth photocatalysts are much less investigated in synthetic chemistry, particularly concerning redox-inactive rare-earth metals. Herein,...