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ISSN: 2666-5549

New avenues for asymmetric synthesis: N–H (+)-sparteine and analogues

Sparteine, a naturally occurring chiral N-centered diamine, has been employed as a useful chiral ligand in numerous synthetic transformations, but due to a shortage of accessible intermediates, its...

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Distance-driving host-guest recognition with boron-based molecular tweezers and its applications in catalysis

Understanding the influence of structural variations on host-guest interactions is crucial for developing selective molecular recognition systems and efficient catalysts for chemical transformations....

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Recent advances in the catalytic asymmetric synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their derivatives

Spirocyclic tetrahydroquinolines (spiro-THQs) and tetrahydroisoquinolines (spiro-iTHQs), along with their derivatives constitute a prominent class of natural products, which exhibit a broad spectrum...

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Heterogeneous difunctional organic polymers with 2,2,6,6-tetramethylpiperidinyloxy and N-methylimidazole for selective oxidation of alcohols

Highly selective transformation of biomass-derived platform chemicals into value-added chemicals is of great significance. Herein, a heterogeneous polymer catalyst was developed for the selective oxidation...

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CO2-promoted hydrosulfonylation of electron-deficient alkenes with sulfinates

Herein, we report a method for direct C–sulfonyl bond formation, which represents a significant advancement in sustainable catalysis and green chemistry. By using carbon dioxide (CO2) as a renewable...

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Engineering galactose oxidase for biocatalytic synthesis of 2-(furan-2-yl)-2-oxoacetic acid, a critical precursor of cefuroxime

2-(Furan-2-yl)-2-oxoacetic acid (2-FOA) is a critical building block for the C7 side chain of cefuroxime, a second-generation antibiotic. Traditional chemical synthesis of 2-FOA involves harsh conditions...

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Electrochemical cascade pyrazole annulation and C-H halogenation for the synthesis of 4-halopyrazoles

The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between N,N-dimethyl enaminones and proper hydrazine reagents in the presence of a halogen source is realized at...

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Water-controlled skeletal editing or peripheral modification of ortho-chalcone-substituted organophosphines

Skeletal editing of organophosphines is highly challenging owing to the high P-C bond dissociation energy. Herein, we report an efficient catalyst- and additive-free skeletal editing strategy to transform...

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Facile synthesis of asymmetric tetrablock copolymer by dual thermal and photochemical initiator

Vesicles obtained by the self-assembly of asymmetric tetrablock copolymers are a class of materials with fascinating properties. However, simple strategies to synthesize asymmetric tetrablock copolymers...

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Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles

Indoles are essential heterocycles in natural products, biological chemistry, and medicinal chemistry. Efficient approaches to their synthesis, therefore, remain in demand. Herein is reported a novel...

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Carbonyl group-assisted 1,3-amine addition to α,β-unsaturated aldehydes

An unusual 1,3-addition products were obtained when amines were reacted with α,β-unsaturated aldehydes compounds in the presence of iodine and an oxidant. The versatile unsaturated α-amino acetals are...

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Efficient toluene degradation using Bacillus subtilis biofilm-supported Mn–Ce/zeolite catalysts

This study investigated a new approach for synthesizing Bacillus subtilis biofilm-supported Mn–Ce/zeolite catalysts for the degradation of gaseous toluene. Four different metal oxide nano-catalysts...

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Photoinduced radical cascade brominative addition/spirocyclization of N-arylpropiolamides and CBr4 with O2 as oxidant

A visible-light-induced brominated spirocyclization of N-arylpropiolamides and CBr4 for the synthesis of 3-bromo-azaspiro[4,5]trienones is reported here. This process allows the formation of C–Br, C–C,...

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Enhancement of CO2 hydrogenation to formate using formate dehydrogenase immobilized on UiO66 and its derivatives

In the present work, a highly stable zirconium-based metal-organic framework (MOF), UiO66, and its derivative, UiO66-NH2, were tested as support materials to immobilize Formate dehydrogenase (FDH) for...

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Ferric nitrate-catalyzed aerobic oxidative ring-opening of substituted furans for the stereoselective synthesis of (Z)-1,4-enediones

A simple and highly efficient catalytic system for the selective aerobic oxidative ring-opening of substituted furans has been achieved using Fe(NO3)3·9H2O as a catalyst and air as an oxidant under...

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Thioamide construction via sulfur interrupted Brook rearrangement

Thioamide was straightforwardly constructed via a chemoselective one-pot synthesis, employing acylsilanes in conjunction with diverse amines and elemental sulfur. The driving force of thioamidation...

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1,7-Hydride transfer-involved dearomatization of quinolines to access C3-spiro hydroquinolines

1,7-Hydride transfer-involved dearomatization of quinolines toward C3-spiro hydroquinoline derivatives has been developed. This method offers a protocol to achieve the dearomatization of electron-deficient...

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Enantioselective synthesis of planar chiral ferrocenes via gold(I)-catalyzed hydroarylation of N-ferrocenyl propiolamides

Herein, we report an intramolecular 6-endo-dig cyclization of N-ferrocenyl propiolamides for the synthesis of planar chiral ferrocenes enabled by gold(I)-catalyzed hydroarylation. By using this protocol,...

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Asymmetric synthesis of allylic sulfonamides with axially and central chirality via palladium-catalyzed of atroposelective N-allylic alkylation

Axially chiral anilide compounds are an emerging but scarcely investigated class of stereogenic molecules with potential applications as chiral catalysts, biologically active scaffolds and functional...

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Electrochemical N-olefination for the regio- and stereo-selective synthesis of vinyl azoles

A selenium-catalyzed electrosynthesis involving regio- and stereo-selective N-olefination of azoles was developed. The room-temperature reaction was efficient (up to 97 ​% yield) and compatible with...

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Iron-catalyzed formation of six-membered rings from alkyne

Iron compounds, exhibiting high catalytic behavior and excellent compatibility, have been considered as low-toxic, cheap, efficient and green catalysts for many important organic transformations. Organic...

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Photoinduced α-addition and hydrogenation of carbazole-based alkenes

The conjugate addition of nucleophiles to electron-deficient alkenes is the fundamental reaction in organic synthesis. However, the regio-inversed α-addition reaction remains largely underexplored at...

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Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients

The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...

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Visible-light-induced cascade radical cyclization of aryl alkynoates with fluoroalkyl carboxylic anhydrides to construct fluoroalkylated coumarins

We herein described an efficient and practical protocol for radical cyclization of aryl alkynoates to access 3-fluoroalkyl-substituted coumarins using readily available, easy-to-handle and low-cost...

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Hydrogenation of organic carbonates and formate derivatives to formaldehyde under one atmosphere of H2 by an unsymmetrical phosphorus-nitrogen PN3P-pincer Mn complex

A well-defined unsymmetrical phosphorus-nitrogen PN3P-Mn(I) complex catalyzed hydrogenation of organic carbonates and formate derivatives with 1 ​atm of H2 was developed, which could be applied in the...

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