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ISSN: 2666-5549

Direct C(sp2)-H thiolation of aldehydes via proton-coupled electron transfer

As an unconventional redox mechanism, reductive proton-coupled electron transfer (PCET) of C ​= ​X bond has become an effective tool for C-C bond formation via a radical process. However, there were...

Bromination and cyclization of 1,7-enynes: Easily access dibromo-3,4-dihydroquinolin-2(1H)-ones

Oxidative cascade bromination/cyclization of 1,7-enynes with tetrabutylammonium tribromide (TBATB) through a radical process has been developed, providing a straightforward method to introduce two bromine...

Robust, catalyst-free electroreduction of unactivated alkenes

A robust, catalyst-free electroreduction protocol of unactivated alkenes without sacrificial anode was developed. This approach demonstrates a wide range of substrates, high chemo- and regioselectivity,...

TsOH-assisted photocatalytic aerobic upcycling of polystyrene waste

The persistent environmental challenge posed by polystyrene (PS) waste calls for efficient and sustainable recycling strategies. Herein, we report a TsOH-assisted, metal-free photocatalytic system for...

Recent advances in electrochemical transformations of p-substituted phenols

At present, the electrochemical transformations of p-substituted phenols have achieved plentiful applications in organic synthesis. The efficient functionalization of two key anodically generated intermediates—p-quinone...

Oxocarbenium Lewis acid complex: A neutral thiol-specific bioconjugation reagent

Oxocarbenium ions are pivotal intermediates in organic synthesis, driving key transformations like glycosylation, rearrangement and cyclization. However, their generation typically requires Lewis or...

Pd@POPs-catalyzed carbonylative transformations of aryl bromides: Efficient synthesis of esters, amides, and topramezone

In this study, we thoroughly investigated the performance of Pd@POPs in the heterogeneous catalytic carbonylation of aryl bromides. A variety of phenols and amines could be efficiently converted into...

Palladium/copper-catalyzed 1,2-arylboration of styrenes with b2pin2 and indoles

Boryldifunctionalization of alkenes has emerged as a valuable synthetic tool for constructing complex organoboron compounds. While significant advances have been achieved in carboboration reactions...

A greener approach to Buchwald-Hartwig coupling. A sustainable Pd/C-catalyzed Csp2–N bond formation under microwave irradiation and bio-based solvent

The Buchwald-Hartwig coupling enables the grafting of nitrogen-containing functionalities onto molecules, facilitating the synthesis of a wide variety of molecular structures. However, several challenges...

Modular synthetic platform for diverse substituted benzylamines through selective amide-aldehyde-aldehyde cross-cyclization reaction

Substituted benzylamines constitute an important structural motif in numerous natural products and pharmaceutical intermediates. Consequently, developing a straightforward and step-economical strategy...

Solvent-polarity-controlled stereoselective synthesis of cis-acyclic indoline via photocatalytic dearomatization of indole

Indolines, a privileged scaffold in natural products and bioactive molecules, hold immense potential in drug discovery and organic synthesis. Herein, we report a photocatalytic dearomatization strategy...

Recent advances in the electrochemical synthesis of oligosaccharides and glycosides

Sugars are fundamental building blocks in biological molecules such as oligosaccharides, glycoproteins, and glycosylated natural products. The construction of glycosidic bonds in a diastereoselective...

One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases

Chiral vicinal diols and their derivatives play pivotal roles in pharmaceutical chemistry and organic synthesis. However, their synthesis remains challenging due to the presence of adjacent chiral centers....

Pd/Ag dual-catalyzed asymmetric synthesis of sulfur-stereogenic sulfoximines via enantioselective intramolecular C−H arylation

Sulfoximines, which often show significant bioactivity, are important motifs in pharmaceutical and agricultural chemicals. However, asymmetric synthesis of sulfoximines bearing S(VI) stereogenic centers...

Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones

Quinolinones have been prepared by an intramolecular radical annulation of α-EWG (electron-withdrawing group) substituted amides and alkynes involving an electrochemical oxidation enabled hydrogen atom...

Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review

Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...

New avenues for asymmetric synthesis: N–H (+)-sparteine and analogues

Sparteine, a naturally occurring chiral N-centered diamine, has been employed as a useful chiral ligand in numerous synthetic transformations, but due to a shortage of accessible intermediates, its...

Distance-driving host-guest recognition with boron-based molecular tweezers and its applications in catalysis

Understanding the influence of structural variations on host-guest interactions is crucial for developing selective molecular recognition systems and efficient catalysts for chemical transformations....

Recent advances in the catalytic asymmetric synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their derivatives

Spirocyclic tetrahydroquinolines (spiro-THQs) and tetrahydroisoquinolines (spiro-iTHQs), along with their derivatives constitute a prominent class of natural products, which exhibit a broad spectrum...

Heterogeneous difunctional organic polymers with 2,2,6,6-tetramethylpiperidinyloxy and N-methylimidazole for selective oxidation of alcohols

Highly selective transformation of biomass-derived platform chemicals into value-added chemicals is of great significance. Herein, a heterogeneous polymer catalyst was developed for the selective oxidation...

CO2-promoted hydrosulfonylation of electron-deficient alkenes with sulfinates

Herein, we report a method for direct C–sulfonyl bond formation, which represents a significant advancement in sustainable catalysis and green chemistry. By using carbon dioxide (CO2) as a renewable...

Engineering galactose oxidase for biocatalytic synthesis of 2-(furan-2-yl)-2-oxoacetic acid, a critical precursor of cefuroxime

2-(Furan-2-yl)-2-oxoacetic acid (2-FOA) is a critical building block for the C7 side chain of cefuroxime, a second-generation antibiotic. Traditional chemical synthesis of 2-FOA involves harsh conditions...

Electrochemical cascade pyrazole annulation and C-H halogenation for the synthesis of 4-halopyrazoles

The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between N,N-dimethyl enaminones and proper hydrazine reagents in the presence of a halogen source is realized at...

Water-controlled skeletal editing or peripheral modification of ortho-chalcone-substituted organophosphines

Skeletal editing of organophosphines is highly challenging owing to the high P-C bond dissociation energy. Herein, we report an efficient catalyst- and additive-free skeletal editing strategy to transform...

Facile synthesis of asymmetric tetrablock copolymer by dual thermal and photochemical initiator

Vesicles obtained by the self-assembly of asymmetric tetrablock copolymers are a class of materials with fascinating properties. However, simple strategies to synthesize asymmetric tetrablock copolymers...

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