Skeletal editing of pyridine for ring transformations
Available online 28 October 2025
The pyridine ring, functioning as a vital framework in numerous bioactive molecules, has recently witnessed significant advancements in precise skeletal editing, which has brought about a revolutionary...
Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
Visible-light induced site-selective C(sp3) –H epoxidation of amides
Available online 11 July 2026
Oxiranes are among the most valuable reagents in the chemical sciences, with applications that span pharmaceuticals, agrochemicals, and functional materials. Although remarkable progress has been achieved...
Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
Recent advances in transition-metal-free conversion of aldehydes to ketones
August 2025
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
April 2026
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
“Control from root design”: A proactive strategy for green and sustainable API process research and development
Available online 21 July 2026
We detail the concept, implementation, and illustrative applications of the “control from root design” (CRD) strategy for developing safe, environmentally benign, simple, health-protective, quality-assured,...
Recent advances in para-selective C–H bond functionalization of aniline derivatives
Available online 17 July 2026
Positional selectivity control in the C–H bond functionalization of aniline derivatives remains a formidable challenge in synthetic organic chemistry. Owing to the broad utility of these compounds across...
Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
Catalytic conversion of furfural to 2-methylfuran: Regulating the synergy between hydrogenation and C–O bond cleavage
Available online 2 August 2026
The selective hydrogenolysis of furfural (FUR) to 2-methylfuran (2-MF) has attracted substantial attention as a representative biomass-upgrading approach. Despite the development of numerous catalytic...
Metal-free electrochemical synthesis of sulfinamides via alkyl radical addition to sulfinylamines
Available online 6 February 2026
Sulfinamides are important sulfur-containing motifs with broad applications in pharmaceuticals, agrochemicals, and materials. Traditional alkyl sulfinamide synthesis often requires prefunctionalized...
Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
August 2026
Organic compounds bearing fluorine atoms have received widespread attention in recent years owing to their specific bioactivity and good biocompatibility compared to their nonfluorinated counterparts....
Photochemical nitrene transfer reactions of iminoiodinanes with sulfoxides
April 2026
Nitrene, as an important and intriguing versatile synthon, is widely utilized for the formation of diverse nitrogenous skeletons under thermal or photochemical conditions. Typically, the N-sulfonyl...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
Photo-free electron donor-acceptor complexes driven divergent synthesis of thioethers and thioimidate esters with aryldiazonium salts and thiols/thiophenols
Available online 1 May 2026
A catalyst- and photo-free strategy for the divergent synthesis of thioethers and thioimidate esters from thiophenols/thiols and aryldiazonium salts has been developed. The reaction pathway is precisely...
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
April 2026
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Recent advances in the catalytic asymmetric synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines, and their derivatives
August 2026
Spirocyclic tetrahydroquinolines (spiro-THQs) and tetrahydroisoquinolines (spiro-iTHQs), along with their derivatives, constitute a prominent class of natural products that exhibit a broad spectrum...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
October 2026
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Dichloromethane-promoted photo-induced aerobic oxidation of methylarenes
Available online 29 August 2026
We present a novel, efficient, and sustainable strategy for the aerobic oxidation of methylarenes to valuable carbonyl products using dichloromethane (DCM) as both solvent and promoter under photo-irradiation....
TBADT/nickel co-catalyzed three-component radical acylarylation of alkenes with aldehydes and aryl iodides
Available online 17 October 2025
Here we report a photo/nickel co-catalyzed three-component acylarylation of alkenes using aldehydes and aryl iodides. Tetrabutylammonium decatungstate (TBADT) serves as a hydrogen-atom-transfer (HAT)...
Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst
November 2025
We have developed a chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes. It offers several advantages, including the use of an environmentally friendly catalyst (5 mol%...
Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
Recent advances in C–B bond formation by borylation with NHC–boranes
Available online 25 September 2025
Organoboron compounds play a pivotal role in synthetic, pharmaceutical, and material chemistry due to their distinctive properties. Developing efficient, regioselective methods for C–B bond construction...
Recent advances in the electrochemical synthesis of oligosaccharides and glycosides
June 2026
Sugars are fundamental building blocks in biological molecules such as oligosaccharides, glycoproteins, and glycosylated natural products. The construction of glycosidic bonds in a diastereoselective...