Effect of esketamine on postoperative neuropathic pain and quality of recovery following debridement for diabetic foot ulcers: A randomized controlled dose-finding study
Available online 6 August 2026
To evaluate the dose-related effects of intraoperative sub-anesthetic esketamine on acute postoperative pain, neuropathic pain, and early quality of recovery in patients undergoing debridement for diabetic...
Computational insights into Anacardium occidentale bioactives targeting PBP2a in MRSA infections
Available online 5 August 2026
Antibiotic treatment is still difficult owing to the emergence of multidrug-resistant strains, namely Methicillin-Resistant Staphylococcus aureus (MRSA). Vancomycin/daptomycin-resistant enterococci...
A qualitative study on the implementation effect evaluation of group-based training in a specialized oncology medical alliance
Available online 5 August 2026
Specialized oncology medical alliances are crucial for optimizing medical resources in China, yet primary healthcare institutions face challenges in professional competence and training effectivene...
Integrated Computational Identification of Natural Product-Derived Candidates Targeting the Bicalutamide-Resistant W741L Androgen Receptor in Castration-Resistant Prostate Cancer
Available online 30 July 2026
Prostate cancer progression is critically dependent on androgen receptor (AR) signaling. The W741L substitution in the AR ligand-binding domain (AR-LBD), arising during bicalutamide treatment and converting...
Advancements in transdermal drug delivery using ionic liquids: Design strategies, functional roles, mechanisms, and future challenges
June 2026
One potential method for improving transdermal medication absorption is ionic liquids (ILs). However, further research is necessary to create effective ILs and clarify their methods of action because...
Reconstruction and optimization of the operational workflow model in an inpatient pharmacy before and after implementation of a wireless communication-based intelligent drug dispensing and traceability system
June 2026
This study aimed to assess workflow changes and identify optimization strategies following the implementation of a wireless communication-based intelligent drug dispensing and traceability system (IDDTS)...
Artificial intelligence in pharmaceutical administration and clinical pharmacy: A comprehensive review of advancements, challenges, and future directions
June 2026
The integration of artificial intelligence (AI) into healthcare is reshaping medical disciplines, with hospital pharmacy undergoing a significant paradigm shift from a labor-intensive model to an intelligence-driven...
Pediatric physiologically based pharmacokinetic models mediated by drug-metabolizing enzymes: Predictions, applications, and challenges
June 2026
Children, as a special population, exhibit significant age-specific characteristics and inter-individual variability in drug metabolism due to the influences of physiological development and genetic...
Mechanistic investigation of the Qizao Baoxin Formula in alleviating trastuzumab-induced cardiotoxicity via regulation of ferroptosis: A network pharmacology and molecular docking approach
June 2026
To investigate the active components and mechanisms of Qizao Baoxin Formula (QBF) in improving trastuzumab-induced cardiotoxicity (TIC) via ferroptosis regulation using network pharmacology and molecular...
Development and empirical validation of a competency-based evaluation index system for standardized residency training
June 2026
Standardized residency training (SRT) is a core component of postgraduate medical education, and its quality is closely linked to residents' clinical performance. Currently, research on residents' post...
Exploring the mechanism of action of Huoxue Quyu San hot package in intervening in sequelae of pelvic inflammatory disease based on network pharmacology and molecular docking
June 2026
To investigate the therapeutic mechanism of Huoxue Quyu San Reyan Bao in treating sequelae of pelvic inflammatory disease (SPID) using network pharmacology and molecular docking....
The association between circulating tumor DNA (ctDNA) and esophageal cancer prognosis: A systematic review and meta-analysis
Available online 26 June 2026
To summarize the current clinic evidence and quantify the association between the ctDNA detection at different timepoints and esophageal cancer (EC) prognostic outcomes....
Efficacy and safety of Aiyu capsules for chemotherapy-induced leukopenia in cancer patients: A multi-center parallel-group randomized controlled trial
Available online 28 May 2026
This study aimed to assess the efficacy and safety of Aiyu capsules, a traditional Chinese medicine (TCM) formulation, in preventing and treating chemotherapy-induced leukopenia, as well as to evaluate...
Efficacy of auricular acupressure on chemotherapy-induced nausea and vomiting in breast cancer patients: a systematic review and meta-analysis of randomized controlled trials
Available online 27 May 2026
Breast cancer (BC) constitutes a significant global health challenge. Chemotherapy-induced nausea and vomiting (CINV) severely impact patient quality of life. Current antiemetics, while providing some...
Clinical utility and readability of large language models’ responses to headache-related inquiries: A comparative evaluation with stratified application recommendations based on Chinese online health communities
Available online 14 May 2026
Headache disorders affect a large proportion of the global population, and Large Language Models (LLMs) show potential in the provision of online health information services, with their response accuracy...
Analysis of influencing factors on the steady-state concentration/dose ratio of vortioxetine based on therapeutic drug monitoring
Available online 11 May 2026
To investigate the influencing factors of the steady-state concentration/dose ratio (C/D) of vortioxetine and promote individualized and rational use of vortioxetine....
Implementation of intelligent pharmacy technologies in hospitals: a cross-sectional nationwide study
Available online 8 May 2026
Medication errors pose critical threat to patient safety. The implementation of intelligent pharmacy technologies demonstrate great potential to reduce medication risks. This study aimed to investigate...
Correlation study on serum TT3 and FT3 levels with disease severity in elderly tuberculosis patients — Exploration of the value of thyroxine level-guided Anti-TB individualized medication
April 2026
Tuberculosis (TB) remains a major global public health issue, with elderly patients (≥ 65 years) at higher risk of severe progression—driven by immune decline, polypharmacy, and impaired drug metabolism,...
Generative artificial intelligence in pharmaceutical drug development: A systematic review of time and cost efficiency across discovery, preclinical, and clinical phases
April 2026
The pharmaceutical drug development process is notoriously complex, lengthy, and costly, often requiring more than a decade and billions of dollars to bring a single compound to market. Generative artificial...
Artificial intelligence assisted design of nanomedicines for colorectal cancer diagnosis and therapy: Advances, challenges, and future directions
April 2026
Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide, with an increasing incidence in both high- and low-income countries. Despite advances in...
Exploration of the mechanism of “Psoralea corylifolia Linn.-Epimedium brevicornu Maxim.” herb pair in the treatment of liver cancer based on network pharmacology
April 2026
Liver cancer treatment remains challenging, and the anti-liver cancer mechanism of the “Psoralea corylifolia Linn.-Epimedium brevicornu Maxim.” herb pair is unclear. This study aims to elucidate its...
The risk of hyperammonemic encephalopathy on epilepsy and psychiatric patients: insight from FAERS data and published case reports
April 2026
Valproate-associated hyperammonemic encephalopathy (VHE) is a serious adverse event. However, its risk profiles and clinical features remain poorly characterized across different patient populations....
Construction and application of an intelligent pharmacy based on robotic-arm automatic dispensing machines and a pre-dispensing mode
April 2026
This study aimed to enhance pharmacy operational efficiency, reduce errors, and improve patient experience by constructing and evaluating an Intelligent Pharmacy system integrating robotic-arm automatic...
Real-world safety profile of Levofloxacin: Pharmacovigilance signals, co-medication patterns, and signal validation
Available online 15 April 2026
To characterize epidemiological features and co-medication patterns of Levofloxacin-associated adverse events (AEs) using spontaneous reports and cross-validate pharmacovigilance signals against the...
Artificial intelligence in predicting personalized nanocarrier formulations for herbal drugs: Bridging phytomedicine and precision nanotechnology
February 2026
Herbal drugs offer significant therapeutic benefits but face challenges such as poor bioavailability, low stability, and variable patient responses. Nanocarrier-based delivery systems can overcome these...