Stratification of cephalosporins based on physicochemical and pharmacokinetic variables using multivariate statistical tools
June 2025
Cephalosporins, a class of beta-lactam antibiotics, are commonly used in medical practice. However, their potential advantages, based on physicochemical and pharmacokinetic variables, are often overlooked....
International expert consensus on hospital intelligent pharmacy
Available online 18 June 2025
As the rapid advancements in medical technology and increasing demands for personalized medication, Hospital Intelligent Pharmacy (HIP) integrates artificial intelligence, large-scale health data analytics,...
Assessing variation among the drug-lists of 16 cities and impact on cardiovascular disease mortality: Evidence from Anhui
Available online 13 May 2025
This study compares the differences in city-level cardiovascular disease (CVD) drug-lists and investigates their relationship with CVD mortality rate across 16 cities in Anhui province, China....
Advancements in contemporary pharmacological innovation: Mechanistic insights and emerging trends in drug discovery and development
April 2025
Developing a new drug and bringing it to the market is a complex and time-consuming process that involves multiple phases of drug discovery and development. However, recent advancements in various technologies,...
Enhancing drug discovery with AI: Predictive modeling of pharmacokinetics using Graph Neural Networks and ensemble learning
April 2025
Accurately predicting pharmacokinetic (PK) parameters such as absorption, distribution, metabolism, and excretion (ADME) is essential for optimizing drug efficacy, safety, and development timelines....
Development and validation of a UPLC-HR-SIM method to quantify semaglutide for its pharmacokinetic study
April 2025
To develop a highly sensitive and interference-resistant ultra performance liquid chromatography (UPLC) coupled with high-resolution selected ion monitoring (HR-SIM) mass spectrometry method for the...
Evaluation of the hypoglycemic and hypotensive efficacy of sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes: A model-based dose–response network meta-analysis
April 2025
To study the dose effect relationship of sodium-glucose cotransporter-2 inhibitor (SGLT-2i) in reducing blood glucose and blood pressure in type 2 diabetes mellitus (T2DM)....
Phytochemical profiling, FT-IR spectroscopy, and antioxidant evaluation of select Lamiaceae species
April 2025
The present study aimed to conduct a preliminary phytochemical analysis of aqueous, ethanol, and hexane leaf extracts from Anisomeles malabarica (L.) R.Br. ex Sims, Leucas aspera (Willd.) Link., Ocimum...
Design, optimization, and characterization of Zolmitriptan loaded liposomal gels for intranasal delivery for acute migraine therapy
February 2025
Zolmitriptan is the primary drug for the treatment of Migraine. However, the bioavailability of the drug is low and requires repetitive administration leading to side effects. Zolmitriptan's bioavailability...
A critical review on zinc oxide nanoparticles: Synthesis, properties and biomedical applications
February 2025
ZnO-NPs is an inorganic metal oxide that meets as medicine, a preservative in packaging, as well as an antibacterial agent without risk. The qualities of ZnO-NPs are influenced by their size, shape,...
Optimization of microwave-assisted green synthesis of zinc oxide nanoparticles using Ocimum americanum and Euphorbia hirta extracts: In vitro evaluation of antioxidant, anti-inflammatory, antibacterial, cytotoxicity, and wound healing properties
February 2025
This investigation optimized the microwave-assisted green synthesis of zinc oxide nanoparticles utilizing Ocimum americanum and Euphorbia hirta extracts for enhanced wound healing applications. The...
Exploring nanoformulation drug delivery of herbal actives for enhanced therapeutic efficacy: A comprehensive review
February 2025
In this present review we have focused on nanoformulation drug delivery approach to deliver active drug constituents. As it can minimizes the limitations associated with conventional therapies such...
Formulation development and evaluation of floating microspheres of drotaverine hydrochloride as gastroretentive dosage form
February 2025
The aim of the current research work is to formulate and characterized the floating microspheres of drotaverine hydrochloride (DRH). DRH is an antispasmodic drug which has a short residence in the intestine...
Enhancing monoclonal antibodies with natural products: Mechanisms and applications
February 2025
Monoclonal antibodies (mAbs) have revolutionized therapeutic strategies across a broad spectrum of diseases, yet their efficacy remains constrained by challenges such as suboptimal tumor penetration...
AI-driven insights into the microbiota: Figuring out the mysterious world of the gut
February 2025
This review delves into the fascinating realm of microbial insights enabled by artificial intelligence (AI), unveiling the mysteries of the intricate gut environment. Research into the human microbiome...
Development, optimization, and in-vivo bioavailability study of erlotinib hydrochloride loaded microsponge for colon targeting
February 2025
The present investigation aimed to develop as well as optimize microsponge containing erlotinib hydrochloride (ETB) that was composed of ethyl cellulose (EC) and pectin. The water solubility and enzymatic...
Trends in research on AI-aided drug discovery from 2009 to 2023: A 15-year bibliometric analysis
February 2025
In recent years, the rapid advancement of artificial intelligence technology has brought opportunities for the acceleration and improvement of the drug discovery process by aiding in all stages of drug...
Artificial intelligence and internet influence on drug utilization: Exploring self-medication trends in South Indian pharmacy students
December 2024
Self-medication refers to usage of drugs by population to cure self-diagnosed medical illnesses or symptoms without seeking medical advice. AI has become the prevailing technology in recent times, experiencing...
