Nanoliposome as a carrier for topical delivery of oxymetazoline hydrochloride: In-vitro assessment and in-vivo anti-inflammatory potential
August 2025
The present investigation on nanoliposome infused with oxymetazoline hydrochloride was fabricated with phosphatidylcholine and cholesterol to effectively deliver the drug to the skin. Oxymetazoline...
Advancements in transdermal drug delivery systems: Enhancing medicine with pain-free and controlled drug release
August 2025
Transdermal Drug Delivery Systems (TDDSs) provide controlled and prolonged drug release, enhance patient compliance, reduce gastrointestinal side effects, and improve drug stability. By delivering medication...
Alkaloids unveiled: A comprehensive analysis of novel therapeutic properties, mechanisms, and plant-based innovations
August 2025
Alkaloids, naturally occurring compounds in a diverse range of plant species (Coffea spp., Erythroxylum coca, Cinchona spp. etc.), hold vast potential for biological, medicinal, and pharmacological...
Nanostructured lipid carriers as a drug delivery system: A comprehensive review with therapeutic applications
August 2025
Recent advances in nanotechnology have enabled significant developments in health through innovative drug delivery systems. Nanostructured lipid carriers (NLCs) have emerged as a key technology in this...
Artificial intelligence in predicting personalized nanocarrier formulations for herbal drugs: Bridging phytomedicine and precision nanotechnology
Available online 27 August 2025
Herbal drugs offer significant therapeutic benefits but face challenges such as poor bioavailability, low stability, and variable patient responses. Nanocarrier-based delivery systems can overcome these...
Machine learning & deep learning tools in pharmaceutical sciences: A comprehensive review
June 2025
Drug discovery and development is an important area of research for pharmaceutical industries and medicinal chemists. This classical approach demanded significant investments of time and resources to...
Harnessing the power of artificial intelligence in pharmaceuticals: Current trends and future prospects
June 2025
Introduction of artificial intelligence (AI) technology in the field of pharmaceutical industry has been driven to discovery and development of drugs, also personalized medicine. In this article The...
Development and evaluation of empagliflozin-loaded solid lipid nanoparticles: Pharmacokinetics and pharmacodynamics for oral delivery
June 2025
Type 2 diabetes mellitus is frequently treated with empagliflozin (EZN), a sodium-glucose cotransporter 2 inhibitor. Solid lipid nanoparticles (SLNs) shield the drug from gastrointestinal breakdown...
Artificial intelligence, computational tools and robotics for drug discovery, development, and delivery
June 2025
The integration of Artificial Intelligence (AI) and robotics into the pharmaceutical sector is rapidly transforming drug discovery, development, and delivery (D-DDD) processes. Traditional drug development...
Smart healthcare: Artificial intelligences impact on drug development and patient care
June 2025
The integration of artificial intelligence (AI) into healthcare has catalyzed significant advancements in drug development and patient care, revolutionizing traditional methodologies. This review explores...
Insulin delivery devices in diabetes management: Applications and advancements
June 2025
With continuous advancements in diabetes management technology, insulin delivery devices have become increasingly central to the treatment of diabetes. This review discusses the applications and development...
Stratification of cephalosporins based on physicochemical and pharmacokinetic variables using multivariate statistical tools
June 2025
Cephalosporins, a class of beta-lactam antibiotics, are commonly used in medical practice. However, their potential advantages, based on physicochemical and pharmacokinetic variables, are often overlooked....
Advancements in contemporary pharmacological innovation: Mechanistic insights and emerging trends in drug discovery and development
April 2025
Developing a new drug and bringing it to the market is a complex and time-consuming process that involves multiple phases of drug discovery and development. However, recent advancements in various technologies,...
Enhancing drug discovery with AI: Predictive modeling of pharmacokinetics using Graph Neural Networks and ensemble learning
April 2025
Accurately predicting pharmacokinetic (PK) parameters such as absorption, distribution, metabolism, and excretion (ADME) is essential for optimizing drug efficacy, safety, and development timelines....
Development and validation of a UPLC-HR-SIM method to quantify semaglutide for its pharmacokinetic study
April 2025
To develop a highly sensitive and interference-resistant ultra performance liquid chromatography (UPLC) coupled with high-resolution selected ion monitoring (HR-SIM) mass spectrometry method for the...
Evaluation of the hypoglycemic and hypotensive efficacy of sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes: A model-based dose–response network meta-analysis
April 2025
To study the dose effect relationship of sodium-glucose cotransporter-2 inhibitor (SGLT-2i) in reducing blood glucose and blood pressure in type 2 diabetes mellitus (T2DM)....
Phytochemical profiling, FT-IR spectroscopy, and antioxidant evaluation of select Lamiaceae species
April 2025
The present study aimed to conduct a preliminary phytochemical analysis of aqueous, ethanol, and hexane leaf extracts from Anisomeles malabarica (L.) R.Br. ex Sims, Leucas aspera (Willd.) Link., Ocimum...
Design, optimization, and characterization of Zolmitriptan loaded liposomal gels for intranasal delivery for acute migraine therapy
February 2025
Zolmitriptan is the primary drug for the treatment of Migraine. However, the bioavailability of the drug is low and requires repetitive administration leading to side effects. Zolmitriptan's bioavailability...