Unravelling the influenza virus inhibitory potential: Ligand-based docking, pharmacophore, MM-GBSA, and molecular dynamic simulation of phytochemicals and cyanobacteria metabolites
February 2024
Viral outbreaks facilitated by global travel and modernity pose significant threats to global health. Influenza viruses, particularly α-influenza and β-influenza strains, have been plaguing human populations...
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Co-Processed Excipients: Advances and Future Trends
February 2024
This review provides a concise overview of recent advances and future perspectives in co-processed excipients which is characterized by their synergistic combinations have become pivotal in pharmaceutical...
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Network pharmacology study of Seleromitrion diffusa (Willd). R. J. Wang and Scutellaria barbata D. Don in the treatment of chronic atrophic gastritis
February 2024
The study aimed to investigate Scutellaria barbata D. Don and Seleromitrion diffusa (Willd). R. J. Wang (HDSB) in the treatment of chronic atrophic gastritis (CAG) by using network pharmacology and...
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Chronomodulated drug delivery: Challenges, benefits, and future directions in asthma treatment
February 2024
This review discusses the challenges in drug delivery and the potential benefits of Chronomodulated drug delivery for antiasthmatic drugs. It explores new drugs, personalized medicine approaches, and...
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Synergistic effects of Woodfordia fruticosa silver nanoparticles accelerating wound healing in Swiss mice in vivo
February 2024
Silver nanoparticles (AgNPs) have gained significant attention in recent years due to their unique physicochemical properties and potential applications in various fields, including medicine, catalysis,...
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Quality by design- newer technique for pharmaceutical product development
February 2024
Regulatory bodies are nowadays concerned with pharmaceutical drug products' safety, efficacy, and quality. Quality is the priority of all regulatory bodies, it is a high priority for the triple P factor...
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Targeting SARS-CoV-2 main protease (Mpro) and human ACE-2: A virtual screening of carotenoids and polyphenols from tomato (Solanum lycopersicum L.) to combat Covid-19
February 2024
Human angiotensin-converting enzyme-2 (ACE-2) and severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) main protease (Mpro) have been established as the prime targets to restrict viral invasion...
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Synthesis of 1,3-substituted 1H-indazole derivatives and evaluation of anti-inflammatory activity in Sprague Dawley rats
February 2024
Indazole is a very significant group of heterocyclics. Aim of the research was thus planned to synthesize novel derivatives of indazole and evaluate their anti-inflammatory activity. Novel compounds...
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Aceclofenac loaded microspheres: Formulation and evaluation of novel preprogrammed drug delivery for the treatment of arthritis
February 2024
Arthritis is a widespread joint disorder globally, the patient completely dependent on NSAIDs which are administered after a fixed interval to subside the pain. This work aims to establish a preprogrammed...
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Metaphorical investigation of aqueous distillate of Cichorium intybus, Foeniculum vulgare and Solanum nigrum along with atorvastatin and orlistat in experimental rodent models of dyslipidaemia and obesity
February 2024
Arq is a traditional Unani liquid formulation. In this study we explored Arq-Makoh, Arq-Badiyan and Arq-Kasni for their pharmacological potential to alleviate the symptoms of hyperlipidaemia and obesity...
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Synthesis and evaluation of antibacterial activity of novel 3-methyl-1H-indazole derivatives
February 2024
Aim of the study was designed to synthesize and evaluate antibacterial activity of novel heterocyclic compounds, 3-methyl-1H-indazole derivatives. The heterocyclic compounds, 3-methyl-1H-indazole derivatives...
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An aqueous extract of Syzygium cumini bark reduces the rate of preterm birth in rats
February 2024
Preterm delivery is a considerable burden on prenatal healthcare and a major risk factor for neurological impairment and disability. A study looked at whether an aqueous extract of Syzygium cumini (AESC)...
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Cyanobacterial metabolites as novel inhibitors of BACE1 implicated in Alzheimer's disease through in silico approaches
February 2024
Alzheimer's disease (AD) is a complex neurodegenerative disease with a limited number of therapeutic options. β-Secretase 1 (BACE1) is a key enzyme involved in the production of amyloid beta peptides,...
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Optimization and characterization of xanthan gum based multiparticulate formulation for colon targeting
Available online 28 February 2024
To optimize and characterize xanthan gum multi-particulate formulation for colon targeting, which increases the residence time at the absorbing surface of the colon. Xanthan gum was dispersed in cold...
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A study on fused deposition modeling (FDM) and laser-based additive manufacturing (LBAM) in the medical field
Available online 28 February 2024
Fused deposition modelling (FDM) and laser-based additive manufacturing (LBAM) are the essential technologies of 3D Printing under the technological platform of additive manufacturing (AM). This process...
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Revolutionizing drug discovery: The impact of artificial intelligence on advancements in pharmacology and the pharmaceutical industry
Available online 24 February 2024
To create novel treatments and treat complex diseases, the pharmaceutical sector is essential. Drug discovery, however, is a time-consuming, pricey, and dangerous endeavor. Artificial intelligence (AI)...
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Evaluation of novel Anti-SARS-CoV-2 compounds by targeting nucleoprotein and envelope protein through homology modeling, docking simulations, ADMET, and molecular dynamic simulations with the MM/GBSA calculation
Available online 21 February 2024
The current prominent virus that induces severe acute respiratory syndrome is SARS-CoV-2. The incidence of COVID-19 cases is increasing, necessitating the immediate development of effective treatments....
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Computational studies demonstrating dithymoquinone of Nigella sativa as a potential anti-dengue agent: Short review
Available online 20 February 2024
Dengue is acute tropical infectious illness, which is spread by mosquitoes, has presented a significant threat to public health worldwide. Unfortunately, there are no drugs that have been clinically...
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AI in Indian healthcare: From roadmap to reality
Available online 19 February 2024
India's vast and diverse population strains its healthcare system. Amidst these complexities, Artificial Intelligence (AI) emerges as a beacon of hope. This transformative technology promises to revolutionize...
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Extracellular vesicles: The future of therapeutics and drug delivery systems
Available online 15 February 2024
Extracellular vesicles (EVs) are nanometric size, a cell-derived drug delivery carrier composed of membrane-bound structures, release into the cellular medium and found in body fluids. EVs serve a dual...
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Recent advances in anticancer approach of traditional medicinal plants: A novel strategy for cancer chemotherapy
Available online 15 February 2024
Cancer is the second leading cause of death worldwide. Although great advancements have been made in the treatment and control of cancer progression, significant deficiencies and room for improvement...
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Combat against antibiotic resistance is a challenge in Bangladesh
Available online 14 February 2024
To the Editor, Antibiotics are a class of drug used to treat or prevent infections caused by bacteria; they function by either eradicating the organism or stopping its growth. Penicillin, cephalosporins,...
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Realizing the potential of AI in pharmacy practice: Barriers and pathways to adoption
Available online 14 February 2024
Artificial intelligence (AI) has immense potential to revolutionize pharmacy operations by simplifying procedures, improving efficiency, and expediting pharmaceutical research. Nevertheless, obstacles...
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