Optimization of Microwave-Assisted Green Synthesis of Zinc oxide nanoparticles Using Ocimum americanum and Euphorbia hirta Extracts: In Vitro Evaluation of Antioxidant, Anti-inflammatory, Antibacterial, Cytotoxicity, and Wound Healing Properties
Available online 11 September 2024
This investigation optimized the microwave-assisted green synthesis of zinc oxide nanoparticles utilizing Ocimum americanum and Euphorbia hirta extracts for enhanced wound healing applications. The...
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Enhancing Monoclonal Antibodies with Natural Products: Mechanisms and Applications
Available online 5 September 2024
Monoclonal antibodies (mAbs) have revolutionized therapeutic strategies across a broad spectrum of diseases, yet their efficacy remains constrained by challenges such as suboptimal tumor penetration...
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Trends in Research on AI-aided drug discovery from 2009 to 2023: a 15-year Bibliometric Analysis
Available online 4 September 2024
In recent years, the rapid advancement of artificial intelligence technology has brought opportunities for the acceleration and improvement of the drug discovery process by aiding in all stages of drug...
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The fermented milk can be a natural ally against obesity? Investigation of bovine milk fermentation by Lacticaseibacillus casei LBC 237, screening, and In silico predictions of bioactive peptides for obesity control
August 2024
The increasing quest for therapeutic alternatives in treating non-communicable chronic diseases like obesity has propelled research into bioactive peptides, with a particular focus on milk due to its...
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Bioactive peptides derived from the enzymatic hydrolysis of cowhide collagen for the potential treatment of atherosclerosis: A computational approach
August 2024
Cowhide collagen hydrolysates (CCHs) are peptides and amino acids obtained from the partial hydrolysis of collagen. These have numerous potential applications in the food, biomedical, and pharmaceutical...
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Association of immunomodulatory therapies with COVID-19 mortality in rheumatoid arthritis: An analysis of the FDA adverse event reporting system
August 2024
The COVID-19 pandemic significantly affects patients with RA and other rheumatic diseases. Our study aims to explore the factors associated with COVID-19-related fatality among Rheumatoid Arthritis...
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Rosmarinic acid: Potential antiviral agent against dengue virus - In silico evaluation
August 2024
A number of dengue viruses can seriously impact public health, and their spread has long been a concern. The development and administration of antiviral drugs have played a crucial role in combating...
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Unveiling the intricacies of phytate antinutrients in millets and their therapeutic implications in breast cancer
August 2024
Breast cancer remains a significant global health concern, necessitating the exploration of novel preventive and therapeutic strategies. Dietary interventions have gained substantial attention due to...
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QSAR application of natural therapeutics inhibitors against Alzheimer's disease through in-silico virtual-screening, docking-simulation, molecular dynamics, and pharmacokinetic prediction analysis
August 2024
Alzheimer's disease (AD) is a brain disorder that is known to be one of the deadliest diseases affecting humanity, especially adults from the age of sixty (60) years and above. It mostly affects thinking...
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Telmisartan-loaded liposomes: An innovative weapon against breast cancer
August 2024
This study focuses on the development of a liposomal preparation for the targeted delivery of Telmisartan in the context of breast cancer treatment. Telmisartan, a pharmaceutical agent with potential...
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The importance of in-silico studies in drug discovery
August 2024
The use of in-silico research in drug development is growing. Aspects of drug discovery and development, such as virtual ligand screening and profiling, target and lead finding, and compound library...
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Nutritional composition, antioxidant properties, and molecular docking strategy of muricidae operculum (Chicoreus ramosus)
August 2024
The murrcidae gastropod operculum has many therapeutic uses in ayurveda, including treating cancer, gastric, hepatic, cardiovascular, and immunological disorders. Antibacterial, cell reinforcement,...
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Acalypha wilkesiana L - A potential anti-stearoyl-CoA desaturase agent: Insilico and network pharmacology studies
August 2024
The activity of Seborrheic dermatitis on the skin of children still remains of the dermatoses of male and female babies in the early days of their existence. Acalypha wilkesiana L have been employed...
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Advancing oral drug delivery: The science of fast dissolving tablets (FDTs)
August 2024
The field of oral drug delivery has witnessed significant advancements, with a focus on developing innovative formulations to address challenges associated with traditional dosage forms, especially...
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Antimicrobial screening and molecular docking of synthesized 4,6-di(1H-indol-3-yl)-1,6-dihydropyrimidin-2-amine
August 2024
A variety of medicinal compounds, including 4,6-di(1H-indol-3-yl)-1,6-dihydropyrimidin-2-amine, were synthesized through a single-step, multicomponent, stepwise reaction. In this reaction, a mixture...
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In-silico design of novel 2-((4-chloro-6-methoxy-1H-indol-3-yl)thio)-N-(2-ethoxyphenyl)acetamide derivatives as potential inhibitors of influenza neuraminidase protein receptor
August 2024
Influenza virus transmission is largely mediated by its mutation and genome reassortment from distinct strains resulting in drug-resistances and pandemics. This necessitates the need for the discovery...
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In-silico screening and ADMET evaluation of therapeutic MAO-B inhibitors against Parkinson disease
August 2024
MAOs are flavoenzymes that aid in the oxidative deamination of neurotransmitters such as dopamine, serotonin, and epinephrine. MAO inhibitors are antidepressants that act by inhibiting neurotransmitter...
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A critical review on zinc oxide nanoparticles: Synthesis, properties and biomedical applications
Available online 22 August 2024
ZnO-NPs is an inorganic metal oxide that meets as medicine, a preservative in packaging, as well as an antibacterial agent without risk. The qualities of ZnO-NPs are influenced by their size, shape,...
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AI's role in revolutionizing personalized medicine by reshaping pharmacogenomics and drug therapy
Available online 20 August 2024
This paper examines the transformative impact of artificial intelligence (AI) on pharmacogenomics, signaling a paradigm shift in personalized medicine. With a focus on enhancing drug response prediction...
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AI-driven insights into the microbiota: figuring out the mysterious world of the gut
Available online 19 August 2024
This review delves into the fascinating realm of microbial insights enabled by artificial intelligence (AI), unveiling the mysteries of the intricate gut environment. Research into the human microbiome...
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“Formulation Development and Evaluation of Floating Microspheres of Drotaverine Hydrochloride as Gastroretentive Dosage Form”.
Available online 14 August 2024
The aim of the current research work is to formulate and characterized the floating microspheres of drotaverine hydrochloride. DRH is an antispasmodic drug which has a short residence in the intestine...
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A systematic review on the effectiveness of Zingiber officinale in reducing dental caries
Available online 5 August 2024
According to the Global Burden of Disease Study and the World Health Organization, dental caries is one of the most prevalent oral diseases globally. It is well known that dental caries are associated...
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Comprehensive evaluation of PD-1 inhibitors marketed in China based on a Quick Guideline for drug evaluation and selection in Chinese Medical Institutions (second edition)
Available online 5 August 2024
To conduct a comprehensive evaluation of PD-1 inhibitors for the treatment of advanced non-small cell lung cancer on the market in China, using A Quick Guideline for Drug Evaluation and Selection in...
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Exploring nanoformulation drug delivery of herbal actives for enhanced therapeutic efficacy: A comprehensive review
Available online 18 July 2024
In this present review we have focused on nanoformulation drug delivery approach to deliver active drug constituents. As it can minimizes the limitations associated with conventional therapies such...
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Design, Optimization, and Characterization of Zolmitriptan Loaded Liposomal Gels for Intranasal delivery for acute migraine therapy
Available online 8 July 2024
Zolmitriptan is the primary drug for the treatment of Migraine. However, the bioavailability of the drug is low and requires repetitive administration leading to side effects. Zolmitriptan's bioavailability...
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